Theem 4 Renal Cell Carcinoma: Metastasis, Cov Nqi Ciaj sia, thiab Kho

Zoo Siab

• Mob raum cell yog dab tsi?
• Nws kis tau licas?
• TNM tawv qog thiab theem ntawm mob raum
• Qhov tshwm sim yog dab tsi?
• Cov kev kho mob yog dab tsi?
• Cov nqa mus

Mob raum cell yog dab tsi?

Mob raum cell carcinoma (RCC), tseem hu ua mob raum cell los yog mob raum cell adenocarcinoma, yog ib hom mob khees xaws rau lub raum. Mob raum cell carcinomas muaj txog li 90 feem pua ​​ntawm tag nrho cov mob qog nqaij hlav hauv lub raum.

RCC feem ntau pib ua cov nqaij hlav loj hlob hauv ib qho ntawm koj ob lub raum. Nws kuj tuaj yeem loj hlob hauv ob lub raum.Tus kab mob yog tshwm sim rau tus txiv neej ntau dua li tus poj niam.

Nws kis tau licas?

Yog tias lub qog nqaij hlav nyob hauv ib qho ntawm koj ob lub raum, cov kev kho mob ib txwm yog mus phais tawm ib feem lossis tag nrho cov raum uas muaj feem.

Yog tias cov qog ntshav tsis raug tshem tawm, feem ntau nws yuav mob qog nqaij hlav yuav kis tau rau koj cov qog lossis lwm yam hauv nrog cev. Kev sib kis mob cancer yog hu ua metastasis.

Hauv RCC, lub qog yuav loj tuaj yeem ua rau txoj hlab ntshav loj tuaj tawm ntawm lub raum. Nws kuj tseem kis tau mus rau cov lymph system thiab lwm yam kabmob. Lub siab lub ntsws yog qhov tshwj xeeb tshaj yog.

TNM tawv qog thiab theem ntawm mob raum

Kab mob hauv lub raum tau piav qhia nyob rau hauv cov theem uas Pab Pawg Asmeskas Kev Sib Koom Tes Kho Mob Cancer. Lub kaw lus zoo dua hu ua TNM system.

• “T” hais txog cov qog. Cov kws kho mob tso npe "T" nrog tus lej uas yog nce raws qhov loj me thiab kev loj hlob ntawm cov qog.
• “N” piav qhia seb tus mob cancer tau kis mus rau ib qho kis twg hauv cov qog ntshav.
• “M” txhais tau tias tus kabmob muaj metastasized.

Raws li cov yam ntxwv saum toj no, cov kws kho mob muab RCC ua ntu zus. Cov theem nyob ntawm qhov loj ntawm lub qog thiab kis mob cancer.

Muaj plaub theem:

• Theem 1 thiab 2 piav qhia txog cov qog nqaij hlav hauv lub qog uas tseem nyob hauv lub raum. Theem 2 txhais tau hais tias cov qog loj dua 7 centimeters thoob plaws.
• Theem 3 thiab 4 txhais hais tias tus kabmob kheesxaws kis mus rau txoj hlab ntshav loj lossis ntaub so ntswg ze lossis lossis cov qog ntshav.
• Theem 4 yog daim ntawv tshaj plaws ntawm tus kabmob. Theem 4 txhais tau hais tias mob cancer tau kis mus rau lub qog adrenal los sis tau kis mus rau tej qog ntshav lossis lwm yam hauv lub cev. Vim hais tias cov qog adrenal txuas nrog lub raum, mob cancer feem ntau kis rau thawj zaug.

Qhov tshwm sim yog dab tsi?

Feem tsib xyoo muaj sia nyob mob qog noj ntshav raum yog raws li feem pua ​​ntawm cov neeg uas muaj tsawg kawg yog 5 xyoos nyob nrog tus mob tom qab nws kuaj pom tau.

Cov American Cancer Society (ACS) qhia txog feem pua ​​ntawm cov neeg nyob 5 xyoo lossis ntau dua tom qab kuaj mob raws li peb theem raws li cov ntaub ntawv los ntawm National Cancer Institute.

