Kev ntsuas CPK isoenzymes

Kev kuaj ntshav ntawm creatine phosphokinase (CPK) isoenzymes ntsuas cov tshuaj sib txawv ntawm CPK hauv cov ntshav. CPK yog ib qho enzyme uas pom muaj nyob hauv lub plawv, lub paj hlwb, thiab pob txha pob txha.

Xav tau cov ntshav ntxiv. Qhov no yuav coj los ntawm cov leeg ntshav. Txoj kev kuaj no hu ua venipuncture.

Yog tias koj nyob hauv tsev kho mob, qhov kev sim no yuav rov ua dua 2 lossis 3 hnub. Ib qho tseem ceeb nce lossis poob rau hauv tag nrho CPK lossis CPK isoenzymes tuaj yeem pab koj tus kws kho mob txheeb xyuas qee yam mob.

Feem ntau tsis muaj kev npaj tshwj xeeb ntxiv rau feem ntau.

Qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv. Qee cov tshuaj tuaj yeem cuam tshuam nrog cov kev sim. Cov tshuaj uas tuaj yeem ua rau kev ntsuas ntau dua ntawm CPK suav nrog cov hauv qab no:

• Cawv
• Amphotericin B
• Tej yam tshuaj loog
• Kab yeeb
• Cibrate tshuaj
• Statins
• Cov tshuaj steroid, xws li dexamethasone

Cov npe no tsis yog txhua yam.

Tej zaum koj yuav hnov ​​mob me ntsis thaum cov koob tso rau kom kos cov ntshav. Ib txhia neeg tsuas hnov ​​tus pleev qhov muag lossis plev. Tom qab ntawd, yuav muaj qee qhov throbbing.

Qhov kev ntsuas no tau ua tiav yog tias CPK ntsuas pom tias koj qib qib siab ntawm CPK nce lawm. Kev ntsuas CPK isoenzyme tuaj yeem pab nrhiav qhov tseeb ntawm cov ntaub so ntswg uas raug puas.

CPK yog tsim los ntawm peb qho tshuaj sib txawv me ntsis:

• CPK-1 (tseem hu ua CPK-BB) yog pom feem ntau hauv lub hlwb thiab lub ntsws
• CPK-2 (tseem hu ua CPK-MB) yog pom feem ntau hauv lub plawv
• CPK-3 (tseem hu ua CPK-MM) yog pom feem ntau hauv cov leeg pob txha

Qib siab dua-dua li qub CPK-1:

Vim tias CPK-1 feem ntau pom hauv lub hlwb thiab lub ntsws, kev raug mob rau ib qho ntawm cov chaw no tuaj yeem nce CPK-1 qib. Nce qib hauv CPK-1 tej zaum yuav yog vim:

• Mob hlwb
• Raug mob rau lub hlwb (vim yog ib qho kev raug mob suav nrog, mob stroke, lossis ntshav tawm hauv lub hlwb)
• Kev kho mob electroconvulsive
• Pulmonary infarction
• Qaug

Qib siab dua-dua li qub CPK-2:

Qib CPK-2 nce 3 mus rau 6 teev tom qab lub plawv nres. Yog tias tsis muaj kev mob plawv hauv lub siab ntxiv, qib yuav nce siab ntawm 12 rau 24 teev thiab rov qab los li qub 12 txog 48 teev tom qab kev tuag ntawm ntaub so ntswg.

Nce qib hauv qib CPK-2 kuj yuav yog vim:

• Hluav taws xob raug mob
• Kev tiv thaiv lub plawv (muaj lub hom phiaj zoo rau lub plawv los ntawm cov neeg kho mob)
• Kev raug mob rau lub plawv (piv txwv li, los ntawm lub tsheb sib nraus)
• Kev mob lub plawv mob feem ntau yog kis los ntawm tus kab mob (myocarditis)
• Qhib lub plawv phais

Kev ua tau zoo dua-ntau dua li ib txwm-qib CPK-3 feem ntau yog cov cim ntawm kev raug mob leeg lossis mob leeg. Lawv yuav yog vim:

• Tsoo kev raug mob
• Mob puas vim yog tshuaj los yog lub cev nyob tsis ntev (rhabdomyolysis)
• Nqaij ua tej leeg
• Myositis (mob pob txha mob)
• Txais ntau cov tshuaj txhaj intramuscular
• Lub paj hlwb tsis ntev los no thiab lub cev ua haujlwm kuaj (electromyography)
• Cov qaug dab peg tsis ntev los no
• Kev phais niaj hnub no
• Kev tawm dag zog

Qhov tseeb uas tuaj yeem cuam tshuam cov kev ntsuas muaj xws li mob catheterization, txhaj tshuaj intramuscular, kev phais mob tsis ntev los no, thiab kev tawm dag zog thiab lub cev ua haujlwm ntev lossis ua haujlwm immobilization.

Isoenzyme kuaj rau cov mob tshwj xeeb yog kwv yees li 90%.

Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes; Kev Tiv Thaiv Plawv - CPK; Tsoo - CPK

• Kuaj ntshav

Anderson JL. St ntu ntu nce myocardial infarction thiab mob ntawm myocardial infarction. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 73.

Marshall WJ, Hnub A, Lapsley M. Plasma cov protein thiab cov enzymes. Hauv: Marshall WJ, Hnub A, Lapsley M, eds. Cov Chaw Kho Mob Soj NtsuamCov. 8 tus ed. Philadelphia, PA: Elsevier; 2017: chap 16.

Nagaraju K, Gladue HS, Lundberg IE. Cov mob o ntawm cov leeg nqaij thiab lwm yam mob myopathies. Hauv: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley thiab Firestein Cov Ntawv Phau Ntawv ntawm RheumatologyCov. 10 tus ed. Philadelphia, PA: Elsevier Saunders; 2017: chap 85.

Selcen D. Cov leeg nqaij. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: cha 421.