Tus mob ntshav siab dysbetalipoproteinemia

Familial dysbetalipoproteinemia yog ib qho kev tsis sib haum kis dhau los ntawm cov tsev neeg. Nws ua rau cov cholesterol thiab triglycerides ntau hauv cov ntshav.

Kev mob caj ces ua rau tus mob no. Qhov tsis zoo tshwm sim los ntawm kev txhim kho cov lipoprotein loj uas muaj cov roj cholesterol thiab ib hom rog hu ua triglycerides. Tus kab mob txuas rau qhov tsis xws luag hauv cov gene rau apolipoprotein E.

Mob Hypothyroidism, rog dhau, lossis ntshav qab zib tuaj yeem ua rau tus mob hnyav dua. Yam txaus ntshai rau tsev neeg dysbetalipoproteinemia muaj xws li tsev neeg keeb kwm ntawm tus mob tsis zoo lossis mob leeg ntshav hlab plawv.

Cov tsos mob yuav tsis pom kom txog hnub nyoog 20 lossis laus dua.

Daj tso tawm ntawm cov khoom siv rog hauv daim tawv nqaij hu ua xanthomas tuaj yeem tshwm rau ntawm daim tawv muag, xib teg ntawm txhais tes, tsuas yog txhais ko taw, lossis ntawm txoj leeg ntawm lub hauv caug thiab lub luj tshib.

Lwm cov tsos mob tuaj yeem suav nrog:

• Mob hauv siab (angina) lossis lwm yam cim ntawm tus kab mob rau txoj hlab ntshav ntawm lub cev tuaj yeem yog thaum tseem hluas
• Kev zawm ntawm ib lossis ob qho thawm thaum taug kev
• Mob rau ntawm cov ntiv taw uas tsis kho
• Cov tsos mob tam sim ntawd xws li hais lus tsis txaus ntseeg, nqis rau ntawm ib sab ntawm lub ntsej muag, tsis muaj zog ntawm caj npab lossis txhais ceg, thiab tsis poob ntawm qhov sib npaug

Tej kev kuaj mob uas yuav ua tau los ntsuas tus mob no suav nrog:

• Kev tshuaj ntsuam caj ces rau apolipoprotein E (apoE)
• Kev kuaj ntshav lipid vaj huam sib luag
• Triglyceride qib
• Tsawg kawg ntom lipoprotein (VLDL) kev ntsuas

Lub hom phiaj ntawm kev kho mob yog tswj hwm cov mob xws li kev rog dhau, hypothyroidism, thiab ntshav qab zib.

Kev hloov pauv zaub mov kom txo tau cov calories, cov rog rog, thiab cov roj cholesterol yuav pab txo cov roj cholesterol.

Yog tias cov roj (cholesterol) thiab qib roj triglyceride tseem nyob siab dua tom qab koj hloov pauv zaub mov, koj tus kws kho mob yuav kom koj noj tshuaj ib yam nkaus. Cov tshuaj kom txo qis ntshav triglyceride thiab roj (cholesterol) ntau ntau muaj xws li:

• Bile acid-sequestering resins.
• Fibrates (gemfibrozil, fenofibrate).
• Nicotinic acid.
• Statins.
• PCSK9 inhibitors, xws li alirocumab (Praluent) thiab evolocumab (Repatha). Cov no sawv cev rau cov chav kawm tshiab uas muaj tshuaj pab kho cov roj (cholesterol).

Cov neeg muaj tus mob no muaj ntau yam yuav ua mob rau txoj hlab ntshav thiab hlab ntshav txhaws.

Nrog rau kev kho mob, neeg feem coob muaj peev xwm txo tau lawv qib roj thiab triglycerides kom ntau.

Teeb meem yuav suav nrog:

• Plawv nres
• Mob stroke
• Peripheral vascular kab mob
• Sib quas dus claudication
• Qaug taw ntawm qhov qis hauv qab

Hu rau koj tus kws khomob yog koj tau kuaj pom tias tus mob no thiab:

• Cov tsos mob tshiab tshwm sim.
• Cov tsos mob tsis zoo nrog kev kho.
• Cov tsos mob mob heev dua.

Kev kuaj cov neeg hauv tsev neeg ntawm cov neeg muaj tus mob no tuaj yeem ua rau paub ntxov thiab kho mob.

Tau txais kev kho mob thaum ntxov thiab txo qis lwm yam kev pheej hmoo xws li haus luam yeeb tuaj yeem pab tiv thaiv kev mob plawv thaum ntxov, mob ntshav nce hlwb, thiab cov ntshav txhaws.

Hom III hyperlipoproteinemia; Tsis haum lossis puas apolipoprotein E

• Kab mob rau cov hlab ntshav

Genest J, Libby P. Lipoprotein cuam tshuam thiab mob plawv. Hauv: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Plawv Lub Plawv: Phau Ntawv Qhia Txog Cov Tshuaj Mob plawvCov. 11th ed. Philadelphia, PA: Elsevier; 2019: chap 48.

Robinson JG. Kev cuam tshuam ntawm lipid metabolism. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 26th ed. Philadelphia, PA: Elsevier; 2020: cha 195.