Fingolimod (Gilenya) Sab Phiv thiab Cov Ntaub Ntawv Kev Nyab Xeeb

Zoo Siab

• Phiv los ntawm thawj koob tshuaj
• Sab sij huam
• FDA ceeb toom
• Cov mob uas muaj kev txhawj xeeb
• Cov tshuaj sib cuam tshuam
• Tham nrog koj tus kws kho mob

Taw qhia

Fingolimod (Gilenya) yog cov tshuaj noj ntawm qhov ncauj los kho cov tsos mob ntawm tus mob rov huam ntau yam mob sclerosis (RRMS). Nws pab txo qis qhov tshwm sim ntawm cov tsos mob ntawm RRMS. Cov tsos mob no tuaj yeem suav nrog:

• mob leeg pob txha
• tsis muaj zog thiab loog
• zais zis tswj teeb meem
• teeb meem hais lus thiab lub zeem muag

Fingolimod tseem ua haujlwm rau ncua lub cev kev ua tsis taus uas tuaj yeem tshwm sim los ntawm RRMS.

Ib yam li nrog txhua yam tshuaj, ntiv tes ntiv tes tuaj yeem ua rau muaj kev mob tshwm sim. Tsawg tsawg zaus, lawv tuaj yeem ua mob hnyav tau.

Phiv los ntawm thawj koob tshuaj

Koj noj thawj koob ntiv tes rau ntawm koj tus kws kho mob lub chaw haujlwm. Tom qab koj coj nws mus, koj yuav tau saib xyuas rau rau lossis ntau tshaj teev. Ib qho electrocardiogram tseem ua tau ua ntej thiab tom qab koj noj cov tshuaj los kuaj koj lub plawv thiab lub suab.

Cov kws kho mob tau txais kev ceev faj vim tias koj thawj zaug ntawm cov ntiv tes tuaj yeem ua rau muaj kev phiv ntxiv, suav nrog cov ntshav siab thiab lub cev bradycardia, lub plawv dhia qeeb uas tuaj yeem tsim kev phom sij. Cov tsos mob ntawm lub plawv dhia qeeb muaj xws li:

• nkees nkees
• kiv taub hau
• mob hauv siab

Cov teebmeem no yuav tshwm sim nrog koj thawj koob tshuaj, tab sis lawv yuav tsum tsis txhob tshwm sim txhua zaus koj noj tshuaj. Yog tias koj muaj cov tsos mob no nyob hauv tsev tom qab koj tau txhaj koob thib ob, hu rau koj tus kws kho mob tam sim ntawd.

Sab sij huam

Fingolimod noj ib hnub ib zaug. Cov kev mob tshwm sim ntau uas tuaj yeem tshwm sim tom qab zaum thib ob thiab lwm yam tshuaj ntxiv tuaj yeem suav nrog:

• zawv plab
• kev hnoos
• mob taub hau
• plaub hau poob
• kev nyuaj siab
• leeg tsis muaj zog
• qhuav thiab khaus ntawm daim tawv nqaij
• mob plab
• rov qab mob

Fingolimod tuaj yeem ua rau kom phiv loj dua. Cov no feem ntau yuav ploj mus yog tias koj tsum tsis haus tshuaj. Lwm yam tshaj li teeb meem mob siab, uas tuaj yeem tshwm sim, cov kev mob tshwm sim no feem ntau tsis tshua muaj. Cov kev mob tshwm sim hnyav tuaj yeem suav nrog:

• Teeb meem mob siab. Koj tus kws kho mob yuav ua kev sim ntshav tas mus li thaum lub sijhawm koj kho mob mus tshuaj xyuas seb puas muaj teeb meem rau daim siab. Cov tsos mob ntawm teeb meem mob siab tuaj yeem suav nrog lub ntsej muag daj, uas ua rau muaj tawv nqaij daj thiab ntsiab tawv ntawm lub qhov muag.
• Nce muaj feem yuav kis tau. Fingolimod txo qis koj cov qe ntshav dawb. Cov hlwb no ua rau qee qhov kev puas hlwb ntawm MS. Txawm li cas los xij, lawv tseem pab koj lub cev tawm tsam kev kis mob.Yog li, koj qhov kev pheej hmoo ntawm kev kis tau nce ntxiv. Qhov no tuaj yeem ntev txog ob lub hlis tom qab koj tsum tsis txhob noj cov ntiv tes.
• Macular edema. Nrog rau cov xwm txheej no, cov kua dej ua rau hauv macula, uas yog ib feem ntawm qhov muag retina. Cov tsos mob tuaj yeem yog ua kom pom kev plooj plooj, pom qhov muag tsis pom kev, thiab pom xim txawv. Koj qhov kev pheej hmoo ntawm cov mob no yuav muaj ntau dua yog tias koj muaj ntshav qab zib.
• Teeb meem ua pa. Ua tsis taus pa tuaj yeem tshwm sim yog tias koj siv ntiv tes.
• Ua rau cov ntshav siab ntxiv. Koj tus kws kho mob yuav tuaj yeem saib xyuas koj cov ntshav siab thaum koj kho nrog cov ntiv tes.
• Leukoencephalopathy. Muaj qee zaus, cov rau tes yuav tuaj yeem tsim teeb meem rau lub hlwb. Cov no suav nrog kev ua ntau yam mob ua kua rau lub ntsej muag thiab cov ntshav txha caj qaum. Cov tsos mob tuaj yeem suav nrog kev hloov pauv ntawm kev xav, txo lub zog, hloov hauv koj lub zeem muag, qaug dab peg, thiab mob taub hau uas mob sai sai. Qhia rau koj tus kws kho mob tam sim ntawd yog tias koj muaj cov tsos mob no.
• Mob Cancer. Basal cell carcinoma thiab melanoma, ob hom mob cancer ntawm daim tawv nqaij tau txuas nrog kev siv cov ntiv tes. Thaum siv cov tshuaj no, koj thiab koj tus kws kho mob yuav tsum saib xyuas pob lossis txawv txav ntawm koj cov tawv nqaij.
• Kev ua xua. Zoo li ntau yam tshuaj, ntiv tes tuaj yeem ua rau muaj kev fab tshuaj. Cov tsos mob tuaj yeem suav nrog ua pob, ua pob thiab ua xua. Koj tsis txhob siv cov tshuaj no yog tias koj paub tias koj muaj kev fab tshuaj tsis haum.

FDA ceeb toom

Cov kev tsis haum rau cov ntiv tes muaj tsawg. Cov ntawv ceeb toom tuag nyob rau xyoo 2011 txuas nrog kev siv thawj cov ntiv tes. Lwm lub sijhawm ntawm kev tuag los ntawm cov teeb meem plawv los kuj raug tshaj tawm. Txawm li cas los xij, FDA tsis tau pom muaj qhov sib txuas ncaj qha ntawm cov kev tuag no thiab kev siv cov taub teg.

Tseem, vim tias cov teebmeem no, FDA tau hloov pauv nws cov lus qhia rau kev siv ntiv tes. Tam sim no nws hais tias cov neeg uas siv qee cov tshuaj tiv thaiv tshuaj tua kab mob lossis muaj cov keeb kwm ntawm qee yam kev mob plawv lossis mob hlab ntsha tawg yuav tsum tsis txhob siv cov ntiv tes.

Kuj tseem tau tshaj tawm tias muaj cov kabmob kis tau tus kabmob tsis tshua muaj hlwb uas hu ua kev paub ntau ntxiv ntawm cov ntshav ntau lub cev tom qab siv cov ntiv tes.

Cov ntawv ceeb toom no yuav ua rau txaus ntshai, tab sis nco ntsoov tias feem ntau cov teeb meem ntawm cov ntiv tes yog tsis tshua muaj. Yog tias koj muaj kev txhawj xeeb txog kev siv cov tshuaj no, nco ntsoov sab laj nrog lawv tus kws kho mob. Yog koj twb tau sau cov tshuaj no lawm, tsis txhob tsum tsis txhob noj tshwj tsis yog koj tus kws khomob hais kom koj ua.

