BCR ABL Kev Tshawb Fawb Txog Kev Ntsuas

Zoo Siab

• BCR-ABL kev tshuaj ntsuam genetic yog dab tsi?
• Nws siv rau dab tsi?
• Vim li cas kuv thiaj xav tau qhov kuaj BCR-ABL caj ces?
• Yuav muaj dab tsi tshwm sim thaum kuaj BCR-ABL caj ces?
• Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?
• Puas muaj kev pheej hmoo rau kev kuaj?
• Cov txiaj ntsig li cas?
• Puas muaj lwm yam ntxiv uas kuv xav paub txog qhov kev kuaj mob BCR-ABL?
• Ua tim khawv

BCR-ABL kev tshuaj ntsuam genetic yog dab tsi?

Kev kuaj BCR-ABL caj nrhiav zoo rau kev hloov caj ces (pauv) ntawm cov chromosome tshwj xeeb.

Cov chromosomes yog cov ntu ntawm koj lub hlwb uas muaj koj cov noob caj noob ces. Cov noob yog cov seem ntawm DNA tso tawm los ntawm koj niam thiab koj txiv. Lawv nqa cov ntaub ntawv uas txiav txim siab koj cov xeeb ceem tshwj xeeb, xws li qhov siab thiab xim qhov muag.

Tib neeg ib txwm muaj 46 chromosomes, muab faib ua 23 khub, nyob hauv txhua lub cell. Ib nkawm ntawm ob tug khub yog los ntawm koj niam, thiab lwm tus khub los ntawm koj txiv.

BCR-ABL yog kev hloov pauv uas tau tsim los ntawm kev sib xyaw ntawm ob caj ces, hu ua BCR thiab ABL. Nws qee zaus qee qhov hu ua fusion noob.

• Cov BCR cov noob ib txwm muaj ntawm tus lej chromosome 22.
• Lub npav ABL yog ib txwm muaj ntawm tus lej chromosome 9.
• Kev hloov pauv BCR-ABL tshwm sim thaum cov pob BCR thiab ABL caj ces tawg thiab hloov chaw.
• Qhov hloov pauv qhia tawm ntawm chromosome 22, qhov twg qhov ntawm chromosome 9 tau txuas nws tus kheej.
• Lub mutated chromosome 22 yog hu ua Philadelphia chromosome vim tias yog lub nroog uas cov kws tshawb nrhiav tau xub pom.
• BCR-ABL gene tsis yog hom kev pauv hloov uas tau txais los ntawm koj niam thiab txiv. Nws yog hom kev hloov pauv somatic, uas txhais tau tias koj tsis yog yug los nrog nws. Koj tau txais nws tom qab nyob rau hauv lub neej.

Cov kab mob BCR-ABL qhia pom hauv cov neeg mob uas muaj qee cov ntshav qog ntshav, mob cancer ntawm cov hlwb pob txha thiab ntshav dawb. BCR-ABL yog pom nyob rau yuav luag txhua tus neeg mob uas muaj hom mob leukemia hu ua mob myeloid leukemia (CML). Lwm lub npe rau CML yog mob ntev myelogenous mob leukemia. Ob lub npe xa mus rau tib qho mob.

BCR-ABL gene kuj tseem pom muaj nyob hauv qee cov neeg mob uas muaj cov mob lymphoblastic leukemia (TAG NRHO) thiab tsis tshua muaj rau cov neeg mob uas muaj tus mob myelogenous leukemia (AML).

Qee hom tshuaj tua kabmob kheesxaws muaj kev tshwj xeeb rau kev kho cov neeg mob qog ntshav nrog BCR-ABL hloov chaw. Cov tshuaj no tseem muaj cov kev mob tshwm sim tsawg dua lwm cov kev kho mob qog noj ntshav. Tib hom tshuaj tsis zoo rau kev kho mob sib txawv rau cov ntshav lossis lwm yam mob qog nqaij hlav.

Lwm lub npe: BCR-ABL1, BCR-ABL1 fusion, Philadelphia chromosome

Nws siv rau dab tsi?

