Kev Siv Tshuaj Biologics thiab Kev Tswj Xyuas Koj Tus Mob Psoriatic Mob

Zoo Siab

• Dab tsi yog roj ntsha?
• Hom kev siv roj ntsha
• Abatacept
• Adalimumab
• Certolizumab pegol
• Kev Liam Vim Tsis Yog
• Golimumab
• Infliximab
• Ustekinumab
• Kev sib tov sib xyaw
• Phiv pob thiab lus ceeb toom
• Kev siv roj ntsha yog ib feem ntawm PsA phiaj xwm tswj hwm

Txheej txheem cej luam

Psoriatic mob caj dab (PsA) yog ib tug mob mus ntev, thiab yuav tsum tau muaj kev kho mob txuas ntxiv kom tiv thaiv kev puas tsuaj ua ke tas mus li. Txoj kev kho zoo kuj tseem tuaj yeem kho tus naj npawb ntawm mob caj dab.

Kev siv roj ntsha tsuas yog ib hom tshuaj siv los kho PsA. Cov no ua haujlwm los ntawm kev thim koj lub cev tiv thaiv kab mob txhawm rau nws nres nres cov pob qij txha noj qab haus huv thiab ua rau mob thiab puas.

Dab tsi yog roj ntsha?

Kev siv roj ntsha yog subtypes ntawm kev hloov kho cov kabmob antirheumatic tshuaj (DMARDs). DMARDs nres koj lub cev tiv thaiv kab mob los ntawm qhov ua rau mob rau PsA thiab lwm yam kev mob autoimmune.

Txo qhov mob o muaj ob lub ntsiab:

• Tej zaum yuav muaj qhov mob tsawg dua vim tias qhov o ntawm cov chaw sib koom tes yog lub hauv paus ntawm kev sib koom ua ke.
• Kev puas tsuaj yuav raug txo kom tsawg.

Cov roj ntsha ua haujlwm los ntawm kev thaiv cov kabmob tiv thaiv kabmob ntawm cov kabmob uas ua rau muaj mob. Tsis zoo li qee DMARDs, kev siv roj ntsha yog muab los ntawm kev lis ntshav lossis txhaj tshuaj nkaus xwb.

Kev kho cov roj ntsha yog kho raws li thawj txoj kev kho mob rau cov neeg muaj lub siab PsA. Yog thawj thawj cov xyoob ntoo uas koj sim tsis daws nws tus mob, koj tus kws kho mob tuaj yeem hloov koj mus rau lwm cov tshuaj sib txawv hauv chav kawm no.

Hom kev siv roj ntsha

Plaub hom roj ntsha yog siv los kho PsA:

• cov qog necrosis factor-alpha (TNF-alpha) inhibitors: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), infliximab (Remicade)
• interleukin 12/23 (IL-12/23) inhibitors: ustekinumab (Stelara)
• interleukin 17 (IL-17 inhibitors): ixekizumab (Taltz), secukinumab (Cosentyx)
• T cell inhibitors: abatacept (Orencia)

Cov tshuaj no yog thaiv cov proteins uas tshwj xeeb uas lub cim ua rau koj lub cev tiv thaiv tsis tau cov hlwb kom noj qab haus huv, lossis lawv lub hom phiaj tiv thaiv lub cev tiv thaiv kab mob hauv lub cev. Lub hom phiaj ntawm txhua lub biologic subtype yog los tiv thaiv cov txheej txheem pib.

Muaj ob peb txoj kev lom zem xyoob ntoo. Cov hauv qab no yog cov feem ntau kho rau PsA.

Abatacept

Abatacept (Orencia) yog T cell inhibitor. T cell yog cov qe ntshav dawb. Lawv ua lub luag haujlwm hauv cov tshuaj tiv thaiv kab mob, thiab hauv kev huam tuaj. Orencia lub hom phiaj rau T cell los txo cov kev mob.

Orencia tseem kho cov kev mob caj dab (RA) thiab cov hluas idiopathic mob caj dab (JIA). Nws muaj raws li qhov Txoj kev lis ntshav los ntawm txoj hlab ntshav, lossis los ntawm kev txhaj tshuaj uas koj muab rau koj tus kheej.

Adalimumab

Adalimumab (Humira) ua haujlwm los ntawm thaiv TNF-alpha, uas yog protein ua txhawb kev o. Cov neeg muaj PsA tsim tawm ntau dhau TNF-alpha hauv lawv cov tawv nqaij thiab pob qij txha.

Humira yog ib qho tshuaj txhaj. Nws kuj tseem raug sau tseg rau Crohn's kab mob thiab lwm yam mob caj dab.

Certolizumab pegol

Certolizumab pegol (Cimzia) yog lwm yam tshuaj TNF-alpha. Nws yog tsim los kho cov qauv mob hnyav ntawm PsA, thiab Crohn's kab mob, RA, thiab ankylosing spondylitis (AS).

Cimzia raug muab raws li kev txhaj tshuaj rau lawv tus kheej.

Kev Liam Vim Tsis Yog

Etanercept (Enbrel) kuj tseem yog TNF-alpha tshuaj. Nws yog ntawm cov tshuaj qub pom zoo rau kev kho mob ntawm PsA, thiab nws tau siv los kho lwm hom mob caj dab.

Enbrel txhaj tshuaj nws tus kheej ib zaug ob zaug hauv ib lub lis piam.

Golimumab

Golimumab (Simponi) yog TNF-alpha tshuaj tsim los kho PsA nquag. Nws tseem tseem ua rau mob RA-rau-hnyav, mob nqaij-rau-mob nyhav rau lub plab (UC), thiab mob AS.

