Psoriasis Kev Kho Mob

Zoo Siab

• Cov ntsiab lus kho tau tus mob psoriasis
• Vitamin D analogues
• Coal tar cream los yog tshuaj pleev
• Cov tshuaj zawv plaub hau
• Salicylic acid thiab lactic acid
• Kev kho kab mob rau cov kab mob psoriasis
• Methotrexate
• Cyclosporine
• PDE4 inhibitors
• Retinoids
• Hydroxyurea
• Cov tshuaj tiv thaiv Immunomodulator (biologics)
• Thioguanine
• Kev siv tshuaj uas tsis yog daim ntawv qhia
  
• Phototherapy (kev kho lub teeb)
• Tshav ntuj
• Kev ntsuas duab UVB
• Museckerman kev kho mob
• Excimer laser
• Photochemotherapy, lossis psoralen ntxiv rau ultraviolet A (PUVA)
• Pulsed zas xim laser

Txheej txheem cej luam

Kho tus mob psoriasis feem ntau yuav tsum tau siv ntau txoj hauv kev. Qhov no suav nrog kev hloov pauv hauv kev ua neej, khoom noj khoom haus, kho kom zoo nkauj, thiab tshuaj noj. Kev kho mob nyob ntawm qhov mob hnyav ntawm koj cov tsos mob, koj hnub nyoog, koj li kev noj qab haus huv tag nrho, thiab lwm yam.

Tsis muaj kev kho tau tus mob psoriasis, yog li cov kws kho mob yuav sim ntau txoj hau kev ua ntej yuav nrhiav txoj kev kho rau koj.

Cov kev xaiv kho mob rau cov mob psoriasis nyob ntawm seb yam hauv qab no:

• qhov mob heev ntawm koj psoriasis
• koj lub cev tau cuam tshuam ntau npaum li cas
• koj hom psoriasis
• zoo li cas ntawm koj cov tawv nqaij teb rau kev kho mob thawj zaug

Ntau txoj kev kho kom zoo yog txhais tau tias yuav kho cov tsos mob ntawm tus kab mob. Lawv sim ua rau kom khaus thiab khaus tawv nqaij thiab txo qis. Kev siv cov khoom siv tshwj xeeb tshaj tawm (OTC) cov dej noo tom qab da dej thiab da dej yuav pab tau kom cov dej noo noo ua kom tawv nqaij tiv thaiv kom tsis txhob muaj pa. Tab sis nws yuav tsis kho qhov mob hauv qab.

Cov kws kho cov kws kho mob tseem pom zoo kom cov neeg muaj psoriasis siv cov tshuaj tsw qab tsis muaj ntxhiab thiab tsis muaj xim, cov tshuaj ntxuav tes, thiab tshuaj pleev kom lub ntsej muag tawv nqaij kom tsawg.

Ntawm no, peb yuav piav qhia txog cov kev kho mob muaj nyob rau psoriasis, los ntawm kev kho ua ntej ib yam li cov tshuaj pleev ib ce mus rau cov chav kawm tshiab ntawm cov tshuaj hu ua biologics.

Cov ntsiab lus kho tau tus mob psoriasis

Cov kev kho mob siv ncaj qha rau ntawm daim tawv nqaij tau hu ua kev kho mob sab saum toj. Lawv suav nrog:

• sawv daws
• tshuaj pleev
• tshuaj pleev
• ntaub xaum

Lawv feem ntau yog thawj kab kev kho mob rau cov neeg uas muaj mob sib khuav ntawm psoriasis. Hauv qee kis, lawv tau siv los ua ke nrog lwm hom kev kho mob.

Corticosteroid muaj cov tshuaj pleev thiab tshuaj pleev yog hom kev kho mob rau feem ntau rau psoriasis. Cov kev siv tshuaj steroid uas tsis tshua muaj txiaj ntsig no ua haujlwm los tswj cov ntau dhau los ntawm daim tawv nqaij ua kom lub cev thiab yuag. Txawm li cas los xij, qee cov corticosteroids suav nrog cov tshuaj steroids uas yuav ua rau koj cov tsos mob tsis zoo. Koj tus kws kho mob yuav paub qhov tseeb ua kom txo qis koj cov tsos mob, dua li nce ntxiv.

