Tus Sau: Gregory Harris
Hnub Kev Tsim: 16 Lub Plaub Hlis Ntuj 2021
Hloov Hnub: 18 Lub Kaum Ib Hli Ntuj 2024
Anonim
Kev Tshuaj Ntsuam Kev Tshawb Fawb PTEN - Tshuaj Kho Mob
Kev Tshuaj Ntsuam Kev Tshawb Fawb PTEN - Tshuaj Kho Mob

Zoo Siab

PTEN caj ces kuaj tau yog dab tsi?

Kev kuaj ntsuas keeb ntawm PTEN saib rau kev hloov pauv, paub tias hloov pauv, hauv tus gene hu ua PTEN. Cov noob yog qhov tseem ceeb ntawm caj ces dhau los ntawm koj niam thiab koj txiv.

Lub cev PTEN pab nres qhov kev loj hlob ntawm cov qog. Nws lub npe hu ua cov tshuaj tiv thaiv qog. Lub qog nqaij hlav hlav hlav zoo li tus nres ntawm lub tsheb. Nws tso "tus tsuj" rau ntawm lub hlwb, yog li lawv tsis faib ceev nrawm. Yog tias koj muaj PTEN caj ces hloov, nws tuaj yeem ua rau kev loj hlob ntawm cov qog hlav tsis tuaj yeem hu ua hamartomas. Hamartomas tuaj yeem tshwm thoob plaws lub cev. Qhov hloov tau tuaj yeem tuaj yeem ua rau kev loj hlob ntawm qog hlav qog ntshav.

PTEN kev hloov caj ces tuaj yeem tau los ntawm koj niam koj txiv, lossis tau txais tom qab hauv lub neej los ntawm ib puag ncig lossis los ntawm kev ua yuam kev uas tshwm sim hauv koj lub cev thaum faib cov cell.

Kev hloov pauv ntawm PTEN hloov pauv tuaj yeem ua rau muaj ntau yam kev mob tsis zoo. Qee qhov no tuaj yeem pib thaum tseem yau lossis thaum yau. Lwm qhov tshwm sim thaum laus. Cov kev tsis zoo no feem ntau tau koom ua ke thiab hu ua PTEN hamartoma syndrome (PTHS) thiab suav nrog:


  • Cov leeg Cowden, ib qho kev tsis sib haum xeeb uas ua rau ntau txoj kev loj hlob ntawm hamartomas thiab ua rau muaj kev pheej hmoo ntawm ntau hom mob cancer, nrog rau mob qog mis, mis, lub qog, thiab mob hnyuv. Cov neeg muaj tus mob Cowden syndrome feem ntau muaj qhov loj dua lub taub hau loj (loj dua me me), kev loj hlob qeeb, thiab / lossis mob vwm.
  • Cov tsos mob Bannayan-Riley-Ruvalcaba kuj ua rau hamartomas thiab macrocephaly. Ib qho ntxiv, cov neeg muaj tus mob no yuav muaj kev tsis taus kawm thiab / lossis muaj mob vwm. Cov txiv neej nrog qhov tsis sib haum xeeb feem ntau muaj qhov tsaus nti ntawm tus qau.
  • Proteus lossis Proteus-zoo li mob ntsws tuaj yeem ua rau mob hla ntawm cov pob txha, tawv nqaij, thiab lwm cov ntaub so ntswg, nrog rau hamartomas thiab macrocephaly.

Tau txais (tseem hu ua somatic) PTEN kev hloov caj ces yog ib qho pom muaj ntau tshwm sim hauv tib neeg mob cancer. Cov kev hloov tshwm sim tau pom muaj ntau hom mob qog nqaij hlav, suav nrog mob cancer prostate, mob cancer ntawm lub tsev menyuam, thiab qee cov qog hlwb.


Lwm lub npe: PTEN gene, cov noob tshuaj ntsuam tag nrho; PTEN ua ntu zus thiab rho tawm / duplication

Nws siv rau dab tsi?

