Advanced Kev Kho Mob Cancer Mis thiab Kev Tshawb Fawb: Dab tsi nyob ntawm qab ntug?

Zoo Siab

• Cov hom phiaj kho
• Cov tshuaj muaj yees nyob rau qab ntug
• Cov tshuaj tiv thaiv angiogenesis
• Cov tshuaj biosimilar
• Kev Txhaj Tshuaj Tiv Thaiv
• PI3 kinase inhibitors
• Txhim kho kev twv ua ntej thiab saib xyuas
• Muab kev koom tes hauv kev kuaj mob

Kev kho tus mob cancer mis feem ntau tuaj yeem kho tau, tab sis feem ntau nws tuaj yeem kho tsis tau. Tamsim no, cov hom phiaj ntawm kev kho mob suav nrog txo koj tus mob, txhim kho koj lub neej kom zoo, thiab ua kom koj lub neej muaj sia ntev dua.

Kev kho mob feem ntau suav nrog kev kho cov tshuaj hormones, kev kho tshuaj, kev kho mob rau lub hom phiaj, lossis kev sib txuas nrog cov no.

Nov yog qee qhov kev kho mob tam sim no thiab tom ntej uas koj tuaj yeem xav hnov ​​txog yog tias koj tau txais kev kuaj mob cancer mis ntau tshaj.

Cov hom phiaj kho

Cov kws tshawb nrhiav tau tsim kho ntau yam tshuaj tshiab tshiab uas lub hom phiaj hloov pauv ntawm tes. Cov kev pauv no ua rau cov kab mob cancer sai thiab loj hlob tuaj. Qhov no txawv dua li kev siv tshuaj kho mob, uas lub hom phiaj txhua lub hlwb loj hlob sai, suav nrog cov qog nqaij hlav cancer thiab cov qe noj qab nyob zoo.

Ntau ntawm cov tshuaj tsom no tau txais kev pom zoo los kho tus mob cancer mis. Lwm qhov yog raug kawm hauv kev sim tshuaj, thiab ntau yam ntxiv muaj nyob hauv kev kuaj ntsuas.

Qee cov piv txwv ntawm cov hom phiaj kho muaj xws li:

• Lapatinib (Tykerb). Cov tshuaj no yog tyrosine kinase inhibitor. Nws ua haujlwm los ntawm thaiv cov hlab enzymes uas pab txhawb kev loj hlob ntawm tes. Nws muaj raws li cov ntsiav tshuaj koj noj txhua hnub los kho tus mob cancer mis. Nws tuaj yeem ua ke nrog qee cov tshuaj kho mob lossis tshuaj kho hormonal.
• Neratinib (Nerlynx). Cov tshuaj no tau txais kev pom zoo los kho HER2-zoo mob cancer mis thaum ntxov. Qee qhov kev tshawb fawb qhia tau tias nws yuav ua haujlwm zoo rau kev kho cov neeg mob qog mis mob cancer mis thiab.
• Olaparib (Lynparza). Qhov kev kho no yog kev pom zoo rau HER2-tsis zoo metastatic mob cancer ntawm lub mis rau cov neeg uas muaj BRCA hloov pauv noob. Nws muaj muaj raws li cov ntsiav tshuaj txhua hnub.

Cov tshuaj CDK4 / 6 inhibitors yog lwm chav qhia kev siv tshuaj kho mob. Cov tshuaj no thaiv qee cov protein ua kom cov cell mob qog noj ntshav. Abemaciclib (Verzenio), palbociclib (Ibrance), thiab ribociclib (Kisqali) yog CDK4 / 6 inhibitors uas tau pom zoo los ntawm Food and Drug Administration (FDA) rau kev kho mob cancer mis. Lawv tau siv los ua ke nrog kev kho tshuaj kho mob los kho HR-zoo thiab HER2-tsis zoo metastatic mis mob qog noj haus.

Cov tshuaj muaj yees nyob rau qab ntug

Muaj ntau txoj kev kho mob los kho tus mob cancer mis, tab sis kev tshawb fawb tseem tab tom tshawb nrhiav kom paub ntau ntxiv txog cov qog hlwb mob cancer no thiab kev hloov pauv mus los li cas. Hauv qab no yog qee qhov kev kho mob tseem tau tshawb fawb.

