Teeb meem thiab kev pheej hmoo ntawm Polycythemia Vera

Zoo Siab

• Kev Ntsuas Koob Yees Duab PV
• Teeb meem
• Mob Siab
• Txhawb nqa spleen thiab mob siab
• Cov qe ntshav liab theem siab
• Myelofibrosis
• Mob ntshav siab
• Teeb meem los ntawm kev kho mob

Txheej txheem cej luam

Polycythemia vera (PV) yog ib hom mob mus ntev thiab zoo zuj zus ntawm cov ntshav qog ntshav ntshav. Kev paub thaum ntxov yuav pab txo tau qhov kev phom sij ntawm lub neej, xws li ntshav txhaws thiab teeb meem los ntshav.

Kev Ntsuas Koob Yees Duab PV

Qhov pom ntawm JAK2 caj ces hloov pauv, JAK2 V617F, tau pab cov kws kho mob kuaj mob neeg nrog PV. Kwv yees 95 feem pua ​​ntawm cov uas muaj PV kuj muaj qhov hloov tau raws caj ces.

Kev hloov JAK2 ua rau cov qe ntshav liab tuaj yeem yug me nyuam raws qhov tsis muaj kev tswj hwm. Qhov no ua rau koj cov ntshav tuab. Thickened ntshav txwv nws ntws mus rau koj cov plab hnyuv siab raum thiab cov nqaij. Qhov no tuaj yeem ua rau lub cev tsis muaj pa oxygen. Nws kuj tseem tuaj yeem ua rau ntshav txhaws.

Kev kuaj ntshav tuaj yeem qhia tau yog tias koj cov ntshav qog txawv txav lossis yog tias koj cov ntshav xam ua siab dhau. Ntshav dawb ntawm cov ntshav thiab lub ntsej muag ntshav kuj tseem tuaj yeem cuam tshuam los ntawm PV. Txawm li cas los xij, nws yog tus naj npawb ntawm cov qe ntshav liab uas txiav txim siab txog kev kuaj mob. Hemoglobin ntau dua 16.0 g / dL rau cov poj niam lossis ntau dua 16.5 g / dL rau cov txiv neej, lossis hematocrit ntau dua 48 feem pua ​​ntawm cov poj niam lossis ntau dua 49 feem pua ​​ntawm cov txiv neej tuaj yeem qhia PV.

Cov kev mob tshwm sim tuaj yeem yog qhov laj thawj ntawm kev teem caij thiab kuaj ntshav. Cov tsos mob no tuaj yeem suav nrog:

• mob taub hau
• kiv taub hau
• kev pom kev hloov
• tag nrho lub cev khaus
• poob phaus
• nkees
• tawm hws ntau dhau

Yog tias koj tus kws kho mob xav tias koj muaj PV, lawv yuav xa koj mus rau tus kws kho ntshav. Tus kws kho mob ntshav no yuav pab txiav txim koj li phiaj xwm kho mob. Qhov no feem ntau yog muaj sij hawm phlebotomy (nqus ntshav), nrog rau cov tshuaj aspirin niaj hnub thiab lwm yam tshuaj.

Teeb meem

PV tso koj qhov kev pheej hmoo rau ntau yam teeb meem. Cov no tuaj yeem suav nrog:

Mob Siab

Thrombosis yog ib qhov kev txhawj xeeb uas hnyav tshaj plaws hauv PV. Nws yog txoj hlab ntshav hauv koj cov hlab ntsha lossis leeg ntshav. Qhov mob ntshav khov npaum li cas yog nyob ntawm qhov uas txhaws qhov ntawd tuaj. Ib qho hnav ris tsho hauv koj:

• lub hlwb tuaj yeem ua rau mob stroke
• lub siab yuav ua rau muaj mob plawv lossis mob leeg
• lub ntsws yuav ua rau mob ntsws
• txoj leeg sib sib zog nqus yuav yog txoj hlab ntshav sib luag (DVT)

Txhawb nqa spleen thiab mob siab

Koj tus po yog nyob rau sab qaum kawg ntawm koj lub plab. Ib qho ntawm nws txoj haujlwm yog lim cov roj ntsha tawm hauv lub cev. Zoo li tsam plab los yog yooj yim tag nrho yog ob qhov tsos mob ntawm PV triggered los ntawm kev hnoos qeev.