Kev ntsuam xyuas yog siv los nrhiav PTEN kev hloov caj dab. Nws tsis yog qhov kev ntsuam xyuas niaj hnub. Feem ntau nws tau muab rau cov tib neeg raws li tsev neeg keeb kwm, cov tsos mob, lossis yav dhau los kuaj mob qog noj ntshav, tshwj xeeb tshaj yog mob cancer ntawm lub mis, thyroid, lossis uterus.

Vim li cas kuv thiaj xav tau txoj kev tshuaj ntsuam genetic PTEN?

Koj lossis koj tus menyuam yuav xav tau kev kuaj keeb kwm ntawm PTEN yog tias koj muaj tsev neeg muaj keeb kwm ntawm PTEN hloov caj ces thiab / lossis ib lossis ntau yam ntawm cov xwm txheej lossis cov tsos mob no:

  • Ntau cov nqaij hamartomas, tshwj xeeb tshaj yog nyob hauv thaj chaw ua haujlwm hauv plab
  • Macrocephaly (loj dua li lub taub hau loj dua)
  • Kev loj hlob qeeb
  • Cuam Tshuam
  • Kev tsaus nti quav ntawm tus qau ua rau txiv neej
  • Tus mob cancer mis
  • Mob qog noj ntshav
  • Uterine cancer hauv cov pojniam

Yog tias koj tau txheeb pom tias koj muaj mob qog noj ntshav thiab tsis muaj keeb kwm kab mob ntawm tsev neeg, koj tus kws kho mob yuav xaj kom kuaj xyuas no seb seb PTEN caj ces yug yuav ua rau koj mob cancer. Paub seb koj puas muaj kev hloov pauv tuaj yeem pab koj tus kws kho mob kwv yees saib koj tus kab mob yuav loj tuaj li cas thiab coj kev kho koj li cas.


Muaj dab tsi tshwm sim thaum kuaj ntshav PTEN?

Kev kuaj ntshav PTEN feem ntau yog kuaj ntshav. Lub sijhawm kuaj ntshav, tus kws saib xyuas kev noj qab haus huv yuav nqa ntshav los ntawm txoj hlab ntshav hauv koj txhais caj npab, siv rab koob me me. Tom qab cov koob raug tso nkag, cov ntshav me me yuav raug sau rau hauv lub khob kuaj lossis vial. Koj tuaj yeem hnov ​​me ntsis thaum cov koob nkag mus lossis tawm. Qhov no feem ntau yuav siv sijhawm tsawg dua tsib feeb.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Feem ntau koj tsis tas yuav muaj ib qho kev npaj tshwj xeeb rau ib qho kev ntsuas PTEN.

Puas muaj kev pheej hmoo rau kev kuaj?

Txoj kev kuaj ntshav muaj feem me me. Koj yuav muaj mob me lossis doog ntshav ntawm qhov chaw tso rab koob, tab sis feem ntau cov tsos mob ploj mus sai.

Cov txiaj ntsig li cas?

Yog tias koj cov txiaj ntsig pom tau tias koj muaj PTEN caj ces hloov, nws tsis txhais tau tias koj muaj mob qog nqaij hlav, tab sis koj qhov kev pheej hmoo siab dua coob leej neeg. Tab sis kev kuaj mob qog noj ntshav ntau dua tuaj yeem txo koj txoj kev pheej hmoo. Kab mob khees xaws raug kho ntau dua thaum pom thaum ntxov. Yog tias koj muaj lub cev hloov, koj tus kws kho mob yuav hais kom ib lossis ob peb yam ntawm cov kev tshuaj ntsuam nram no:

  • Kev kuaj mob hnyuv, pib thaum hnub nyoog 35-40
  • Mammogram, pib txij hnub nyoog 30 rau cov poj niam
  • Kev ntsuas tus kheej lub mis ib hlis rau cov pojniam
  • Kev ntsuas ntsuas pojniam txhua xyoo rau cov poj niam
  • Kev kuaj cov thyroid txhua xyoo
  • Kev kuaj xyuas daim tawv nqaij txhua xyoo rau kev loj hlob
  • Kev kuaj raum txhua xyoo

Txhua xyoo cov thyroid thiab kuaj daim tawv nqaij tseem pom zoo rau cov menyuam yaus uas muaj PTEN hloov caj ces.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv uas kuv xav paub txog kev kuaj ntsuas ntawm PTEN?