Cov theem no yog:

• laus hauv zos (mob qog tsis kis mus dhau lub raum)
• lub regional (mob cancer tau kis nyob ze)
• nyob deb (mob cancer tau kis mus rau qhov deb ntawm lub cev)

Raws li ACS, tus nqi RCC muaj sia nyob raws li peb qib no yog:

• laus: 93 feem pua
• lub regional: 70 feem pua
• nyob deb: 12 feem pua

Cov kev kho mob yog dab tsi?

Hom kev kho koj txais feem ntau nyob ntawm theem ntawm koj qhov mob qog noj ntshav. Theem 1 RCC tuaj yeem kho nrog kev phais mob.

Txawm li cas los xij, los ntawm lub sijhawm cov kabmob tau nce mus rau theem 4, kev phais mob yuav tsis yog ib txoj kev xaiv.

Yog tias cov qog thiab metastasis tuaj yeem sib cais, kev tshem tawm kev mob qog nqaij hlav thiab / lossis kev kho mob ntawm cov qog metastatic los ntawm kev tshem tawm lossis lwm cov txheej txheem xws li stereotactic lub cev hluav taws xob kho los yog thermal ablation kuj tseem muaj peev xwm ua tau.

Yog tias koj muaj theem 4 RCC, koj tus kws kho mob yuav txiav txim qhov chaw thiab kis mob ntawm koj mob qog nqaij hlav thiab koj li kev noj qab haus huv tag nrho los txiav txim koj qhov muaj cai rau kev phais mob.

Yog tias kev phais mob tsis yog qhov kev xaiv tiag tiag los kho rau theem 4 RCC, koj tus kws kho mob yuav pom zoo kom siv cov kev kho mob kaw lus siv cov tshuaj sib xyaw ua ke.

Ib qhov piv txwv ntawm koj cov qog nqaij hlav, hu ua biopsy, tuaj yeem nrhiav kom pab txiav txim siab txog qhov kev kho mob zoo tshaj plaws rau koj hom qog nqaij hlav tshwj xeeb. Kev kho mob yuav yog nyob ntawm seb koj puas muaj lub hlwb ntshiab lossis tsis tawg.

Cov hom phiaj kho kev kho mob thiab kev siv tshuaj tiv thaiv kab mob, suav nrog tyrosine kinase inhibitors thiab tshuaj tiv thaiv PD-1 monoclonal tiv thaiv kab mob, tuaj yeem siv los kho qib 4 RCC. Ib hom tshuaj tshwj xeeb tuaj yeem muab rau ib leeg lossis ua ke nrog lwm yam tshuaj.

Cov kev kho mob yuav suav nrog:

• axitinib + pembrolizumab
• pazopanib
• hnubsibib
• ipilimumab + nivolumab
• cabozantinib

Kev kho mob tshiab tuaj yeem muaj los ntawm kev sim kuaj mob. Koj tuaj yeem sib tham txog cov kev xaiv ntawm kev cuv npe nrog ib tus kws kho mob.

Koj tus kws kho mob kuj tseem yuav qhia cov kev kho mob kom pab txhawb rau kev phiv lossis cov tsos mob.

Cov nqa mus

Yog tias koj raug kuaj pom nyob rau theem 4 RCC, nco ntsoov tias cov nqi luam tawm raug kwv yees yog kev kwv yees.

Koj qhov kev kuaj mob yuav nce rau ntawm hom kabmob tshwj xeeb thiab seb nws tau nce qib licas, cov lus teb rau kev khomob, thiab koj kev noj qab haus huv tag nrho.

Qhov tseem ceeb yog:

• ua raws li koj tus kws kho mob qhia
• mus rau koj lub sijhawm teem sijhawm
• noj koj cov tshuaj

Tsis tas li, nco ntsoov ua raws cov lus qhia kho mob lossis kev hloov pauv hauv lub neej txhawm rau daws cov kev mob tshwm sim thiab cov tsos mob. Qhov no tuaj yeem pab txhawb koj kev noj qab haus huv thiab kev nyob zoo thaum mus kho mob.