Phenylalanine: Cov txiaj ntsig, Qhov tshwm sim thiab Cov Khoom Noj Khoom Noj

Zoo Siab

• Phenylalanine yog dab tsi?
• Nws tseem ceeb heev rau Kev Ua Haujlwm ntawm Koj Lub Cev
• Yuav Tau Txais Txiaj Ntsig Txog Qee Cov Mob
• Sab sij huam
• Khoom Noj Muaj Ntau Hauv Phenylalanine
• Rau hauv qab Kab

Phenylalanine yog ib qho amino acid nyob hauv ntau cov zaub mov thiab siv los ntawm koj lub cev los tsim cov protein thiab lwm cov molecules tseem ceeb.

Nws tau kawm txog nws cov teebmeem ntawm kev nyuaj siab, mob thiab tawv nqaij tsis zoo.

Kab lus no qhia rau koj txhua yam koj yuav tsum paub txog phenylalanine, suav nrog nws cov txiaj ntsig, kev phiv thiab cov zaub mov.

Phenylalanine yog dab tsi?

Phenylalanine yog ib qho amino acid, uas yog cov tsev tsim ntawm cov protein nyob hauv koj lub cev.

Cov qauv no tshwm sim ua ob hom los yog npaj: L-phenylalanine thiab D-phenylalanine. Lawv muaj yuav luag zoo ib yam tab sis muaj cov qauv sib txawv me ntsis ().

Daim L-form pom nyob hauv cov zaub mov thiab siv los ua cov protein nyob hauv koj lub cev, thaum D-daim ntawv tuaj yeem raug coj los siv ua ke hauv qee yam kev kho mob (2, 3).

Koj lub cev tsis tuaj yeem tsim cov L-phenylalanine txaus ntawm nws tus kheej, yog li nws tau suav hais tias yog ib qho tseem ceeb amino acid uas yuav tsum tau txais los ntawm koj cov khoom noj (4).

Nws pom nyob hauv ntau cov khoom noj - ob qho tib si cog thiab tsiaj ().

Ntxiv rau nws lub luag haujlwm hauv kev tsim cov protein, phenylalanine yog siv los ua lwm cov lwg me me tseem ceeb hauv koj lub cev, ob peb qhov xa cov cim ntawm qhov sib txawv ntawm koj lub cev ().

Phenylalanine tau raug kawm ua kev kho rau ntau yam mob, suav nrog kev cuam tshuam ntawm daim tawv nqaij, kev nyuaj siab thiab mob (3).

Txawm li cas los xij, nws yuav muaj kev phom sij rau cov neeg muaj caj ces phenylketonuria (PKU) (7).

Phenylalanine yog ib qho tseem ceeb amino acid uas yog siv los tsim cov protein thiab taw qhia cov lwg me me. Nws tau kawm raws li kev kho mob rau ntau yam mob tab sis muaj kev phom sij rau cov neeg mob caj ces tsis meej.

Nws tseem ceeb heev rau Kev Ua Haujlwm ntawm Koj Lub Cev

Koj lub cev xav tau cov phenylalanine thiab lwm cov amino acids los ua cov protein.

Ntau cov protein ntau muaj nyob hauv koj lub hlwb, ntshav, nqaij, nqaij hauv nruab nrog thiab txhua qhov chaw hauv koj lub cev.

Dab tsi ntxiv, phenylalanine yog qhov tseem ceeb rau kev tsim khoom ntawm lwm cov lwg me me, suav nrog (3):

• Tyrosine: Cov amino acid no tsim tawm ncaj qha los ntawm phenylalanine. Nws tuaj yeem siv los ua cov protein tshiab lossis hloov mus rau lwm cov lwg me nyob hauv daim ntawv no (,).
• Epinephrine thiab norepinephrine: Thaum koj ntsib kev ntxhov siab, cov lwg me me no nws tseem ceeb heev rau koj lub cev kev sib ntaus lossis ya davhlau ().
• Dopamine: Cov molecule no koom nrog txoj kev xav ntawm kev lom zem hauv koj lub hlwb, nrog rau kev tsim kev nco thiab kev kawm paub ().