Cov tshuaj tiv thaiv angiogenesis

Angiogenesis yog txheej txheem uas tsim cov hlab ntsha tshiab. Cov tshuaj tiv thaiv angiogenesis yog tsim los txiav tawm cov ntshav rau cov hlab ntsha. Qhov no ua tsis tau cov kab mob cancer ntshav ntawm cov ntshav uas xav tau kom loj tuaj.

Cov tshuaj tiv thaiv angiogenesis tshuaj bevacizumab (Avastin) yog tam sim no FDA pom zoo los kho lwm cov qog nqaij hlav. Cov tshuaj no tau qhia qee qhov kev ua tau zoo rau cov poj niam uas muaj mob cancer mis, tab sis FDA tau thim kev pom zoo rau qhov kev siv ntawd xyoo 2011. Bevacizumab thiab lwm yam tshuaj tiv thaiv angiogenesis tseem tab tom tshawb fawb txog kev kho mob cancer mis mis.

Cov tshuaj biosimilar

Cov tshuaj biosimilar zoo li cov tshuaj lag luam muaj npe, tab sis yuav raug nqi tsawg dua. Lawv yog cov kev xaiv kho tau.

Peb kawm txog ntau cov tshuaj biosimilar rau mob qog noj ntshav mis. Daim biosimilar ntawm trastuzumab (Herceptin), tshuaj kho mob, yog tib qho kev pom zoo rau kev kho mob HER2-zoo metastatic mis mob cancer. Nws tau hu ua trastuzumab-dkst (Ogivri).

Kev Txhaj Tshuaj Tiv Thaiv

Kev txhaj tshuaj tiv thaiv kab mob yog ib txoj kev kho mob uas pab lub cev tiv thaiv kab mob hauv lub cev kom tua cov qog noj ntshav.

Ib chav kawm tshuaj tiv thaiv kab mob yog PD1 / PD-L1 inhibitors. Pembrolizumab (Keytruda) tau txais kev pom zoo los kho mob qog nqaij hlav cancer. Nws tab tom soj ntsuam sim kho nws cov hauj lwm zoo rau cov neeg mob uas muaj mob cancer mis ob npaug.

PI3 kinase inhibitors

Tus PIK3CA cov gene pab tswj PI3 kinase, cov enzyme uas ua rau cov qog hlav loj tuaj. PI3 kinase inhibitors yog qhov tsim los cuam tshuam thiab nres qhov kev loj hlob ntawm P13 enzyme. Cov no tau raug kawm los kho mob cancer mis mob ntau yam.

Txhim kho kev twv ua ntej thiab saib xyuas

Hmoov tsis zoo, tib neeg kuj tuaj yeem tsim kho qee yam kev kho mob cancer. Qhov no ua rau cov kev kho mob tsis ua hauj lwm zoo. Cov kws tshawb nrhiav tau tsim dua txoj hauv kev tshiab los soj ntsuam seb cov neeg mob teb rau kev kho mob li cas.

Kev soj ntsuam ntawm kev nthuav tawm lub qog DNA (tseem hu ua kua los kuaj) yog tau kawm raws li txoj kev qhia kev kho. Cov kws tshawb nrhiav tseem tabtom txiav txim siab seb qhov kev sim no puas muaj txiaj ntsig zoo rau kev saib xyuas cov neeg mob qog mis mob cancer mis thiab kev twv seb lawv yuav teb licas rau kev khomob.

Muab kev koom tes hauv kev kuaj mob

Kev koom nrog kev sim kho mob tuaj yeem pab tshawb xyuas qhov tseeb yog qhov kev kho tshiab yuav ua haujlwm. Yog hais tias koj xav nyob rau hauv koom ib qho, qhov pib zoo yog ClinicalTrials.gov, cov ntaub ntawv tshawb fawb txog kev tshawb nrhiav tam sim no nrhiav thoob ntiaj teb. Kuj kuaj xyuas cov thawj kauj ruam xws li Metastatic Cancer Cancer Project. Lub vev xaib is taws nem no sib txuas cov neeg uas tau mob cancer mis nrog cov kws tshawb fawb uas tau siv thev naus laus zis los kawm qhov ua rau muaj mob qog noj ntshav.

Tham nrog koj tus kws kho mob saib seb puas koom nrog kev sim kho mob rau koj.Lawv yuav pab koj txiav txim siab yog tias koj tsim nyog thiab pab koj teev npe.