Yog tias koj tau kuaj pom nrog PTEN kev hloov caj ces lossis xav txog kev sim, nws yuav pab tau hais lus rau tus kws sab laj tswv yim. Tus kws pab tswv yim txog caj ces yog tus kws tshaj lij kawm tiav los ntawm kev tshawb fawb caj ces thiab kev tshuaj ntsuam caj ces. Yog koj tseem tsis tau raug sim, tus kws pab tswv yim tuaj yeem pab koj nkag siab txog cov kev pheej hmoo thiab cov txiaj ntsig ntawm kev xeem. Yog tias koj tau sim koj, tus kws pab tswv yim tuaj yeem pab koj nkag siab qhov txiaj ntsig thiab coj koj mus txhawb cov kev pabcuam thiab lwm yam kev pabcuam.

Ua tim khawv

  1. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Oncogenes thiab cov qog noj hlav hlav hlav hlav tawm tshiab [kho tawm 2014 Jun 25; hais 2018 Jul 3]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-Suppressor-genes.html
  2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Cov Kab Mob Khees Xaws Cancer; [kho tshiab 2017 Feb 9; hais 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/thyroid-cancer/causes-risks-prevention/risk-factors.html
  3. Cancer.Net [Is Taws Nem].Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Cowden Syndrome; 2017 Oct [qhia 2018 2018 Jul 3]; [txog 2 ntxaij]. Muaj los ntawm: https://www.cancer.net/cancer-types/cowden-syndrome
  4. Cancer.Net [Is Taws Nem]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Kev Tshuaj Ntsuas Genetic rau Cov Kab Mob Cancer; 2017 Jul [hais 2018 2018 3]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.net/navigating-cancer- zov/cancer-basics/genetics/genetic-testing-cancer-risk
  5. Cancer.Net [Is Taws Nem]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Cov Kab Mob Txuas Qog Mis thiab Ovarian Cancer; 2017 Jul [hais 2018 2018 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
  6. Cov Chaw Tiv Thaiv thiab Tiv Thaiv Kab Mob [Is Taws Nem]. Atlanta: Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Kev Tiv Thaiv thiab Tswj Cancer: Kev Tshuaj Ntsuam Xyuas [kho tshiab 2018 Tsib 2; hais 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cdc.gov/cancer/dcpc/prevention/screening.htm
  7. Cov Me Nyuam Tsev Kho Mob ntawm Philadelphia [Is Taws Nem]. Philadelphia: Tsev Kho Mob Menyuam Cov Tsev Kho Mob ntawm Philadelphia; c2018. PTEN Hamartoma Cov Mob Tumour (raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.chop.edu/conditions-diseases/pten-hamartoma-tumor-syndrome
  8. Lub koom haum Cancer Dana-Farber [Internet]. Boston: Lub koom haum Dana-Farber Cancer; c2018. Kev Tshawb Fawb Cancer thiab Kev Tiv Thaiv: Cowden Syndrome (CS); 2013 Aug [raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.dana-farber.org/legacy/uploadedfiles/library/adult-care/treatment-and-Support/centers-and-programs/cancer-genetics-and-prevention/cowden-syndrome.pdf
  9. Mayo Clinic: Mayo Medical Laboratories [Is Taws Nem]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1995–2018. Kev kuaj ID: BRST6: Cov Kab Mob Hlav Quav Hnav Qog 6 Ntshav Vaj Huam Sib Luag: Chaw Kho Mob thiab Kev Txhais Lus [muab 2018 Jul 3]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/64332
  10. Mayo Clinic: Mayo Medical Laboratories [Is Taws Nem]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1995–2018. Test ID: PTENZ: PTEN Gene, Cov Pwm Ntsuam Xyuas Tag Nrho: Soj Ntsuam thiab Txhais Lus [muab 2018 Jul 3]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35534
