Tus Sau: Clyde Lopez
Hnub Kev Tsim: 17 Lub Xya Hli Ntuj 2021
Hloov Hnub: 11 Lub Kawm Ob Hlis Ntuj 2024
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Congenital adrenal hyperplasia : Etiology ,Pathophysiology ,Clinical features ,Diagnosis ,Treatment
Daim Duab: Congenital adrenal hyperplasia : Etiology ,Pathophysiology ,Clinical features ,Diagnosis ,Treatment

Zoo Siab

17-hydroxyprogesterone (17-OHP) yog dab tsi?

Qhov ntsuas no ntsuas ntau npaum li cas ntawm 17-hydroxyprogesterone (17-OHP) hauv cov ntshav. 17-OHP yog yam tshuaj tsim los ntawm cov qog adrenal, ob lub qog nyob rau sab saum toj ntawm ob lub raum. Cov qog adrenal ua rau ntau cov tshuaj hormones, suav nrog cortisol. Cortisol yog qhov tseem ceeb rau kev tswj xyuas cov ntshav siab, ntshav qab zib thiab qee yam haujlwm ntawm lub cev tiv thaiv kab mob. 17-OHP yog tsim los ua cov txheej txheem ntawm kev tsim cov cortisol.

Kev kuaj 17-OHP pab tshawb nrhiav pom qhov tsis tshua pom muaj caj ces hu ua Congenital adrenal hyperplasia (CAH). Hauv CAH, kev hloov caj ces, hu ua kev hloov chaw, tiv thaiv cov qog adrenal los ua kom tsis txaus cortisol. Raws li cov qog adrenal ua haujlwm ntau dua los ua kom ntau dua cortisol, lawv tsim cov 17-OHP ntxiv, nrog rau qee yam txiv neej pw ua ke.

CAH tuaj yeem ua rau tsis muaj kev txhim kho kabmob sib deev thiab tus cwj pwm kev sib deev. Cov tsos mob ntawm tus mob tsis sib haum yog me me mus rau mob hnyav. Yog tias tsis kho, CAH hnyav dua tuaj yeem ua rau muaj kev mob hnyav, nrog rau lub cev qhuav dej, ntshav siab, thiab lub plawv dhia tsis zoo (tsis ua haujlwm).


Lwm lub npe: 17-OH progesterone, 17-OHP

Nws siv rau dab tsi?

Kev ntsuas 17-OHP feem ntau yog siv los kuaj xyuas CAH hauv cov menyuam mos yug tshiab. Nws kuj tseem siv tau:

  • Kev kuaj mob CAH rau cov menyuam yaus thiab cov neeg laus uas tej zaum yuav muaj qhov tshwm sim me me ntawm qhov tsis zoo. Hauv CAH tsis me, cov tsos mob yuav tshwm sim hauv lub neej yav tom ntej, lossis qee zaum tsis muaj kiag li.
  • Saib xyuas kev kho mob rau CAH

Vim li cas kuv thiaj xav tau 17-OHP kev xeem?

Koj tus menyuam yuav xav kuaj 17-OHP, feem ntau nyob hauv 1-2 hnub tom qab yug. 17-OHP kev xeem rau CAH tam sim no tseev kom muaj los ntawm txoj cai lij choj los ntawm kev kuaj xyuas cov menyuam mos. Kev kuaj xyuas cov menyuam mos yog txoj kev kuaj ntshav yoojyim uas yog kuaj xyuas ntau yam kabmob hnyav.

Cov menyuam loj dua thiab cov neeg laus yuav tsum tau kuaj yog tias lawv muaj cov tsos mob ntawm CAH. Cov tsos mob yuav sib txawv raws li kev puas siab puas ntsws loj npaum li cas, hnub nyoog thaum cov tsos mob tshwm sim, thiab seb koj puas yog txiv neej los poj niam.

Cov tsos mob ntawm kev mob hnyav tshwm sim feem ntau tshwm sim hauv 2-3 lub lis piam tom qab yug.

