Tus Sau: Virginia Floyd
Hnub Kev Tsim: 11 Lub Yim Hli Ntuj 2021
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Synthesis of Tolbutamide | Structure, MOA, Uses | Sulfonylureas | BP 501T | L~55
Daim Duab: Synthesis of Tolbutamide | Structure, MOA, Uses | Sulfonylureas | BP 501T | L~55

Zoo Siab

Tolbutamide siv nrog rau kev noj haus thiab kev tawm dag zog, thiab qee zaum nrog lwm cov tshuaj, los kho ntshav qab zib hom 2 (mob uas lub cev tsis siv insulin ib txwm thiab, yog li ntawd, tsis tuaj yeem tswj cov piam thaj hauv ntshav). Tolbutamide nyob hauv chav kawm ntawm cov tshuaj hu ua sulfonylureas. Tolbutamide txo qis cov ntshav qab zib los ntawm kev ua rau tus txiav ua tiav insulin (ib yam khoom uas xav tau los rhuav tshem piam thaj hauv lub cev) thiab pab lub cev siv cov insulin zoo. Cov tshuaj no tsuas yog pab txo cov ntshav qab zib hauv cov neeg uas lawv lub cev tsim cov tshuaj insulin lawm xwb. Tolbutamide tsis yog siv los kho ntshav qab zib hom 1 (mob uas lub cev tsis tsim cov tshuaj insulin thiab, yog li ntawd, tsis tuaj yeem tswj cov piam thaj hauv ntshav) lossis ntshav qab zib ketoacidosis (mob hnyav uas yuav tshwm sim yog tias ntshav qab zib tsis kho )).

Sij hawm dhau mus, cov neeg muaj ntshav qab zib thiab ntshav qab zib yuav tsim teeb meem loj lossis txaus ntshai rau lub neej, nrog rau kev mob plawv, mob hlab ntsha tawg, raum teeb meem, puas hlab ntshav, thiab teeb meem qhov muag. Noj tshuaj, hloov kev ua neej (xws li kev noj haus, kev tawm dag zog, txiav kev haus luam yeeb), thiab kev tshuaj xyuas koj cov piam thaj hauv ntshav tas li yuav pab tswj koj cov ntshav qab zib thiab txhim kho koj kev noj qab haus huv. Qhov kev kho no tseem yuav ua rau koj muaj feem yuav muaj mob plawv, mob stroke, lossis lwm yam mob ntsig txog ntshav qab zib xws li lub raum tsis ua hauj lwm, mob hlab hlwb (loog, ceg txias lossis txhais taw; txo qis kev sib deev hauv txiv neej thiab poj niam), teeb meem qhov muag, suav nrog kev hloov pauv los sis tsis pom kev, lossis pos hniav mob. Koj tus kws kho mob thiab lwm tus kws saib xyuas kev noj qab haus huv yuav tham nrog koj txog txoj kev zoo tshaj plaws los tswj koj cov ntshav qab zib.


Tolbutamide los ua cov ntsiav tshuaj los noj ntawm qhov ncauj. Nws feem ntau yuav noj ib zaug ib hnub thaum sawv ntxov. Qhia rau koj tus kws kho mob yog tias tolbutamide mob koj lub plab. Tej zaum koj tus kws khomob yuav qhia koj kom noj tshuaj tolbutamide me dua ntau dua ib hnub ib zaug. Txhawm rau kom koj nco qab noj tshuaj tolbutamide, coj nws ncig ntawm lub sijhawm ua ke nyob rau txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj tolbutamide raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Koj tus kws kho mob tej zaum yuav pib koj noj tsawg kawg yog tolbutamide thiab maj mam nce koj cov koob tshuaj yog tias xav tau. Tom qab koj tau haus tolbutamide rau qee lub sijhawm, tolbutamide tsis tuaj yeem tswj koj cov ntshav qab zib kom zoo li nws tau ua thaum pib kho koj. Koj tus kws kho mob tuaj yeem hloov kho qhov muab tshuaj rau koj raws li qhov xav tau kom cov tshuaj yuav ua haujlwm zoo tshaj rau koj. Nco ntsoov qhia koj tus kws kho mob seb koj nyob zoo li cas thiab yog tias koj cov txiaj ntsig ntsuas ntshav qab zib tau siab dua lossis qis dua li ib txwm muaj thaum lub sijhawm koj kho.


