Tisagenlecleucel Txhaj

Zoo Siab

• Ua ntej yuav tau txais tisagenlecleucel txhaj,
• Kev txhaj tshuaj Tisagenlecleucel tuaj yeem tshwm sim phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

Kev txhaj tshuaj Tisagenlecleucel tuaj yeem ua rau mob hnyav lossis tuag taus uas yog hu ua cytokine release syndrome (CRS). Tus kws kho mob lossis tus nais maum yuav saib xyuas koj kom zoo thaum lub sijhawm koj nqus dej thiab tsawg kawg 4 lub lis piam tom qab. Qhia koj tus kws kho mob yog tias koj muaj mob voos los sis yog tias koj muaj lossis xav tias koj muaj qee yam mob tam sim no. Koj yuav tau muab tshuaj rau 30 mus rau 60 feeb ua ntej koj txoj kev tawm tsam los pab tiv thaiv kev tsis haum rau tisagenlecleucel. Yog tias koj pom cov tsos mob hauv qab no thaum lub sijhawm thiab tom qab koj nqus dej, qhia koj tus kws kho mob tam sim ntawd: kub taub hau, ua daus no, tshee tshee, hnoos, tsis qab los noj, raws plab, mob nqaij lossis mob pob txha, nkees, nyuaj ua pa, ua tsis taus pa, tsis meej pem, xeev siab. , ntuav, kiv taub hau, lossis tsaus muag.

Kev txhaj koob tshuaj Tisagenlecleucel tuaj yeem ua rau mob hnyav los yog tuag taus rau lub cev. Yog tias koj muaj cov tsos mob li hais hauv qab no, qhia rau koj tus kws kho mob tam sim ntawd: mob taub hau, nyob tsis tswm, ntxhov siab, ntxhov siab, pw tsis tsaug zog lossis pw tsaug zog, tswj tsis tau qee qhov ntawm lub cev, tsis nco qab, tsis meej pem, ntxhov siab, qaug dab peg, mob lossis loog hauv ib sab caj npab lossis txhais ceg, poob ntawm kev tshuav, tsis nkag siab, lossis nyuaj hais lus.

Tisagenlecleucel kev txhaj tshuaj tsuas yog muaj los ntawm cov kev txwv tshwj xeeb txwv txoj kev pabcuam. Ib qhov kev pab hu ua Kymriah REMS (Qhov Kev Ntsuam Xyuas Kev Phom Sij thiab Kev Tawm Tsam Nyuaj Siab) tau teeb tsa vim tias muaj kev pheej hmoo ntawm CRS thiab neurological lom. Koj tsuas tau txais cov tshuaj los ntawm kws kho mob thiab chaw kho mob uas koom nrog txoj haujlwm.Nug koj tus kws kho mob yog tias koj muaj lus nug dab tsi txog txoj haujlwm no.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (Kev Siv Tshuaj Kho Mob) thaum koj pib kho nrog tisagenlecleucel. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Kev txhaj tshuaj Tisagenlecleucel yog siv los kho qee tus mob lymphoblastic leukemia (Txhua yam; tseem hu ua mob lymphoblastic leukemia thiab mob lymphatic leukemia; ib hom mob cancer uas pib hauv cov ntshav dawb) hauv cov neeg 25 xyoo rov hauv los sis hluas dua uas tau rov qab los lwm yam kev kho mob (s). Nws kuj tseem siv los kho qee yam mob uas tsis yog Hodgkin's lymphoma (hom mob cancer uas pib ntawm cov qe ntshav dawb uas feem ntau sib ntaus sib tua) hauv cov neeg laus uas tau rov qab los yog tsis lees paub tom qab kho nrog tsawg kawg yog ob yam tshuaj ntxiv. Tisagenlecleucel txhaj yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua autologous cellular immunotherapy, ib hom tshuaj uas tau npaj siv cov hlwb los ntawm tus neeg mob cov ntshav. Nws ua haujlwm los ntawm kev ua rau lub cev tiv thaiv kab mob (ib pawg ntawm cov hlwb, cov nqaij thiab lub cev uas tiv thaiv lub cev los ntawm kev tua los ntawm cov kab mob, kab mob, mob hlwb, thiab lwm yam khoom uas ua rau muaj kabmob) los tua cov qog nqaij hlav cancer.

Tus kws kho mob lossis tus nais maum hauv kws kho mob lub chaw ua haujlwm lossis lub chaw nqus ntshav tau muab qhov tshuaj txhaj Tisagenlecleucel los tso tawm (ua kua) txhawm rau txhaj tshuaj rau hauv ntshav (los ntshav). Nws ib txwm muab rau ncua sijhawm li 60 feeb raws li kev noj ib zaug. Ua ntej koj tau txais koj cov tshuaj tisagenlecleucel, koj tus kws kho mob lossis tus nais maum yuav muab lwm cov tshuaj kho mob los kho koj lub cev rau tisagenlecleucel.