Yog tias koj tus menyuam yug nyob sab nraud Tebchaws Asmeskas thiab tsis tau kuaj mob tshiab, lawv yuav tsum tau kuaj yog tias lawv muaj ib lossis ntau cov tsos mob hauv qab no:


  • Tus qau uas tsis meej txiv neej lossis poj niam (tsis meej qhov chaw mos)
  • Lub cev qhuav dej
  • Ntuav thiab lwm yam teeb meem pub mis
  • Mob lub plawv tsis zoo (rhais ruam)

Cov menyuam hnub nyoog loj dua yuav tsis muaj tsos mob mus txog thaum tiav nkauj tiav nraug. Hauv cov menyuam ntxhais, cov tsos mob ntawm CAH suav nrog:

  • Kev coj khaub ncaws tsis xwm yeem, los sis tsis muaj ib lub sijhawm ib zaug li
  • Cov tsos kom pom ntxov thiab / lossis plaub hau npab
  • Ntau cov plaub hau ntawm lub ntsej muag thiab lub cev
  • Lub suab sib sib zog nqus
  • Ntug clitoris

Hauv cov tub hluas, cov tsos mob muaj xws li:

  • Ntug noov
  • Thaum ntxov tiav nkauj tiav nraug (ceev faj pub pub dawb)

Hauv cov neeg laus thiab poj niam, cov tsos mob tuaj yeem suav nrog:

  • Ntxiv lawm tshob (tsis muaj peev xwm xeeb tub los yog muaj ib tus khub xeeb tub)
  • Hnyav ntxau

Muaj dab tsi tshwm sim thaum 17-OHP xeem?

Kev kuaj menyuam mos, tus kws saib xyuas kev noj qab haus huv yuav ntxuav koj tus menyuam pob taws nrog cawv thiab nchuav caj dab nrog rab koob me me. Tus kws khomob yuav khaws ob peb ncos ntshav thiab muab ntaub qhwv rau ntawm qhov chaw.


Lub sijhawm kuaj ntshav rau menyuam yaus thiab tus neeg laus, tus kws saib xyuas kev noj qab haus huv yuav nqa ib qho ntshav los ntawm txoj hlab ntshav hauv koj txhais caj npab, siv rab koob me me. Tom qab cov koob raug tso nkag, cov ntshav me me yuav raug sau rau hauv lub khob kuaj lossis vial. Koj tuaj yeem hnov ​​me ntsis thaum cov koob nkag mus lossis tawm. Qhov no feem ntau yuav siv sijhawm tsawg dua tsib feeb.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Tsis muaj kev npaj tshwj xeeb xav tau rau 17-OHP kev xeem.

Puas muaj kev pheej hmoo rau kev kuaj?

Nws tsis tshua muaj kev pheej hmoo rau koj lossis koj tus menyuam uas muaj 17-OHP. Koj yuav muaj mob me lossis doog ntshav ntawm qhov chaw tso rab koob, tab sis feem ntau cov tsos mob ploj mus sai. Koj tus menyuam tuaj yeem hnov ​​me ntsis thaum lub pob taws los, thiab ua pob me me rau ntawm thaj chaw. Qhov no yuav tsum ploj mus sai heev.

Cov txiaj ntsig li cas?

Yog tias cov qhab nia tshwm sim siab txog 17-OHP, tej zaum koj lossis koj tus menyuam muaj CAH. Feem ntau, cov theem siab dhau txhais tau hais tias daim ntawv hnyav dua ntawm tus mob, hos cov neeg siab nyob theem siab feem ntau txhais tau tias daim ntawv me dua.

Yog tias koj lossis koj tus menyuam raug kho rau CAH, qis dua 17-OHP txhais tau tias kev kho mob ua haujlwm. Txoj kev kho yuav suav cov tshuaj los hloov cortisol uas ploj lawm. Qee zaum phais yog ua kom pauv qhov txawv thiab ua haujlwm ntawm lub qog.

Yog tias koj muaj lus nug txog koj cov txiaj ntsig lossis koj cov txiaj ntsig ntawm menyuam, nrog koj tus kws kho mob tham.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv uas kuv xav paub txog 17-OHP kev xeem?

Yog tias koj lossis koj tus menyuam raug kuaj mob CAH, tej zaum koj yuav xav sab laj nrog tus kws sab laj tswv yim txog caj ces, tus kws tshaj lij hauv cov noob caj noob ces. CAH yog kev muaj keeb caj ces tus niam thiab txiv ob leeg yuav tsum muaj kev hloov hauv caj ces uas ua rau CAH. Leej niam leej txiv yuav yog tus xeeb txawm muaj ntawm cov gene, txhais tau tias lawv muaj tus gene tab sis feem ntau tsis muaj tsos mob tshwm sim. Yog tias niam thiab txiv ob leeg yog tus tsav tsheb, txhua tus me nyuam muaj 25% ntawm qhov muaj qhov mob.