Cov tshuaj no qee zaum sau tseg rau lwm qhov kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj tolbutamide,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau tolbutamide, lwm yam tshuaj, lossis lwm yam tshuaj hauv tolbutamide. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog anticoagulants ('ntshav cov ntshav') xws li warfarin (Coumadin); cov tshuaj aspirin thiab lwm cov tshuaj tiv thaiv tsis haum (NSAIDs) xws li ibuprofen (Advil, Motrin) thiab naproxen (Aleve, Naprosyn); beta blockers xws li atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), thiab propranolol (Inderal); calcium channel blockers xws li amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, lwm tus), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop) Sular), thiab verapamil (Calan, Isoptin, Verelan); chloramphenicol; diuretics ('dej tshuaj'); fluconazole (Diflucan), kev hloov kho tshuaj hormone thiab tshuaj tiv thaiv cev xeeb tub (tshuaj txwv, tshuaj pleev ib ce, ib ncig, pleev, thiab txhaj); tshuaj insulin lossis lwm yam tshuaj los kho ntshav qab zib lossis ntshav qab zib; isoniazid (INH); MAO inhibitors xws li isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), thiab tranylcypromine (Parnate); tshuaj rau mob hawb pob thiab mob khaub thuas; tshuaj rau kev mob hlwb thiab xeev siab; miconazole (Monistat); niacin; qhov ncauj steroids xws li dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), thiab prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); salicylate mob mob xws li choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, lwm tus), thiab salsalate (Argesic, Disalcid, Salgesic); cov tshuaj tua kab mob sulfa xws li co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); thiab cov tshuaj kho cov thyroid. Thiab nco ntsoov qhia koj tus kws kho mob lossis kws muag tshuaj yog tias koj tsum tsis noj tshuaj thaum noj tolbutamide. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
  • qhia rau koj tus kws kho mob yog tias koj muaj lossis tsis tau muaj G6PD tsis txaus (ib qho mob uas tau muaj los ua rau cov ntshav liab los sis ntshav liab tsawg); yog tias koj muaj cov tshuaj hormone cuam tshuam nrog adrenal, pituitary, lossis thyroid caj pas; lossis yog tias koj muaj mob plawv, raum, lossis mob siab.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj xeeb tub thaum tab tom noj tolbutamide, hu rau koj tus kws kho mob.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav uas koj noj tolbutamide.
  • nug koj tus kws kho mob txog kev haus cawv zoo thaum koj siv tshuaj tolbutamide. Cawv yuav ua rau muaj kev phiv los ntawm tolbutamide ntau tuaj. Kev haus dej haus cawv thaum noj tolbutamide tseem yuav ua rau cov tsos mob xws li dej ntws yaug (liab ntawm ntsej muag), mob taub hau, xeev siab, ntuav, mob hauv siab, tsis muaj zog, plooj tsis pom kev, tsis meej pem, hws, txhawm chim, ua pa nyuaj, thiab ntxhov siab.
  • npaj ua kom tsis txhob muaj qhov phom sij lossis tsis haum rau lub hnub ci thiab hnav khaub ncaws tiv thaiv, tsom iav, thiab tshuaj pleev thaiv hnub. Tolbutamide tuaj yeem ua rau koj cov tawv nqaij raug tshav ntuj.
  • nug koj tus kws kho mob seb yuav ua li cas yog tias koj mob, kis kab mob lossis ua npaws, muaj kev ntxhov siab txawv txawv, lossis raug mob. Cov mob no tuaj yeem cuam tshuam koj cov ntshav qab zib thiab cov ntshav tolbutamide uas koj xav tau.

