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Safety and efficacy of zanubrutinib in patients with B-cell malignancies
Daim Duab: Safety and efficacy of zanubrutinib in patients with B-cell malignancies

Zoo Siab

Zanubrutinib yog siv los kho mantle cell lymphoma (MCL; mob qog nqaij hlav loj sai uas pib hauv cov kab mob hauv lub nruab nrog cev) hauv cov neeg laus uas twb tau kho mob tsawg kawg yog ib qho kev kho mob rau tshuaj kho mob. Zanubrutinib nyob hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus ntseeg uas ua teeb liab rau cov cell mob qog hlav. Qhov no yuav pab kom tsis txhob kis mob hlwb.

Zanubrutinib los ua tshuaj ntsiav los noj ntawm qhov ncauj. Nws feem ntau yog noj ib zaug lossis ob zaug ib hnub nrog lossis tsis muaj zaub mov. Siv zanubrutinib nyob ib ncig ntawm tib lub sijhawm (s) txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj zanubrutinib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov tsiav tshuaj tag nrho nrog ib khob dej; tsis txhob sib faib, zom, lossis tsoo lawv.

Koj tus kws kho mob tuaj yeem txo koj cov koob tshuaj, lossis cuam tshuam lossis ncua kev kho mob. Qhov no nws nyob ntawm seb cov tshuaj ua hauj lwm zoo npaum li cas rau koj thiab kev phiv uas koj ntsib. Tham nrog koj tus kws kho mob txog saib koj xav li cas thaum kho koj tus mob. Txuas ntxiv noj zanubrutinib txawm hais tias koj xis neej. Tsis txhob tsum noj zanubrutinib yam tsis tham nrog koj tus kws kho mob.


Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj zanubrutinib,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau zanubrutinib, lwm yam tshuaj, lossis lwm yam tshuaj hauv zanubrutinib tsiav tshuaj. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: cov tshuaj tiv thaiv anticoagulant ('ntshav cov ntshav') xws li warfarin (Coumadin, Jantoven); cov tshuaj tiv thaiv xws li fluconazole (Diflucan), itraconazole (Onmel, Sporanox), lossis ketoconazole; aprepitant (Cinvanti, Kho); clarithromycin (Biaxin, hauv Prevpac); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, lwm tus); erythromycin (E.E.S., Erythrocin, lwm tus); qee cov tshuaj siv los kho tib neeg cov tshuaj tiv thaiv kab mob (HIV) lossis tau txhaj tshuaj tiv thaiv kab mob (AIDS) xws li efavirenz (Sustiva, hauv Atripla), nelfinavir (Viracept), ritonavir (Norvir, hauv Kaletra), thiab saquinavir (Invirase); nefazodone; omeprazole (Prilosec); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); phom phom (Rifadin, Rifamate, Rimactane, lwm tus); midazolam; thiab cov tshuaj steroid qhov ncauj xws li dexamethasone, methylprednisolone (Medrol), thiab prednisone (Rayos). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
  • qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John's Wort.
  • qhia rau koj tus kws kho mob yog tias koj muaj mob lossis nyuam qhuav raug phais. Thiab qhia koj tus kws kho mob yog tias koj tau lossis muaj lub plawv dhia tsis xwm yeem, ntshav siab, ntshav ntws, lossis lub plawv lossis daim siab.
  • qhia rau koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis yog koj npaj yuav leej txiv. Koj yuav tsum tsis txhob cev xeeb tub thaum koj tab tom noj zanubrutinib. Yog tias koj yog poj niam, koj yuav tsum tau kuaj cev xeeb tub ua ntej koj pib kho thiab yuav tsum siv kev tswj kom tsis txhob muaj menyuam kom tiv thaiv kev xeeb tub lub sijhawm koj kho thiab rau 1 lub lis piam tom qab koj cov tshuaj zaum kawg. Yog tias koj yog txiv neej, koj thiab koj tus poj niam tus khub yuav tsum siv tshuaj tswj kom tsis txhob muaj menyuam thaum lub sijhawm kho nrog zanubrutinib thiab txuas ntxiv li 1 lub lis piam tom qab koj zaum kawg. Yog tias koj lossis koj tus khub xeeb tub thaum tab tom noj zanubrutinib, hu rau koj tus kws kho mob tam sim ntawd. Zanubrutinib tuaj yeem ua rau mob me nyuam hauv plab.
  • qhia rau koj tus kws kho mob yog tias koj pub mis. Tsis txhob noj mis thaum koj tab tom noj zanubrutinib thiab rau 2 lub lis piam tom qab koj zaum kawg.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav uas koj noj zanubrutinib. Koj tus kws kho mob yuav qhia koj kom tsis txhob noj zanubrutinib lub sijhawm ua ntej thiab tom qab phais lossis cov txheej txheem.
  • npaj ua kom tsis txhob muaj qhov phom sij lossis tsis haum rau lub hnub ci thiab hnav khaub ncaws tiv thaiv, tsom iav, thiab tshuaj pleev thaiv hnub. Zanubrutinib yuav ua rau koj cov tawv nqaij ua rau muaj kev phom sij los ntawm lub hnub ci, thiab yuav ua rau koj muaj kev pheej hmoo ntawm kev tsim mob qog nqaij daim tawv.

Tham nrog koj tus kws kho mob txog kev noj txiv kab ntxwv qaub thiab haus kua txiv thaum lub sijhawm noj cov tshuaj no.


Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco ntsoov nws hnub ntawd thiab txuas ntxiv koj lub sijhawm noj tshuaj ntxiv rau hnub tom qab. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Zanubrutinib yuav tshwm sim phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • zawv plab
  • cem quav
  • hnoos
  • leeg, pob qij txha, lossis mob nraub qaum

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

  • kub taub hau, mob caj pas, ua daus no, los yog lwm yam cim ntawm tus kab mob
  • mob, nquag, los sis ceev tso zis
  • hnoos, txog siav, mob hauv siab thaum koj nqus lossis hnoos, lossis kub taub hau
  • doog ntshav los ntshav tsis txawv
  • cov ntshav hauv koj cov quav lossis dub, tarry tso quav; liab los yog daj tso zis; ntuav ntshav lossis kas fes ntuav hauv av; hnoos tau ntshav
  • zoo li kiv taub hau, qaug zog, los yog tsis meej pem; hloov hais lus; mob taub hau uas kav ntev
  • ua pob
  • lub plawv dhia ceev lossis tsis meej, hais lus zoo nkauj, hnov ​​lub ntsej muag lossis kiv taub hau, tsaus muag, ua pa ceev, mob hauv siab

Zanubrutinib tuaj yeem ua kom koj txoj kev pheej hmoo ntawm kev tsim qee yam mob khees xaws nrog nrog mob qog nqaij hlav. Tham nrog koj tus kws kho mob txog kev pheej hmoo ntawm kev noj zanubrutinib.


Zanubrutinib tuaj yeem ua lwm yam phiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim kuaj xyuas koj lub cev lus teb rau zanubrutinib.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Pob Tsuas Xyooj®
Kawg Kho - 02/15/2020

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