Pemphigoid Gestationis Thaum Cev Xeeb Tub

Zoo Siab

• Cov duab ntawm pemphigoid gestationis
• Cov tsos mob Pemphigoid gestationis
• Ua rau Pemphigoid gestationis ua
• Pemphigoid gestationis thiab PUPPP
• Kev kuaj mob Pemphigoid gestationis
• Kev kho tus mob pemphigoid gestationis
• Tshuaj kho tsev
• Muaj ntau hom mob hnyav
• Pemphigoid gestationis muaj teeb meem
• Qhov kev xam pom yog

Txheej txheem cej luam

Pemphigoid gestationis (PG) yog ib qho tsis tshua muaj khaus khaus tawv nqaij uas feem ntau tshwm sim hauv lub hlis thib ob lossis peb lub hlis uas cev xeeb tub. Feem ntau nws pib tshwm los ntawm tawv nqaij liab ua tawm los yog ua hlwv ntawm koj lub plab thiab pob tw, tab sis nws tuaj yeem tshwm rau lwm qhov ntawm koj lub cev.

PG tshwm sim los ntawm koj lub cev tiv thaiv tsis tau koj tus kheej cov tawv nqaij. Nws feem ntau yuav ploj nws tus kheej hauv cov hnub los yog lub lis piam tom qab xa khoom. Tsawg tsawg zaus, nws tuaj yeem siv sijhawm ntev dua.

PG raug kwv yees pom muaj tshwm sim hauv 1 ntawm txhua 40,000 txog 50,000 cev xeeb tub.

Pemphigoid gestationis siv los ua tus mob herpes gestationis, tab sis tam sim no nws nkag siab tias nws tsis muaj kev sib txuas nrog tus mob herpes. Nws kuj tseem muaj lwm yam ntawm pemphigus lossis pemphigoid tawv nqaij tawg, tsis cuam tshuam nrog cev xeeb tub.

Pemphigus hais txog lub hlwv los yog pustule, thiab kev xeeb tub txhais tau tias "cev xeeb tub" hauv Latin.

Cov duab ntawm pemphigoid gestationis

Cov tsos mob Pemphigoid gestationis

Nrog PG, cov pob liab liab tshwm nyob ib ncig ntawm lub plab khawm thiab kis mus rau lwm qhov ntawm lub cev tsis dhau ob peb hnub lossis vas thiv. Koj lub ntsej muag, tawv taub hau, xib teg, thiab lub xib taws ntawm txhais taw feem ntau tsis cuam tshuam.

Tom qab ob rau plaub asthiv, cov pob tawm mus rau hauv cov hlwv loj, liab, ua kua. Cov tsoo no kuj tuaj yeem hu ua bulla. Lawv tuaj yeem ua rau tsis muaj kev yoojyim.

Hloov ntawm blisters lossis bulla, qee tus neeg txhim kho tsa thaj ua rau thaj liab hu ua plaques.

Cov hlwv PG yuav ploj zuj zus lossis ploj mus lawv tus kheej ze rau thaum kawg ntawm koj lub cev xeeb tub, tab sis 75 txog 80 feem pua ​​ntawm cov poj niam nrog PG muaj kev kub ntxhov nyob ib puag ncig lub sijhawm yug.

PG tuaj yeem rov muaj dua thaum coj khaub ncaws lossis cev xeeb tub tom ntej. Kev siv ntawm qhov ncauj tiv thaiv tsis zoo kuj tseem tuaj yeem ua rau lwm tus nres.

Hauv qee qhov tsis tshua muaj tshwm sim - txog - PG tuaj yeem tshwm hauv cov menyuam tshiab.

Ua rau Pemphigoid gestationis ua

Pemphigoid gestationis tam sim no to taub hais tias yog kab mob autoimmune. Qhov ntawd txhais tau hais tias koj lub cev tiv thaiv kab mob pib tawm tsam qhov chaw ntawm koj lub cev. Hauv PG, cov hlwb ua tuaj tawm tsam yog cov me nyuam ntawm qhov tso tseg.

Cov nqaij mos Placental muaj cov keeb ntawm ob leeg niam txiv. Cov xoos uas tau muab los ntawm leej txiv tuaj yeem muaj cov lwg me uas tau lees paub txawv teb chaws los ntawm leej niam lub cev tiv thaiv kab mob. Qhov no ua rau leej niam lub cev tiv thaiv kab mob tawm tsam lawv.

Leej txiv lub cev muaj nyob rau txhua qhov kev xeeb tub, tab sis cov kab mob autoimmune zoo li PG tsuas yog tshwm sim hauv qee kis. Nws tsis to taub tag vim li cas kev tiv thaiv kab mob ntawm niam cev ua li cas qee qhov xwm txheej, thiab tsis yog rau lwm tus.