Cov teeb meem nrog cov haujlwm qub ntawm cov lwg me me no tuaj yeem ua rau tsis muaj kev noj qab haus huv (,).

Txij thaum phenylalanine tau siv los ua cov lwg me hauv koj lub cev, nws tau kawm ua kev kho mob rau qee yam mob, suav nrog kev nyuaj siab ().

Phenylalanine tuaj yeem hloov mus rau cov amino acid tyrosine, uas tom qab ntawd siv los tsim cov paib tseem ceeb xaib. Cov lwg me no koom rau hauv koj lub cev kev ua haujlwm li qub, suav nrog koj cov kev xav thiab kev ntxhov siab.

Yuav Tau Txais Txiaj Ntsig Txog Qee Cov Mob

Ntau cov kev tshawb fawb tau soj ntsuam seb puas yog phenylalanine yuav muaj txiaj ntsig zoo hauv kev kho ib qho mob tshwj xeeb.

Qee qhov kev tshawb fawb tau taw qhia tias nws yuav ua haujlwm tau zoo hauv kev kho vitiligo, kev ua kom tawv nqaij uas ua rau poob ntawm daim tawv nqaij thiab plhws ().

Lwm cov kev tshawb fawb tau tshaj tawm tias ntxiv cov phenylalanine pab ntxiv rau ultraviolet (UV) lub teeb kis tau zoo tuaj yeem txhim kho tawv nqaij tawv nqaij hauv cov neeg uas muaj tus mob no (,).

Phenylalanine tuaj yeem siv los ua cov tshuaj molecule dopamine. Dopamine malfunction hauv lub hlwb yog txuam nrog qee yam kev mob siab ntsws (,).

Ib qho kev qhia me me ntawm 12-tus neeg pom tias muaj txiaj ntsig tau los ntawm kev sib xyaw ntawm D- thiab L-cov qauv ntawm cov amino acid no los kho kev nyuaj siab, nrog 2/3 ntawm cov neeg mob qhia kev txhim kho ().

Txawm li cas los xij, muaj tsawg kawg nkaus txhawb lwm tus rau phenylalanine qhov cuam tshuam rau kev nyuaj siab, thiab kev tshawb fawb feem ntau tsis pom cov txiaj ntsig meej (,,).

Ntxiv nrog rau vitiligo thiab kev nyuaj siab, phenylalanine tau tau kawm rau cov txiaj ntsig zoo rau:

• Mob: D-daim ntawv ntawm phenylalanine tuaj yeem pab ua kom zoo mob rau qee qhov xwm txheej, txawm tias cov txiaj ntsig kev tshawb fawb tau sib xyaw (2,,,).
• Cawv tshem tawm: Kev tshawb nrhiav me me qhia tau hais tias cov amino acid no, nrog rau lwm cov amino acids yuav pab txo cov tsos mob ntawm kev haus cawv ().
• Tus kab mob Parkinson: Cov ntaub ntawv pov thawj tsawg tsawg qhia tias phenylalanine tuaj yeem muaj txiaj ntsig zoo los kho tus kab mob Parkinson, tab sis yuav tsum muaj kev tshawb fawb ntxiv ().
• ADHD: Tam sim no, kev tshawb fawb tsis qhia txog cov txiaj ntsig ntawm no amino acid rau kev kho mob ntawm kev saib xyuas kev tsis txaus siab hyperactivity tsis meej (ADHD) (,).

Phenylalanine tuaj yeem yuav muaj txiaj ntsig zoo rau kev kho mob ntawm daim tawv nqaij kho mob vitiligo. Cov ntaub ntawv pov thawj tsis muab kev txhawb nqa zoo rau qhov ua tau zoo ntawm cov amino acid hauv kev kho mob rau lwm yam mob, txawm tias muaj kev txwv zoo heev los tshawb nrhiav.

Sab sij huam

Phenylalanine tau pom nyob hauv ntau cov zaub mov muaj protein thiab "feem ntau lees paub tias muaj kev nyab xeeb" los ntawm FDA (27).