Nco ntsoov ua raws li tag nrho cov kev tawm dag zog thiab kev noj haus pom zoo ua los ntawm koj tus kws kho mob lossis tus kws qhia noj zaub mov. Nws yog ib qho tseem ceeb kom noj zaub mov zoo, tawm dag zog kom tsis tu ncua, thiab poob ceeb thawj yog tsim nyog.


Ua ntej koj pib noj cov tshuaj tolbutamide, nug koj tus kws kho mob tias koj yuav tsum ua li cas yog tias koj tsis nco qab noj tshuaj. Sau cov lus qhia no sab hauv kom koj tuaj yeem xa lawv tom qab.

Raws li txoj cai dav dav, noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Yog tias nws yuav luag txog rau kev noj tshuaj ntxiv, hla cov tshuaj tsis nco qab thiab txuas ntxiv rau koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Cov tshuaj no tuaj yeem hloov pauv hauv koj cov piam thaj hauv ntshav. Koj yuav tsum paub cov tsos mob uas muaj ntshav qab zib thiab ntshav qab zib thiab yuav ua li cas yog tias koj muaj cov tsos mob no.

Tolbutamide yuav ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • xeev siab
  • lub plab zom mov puv nkaus
  • Kev mob siab
  • ua pob
  • mob taub hau
  • hloov pauv hauv saj

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • daj ntawm daim tawv nqaij lossis qhov muag
  • lub teeb xim ua kom nruj
  • tsaus zis
  • mob hauv sab saud hauv plab
  • doog ntshav los ntshav tsis txawv
  • zawv plab
  • ua npaws
  • mob caj pas

Tolbutamide tuaj yeem ua lwm yam phiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Hauv ib txoj kev tshawb nrhiav, cov neeg uas tau siv tshuaj tolbutamide los kho lawv cov ntshav qab zib muaj feem ntau yuav tuag ntawm kev muaj mob plawv dua li cov neeg uas tau raug kho los ntawm insulin thiab kev hloov pauv zaub mov. Tham nrog koj tus kws kho mob txog kev pheej hmoo ntawm kev noj tshuaj tolbutamide.

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm lub teeb, tshaj cua sov, thiab noo noo (tsis nyob hauv chav dej).

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm overdose tej zaum yuav muaj xws li hypoglycemia cov tsos mob raws li nram qab no:

  • qaug dab peg
  • tsis nco qab

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj cov ntshav qab zib thiab ntshav qab zib cov ntshav qab zib yuav tsum tau kuaj xyuas tsis tu ncua los txiav txim koj cov lus teb rau tolbutamide. Koj tus kws kho mob tuaj yeem hais kom ua lwm yam kev kuaj ntsuas, suav nrog glycosylated hemoglobin (HbA1c), txhawm rau tshuaj xyuas koj cov lus teb rau tolbutamide. Koj tus kws kho mob tseem yuav qhia koj txog kev tshuaj xyuas koj cov lus teb rau cov tshuaj no li cas los ntawm kev ntsuas koj cov ntshav lossis ntshav qab zib kom ntshav nyob hauv tsev. Ua raws li cov lus qhia no kom zoo.

Ua ntej muaj kev sim ntsuas, qhia rau koj tus kws kho mob thiab cov neeg ua haujlwm hauv chav kuaj pom tias koj noj tolbutamide.

Koj yuav tsum hnav txoj hlua tes uas muaj ntshav qab zib kom paub tseeb tias koj tau txais kev kho mob tau zoo thaum muaj xwm txheej ceev.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Orinase®

Cov khoom muaj npe khoom no tsis nyob rau ntawm kev ua lag luam. Muaj lwm cov kev xaiv uas siv tau.

Kawg Kho - 07/15/2017

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