Dab tsi yog Polycythemia Vera, kuaj mob, tsos mob thiab kho mob

Zoo Siab

• Cov cim thiab tsos mob yog dab tsi
• Yuav kuaj li cas
• Teeb meem ntawm polycythemia vera
• 1. Tsim cov ntshav txhaws
• 2. Splenomegaly
• 3. Muaj tshwm sim ntawm lwm cov kab mob
• Yuav tiv thaiv cov nyom li cas
• Cov teeb meem muaj peev xwm
• Yuav kho tus mob li cas

Polycythemia Vera yog myeloproliferative kab mob ntawm cov ntshav hematopoietic, uas yog pom los ntawm kev tswj tsis tau cov kabmob ntshav liab, ntshav dawb thiab ntshav.

Kev nce hauv cov hlwb no, tshwj xeeb tshaj yog cov qe ntshav liab, ua rau cov ntshav ntshav ntau dua, uas tuaj yeem ua rau lwm qhov mob hnyav ntxiv xws li nce ntshav thiab nce ntshav ntxiv, yog li ua rau muaj kev pheej hmoo ntawm thrombosis, plawv nres lossis mob stroke lossis tseem ua rau lwm cov kab mob zoo li mob hnyav myeloid leukemia los yog myelofibrosis.

Txoj kev kho yog ua raws li tus txheej txheem hu ua phlebotomy thiab tswj kev noj tshuaj uas pab tswj cov hlwb hauv cov ntshav.

Cov cim thiab tsos mob yog dab tsi

Cov ntshav liab ntau heev ua rau muaj ntau ntxiv rau hemoglobin thiab ntshav viscosity, uas tuaj yeem ua rau cov leeg mob xws li mob ntshav khov, mob taub hau, nce ntshav siab, pom kev hloov thiab hloov pauv ischemic raug mob.

Tsis tas li ntawd, cov neeg muaj tus kab mob no feem ntau hnov ​​tus khaus khaus, tshwj xeeb yog tom qab da dej kub, tsis muaj zog, poob ceeb thawj, nkees, lub qhov muag plooj, tawm hws ntau dhau, mob pob qij txha, ua tsis taus pa thiab loog, txhaws qa, hlawv lossis qaug zog ntawm cov tswv cuab.

Yuav kuaj li cas

Txhawm rau kuaj mob tus kab mob, yuav tsum tau kuaj ntshav, uas nyob hauv cov neeg mob Polycythemia Vera, qhia cov ntshav nce ntxiv, thiab hauv qee kis, kev nce ntshav hauv cov ntshav dawb thiab platelets, ntshav ntau ntau ntawm hemoglobin thiab theem qis ntawm erythropoietin.

Ib qho ntxiv, txoj kev xav ua kom cov leeg mob pob txha los yog kuaj me me kuj tseem tuaj yeem ua kom tau ib qho qauv coj los tshuaj xyuas tom qab.

Teeb meem ntawm polycythemia vera

Muaj qee kis ntawm cov neeg muaj Polycythemia Vera uas tsis qhia tus yam ntxwv thiab cov tsos mob, txawm li cas los xij, qee qhov xwm txheej tuaj yeem tsim teeb meem loj dua:

1. Tsim cov ntshav txhaws

Qhov nce ntawm cov ntshav tuab thiab qhov tshwm sim txo qis txaus thiab hloov mus rau hauv cov ntshav platelets, tuaj yeem ua rau cov ntshav txhaws, tuaj yeem ua rau lub plawv nres, mob stroke, mob ntsws embolism lossis thrombosis. Kawm ntxiv txog kab mob plawv.

2. Splenomegaly

Tus po yog pab rau lub cev kom tua tau cov kab mob thiab pab tshem tawm cov qe ntshav uas puas lawm. Kev nce ntxiv ntawm cov qe ntshav liab lossis txawm lwm cov qe ntshav, ua rau tus po tau ua haujlwm hnyav dua li ib txwm, uas ua rau muaj qhov loj me. Saib ntxiv txog splenomegaly.