  11. MD Anderson Cancer Center [Is Taws Nem]. University of Texas MD Anderson Cancer Center; c2018. Kab Mob Hlav Hiv Ntshav Tes Muaj Mob [Suav Muab Cai 2018 Jul 3]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mdanderson.org/prevention- screening/family-history/hereditary-cancer-syndromes.html
  12. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Kev tshuaj ntsuam Genetic rau cov Neeg Muaj Kab Mob Hlav Hlew Syndromes [raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
  13. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI phau ntawv txhais lus ntawm Cancer Cov Lus Cog Tseg: gene [hais los ntawm 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
  14. Teb Chaws Lub Plawv, Lub Ntsws, thiab Koom Haum Ntshav [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Kuaj ntshav [cited 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.nhlbi.nih.gov/health-topics/blood-tests
  15. Lub Koom Haum Tebchaws rau Cov Muaj Teeb Meem Tsis Zoo [Internet]. Danbury (CT): Lub Koom Haum Hauv Lub Tebchaws rau Cov Tsis Txaus; c2018. PTEN Hamartoma Cov Mob Tumour (raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://rarediseases.org/rare-diseases/pten-hamartoma-tumor-syndrome
  16. NeoGenomics [Is Taws Nem]. Fort Myers (FL): NeoGenomics Lub chaw soj nstuam Inc .; c2018. PTEN Kev Tshawb Nrhiav Hloov [muab 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://neogenomics.com/test-menu/pten-mutation-analysis
  17. NIH Lub Tebchaws Asmeskas Cov Tsev Kuaj Tshuaj (Genetics) Hauv Tsev [Hauv Is Taws Nem]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; PTEN noob; 2018 Jul 3 [raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://ghr.nlm.nih.gov/gene/PTEN
  18. NIH Lub Tebchaws Asmeskas Cov Tsev Kuaj Tshuaj (Genetics) Hauv Tsev [Hauv Is Taws Nem]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Lub cev hloov pauv tau zoo li cas thiab kev hloov pauv muaj li cas ?; 2018 Jul 3 [raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
  19. Kev Tshawb Nrhiav Yeeb Yam [Internet]. Kev Tshawb Nrhiav Yeeb Yam; c2000–2017. Lub Chaw Ntsuas: PTEN Sequencing thiab Muab Tawm / Ua Dua Zaum [muab los ntawm 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=92566
  20. St. Jude Cov Tsev Kawm Ntawv Tshawb Nrhiav Tsev Kawm Ntawv [Is Taws Nem]. Memphis (TN): St. Jude Cov Tsev Kawm Ntawv Tshawb Nrhiav; c2018. PTEN Hamartoma Cov Mob Tumour (raug nplua 2018 Jul 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.stjude.org/disease/pten-hamartoma-tumor-syndrome.html
  21. University of Rochester Medical Center [Internet]. Rochester (NY): Tsev kawm qib siab Rochester Medical Center; c2018. Cov Ntawv Kho Mob Noj Qab Haus Huv: Cancer Mis: Ntsuas Ntsuas Ntsuas [hais tawm 2018 Jul 3]; [txog 2 ntxaij]. Muaj los ntawm: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=16421-1

Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.

Peb Qhia Koj Nyeem

Siv tau thiab txhawb nqa kev noj qab haus huv hlwb rau Black Womxn

Siv tau thiab txhawb nqa kev noj qab haus huv hlwb rau Black Womxn

Qhov t eeb: Dub lub neej t eem ceeb. Kuj muaj t eeb? Dub teeb meem kev mob hlwb - ib txwm thiab t hwj xeeb t haj yog muab cov huab cua tam im no.Nyob nruab nrab ntawm qhov kev tua neeg t i ncaj ncee t...
Txoj hauv kev zoo los siv cov zib ntab hauv koj lub pantry

Txoj hauv kev zoo los siv cov zib ntab hauv koj lub pantry

Paj thiab nplua nuj t eem t i txau txau kom muaj ntau yam ntxiv - qhov ntxim nyiam ntawm zib ntab, thiab yog vim li ca Emma Bengt on, tu thawj coj kw ua zaub mov ntawm Aquavit hauv New York, yog tu ki...