Koj tus hnoos qeev loj zuj zus thaum nws sim lim cov ntshav ntau dhau ntawm koj cov hlwb pob txha tsim. Yog tias koj tus hnoos qeev tsis rov qab los nrog qhov qub nrog kev kho mob PV, nws yuav raug tshem tawm.

Koj lub siab yog nyob rau sab xis kawg ntawm koj lub plab. Zoo li tus po, nws kuj tuaj yeem dhau los nyob rau hauv PV. Qhov no tuaj yeem ua tau vim yog hloov ntshav txav mus rau lub siab lossis txoj haujlwm ua ntxiv uas daim siab ua haujlwm hauv lub siab. Ib lub siab ua haujlwm tuaj yeem ua kom mob plab los yog kua dej ntxiv hauv lub cev

Cov qe ntshav liab theem siab

Kev nce ntxiv ntawm cov ntshav liab tuaj yeem ua rau mob pob qij txha, nrog rau kev nkag siab, mob taub hau, teeb meem tsis pom kev, thiab loog thiab caj dab hauv koj txhais tes thiab taw. Koj hematologist yuav qhia cov kev los kho cov tsos mob no.

Kev yuav tso ntshav mus ib txhis yuav pab ua kom cov ntshav liab nyob hauv tus nqi. Thaum cov kev xaiv no tsis ua haujlwm lossis cov tshuaj tsis pab, koj tus kws kho mob yuav hais kom hloov qog cell los tswj tus mob.

Myelofibrosis

Myelofibrosis, tseem hu ua "siv sijhawm" ntawm PV, cuam tshuam ze li 15 feem pua ​​ntawm cov neeg kuaj pom nrog PV. Qhov no tshwm sim thaum koj cov pob txha pob txha tsis ua cov hlwb zoo lossis ua haujlwm zoo. Hloov koj cov hlwb pob txha yog hloov los ntawm qhov caws pliav. Myelofibrosis tsis yog cuam tshuam rau cov qe ntshav liab tsawg xwb, tab sis koj cov qe ntshav dawb thiab ntshav ntau dhau.

Mob ntshav siab

PV lub sijhawm ntev tuaj yeem ua rau mob ntshav nce hlwb, lossis mob qog ntshav thiab ntshav pob txha. Qhov kev tsis txaus ntseeg no tsawg dua li ntawm myelofibrosis, tab sis nws qhov kev pheej hmoo nce nrog lub sijhawm. Ntev npaum li cas ib tug neeg muaj PV, qhov ntau dua ntawm kev tsim muaj leukemia.

Teeb meem los ntawm kev kho mob

Kev kho PV tuaj yeem ua rau muaj kev phom sij thiab phiv.

Koj yuav hnov ​​zoo li nkees lossis sab sab heev tom qab lub phlebotomy, tshwj xeeb yog tias koj pheej niaj hnub ua li no. Koj cov leeg yuav raug puas los ntawm kev coj tus txheej txheem no.

Muaj qee kis, kev noj cov tshuaj aspirin tsawg yuav tuaj yeem ua rau ntshav los ntshav.

Hydroxyurea, uas yog ib hom tshuaj khomob, tuaj yeem txo koj cov ntshav liab thiab ntshav dawb thiab plasmaets ntau dhau. Hydroxyurea yog kev kho cov ntawv cim npe rau PV. Qhov no txhais tau tias cov tshuaj no tsis pom zoo rau kev kho mob ntawm PV, tab sis nws tau pom tias nws muaj txiaj ntsig ntau hauv ntau tus neeg. Cov kev mob tshwm sim ntawm kev kho hydroxyurea hauv PV tuaj yeem suav nrog mob plab, mob pob txha, thiab kiv taub hau.

Ruxolitinib (Jakafi), tsuas yog FDA pom zoo kho mob rau myelofibrosis thiab PV, tuaj yeem tiv thaiv koj cov ntshav suav ntau dhau. Lwm qhov kev tshwm sim tuaj yeem suav tau kiv taub hau, mob taub hau, qaug zog, mob pob txha, mob plab, ua pa nyuaj, thiab.

Yog tias koj muaj kev mob tshwm sim ntau los ntawm ib qho ntawm koj cov kev kho mob lossis tshuaj noj, tham nrog pab neeg tu koj. Koj thiab koj hematologist tuaj yeem nrhiav cov kev kho mob uas ua hauj lwm zoo tshaj rau koj.