Kev kuaj BCR-ABL feem ntau yog siv los kuaj lossis txiav tawm cov mob myeloid leukemia (CML) lossis ib daim ntawv tshwj xeeb ntawm cov mob lymphoblastic leukemia (Txhua yam) hu ua Ph-positive TXHUA. Ph-zoo txhais tau tias Philadelphia chromosome tau pom. Qhov kev kuaj mob no tsis yog siv rau kev kuaj mob lwm yam mob leukemia.

Kev ntsuas kuj tseem siv tau:

• Kuaj seb puas muaj kev kho mob qog noj ntshav.
• Saib seb tus neeg mob puas tau tiv taus qee qhov kev kho mob. Nws txhais tau tias kev kho mob uas siv los ua haujlwm zoo tsis ua haujlwm ntxiv lawm.

Vim li cas kuv thiaj xav tau qhov kuaj BCR-ABL caj ces?

Koj yuav tsum tau kuaj BCR-ABL yog tias koj muaj cov tsos mob ntawm tus mob myeloid leukemia (CML) lossis Ph-positive mob lymphoblastic leukemia (TXHUA). Cov no suav nrog:

• Nkees
• Ua npaws
• Lub cev yuag
• Hmo ntuj tawm fws (tawm hws ntau dhau thaum pw)
• Mob pob txha los yog mob pob txha

Qee tus neeg uas muaj CML lossis Ph-zoo TXHUA yam tsis muaj tsos mob tshwm sim, lossis cov tsos mob me me, tshwj xeeb tshaj yog thaum nyuam qhuav pib mob. Yog li koj tus kws kho mob yuav hais tau cov ntawv no yog tias cov ntshav suav ua tiav lossis lwm cov kev kuaj ntshav pom cov txiaj ntsig tsis zoo. Koj yuav tsum qhia koj tus kws kho mob paub yog tias koj muaj cov tsos mob uas cuam tshuam koj. CML thiab Ph-zoo TXHUA Yooj yim kho thaum ntxov pom.

Koj tseem yuav xav tau qhov kev ntsuas no yog tias tam sim no koj tau raug kho rau CML lossis Ph-zoo TXHUA. Qhov sim sim tuaj yeem pab koj tus kws kho mob saib seb qhov kev kho mob puas ua haujlwm.

Yuav muaj dab tsi tshwm sim thaum kuaj BCR-ABL caj ces?

Kev kuaj BCR-ABL feem ntau yog kuaj ntshav lossis cov txheej txheem hu ua kev hloov pob txha pob txha thiab cov xyoob ntoo.

Yog tias koj tau mus kuaj ntshav, tus kws saib xyuas kev noj qab haus huv yuav nqa ntshav los ntawm txoj hlab ntshav hauv koj txhais caj npab, siv rab koob me me. Tom qab cov koob raug tso nkag, cov ntshav me me yuav raug sau rau hauv lub khob kuaj lossis vial. Koj tuaj yeem hnov ​​me ntsis thaum cov koob nkag mus lossis tawm. Qhov no feem ntau yuav siv sijhawm tsawg dua tsib feeb.

Yog tias koj tau txais pob txha caj qaum kev xav thiab qog nqaij, koj cov txheej txheem yuav suav nrog cov theem hauv qab no:

• Koj yuav tau pw ntawm koj sab lossis koj lub plab, nyob ntawm seb cov pob txha twg yuav siv rau kev sim. Kev ntsuam xyuas mob pob txha feem ntau yog coj los ntawm lub pob txha txha.
• Koj lub cev yuav tau them nrog daim ntaub, kom tsuas yog thaj chaw ib puag ncig ntawm cov chaw sim qhia pom.
• Lub vev xaib yuav muab ntxuav nrog kev siv tshuaj tua kab mob.
• Koj yuav tau txais kev txhaj tshuaj ntawm cov lej daws. Tej zaum nws yuav plev.
• Thaum uas thaj chaw loog, lub tsev kho mob mam li coj tus qauv. Koj yuav xav tau dag heev thaum tseem muaj kev ntsuam xyuas.
  • Rau cov pob txha ua pob txha tawm, uas feem ntau ua tiav ua ntej, cov kws kho mob yuav ntxig ib rab koob ntawm cov pob txha thiab rub tawm cov hlwb pob txha tawm thiab ua hlwb. Tej zaum koj yuav hnov ​​ib qho mob siab heev tab sis qhov mob luv thaum lub koob tau ntxig.
  • Txog kev tshem tawm cov pob txha ntawm cov pob txha, cov kws kho mob yuav siv cov cuab yeej tshwj xeeb uas ntswj rau hauv cov pob txha kom coj tawm cov qauv ntawm cov pob txha ua pob txha. Koj tuaj yeem hnov ​​qee qhov kev nyuab siab rau lub xaib thaum lub sijhawm coj mus kuaj.
• Nws yuav siv sijhawm li 10 feeb los ua ob qho kev sim.
• Tom qab sim, tus kws kho mob yuav npog cov vev xaib nrog daim ntaub qhwv.
• Npaj kom muaj ib tug neeg tsav koj mus tsev, vim tias koj yuav tau muab tshuaj tsaug zog ua ntej kev ntsuam xyuas, uas yuav ua rau koj tsaug zog.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Koj tsis tas yuav tau muaj kev npaj tshwj xeeb rau kev kuaj ntshav lossis mob pob txha.

Puas muaj kev pheej hmoo rau kev kuaj?

Txoj kev kuaj ntshav muaj feem me me. Koj yuav muaj mob me lossis doog ntshav ntawm qhov chaw tso rab koob, tab sis feem ntau cov tsos mob ploj mus sai.

Tom qab kuaj pob txha pob txha, koj yuav hnov ​​txhav txhaus lossis mob ntawm qhov chaw txhaj tshuaj. Qhov no feem ntau yuav ploj mus nyob hauv ob peb hnub. Koj tus kws kho mob yuav hais kom noj tshuaj los yog sau tshuaj kom pab daws qhov mob kom zoo.

Cov txiaj ntsig li cas?

Yog tias koj cov txiaj ntsig pom tau tias koj muaj BCR-ABL gene, nrog rau cov qog ntshav dawb tsis txaus, koj yuav pom tias muaj tus mob myeloid leukemia (CML) lossis Ph-zoo, mob lymphoblastic leukemia (TXHUA).

Yog tias tam sim no koj tau raug kho rau CML lossis Ph-zoo TXHUA, koj cov txiaj ntsig yuav tshwm sim:

• Qhov ntau ntawm BCR-ABL hauv koj cov ntshav lossis pob txha pob txha tau nce ntxiv. Qhov no txhais tau tias koj qhov kev kho mob tsis ua haujlwm thiab / lossis koj yuav tiv taus qhov kev kho qee yam.
• Qhov nyiaj ntawm BCR-ABL hauv koj cov ntshav lossis pob txha pob txha tsawg zuj zus. Qhov no txhais tau tias koj qhov kev kho mob ua haujlwm.
• Qhov nyiaj ntawm BCR-ABL hauv koj cov ntshav lossis pob txha pob txha tsis tau nce los yog tsawg dua. Qhov no txhais tau tias koj tus kab mob tseem nyob ruaj khov.

Yog koj muaj lus nug txog koj cov txiaj ntsig, nrog koj tus kws kho mob tham.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv uas kuv xav paub txog qhov kev kuaj mob BCR-ABL?

Cov kev kho mob rau tus mob myeloid leukemia (CML) thiab Ph-zoo, cov mob lymphoblastic leukemia (TXHUA) tau muaj kev vam meej rau cov neeg mob uas muaj cov ntshav leukemia no. Nws yog ib qho tseem ceeb kom pom koj tus kws kho mob tsis tu ncua kom ntseeg tau tias koj cov kev kho mob txuas ntxiv mus. Yog tias koj tiv taus kev kho mob, koj tus kws kho mob yuav qhia lwm hom kev kho mob cancer.

Ua tim khawv

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Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.