Cov Lus Qhia Yooj Yim rau Endocannabinoid System

Zoo Siab

• Nws ua haujlwm li cas?
• Endocannabinoids
• Endocannabinoid receptors
• Cov Enzymes
• Nws cov haujlwm yog dab tsi?
• THC cuam tshuam nrog ECS ​​li cas?
• CBD cuam tshuam nrog ECS ​​li cas?
• Yuav ua li cas txog endocannabinoid deficiency?
• Hauv qab kab

Endocannabinoid system (ECS) yog cov ua haujlwm ntawm lub ntsej muag muaj npe ua haujlwm tau tshawb pom nyob rau thaum xyoo 1990 los ntawm cov kws tshawb fawb tshawb nrhiav THC, kev paub zoo txog cannabinoid. Cannabinoids yog cov sib txuas pom nyob rau hauv cannabis.

Cov kws tshaj lij tseem tab tom sim ua kom nkag siab txog ECS. Tab sis tam sim no, peb paub nws lub luag haujlwm hauv kev tswj hwm ntau yam ntawm cov haujlwm thiab cov txheej txheem, suav nrog:

• pw tsaug zog
• mus ob peb vas
• qab los
• kev nco
• kev ua me nyuam thiab kev muaj tub ki

Lub ECS tshwm sim thiab muaj kev nyob hauv koj lub cev txawm tias koj tsis siv cov cannabis.

Nyeem rau kom paub ntau ntxiv txog ECS ​​suav nrog seb nws ua haujlwm thiab cuam tshuam nrog cannabis.

Nws ua haujlwm li cas?

Qhov ECS cuam tshuam nrog peb feem tseem ceeb: endocannabinoids, receptors, thiab enzymes.

Endocannabinoids

Endocannabinoids, tseem hu ua endogenous cannabinoids, yog cov khoom tsim los ntawm koj lub cev. Lawv zoo sib xws nrog cannabinoids, tab sis lawv tau tsim los ntawm koj lub cev.

Cov kws tshaj lij tau txheeb xyuas ob qhov tseem ceeb endocannabinoids:

• anandamide (AEA)
• 2-arachidonoylglyerol (2-AG)

Cov no pab kom cov haujlwm sab hauv khiav tau zoo. Koj lub cev tsim tawm lawv raws li xav tau, ua rau nws tsis yooj yim paub txog qib dab tsi uas muaj rau txhua.

Endocannabinoid receptors

Cov receptors no muaj nyob thoob plaws koj lub cev. Endocannabinoids khi rau lawv txhawm rau taw qhia tias ECS yuav tsum nqis tes ua.

Muaj ob lub ntsiab endocannabinoid receptors:

• CB1 receptors, uas feem ntau pom hauv nruab nrab lub paj hlwb
• CB2 receptors, uas feem ntau pom hauv koj lub paj hlwb peripheral, tshwj xeeb tshaj yog cov kab mob tiv thaiv kab mob

Endocannabinoids tuaj yeem khi rau tog twg los tshuaj. Qhov cuam tshuam uas tau tshwm sim nyob ntawm qhov chaw txais khoom nyob thiab qhov twg endocannabinoid nws khi rau.

Piv txwv, endocannabinoids yuav phiaj CB1 receptors hauv cov leeg nroo txhawm rau kom txo qhov mob. Lwm tus yuav khi rau CB2 receptor nyob rau hauv koj lub cev tiv thaiv kab mob ua lub cim qhia tias koj lub cev tau mob o, cov cim ntawm lub cev tsis ua haujlwm.

Cov Enzymes

Cov Enzymes yog lub luag haujlwm rau rhuav tshem endocannabinoids thaum lawv tau ua lawv txoj haujlwm.

Nws muaj ob lub ntsiab enzymes lub luag haujlwm rau qhov no:

• fatty acid amide hydrolase, uas tawg rau AEA
• monoacylglycerol acid lipase, uas ib txwm tawg 2-AG

Nws cov haujlwm yog dab tsi?

Lub ECS yog qhov nyuaj, thiab cov kws tshaj lij tsis tau txiav txim siab meej tias nws ua haujlwm lossis tag nrho nws lub luag haujlwm.

tau txuas ECS rau cov txheej txheem hauv qab no:

• qab los noj mov thiab kev zom mov
• metabolism hauv
• mob mob mus ntev
• o thiab lwm yam kev tiv thaiv kab mob hauv lub cev
• mus ob peb vas
• kev kawm thiab kev nco
• lub cev muaj zog tswj
• pw tsaug zog
• kev mob plawv ua haujlwm
• leeg tsim
• kho pob txha kho thiab loj tuaj
• daim siab ua haujlwm
• kev ua me nyuam muaj nuj nqi
• kev ntxhov siab
• daim tawv nqaij thiab cov hlab ntaws muaj nuj nqi

Cov haujlwm no txhua tus ua rau homeostasis, uas hais txog kev ruaj ntseg ntawm koj ib puag ncig sab hauv. Piv txwv li, yog sab nraud quab yuam, xws li mob los ntawm kev raug mob lossis kub taub hau, cuam tshuam tawm ntawm koj lub cev lub cev, koj ECS ncaws rau pab koj lub cev rov qab ua haujlwm zoo tagnrho.