Cov tshuaj retinoids yog qhov sib txawv ntawm cov tshuaj pleev los ntawm cov tshuaj vitamin A. Lawv ua haujlwm rau cov haujlwm loj hlob ntawm cov nqaij hauv lub cev. Qhov no ua rau qeeb txheej txheem. Txawm hais tias tsis ua nrawm li corticosteroid tshuaj pleev, tshuaj pleev retinoids muaj tsawg dua phiv. Cov poj niam cev xeeb tub lossis xeeb menyuam hauv plab yuav tsum tsis txhob siv cov no vim muaj kev pheej hmoo rau lub sijhawm yug menyuam.

Vitamin D analogues

Cov no yog cov ntaub ntawv hluavtaws (vitamin D) uas ua rau cov cell huam loj hlob qeeb. Koj tus kws kho mob yuav sau ntawv rau lawv ib leeg lossis nrog rau lwm yam kev kho mob los kho mob sib khuav xws li mob sib khuav. Lawv suav nrog:

• calcipotriene (Dovonex)
• calcitriol (Rocaltrol)

Coal tar cream los yog tshuaj pleev

Coal tar yog qhov kev kho mob qub tshaj plaws rau psoriasis. Nws tau tsim los ntawm kev ua tiav ntawm kev tsim cov roj av. Coal tar cov khoom txo qis scaling, khaus, thiab o. Muaj ntau qhov ntau yog muaj los ntawm cov tshuaj.

Cov cream no muaj qee qhov downsides, txawm li cas los xij. Coal tar yog qhov quav, thiab nws tuaj yeem stain khaub ncaws thiab pam vov. Nws kuj tseem tuaj yeem muaj lub zog tsw thiab tsis hnov ​​tsw.

Cov tshuaj zawv plaub hau

Tshuaj thiab muaj zog-muab tshuaj zawv plaub hau muaj tshuaj los ntawm koj tus kws kho mob los kho tus mob psoriasis ntawm koj hau.

Salicylic acid thiab lactic acid

Ob qho ntawm cov kua qaub no txhawb kev ua haujlwm qeeb ntawm cov tuag ntawm daim tawv nqaij tuag, uas txo qis kev ua haujlwm. Lawv kuj tseem tuaj yeem siv nrog kev kho mob lwm yam. Lawv muaj nyob hauv OTC thiab cov qauv tshuaj.

Kev kho kab mob rau cov kab mob psoriasis

Cov tshuaj noj tshuaj tuaj yeem pab tawm tsam kev sib kis ntawm tus mob psoriasis los ntawm kev hais tawm qhov mob.

Cov kws kho mob feem ntau nyiam siv qib qis tshaj plaws ntawm kev kho mob uas xav tau kom nres cov tsos mob. Lawv pib nrog kev kho mob hauv siab feem ntau. Xws li daim tawv yuav tiv taus thiab tsis teb rau ib qho kev kho mob, kev kho muaj zog tuaj yeem siv.

Koj tus kws kho mob tuaj yeem sau tshuaj noj rau qhov ncauj lossis hno tshuaj yog tias koj qhov kev mob psoriasis loj dua lossis tsis teb rau cov kev xaiv. Ntau ntawm cov tshuaj no muaj cov kev mob tshwm sim, yog li cov kws kho mob txwv kev siv rau qhov xwm txheej nyuaj lossis pheej mob xwb.

Methotrexate

Methotrexate txo qis ntawm cov tawv nqaij ua tawm thiab txhawb kev tiv thaiv kev tsis muaj zog. Cov kws kho mob feem ntau sau ntawv rau qhov no rau cov neeg uas muaj tsawv mus rau mob hnyav psoriasis. Nws yog ib qho kev kho mob zoo tshaj plaws rau cov neeg muaj kab mob erythrodermic psoriasis lossis pustular psoriasis. Tsis ntev los no, cov kws kho mob tau pib sau ntawv nws yog ib qho kev kho mob rau kev mob caj dab.

Cov kev phiv nrog:

• tsis qab los noj mov
• nkees
• mob plab

Cyclosporine

Cyclosporine yog ib qho tshuaj zoo tsim los tiv thaiv lub cev muaj zog. Cov kws kho mob feem ntau muab cov tshuaj no rau cov neeg uas muaj tus mob psoriasis hnyav vim nws ua rau lub cev tsis muaj zog.

Feem ntau cov kws kho mob tsuas yog sau ntawv rau cov tshuaj no rau lub sijhawm luv luv vim tias muaj kev pheej hmoo rau ntshav siab. Yog tias koj noj cov tshuaj no, koj yuav tsum tau kuaj ntshav tas li thiab kuaj ntshav siab kom paub soj ntsuam seb puas muaj teeb meem.