Tus nqi ntawm cov amino acid uas muaj nyob hauv cov khoom noj yuav tsum tsis tsim kev pheej hmoo rau lwm tus neeg noj qab haus huv.

Dab tsi ntxiv, ob peb lossis tsis muaj kev phiv feem ntau pom ntawm cov koob tshuaj ntxiv ntawm 23–45 mg rau ib phaus (50–100 mg rau ib kg) ntawm lub cev hnyav (,).

Txawm li cas los xij, nws yuav zoo rau cov poj niam cev xeeb tub kom tsis txhob noj phenylalanine ntxiv.

Tsis tas li ntawd, muaj qhov tshwj xeeb heev uas tsis suav txog kev nyab xeeb ntawm cov amino acid no.

Cov tib neeg muaj cov amino acid metabolism tsis meej phenylketonuria (PKU) tsis muaj peev xwm ua cov txheej txheem phenylalanine zoo. Lawv yuav muaj qhov ntau ntawm phenylalanine hauv lawv cov ntshav kwv yees li 400 zaus dua li cov tsis muaj PKU (3, 7).

Cov kev txaus ntshai heev no tuaj yeem ua rau lub hlwb puas thiab lub hlwb tsis ua haujlwm, nrog rau teeb meem nrog kev thauj mus los ntawm lwm cov amino acids mus rau lub hlwb (7,).

Vim tias qhov loj ntawm cov kev tsis txaus siab no, feem ntau cov menyuam yaus raug kuaj xyuas PKU sai sai tom qab yug.

Cov tib neeg muaj PKU raug tso rau hauv kev noj zaub mov muaj protein tsawg tshwj xeeb, uas feem ntau tswj hwm lub neej (7).

Phenylalanine pom tias muaj kev nyab xeeb rau hauv cov khoom pom hauv cov zaub mov ib txwm muaj. Txawm li cas los xij, cov tib neeg uas muaj tus kab mob phenylketonuria (PKU) tsis tuaj yeem hloov cov amino acid no thiab yuav tsum tau noj tsawg dua vim muaj kev mob txaus ntshai.

Khoom Noj Muaj Ntau Hauv Phenylalanine

Ntau cov zaub mov muaj phenylalanine, suav nrog cov khoom cog thiab tsiaj.

Soy cov khoom yog qee cov cog ntoo zoo tshaj plaws ntawm cov amino acid no, nrog rau qee cov noob thiab noob txiv, suav nrog cov taum pauv, cov noob taub thiab cov noob taub ().

Soy protein pabcuam ntxiv tau tuaj yeem muab kwv yees li 2.5 gram phenylalanine rau ib 200-calorie muab rau (, 29).

Rau cov khoom tsiaj, qe, nqaij nruab deg thiab qee yam nqaij yog cov khoom siv zoo, muab tau txog 2-3 grams tauj ib 200-calorie pab (, 29).

Tshaj tag nrho, koj yuav tsis tas xaiv cov khoom noj raws cov ntsiab lus siab phenylalanine.

Noj ntau yam khoom noj muaj protein ntau nyob rau ib hnub yuav pab koj tag nrho cov phenylalanine uas koj xav tau, nrog rau lwm cov amino acids tseem ceeb.

Ntau cov khoom noj, suav nrog cov kua zaub, qe, nqaij nruab deg thiab nqaij, muaj phenylalanine. Noj ntau yam khoom noj muaj protein ntau nyob rau ib hnub yuav pab koj txhua yam amino acids uas koj lub cev xav tau, suav nrog phenylalanine.

Rau hauv qab Kab

Phenylalanine yog ib qho tseem ceeb amino acid nyob hauv cov cog thiab tsiaj txhu.

Tej zaum nws yuav muaj txiaj ntsig zoo rau daim tawv nqaij ua tsis taus pa vitiligo, tab sis kev tshawb fawb ntawm nws cov kev cuam tshuam ntawm kev nyuaj siab, mob lossis lwm yam mob uas muaj tsawg.

Feem ntau suav tias yog kev nyab xeeb, tab sis cov neeg muaj phenylketonuria (PKU) yuav muaj kev phom sij txaus ntshai.