Koj noj Simponi ib hlis ib zaug los ntawm kev txhaj tshuaj nws tus kheej.

Infliximab

Infliximab (Remicade) yog ib qho kev hloov kho ntawm TNF-alpha tshuaj kho mob. Koj tau txais Txoj kev lis ntshav nyob ntawm tus kws kho mob lub chaw haujlwm peb zaug thaum rau lub lis piam. Tom qab thawj zaug kev kho mob, infusions raug muab txhua txhua ob lub hlis.

Remicade tseem kho cov kab mob Crohn's, UC, thiab AS. Cov kws kho mob tuaj yeem sau nws rau RA, ua ke nrog methotrexate.

Ixekizumab

Ixekizumab (Taltz) yog IL-17 inhibitor. Nws nplov IL-17, uas cuam tshuam nrog lub cev ua teb.

Koj tau txais Taltz raws li kev txhaj tshuaj raws li tawv nqaij txhua ob lub lis piam, thiab tom qab ntawd txhua plaub asthiv.

Secukinumab

Secukinumab (Cosentyx) yog lwm qhov IL-17 inhibitor. Nws raug pom zoo rau kev kho mob psoriasis thiab PsA, thiab AS.

Koj coj nws raws li kev txhaj tshuaj hauv qab koj cov tawv nqaij.

Ustekinumab

Ustekinumab (Stelara) yog IL-12/23 inhibitor. Nws nplov cov protein IL-12 thiab IL-23, uas ua rau muaj kab mob hauv PsA. Stelara raug pom zoo los kho tus mob PsA, plaque psoriasis, thiab mob khaub thuas-rau-hnyav Crohn's mob.

Stelara los yog txhaj tshuaj. Tom qab txhaj tshuaj thawj zaug, nws tau siv dua tom qab plaub lub lim tiam, thiab tom qab ntawd ib zaug txhua 12 asthiv.

Kev sib tov sib xyaw

Txog rau qib nrab mus rau qhov mob hnyav PsA, biologics yog qhov tseem ceeb hauv kev tswj cov tsos mob luv thiab ntev thiab teeb meem. Txawm li cas los xij, koj tus kws kho mob kuj tseem yuav pom zoo lwm txoj kev kho mob.

Koj tus kws kho mob tuaj yeem sau tshuaj nonsteroidal anti-inflammatory (NSAIDs) rau kev mob sib koom tes. Cov no tseem yuav txo tau qhov o. Cov tshuaj siv tsis ntau dhau (OTC), xws li ibuprofen (Advil), muaj dav, nrog rau cov qauv tshuaj uas muaj zog.

Txij li siv ntev ntev tuaj yeem ua rau muaj kev pheej hmoo hauv lub plab cov ntshav, mob plawv, thiab mob hlab ntsha tawg, NSAIDs yuav tsum tau siv tsawg thiab qhov koob tshuaj qis dua.

Yog tias koj muaj tus mob psoriasis ua ntej PsA, tom qab ntawd koj kuj tseem xav tau kev kho mob los pab txo cov tawv nqaij ua pob thiab cov teeb meem ntsia hlau. Cov kev kho mob uas yuav kho tau muaj xws li corticosteroids, kho lub teeb, thiab tshuaj pleev.

Phiv pob thiab lus ceeb toom

Feem ntau cov kev mob tshwm sim ntawm biologics yog cov tshuaj tiv thaiv ntawm daim tawv nqaij (xws li liab thiab pob) ntawm qhov chaw ntawm kev txhaj tshuaj. Vim hais tias cov tsiaj txhu roj ntsha tswj koj lub cev thev naus laus zis, koj kuj yuav muaj kev pheej hmoo kis mob yooj yim.

Tsis tshua muaj, tab sis, muaj mob loj, cov kev mob tshwm sim muaj xws li:

• psoriasis zuj zus
• sab sauv mob sib kis
• tuberculosis
• lupus zoo li cov tsos mob (xws li mob leeg thiab mob pob txha, kub taub hau, thiab plaub hau)

Tham nrog kws kho mob rheumatologist txog cov kev mob tshwm sim no, thiab saib xyuas koj tus mob kom zoo. Hu tam sim yog koj xav tias koj muaj qhov phiv tshuaj rau koj cov tshuaj.

Tsis tas li, cov poj niam cev xeeb tub lossis npaj yuav muaj menyuam yuav tsum siv roj ntsha nrog kev saib xyuas.

Txawm hais tias qhov tshwm sim hauv kev loj hlob ntawm tus menyuam tsis nkag siab zoo, nws tseem muaj peev xwm ua kom muaj teeb meem nrog kev xeeb tub. Ua raws li qhov mob hnyav ntawm PsA, qee cov kws kho mob pom zoo kom tsis txhob kho mob thaum cev xeeb tub.

Kev siv roj ntsha yog ib feem ntawm PsA phiaj xwm tswj hwm

Kev siv roj ntsha coj kev cia siab rau ntau tus nrog PsA. Tsis yog tsuas yog siv cov roj ntsha txhawm rau pab tswj hwm tus mob PsA, lawv kuj tseem txo qhov kev rhuav tshem ntawm lub hauv paug.

Tseem, nws yog ib qho tseem ceeb kom nco ntsoov tias kev siv roj ntsha tsuas yog ib feem ntawm koj qhov kev npaj tswj PsA ntev. Tham nrog koj tus kws kho mob txog kev hloov pauv ntawm kev ua neej thiab lwm yam tshuaj uas tuaj yeem pab tau.