Kev kuaj GH yog dab tsi rau thiab thaum twg xav tau

Zoo Siab

• Dab tsi yog nws rau
• Ua li cas tiav lawm

Kev loj hlob hormone, tseem hu ua GH lossis somatotropin, yog yam tshuaj tseem ceeb uas tsim los ntawm lub caj pas pituitary uas ua rau kev loj hlob ntawm menyuam yaus thiab cov hluas thiab kuj tseem koom nrog cov txheej txheem hauv lub cev hauv lub cev.

Qhov kev kuaj no yog ua tiav nrog cov koob tshuaj hauv cov ntshav uas tau sau hauv qhov chaw kuaj thiab feem ntau yog thov los ntawm cov kws kho mob endocrinologist thaum muaj kev xav tias tsis muaj GH ntau lawm, tshwj xeeb tshaj yog nyob rau cov menyuam yaus uas nthuav tawm txoj kev loj hlob qis dua qhov kev cia siab, lossis ntawm ntau dhau ntawm nws. , hom nyob rau hauv gigantism lossis acromegaly.

Kev siv GH raws li cov tshuaj yog qhia thaum muaj qhov tsis txaus rau hauv cov khoom no, hauv menyuam yaus lossis neeg laus, raws li kws kho mob hais. Txhawm rau paub ntau ntxiv tias nws siv li cas, cov nqi thiab cov txiaj ntsig ntawm kev loj hlob hormone, kos lub npe rau cov tshuaj GH.

Dab tsi yog nws rau

Thov kom kuaj GH yog tias koj xav tias:

• Dab Tuag Yog Dab, uas yog qhov tsis txaus ntawm kev loj hlob hormone rau menyuam yaus, ua rau luv luv stature. Nkag siab tias nws yog dab tsi thiab dab tsi tuaj yeem ua rau dwarfism;
• Neeg laus GH tsis txaus, tshwm sim los ntawm kev tsim tawm ntawm GH qis dua li qub, uas ua rau cov tsos mob xws li kev qaug zog, cov rog rog ntau dua, cov nqaij ntshiv tsawg, tsis muaj peev xwm ua kom ib ce muaj zog, txo pob txha ceev thiab nce kev pheej hmoo ntawm kev tsim kab mob plawv;
• Gigantism, tus yam ntxwv dhau ntawm GH kev zais cia rau hauv tus menyuam lossis cov hluas, ua rau muaj kev nthuav dav;
• Acromegaly, uas yog cov tsos mob los ntawm kev ua haujlwm dhau ntawm GH hauv cov neeg laus, ua rau muaj kev hloov pauv ntawm daim tawv nqaij, tes, taw thiab ntsej muag. Saib qhov sib txawv ntawm acromegaly thiab gigantism;

Qhov tsis txaus GH hauv lub cev tuaj yeem muaj ntau yam ua rau mob, xws li kev mob caj ces, hloov hauv lub hlwb, xws li qog, kis lossis tawg lossis vim muaj kev phiv los ntawm chemo lossis mob hlwb, piv txwv. Qhov dhau heev ntawm GH, ntawm qhov tod tes, feem ntau tshwm sim vim yog lub pituitary adenoma.

Ua li cas tiav lawm

Qhov ntsuas GH hormone yog ua los ntawm kev kuaj ntshav cov ntshav hauv chav kuaj thiab tau ua raws li 2 txoj kev:

1. Kev ntsuas GH ntsuas: nws ua tiav nrog tsawg kawg 6 teev ntawm kev yoo mov rau menyuam yaus thiab 8 teev rau cov neeg hluas thiab cov neeg laus, uas tau soj ntsuam cov tshuaj no hauv lub cev thaum sawv ntxov cov ntshav;
2. Kev kuaj GH stimulation (nrog Clonidine, Insulin, GHRH lossis Arginine): nws yog ua tiav nrog kev siv tshuaj uas tuaj yeem txhawb GH tso pa tawm, nyob rau lub sijhawm thaum twg xav tias tsis muaj cov tshuaj no. Tom ntej no, cov ntshav GH concentration tsom xam tau ua tom qab 30, 60, 90 thiab 120 feeb ntawm kev siv tshuaj.

Kev ntsuam xyuas GH stimulation yog qhov tsim nyog vim tias kev tsim cov GH hormone los ntawm lub cev tsis sib xws, thiab tuaj yeem cuam tshuam los ntawm ntau yam, xws li yoo mov, ntxhov siab, pw tsaug zog, ua si kis las lossis thaum cov piam thaj hauv ntshav poob. Yog li, qee cov tshuaj siv uas siv yog Clonidine, Insulin, Arginine, Glucagon lossis GHRH, piv txwv, uas txhawb lossis tiv thaiv kev tsim cov tshuaj hormone.

Ntxiv rau, tus kws kho mob kuj tseem yuav txiav txim siab lwm yam kev ntsuas, xws li ntsuas ntsuas cov tshuaj hormones xws li IGF-1 lossis IGFBP-3 protein, uas hloov nrog GH hloov pauv: MRI scan ntawm lub hlwb, kom ntsuas kev hloov pauv hauv lub qog pituitary, ib yam nkaus nws tuaj yeem pab tau txhawm rau txheeb xyuas qhov teeb meem.