PDE4 inhibitors

Tsuas yog ib qho tshuaj noj hauv qhov ncauj, hu ua apremilast (Otezla), tam sim no muaj nyob rau hauv chav kawm tshiab no ntawm cov tshuaj rau psoriasis. Nws tsis tshua nkag siab yuav ua li cas apremilast ua haujlwm los kho tus mob psoriasis. Nws tau xav los ua haujlwm los ntawm kev txo koj lub cev cov lus teb rau ntawm o.

Retinoids

Retinoids yog tsim los ntawm cov tshuaj vitamin A derivatives. Lawv kho cov mob psoriasis muaj mob nyhav los sis txo qis los ntawm kev txo cov kab mob ntawm daim tawv nqaij. Koj tus kws kho mob yuav qhia tias koj siv cov no nrog kev kho lub teeb.

Raws li nrog rau lwm cov tshuaj kab ke, cov no muaj qee qhov kev mob tshwm sim loj. Koj tus kws kho mob tuaj yeem xaj kuaj ntshav mus kuaj txhawm rau saib cov roj cholesterol siab, uas yog cov teeb meem feem ntau rau tib neeg ntawm cov tshuaj no. Retinoids tseem tuaj yeem ua rau muaj kev tsis taus ntawm lub hnub yug. Cov poj niam cev xeeb tub los yog xav cev xeeb tub yuav tsum tsis txhob noj cov tshuaj no.

Tsuas FDA-pom zoo qhov ncauj retinoid rau kev kho mob ntawm psoriasis yog acitretin (Soriatane).

Hydroxyurea

Hydroxyurea belongs rau chav kawm ntawm cov tshuaj hu ua antimetabolites. Nws tau xav ua haujlwm los ntawm inhibiting DNA replication. Nws tuaj yeem siv nrog kev kho duab, tab sis nws tsis ua hauj lwm zoo li cyclosporine thiab methotrexate.

Cov kev mob tshwm sim muaj xws li cov qe ntshav liab uas qis dhau (ntshav liab) thiab muaj cov qe ntshav dawb thiab qe ntshav tsawg. Cov poj niam cev xeeb tub lossis npaj yuav muaj menyuam hauv plab yuav tsum tsis txhob siv hydroxyurea vim muaj kev pheej hmoo ntawm kev yug menyuam thiab nchuav menyuam.

Cov tshuaj tiv thaiv Immunomodulator (biologics)

Cov roj ntsha yog cov tshuaj tshiab tshiab uas lub hom phiaj ua rau koj lub cev tiv thaiv kab mob. Cov tshuaj no tau muab los ntawm kev txhaj tshuaj lossis ua paug ntshav (IV). Cov kws kho mob feem ntau sau ntawv rau cov tib neeg muaj mob sib khuav mus rau mob hnyav psoriasis tsis tau teb rau kev kho mob ib txwm muaj.

Cov tshuaj lom neeg pom zoo rau kev kho mob ntawm psoriasis yog:

• adalimumab (Humira)
• etanercept (Enbrel)
• certolizumab (Cimzia)
• infliximab (Nco)
• ustekinumab (Stelara)
• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)
• guselkumab (Tremfya)
• tildrakizumab (Ilumya)
• risankizumab (Skyrizi)

Biosimilars kuj tseem muaj tshiab, uas zoo ib yam li cov khoom lag luam tshuaj npe biologic, tab sis tsis muaj daim ntawv qhia tseeb. Lawv cia siab tias yuav muaj cov cuam tshuam zoo ib yam li cov tshuaj ib txwm muaj. Tam sim no muaj biosimilars rau infliximab thiab etanercept.

Thioguanine

Thioguanine yog siv sab-daim ntawv lo los kho tus mob psoriasis. Txawm tsis zoo li methotrexate lossis cyclosporine, thioguanine muaj cov kev mob tshwm sim tsawg dua. Qhov no ua rau nws cov kev xaiv kho kom zoo nkauj dua. Txawm li cas los xij, nws tseem tuaj yeem ua rau muaj menyuam tsis taus. Cov poj niam cev xeeb tub los yog npaj yuav ua kom cev xeeb tub yuav tsum zam kom txhob noj.