Cov mob uas muaj kev txhawj xeeb

Fingolimod tuaj yeem tsim teeb meem yog tias koj muaj qee yam mob. Ua ntej noj cov ntiv tes, nco ntsoov qhia koj tus kws kho mob yog tias koj muaj:

• arrhythmia, lossis lub plawv dhia tsis xwm yeem lossis txawv txav
• keeb kwm ntawm mob stroke lossis mini-stroke, tseem hu ua kev hloov pauv ischemic
• teeb meem mob plawv, suav nrog mob plawv lossis mob hauv siab
• keeb kwm ntawm rov qab tsaus muag
• kub taub hau lossis tus kab mob
• ib qho mob uas ua rau koj tsis muaj zog tiv thaiv kab mob, xws li HIV lossis mob ruas
• tshuaj tiv thaiv qhua maj los yog mob dej qhua taum
• teeb meem qhov muag, suav nrog ib yam mob hu ua uveitis
• mob ntshav qab zib
• cov teeb meem ua pa, suav nrog thaum pw tsaug zog
• teeb meem mob siab
• ntshav siab
• hom mob qog nqaij hlav, tshwj xeeb tshaj yog basal cell carcinoma lossis melanoma
• cov mob qog
• nws cov calcium, sodium, los yog poov tshuaj tsawg
• npaj kom cev xeeb tub, cev xeeb tub, lossis yog koj pub mis niam rau menyuam

Cov tshuaj sib cuam tshuam

Fingolimod tuaj yeem cuam tshuam nrog ntau yam tshuaj sib txawv. Kev sib cuam tshuam tuaj yeem ua rau muaj teebmeem kev noj qab haus huv lossis ua rau cov tshuaj tsis ua haujlwm.

Qhia rau koj tus kws kho mob txog txhua yam tshuaj, vitamins, thiab cov tshuaj uas koj noj, tshwj xeeb tshaj yog cov paub nrog rau cov ntiv tes. Ib co piv txwv ntawm cov tshuaj muaj xws li:

• tshuaj uas ua rau lub cev tsis muaj zog, suav nrog corticosteroids
• nyob tshuaj tiv thaiv
• tshuaj uas ua rau koj lub plawv dhia qeeb, xws li beta-blockers lossis calcium channel blockers

Tham nrog koj tus kws kho mob

Tsis muaj tshuaj kho tau rau MS. Yog li, cov tshuaj noj zoo li ntiv tes yog txoj hauv kev tseem ceeb txhawm rau txhim kho lub neej zoo thiab ncua kev tsis taus rau cov neeg mob RRMS.

Koj thiab koj tus kws kho mob tuaj yeem ntsuas qhov txiaj ntsig uas yuav muaj thiab kev pheej hmoo ntawm kev noj cov tshuaj no. Cov lus nug uas koj xav nug koj tus kws kho mob suav nrog:

• Kuv puas yuav muaj feem pheej phiv los ntawm cov ntiv tes?
• Kuv puas noj cov tshuaj uas yuav cuam tshuam nrog cov tshuaj no?
• Puas muaj lwm yam tshuaj MS uas tuaj yeem ua rau muaj kev mob tshwm sim tsawg rau kuv?
• Kuv yuav tsum qhia yam kev mob tshwm sim dab tsi rau koj tam sim ntawd yog tias kuv muaj tej yam no?

Fingolimod tau nyob rau tom khw txij li xyoo 2010. Nws yog thawj qhov ncauj noj tshuaj rau qhov MS tau pom zoo los ntawm FDA. Txij thaum ntawd, ob lwm hom tshuaj ntxiv tau txais kev pom zoo: teriflunomide (Aubagio) thiab dimethyl fumarate (Tecfidera).