3. Muaj tshwm sim ntawm lwm cov kab mob

Txawm hais tias muaj tsawg, Polycythemia Vera tuaj yeem ua rau muaj lwm cov kab mob loj dua, xws li mob myelofibrosis, mob myelodysplastic syndrome lossis mob ntshav siab. Muaj qee kis, mob hlwb pob txha kuj tseem tuaj yeem txhim kho cov qog pob txha thiab hypocellularity.

Yuav tiv thaiv cov nyom li cas

Txhawm rau tiv thaiv kom tsis txhob muaj kev nyuaj ntxiv, ntxiv rau kev pom zoo kom ua raws li kev kho mob kom raug, nws kuj tseem ceeb rau kev noj qab haus huv lub neej, qoj ib ce tsis tu ncua, uas txhim kho ntshav ncig thiab txo cov ntshav txhaws. Kev haus luam yeeb kuj yuav tsum zam dhau, vim tias nws yuav ua kom muaj kev pheej hmoo ntawm lub plawv thiab mob ntshav nce hlwb.

Tsis tas li ntawd, daim tawv nqaij yuav tsum tau kho kom zoo, txhawm rau txo qhov khaus, noj da dej nrog dej sov, siv cov tshuaj pleev me me thiab pleev tshuaj pleev ib ce thiab zam qhov kub thiab txias, uas tuaj yeem ua rau cov ntshav txaus tuaj. Rau qhov no, ib qho yuav tsum zam lub hnub nyob rau hauv lub sijhawm kub ntawm lub hnub thiab tiv thaiv lub cev kom tsis txhob raug rau huab cua txias heev.

Cov teeb meem muaj peev xwm

Polycythemia Vera tshwm sim thaum lub JAK2 gene hloov pauv, uas ua rau muaj teeb meem hauv kev tsim cov qe ntshav. Qhov no yog tus mob uas tsis tshua muaj tshwm sim, uas tshwm sim thaj tsam li 2 ntawm txhua 100,000 tus neeg, feem ntau muaj hnub nyoog 60 xyoo.

Feem ntau, cov kab mob noj qab haus huv tswj hwm tus nqi ntawm txhua qhov ntawm peb ntawm cov qe ntshav: liab, ntshav dawb thiab ntshav, tab sis nyob rau hauv Polycythemia Vera, muaj ib qho kev ua kom txawv txav ntawm ib lossis ntau hom qe ntshav.

Yuav kho tus mob li cas

Polycythemia vera yog ib qho muaj mob uas tsis muaj kev kho mob thiab kev kho mob muaj qhov txo cov ntshav tsawg, thiab qee qhov tuaj yeem txo tus mob pheej hmoo:

Kev kho phlebotomy: Cov txheej txheem no muaj cov ntshav tawm ntawm cov leeg, uas feem ntau yog thawj txoj kev kho mob rau cov neeg muaj tus kab mob no. Cov txheej txheem no ua kom muaj cov qe ntshav liab tsawg, thaum tseem txo cov ntshav hauv lub cev.

Tshuaj aspirin: Tus kws kho mob tuaj yeem sau ntawv rau cov tshuaj aspirin hauv ib lub cev tsawg, ntawm 100 txog 150 mg, txhawm rau txo kev pheej hmoo ntawm cov ntshav txhaws.

Tshuaj noj kom txo tau cov qe ntshav: Yog tias phlebotomy tsis txaus rau kev kho kom ua tiav, nws yuav tsum tau noj tshuaj xws li:

• Hydroxyurea, uas tuaj yeem txo qis cov qe ntshav hauv cov hlwb pob txha;
• Alpha interferon, uas ua rau lub cev tsis muaj zog tiv thaiv kev ua haujlwm ntawm cov ntshav, rau cov neeg uas tsis teb rov qab zoo rau hydroxyurea;
• Ruxolitinib, uas pab lub cev tiv thaiv kab mob rau kev ua kom cov hlav qog thiab tuaj yeem txhim kho cov tsos mob;
• Cov tshuaj noj kom txo qhov khaus, xws li tshuaj antihistamines.

Yog tias qhov khaus heev heev, nws yuav tsum tau muaj kev kho mob sab hnub ci lossis siv cov tshuaj xws li paroxetine lossis fluoxetine.