Tab sis qee cov molecules hu ua MHC II uas ib txwm tsis muaj nyob hauv tus me nyuam no tau pom nyob hauv cov poj niam uas muaj PG. Thaum tus poj niam cev xeeb tub hauv lub cev tiv thaiv kab mob paub txog cov molecules, nws pib tawm tsam.

Lub MHC II-chav kawm cov lwg me yog lub luag hauj lwm rau lo ua ke ntawm koj cov khaubncaws sab nraud povtseg ntawm cov tawv nqaij. Thaum koj lub cev tiv thaiv kab mob pib tua lawv, nws tuaj yeem ua rau lub hlwv thiab cov quav hniav uas yog cov tsos mob tseem ceeb ntawm PG.

Ib qho kev ntsuas ntawm qhov kev tiv thaiv autoimmune no yog qhov muaj cov protein tam sim no hu ua Collagen XVII (yav dhau los hu ua BP180).

Pemphigoid gestationis thiab PUPPP

Lwm qhov tawv nqaij uas paub zoo li PUPPP (pruritic urticarial papules thiab plaques of cev xeeb tub) tuaj yeem zoo li pemphigoid gestationis. Raws li lub npe qhia, PUPPP yog khaus (pruritic) thiab khaus-zoo li (urticarial).

PUPPP tshwm sim feem ntau hauv peb lub hlis thib peb, uas kuj yog lub sijhawm ib txwm muaj rau PG tshwm sim. Thiab zoo li PG, nws feem ntau pom tshwm thawj zaug ntawm lub plab raws li khaus liab pob lossis cov quav me.

Tab sis PUPPP feem ntau tsis pom muaj kev loj hlob ntawm cov hlwv dej ntau, zoo li PG. Thiab tsis zoo li PG, nws feem ntau kis rau ob txhais ceg thiab qee zaum qis qis.

PUPPP yog kho nrog cov tshuaj pleev xaj thiab pleev tshuaj, thiab qee zaum muaj cov tshuaj antihistamine. Cov pob khaus no feem ntau ploj nws tus kheej li ntawm rau lub lis piam tom qab xa khoom.

PUPPP tshwm sim hauv kwv yees li ntawm 1 ntawm txhua 150 cev xeeb tub, ua rau nws muaj ntau dua li PG. PUPPP tseem muaj ntau dua nyob rau hauv kev cev xeeb tub thawj zaug, thiab hauv cov poj niam nqa menyuam ntxaib, peb npaug, lossis ntau dua qhov sib npaug.

Kev kuaj mob Pemphigoid gestationis

Yog tias koj tus kws kho mob xav tias PG, lawv tuaj yeem xa koj mus rau kws kho qhov tawv nqaij kom kuaj qhov nqaij. Qhov no suav nrog kev thov tshuaj pleev ib ce lossis tshuaj pleev ib thaj rau thaj chaw me me ntawm daim tawv nqaij thiab txiav ib qho qauv me me kom raug xa mus rau qhov chaw kuaj mob.

Yog tias qhov kuaj pom pom cov tsos mob ntawm pemphigoid hauv lub tshuab tsom kab mob, lawv yuav ua ib qho kev sim txuas ntxiv uas hu ua kev soj ntsuam tshuaj tiv thaiv kab mob uas tuaj yeem paub tseeb PG.

Koj tus kws kho mob tseem yuav kuaj ntshav mus txiav txim seb theem ntshav qibphigoid antigen Collagen XVII / BP180 hauv cov ntshav yog dabtsi. Qhov no yuav pab lawv ntsuam xyuas tus kab mob.

Kev kho tus mob pemphigoid gestationis

Yog tias koj cov tsos mob me, koj tus kws kho mob tuaj yeem sau tshuaj tiv thaiv pob khaus ib lub npe hu ua cov tshuaj pleev corticosteroids. Cov no ua rau cov tawv nqaij nqig los ntawm kev txo qib ntawm kev tiv thaiv kab mob ntawm thaj chaw ntawm lub hlwv.

Cov tshuaj tiv thaiv fab ua xua (antihistamines) kuj tuaj yeem pab tau. Cov no suav nrog cov khoom uas tsis yog-nkees:

• cetirizine (Zyrtec)
• fexofenadine (Allegra)
• loratadine (Claritin)

Diphenhydramine (Benadryl) ua rau qaug zog thiab zoo tshaj thaum hmo ntuj. Nws mam li ua haujlwm pabcuam tsaug zog ntxiv rau nws cov yam ntxwv ua rau khaus tawm tsam.