Kev siv tshuaj uas tsis yog daim ntawv qhia

• Kev siv tshuaj tua cov tshuaj txhais tau tias cov tshuaj uas tau pom zoo los ntawm FDA rau ib qho yog siv rau lub hom phiaj sib txawv uas tsis tau pom zoo. Txawm li cas los xij, ib tus kws kho mob tseem tuaj yeem siv cov tshuaj rau qhov laj thawj ntawd. Qhov no vim tias FDA tswj kev ntsuam xyuas thiab pom zoo cov tshuaj, tab sis tsis yog cov kws kho mob siv tshuaj los kho lawv tus neeg mob. Yog li, koj tus kws kho mob tuaj yeem sau tshuaj rau ib qho txawm li cas los xij lawv xav tias zoo tshaj rau koj txoj kev kho mob.

Phototherapy (kev kho lub teeb)

Kev siv tshuaj pleev yog txheej txheem nyob rau hauv daim tawv nqaij ua tib zoo saib rau lub ntuj lossis cuav duab tshav.

Nws yog ib qho tseem ceeb sib tham txog kev kho duab kos nrog koj tus kws kho nqaij daim tawv ua ntej yuav ua rau koj tus kheej tawm txog UV siab. Kev thaij duab ntev ntev yog txuam nrog kev tshwm sim ntawm daim tawv nqaij nce, tshwj xeeb yog mob melanoma. Tsis txhob sim kho tus kheej nrog lub txaj tanning lossis kev tshav ntuj.

Tshav ntuj

Qhov ntuj tshaj plaws los ntawm UV teeb yog lub hnub. Nws tsim cov duab UVA. UV teeb ua kom T cell ntau lawm thiab tom qab ua rau tua cov T cell. Qhov no ua rau qeeb qeeb hauv cov lus teb inflammatory thiab daim tawv nqaij hloov pauv.

Cov lus qhia luv luv li ntawm feem ntau ntawm tshav ntuj yuav txhim kho psoriasis. Txawm li cas los xij, kev tiv thaiv tshav kub ntev lossis lub hnub ntev ntev yuav cuam tshuam cov tsos mob. Nws kuj tseem tuaj yeem ua rau tawv nqaij puas thiab tuaj yeem ua rau koj muaj feem ntawm kev mob qog nqaij tawv.

Kev ntsuas duab UVB

Rau cov mob me ntawm psoriasis, kev kho teeb pom kev zoo nrog UVB lub teeb yuav raug coj los siv.Vim tias UVB-emitting lub teeb lub thawv tau siv ntau zaus rau kev kho no, ib qho kev thaj av lossis thaj chaw me me ntawm daim tawv nqaij tuaj yeem kho tau, tsis tas yuav ua rau tag nrho lub cev.

Cov kev mob tshwm sim suav nrog khaus, daim tawv nqaij qhuav thiab liab ntawm thaj chaw kho.

Museckerman kev kho mob

Ua ke nrog kev kho mob UVB nrog kev kho tar tar ua rau ob txoj kev kho kom zoo dua li kev kho ib leeg. Coal tar ua rau tawv nqaij txais tau ntau dua rau UVB teeb. Qhov kev kho mob no yog siv rau qhov mob me rau mob me.

Excimer laser

Laser txoj kev kho yog kev cog lus txhim kho hauv kev kho mob ntawm cov mob sib khuav ntawm psoriasis. Lasers tuaj yeem tsom cov kab ke muaj hnub ci ntawm UVB teeb ntawm cov tshuaj pleev xim rau lub ntsej muag yam tsis muaj kev cuam tshuam rau daim tawv nqaij ncig. Tab sis nws tsuas yog pab tau los kho thaj ua rau thaj chaw me me vim tias lub laser tsis tuaj yeem npog thaj chaw loj.

Photochemotherapy, lossis psoralen ntxiv rau ultraviolet A (PUVA)

Psoralen yog lub teeb pom kev zoo tshuaj uas tej zaum yuav xyaw nrog UVA kho lub teeb raws li kev kho mob rau tus mob psoriasis. Cov neeg mob siv tshuaj los yog siv tshuaj pleev xim rau daim tawv thiab tso rau hauv lub npov UVA. Qhov kev kho mob no muaj kev txhoj puab heev thiab feem ntau tsuas yog siv rau hauv cov neeg mob uas muaj mob me rau mob hnyav ntawm kev mob psoriasis.

Pulsed zas xim laser

Koj tus kws kho mob yuav pom zoo rau lub teeb zas xim laser yog tias lwm yam kev kho mob tau txwv qis. Tus txheej txheem no tau rhuav tshem cov hlab ntshav me me hauv thaj chaw ib ncig ntawm psoriasis plaques, txiav cov ntshav khiav thiab txo cov cell nyob hauv thaj chaw ntawd.