Txog li 3 rau 4 lub lis piam ua ntej koj txoj kev txhaj tshuaj tisagenlecleucel yuav tsum tau txhaj, ib qhov piv txwv ntawm koj cov qe ntshav dawb yuav raug coj los ntawm lub chaw tso ntshav ntawm tes uas siv cov txheej txheem hu ua leukapheresis (txheej txheem uas tshem cov qe ntshav dawb hauv lub cev). Tus txheej txheem no yuav siv li 3 mus rau 6 teev thiab tej zaum yuav tsum tau ua dua. Vim tias cov tshuaj no yog tsim los ntawm koj tus kheej lub hlwb, nws yuav tsum tau muab rau koj nkaus xwb. Nws yog ib qho tseem ceeb yuav tsum tuaj kom ncav sij hawm thiab kom tsis txhob ncua koj lub sijhawm teem mus kuaj ntawm tes lossis kom tau txais qhov tshuaj kho koj. Koj yuav tsum npaj kom nyob tsis pub dhau 2 teev ntawm qhov chaw uas koj tau txais koj cov kev kho tis tislecleucel tsawg kawg 4 lub lis piam tom qab koj tau noj tshuaj. Koj tus neeg saib xyuas kev noj qab haus huv yuav tshuaj xyuas seb koj txoj kev khomob puas ua haujlwm thiab saib xyuas koj rau cov kev phiv uas tuaj yeem tshwm sim. Tham nrog koj tus kws kho mob txog kev npaj rau leukapheresis thiab dab tsi yuav tshwm sim thaum thiab tom qab ua txoj kev.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej yuav tau txais tisagenlecleucel txhaj,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau tisagenlecleucel, lwm yam tshuaj noj, dimethyl sulfoxide (DMSO), dextran 40, lossis lwm yam tshuaj hauv tisagenlecleucel txhaj. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: cov tshuaj steroids xws li dexamethasone, methylprednisolone (Medrol), prednisolone, thiab prednisone (Rayos). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia rau koj tus kws kho mob yog tias koj tau muaj kev tawm tsam dua los ntawm kev kho cov tshuaj kho mob yav dhau los xws li teeb meem ua pa lossis plawv dhia tsis xwm yeem. Thiab, qhia koj tus kws kho mob yog tias koj tau lossis muaj mob ntsws, raum, mob plawv, lossis mob siab.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum muaj kev ntsuas cev xeeb tub ua ntej koj pib kev kho tisagenlecleucel. Yog tias koj xeeb tub thaum tau txais kev txhaj tshuaj tisagenlecleucel, hu rau koj tus kws kho mob tam sim ntawd. Kev txhaj tshuaj Tisagenlecleucel tuaj yeem ua rau muaj kev phom sij ntawm menyuam hauv plab.
• koj yuav tsum paub tias kev txhaj tshuaj tisagenlecleucel tuaj yeem ua rau koj nkees nkees thiab ua rau feeb tsis meej, tsis muaj zog, kiv taub hau, thiab qaug dab peg. Tsis txhob tsav tsheb los yog tsav lub tshuab ua haujlwm tsawg kawg yog 8 lub lis piam tom qab koj cov tisagenlecleucel koob tshuaj.
• tsis txhob tso cov ntshav, plab hnyuv siab raum, ntaub so ntswg, lossis lub hlwb rau kev hloov ntshav tom qab koj tau txais tisagenlecleucel kev txhaj tshuaj.
• Nug koj tus kws kho mob seb koj puas yuav tsum tau txhaj tshuaj tiv thaiv kab mob. Tsis muaj kev txhaj tshuaj yam tsis tau tham nrog koj tus kws kho mob tsawg kawg 2 lub lis piam ua ntej pib siv tshuaj, thaum kho koj tus kab mob tislelecleucel, thiab txog thaum koj tus kws kho mob qhia koj tias koj lub cev tau rov qab zoo dua.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Yog tias koj tsis tau mus ntsib raws li tau teem tseg, koj yuav tsum hu rau koj tus kws kho mob thiab lub chaw khaws khoom sai sai. Yog tias koj plam lub sijhawm teem sijhawm kom tau txais koj cov tshuaj tisagenlecleucel, koj yuav tsum hu rau koj tus kws kho mob tam sim ntawd.

Kev txhaj tshuaj Tisagenlecleucel tuaj yeem tshwm sim phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• cem quav
• mob plab
• rov qab mob

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

• ntshav txawv lossis doog ntshav
• ntshav hauv zis
• tsis tso zis ntau zaus lossis ntau npaum li cas
• o ntawm lub qhov muag, ntsej muag, daim di ncauj, tus nplaig, caj pas, caj npab, tes, taw, pob taws, lossis ceg qis
• teeb meem nqos
• ua pob
• khaus
• khaus

Kev txhaj tshuaj Tisagenlecleucel yuav ua rau koj muaj feem mob qog nqaij hlav cancer. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev tau txais cov tshuaj no.

Kev txhaj tshuaj Tisagenlecleucel tuaj yeem ua rau muaj kev phiv ntxiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum tau txais cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws tag nrho cov kev teem caij ntsib nrog koj tus kws kho mob, chav tsev khaws cia ntawm tes, thiab chaw kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim ua ntej, thaum, thiab tom qab koj txoj kev kho mob kuaj koj lub cev teb rau tisagenlecleucel txhaj.

Ua ntej muaj kev sim ntsuas, qhia koj tus kws kho mob thiab cov neeg ua haujlwm hauv chaw kuaj mob tias koj tau txais cov tshuaj tisagenlecleucel. Cov tshuaj no yuav cuam tshuam rau qee yam kev sim hauv tsev sim.

Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev txhaj tshuaj tisagenlecleucel.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Kymriah^®