Ua tim khawv

  1. Cares Foundation [Is Taws Nem]. Union (NJ): Cares Foundation; c2012. Congenital Adrenal Hyperplasia (CAH) yog dab tsi ?; [hais tawm 2019 Aug 17]; [txog 3 ntxaij]. Muaj los ntawm: https://www.caresfoundation.org/what-is-cah
  2. Eunice Kennedy Shriver Koom Haum Tebchaws ntawm Menyuam Kev Noj Qab Haus Huv thiab Tib Neeg [Is Taws Nem]. Rockville (MD): Asmeskas Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Congenital Adrenal hyperplasia (CAH): Ntaub Ntawv Mob; [hais tawm 2019 Aug 17]; [txog 3 ntxaij]. Muaj los ntawm: https://www.nichd.nih.gov/health/topics/cah/conditioninfo
  3. Hormone Health Network [Is Taws Nem]. Endocrine Kev Ua Neej; c2019. Congenital Adrenal hyperplasia; [kho tshiab 2018 Sep; hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://www.hormone.org/diseases-and-conditions/congenital-adrenal-hyperplasia
  4. Kev Noj Qab Haus Huv Menyuam Yaus los ntawm Nemours [Is Taws Nem]. Jacksonville (FL): Lub Chaw Nemours; c1995–2019. Congenital Adrenal hyperplasia; [hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://kidshealth.org/en/parents/congenital-adrenal-hyperplasia.html
  5. Kev Noj Qab Haus Huv Menyuam Yaus los ntawm Nemours [Is Taws Nem]. Jacksonville (FL): Lub Chaw Nemours; c1995–2019. Kev Kuaj Menyuam Mos; [hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://kidshealth.org/en/parents/newborn-saib-taw.html
  6. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .; Cov Koom Haum Asmeskas rau Chaw Kho Mob Soj Ntsuam; c2001–2019. 17-Hydroxyprogesterone; [kho tshiab 2018 Dec 21; hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/tests/17-hydroxyprogesterone
  7. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .; Cov Koom Haum Asmeskas rau Chaw Kho Mob Soj Ntsuam; c2001–2019. Ntxiv lawm tshob; [hloov tshiab 2017 Nov 27; hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/conditions/infertility
  8. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI Lus Txhais ntawm Cancer Cov Lus Cog Tseg: tus kws pab tswv yim caj; [hais tawm 2019 Aug 17]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/794108
  9. National Center for Advancing Translational Sciences: Neeg Keeb Kwm thiab Cov Ntaub Ntawv Kab Mob Tsis Muaj Tseeb [Is Taws Nem]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; 21-hydroxolase tsis muaj peev xwm; [kho tshiab 2019 Apr 11; hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://rarediseases.info.nih.gov/diseases/5757/21-hydroxylase-deficiency
  10. Lub Khawv koob Foundation [Internet]. Warrenville (IL): Khawv koob Foundation; c1989–2019. Congenital Adrenal hyperplasia; [hais tawm 2019 Aug 17]; [txog 4 ntxaij]. Muaj los ntawm: https://www.magicfoundation.org/Growth-Disorders/Congenital-Adrenal-Hyperplasia
  11. Lub Peb Hlis Dimes [Is Taws Nem]. Arlington (VA): Lub Peb Hlis Ntuj ntawm Dimes; c2020. Kev Kuaj Menyuam Mos Rau Koj Cov Menyuam; [hais tawm 2020 Aug 8]; [txog 3 ntxaij]. Muaj los ntawm: https://www.marchofdimes.org/baby/newborn-vaj-vaj-for-your-baby.aspx
  12. Kev Noj Qab Haus Huv UF: University of Florida Health [Is Taws Nem]. Gainesville (IBCE): University of Florida Kev Noj Qab Haus Huv; c2019. 17-OH progesterone: Txheej txheem cej luam; [kho tshiab 2019 Aug 17; hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://ufhealth.org/17-oh-progesterone
  13. Kev Noj Qab Haus Huv UF: University of Florida Health [Is Taws Nem]. Gainesville (IBCE): University of Florida Kev Noj Qab Haus Huv; c2019. Congenital adrenal hyperplasia: Txheej txheem cej luam; [kho tshiab 2019 Aug 17; hais tawm 2019 Aug 17]; [txog 2 ntxaij]. Muaj los ntawm: https://ufhealth.org/congenital-adrenal-hyperplasia

Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.

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