Niaj hnub no, cov kws tshaj lij ntseeg hais tias tswj kev homeostasis yog tias lub luag haujlwm tseem ceeb ntawm ECS.

THC cuam tshuam nrog ECS ​​li cas?

Tetrahydrocannabinol (THC) yog ib qho tseem ceeb ntawm cannabinoids pom nyob rau hauv cannabis. Nws yog qhov sib txuas uas ua rau koj "siab."

Ib zaug hauv koj lub cev, THC cuam tshuam nrog koj ECS los ntawm khi rau cov neeg txais, zoo ib yam li endocannabinoids. Nws muaj zog ib nrab vim tias nws tuaj yeem khi rau CB1 thiab CB2 receptors.

Qhov no tso cai rau nws kom muaj cov kev cuam tshuam ntawm koj lub cev thiab lub siab, qee qhov xav tau ntau dua li lwm tus. Piv txwv li, THC tuaj yeem pab txo qhov mob thiab txhawb nqa koj lub siab. Tab sis nws kuj tseem tuaj yeem ua rau paranoia thiab ntxhov siab hauv qee kis.

Cov kws txawj tam sim no nrhiav txoj hauv kev los tsim hluavtaws THC cannabinoids uas cuam tshuam nrog ECS ​​hauv txoj hauv kev muaj txiaj ntsig zoo.

CBD cuam tshuam nrog ECS ​​li cas?

Lwm qhov tseem ceeb cannabinoid pom nyob rau hauv cannabis yog cannabidiol (CBD). Tsis zoo li THC, CBD tsis ua rau koj "siab" thiab feem ntau yuav tsis ua rau muaj kev cuam tshuam tsis zoo.

Cov kws tshaj lij tsis paub meej tias CBD cuam tshuam nrog ECS ​​li cas. Tab sis lawv paub tias nws tsis khi rau CB1 lossis CB2 receptors li THC ua.

Hloov chaw, ntau tus neeg ntseeg nws ua haujlwm los ntawm kev tiv thaiv endocannabinoids los ntawm kev tawg. Qhov no tso cai rau lawv kom muaj ntau lub zog rau koj lub cev. Lwm tus ntseeg tias CBD khi rau ib tus txais uas tseem tsis tau pom dua.

Thaum cov ntsiab lus ntawm nws ua haujlwm li cas tseem nyob hauv kev sib cav, kev tshawb fawb qhia tau tias CBD tuaj yeem pab nrog kev mob, xeev siab thiab lwm yam tsos mob cuam tshuam nrog ntau yam mob.

Yuav ua li cas txog endocannabinoid deficiency?

Qee cov kws tshaj lij ntseeg nyob rau hauv lub hom phiaj hu ua kev saib xyuas endocannabinoid deficiency (CECD). Qhov kev tshawb xav no qhia tau hais tias cov qib endocannabinoid qis hauv koj lub cev lossis ECS ua haujlwm tsis zoo tuaj yeem pab txhawb kev txhim kho ntawm qee yam kev mob.

Kev tshuaj xyuas ntau tshaj 10 xyoo ntawm kev tshawb fawb ntawm cov kev qhia tau qhia qhov kev tshawb xav tuaj yeem piav qhia vim li cas qee tus neeg thiaj li mob taub hau, mob fibromyalgia, thiab mob plab hnyuv.

Tsis muaj ib yam ntawm cov mob no muaj lub hauv paus hauv paus hauv ntsis. Lawv ib txwm muaj peev xwm tiv taus qhov kev kho mob thiab qee zaum kuj tshwm sim sib xws.

Yog tias CECD ua si txhua yam haujlwm hauv cov xwm txheej no, kev tsom mus rau ECS lossis endocannabinoid ntau lawm tuaj yeem yog qhov tseem ceeb ploj ntawm kev kho mob, tab sis kev tshawb fawb ntxiv yog xav tau.

Hauv qab kab

Cov ECS ua lub luag haujlwm loj hauv kev ua kom koj lub hauv paus ua haujlwm ruaj khov. Tab sis tseem tshuav ntau yam peb tsis paub txog nws. Raws li cov kws tshaj lij txhim kho kev nkag siab zoo dua ntawm ECS, thaum kawg nws tuaj yeem tuav tus yuam sij rau kev kho mob ntau yam.