Tag nrho cov no muaj nyob ntawm txee. Cov qauv siv dav dav yog sib npaug hauv kev ua hauv hom cov npe, thiab feem ntau txiav txim siab tsis tshua kim.

Nco ntsoov nrog koj tus kws kho mob tham ua ntej yuav noj ib yam tshuaj, txawm tias tsis yog khoom muag, thaum xeeb menyuam.

Tshuaj kho tsev

Koj tus kws kho mob tseem tuaj yeem hais qhia tshuaj kho mob hauv tsev kom tiv thaiv pob khaus thiab tsis xis nyob ntawm me me ntawm PG. Cov no tuaj yeem suav nrog:

• ua kom daim tawv nqaij txias nrog dej khov lossis dej txias
• nyob hauv qhov chaw txias lossis cua txias
• da dej hauv Epsom ntsev los yog oatmeal npaj
• hnav khaub ncaws txias paj rwb

Muaj ntau hom mob hnyav

Thaum khaus thiab voos ua mob hnyav dua, koj tus kws kho mob yuav tuaj yeem sau ntawv noj tshuaj corticosteroids. Raws li cov tshuaj no ua los ntawm kev txo cov haujlwm ntawm lub cev tiv thaiv kab mob, qhov kev siv tshuaj tiv thaiv tsawg yuav tsum tau siv tas li.

Koj tus kws kho mob yuav tsum coj mus rau hauv qhov tshwm sim rau koj thiab koj tus menyuam, thiab yuav tau noj npaum li cas thiab kev kho ntev npaum li cas.

Cov tshuaj tiv thaiv kab mob xws li azathioprine lossis cyclosporine kuj tseem siv tau los pab txo qhov khaus thiab tsis xis nyob. Saib xyuas kom zoo rau cov kev mob tshwm sim. Qhov no yuav suav nrog:

• kuaj xyuas ntshav siab ib zaug lossis ob zaug ib lub lim tiam rau thawj lub hlis uas siv
• saib xyuas raum kev ua haujlwm nrog kuaj ntshav thiab zis
• soj ntsuam daim siab kev ua haujlwm, uric acid, thiab ua kom qib lipid nrawm

Pemphigoid gestationis muaj teeb meem

Ib txoj kev tshawb nrhiav xyoo 2009 pom tau hais tias kev kis tus kab mob PG hlwv rau thawj lub hlis lossis zaum ob tuaj yeem ua rau muaj txiaj ntsig tsis zoo ntawm kev xeeb tub.

Txoj kev tshawb no tau soj ntsuam cov ntaub ntawv ntawm 61 tus poj niam cev xeeb tub nrog PG los ntawm Tebchaws Askiv thiab Taiwan. Cov txiaj ntsig tsis zoo pom nyob hauv cov poj niam nrog qhov pib-pib (thawj ib lossis ob hlis) PG suav nrog:

• preterm yug
• tsawg yug me nyuam hnyav
• me rau nruab hnub nyoog laus

Nws tshwm sim ntau dua rau PG tshwm sim tom qab cev xeeb tub. Thaum nws tshwm sim rau thawj ib lossis ob lub hlis, cov kws tshawb fawb pom zoo kom kho nws ua kev xeeb menyuam muaj feem yuav ua tib zoo saib xyuas thiab saib xyuas.

Ntawm qhov muaj txiaj ntsig zoo, txoj kev tshawb nrhiav tseem pom tias kev kho mob nrog corticosteroids tsis muaj qhov cuam tshuam rau cov txiaj ntsig ntawm cev xeeb tub.

Qhov kev xam pom yog

Pemphigoid gestationis yog ib qho tshwm sim ntawm daim tawv nqaij ib txwm muaj tshwm sim rau thaum cev xeeb tub. Nws khaus thiab khaus, tab sis yuav tsis phom sij rau koj lossis koj tus menyuam.

Thaum nws tshwm sim thaum ntxov cev xeeb tub muaj qhov feem me me muaj hnub nyoog tsis txwm xeeb menyuam lossis cov menyuam mos yug hauv plab qis. Xav kom muaj kev tshuaj xyuas zoo los ntawm koj tus kws kho mob OB-GYN thiab kev saib xyuas kev kho mob nrog koj tus kws kho nqaij tawv nqaij pom zoo.

Tej zaum koj yuav xav tau nyob rau hauv kev sib cuag nrog International Pemphigus thiab Pemphigoid Foundation, uas muaj cov pab pawg sib tham thiab cov phooj ywg pab rau cov neeg muaj PG.