Cov Kev Kho Mob Tshiab thiab Tshuaj Noj rau Ulcerative Colitis

Zoo Siab

• Cov kev kho mob tam sim no
• Aminosalicylates
• Corticosteroids
• Cov tshuaj tiv thaiv kab mob ntshav
• TNF blockers
• Kev phais mob
• Cov tshuaj tshiab
• Tofacitinib (Xeljanz)
• Biosimilars
• Cov kev kho mob hauv kev tshawb nrhiav
• Fecal hloov
• Qia cell kho
• Cov chaw kuaj mob
• Nqa Nyiaj

Txheej txheem cej luam

Thaum koj muaj mob ua kiav txhab (UC), lub hom phiaj kho yog txwv koj tsis muaj zog tiv thaiv tus kab mob ntawm koj txoj hnyuv. Qhov no yuav coj qhov mob ua rau koj tus mob tshwm sim, thiab muab tso rau hauv kev zam txim. Koj tus kws kho mob tuaj yeem xaiv los ntawm ntau hom tshuaj kho mob los pab koj ua tiav cov hom phiaj no.

Ob peb xyoos dhau los, cov tshuaj siv los kho UC tau nce ntau. Cov kws tshawb nrhiav tau kawm dua lwm yam tshiab thiab tejzaum yuav kho tau zoo dua hauv kev sim kho mob.

Cov kev kho mob tam sim no

Muaj ob peb hom tshuaj muaj pab kho UC. Koj tus kws kho mob yuav pab koj xaiv ib qho ntawm cov kev kho raws li:

• koj tus mob hnyav (mob hnyav, hauj sim, lossis hnyav)
• cov tshuaj uas koj tau noj tas lawm
• zoo li cas koj teb rau cov tshuaj ntawd
• koj kev noj qab haus huv tag nrho

Aminosalicylates

Pawg tshuaj no muaj cov tshuaj 5-aminosalicylic acid (5-ASA). Lawv suav nrog:

• sulfasalazine (Azulfidine)
• mesalamine (Canasa)
• olsalazine (Dipentum)
• balsalazide (Colazal, Giazo)

Thaum koj noj cov tshuaj no los ntawm qhov ncauj lossis siv tshuaj, lawv pab txo cov leeg hauv koj txoj hnyuv. Aminosalicylates ua hauj lwm zoo tshaj plaws rau me ntsis-rau-ntsuas nruab nrab UC, thiab tuaj yeem pab tiv thaiv nplaim taws.

Corticosteroids

Corticosteroids (tshuaj steroid) tswj kev tiv thaiv kab mob hauv lub cev kom txo qis kev mob. Piv txwv li:

• prednisone
• prednisolone
• methylprednisolone
• budesonide

Koj tus kws kho mob yuav sau ntawv rau ib qho ntawm cov tshuaj no kom ncua nqig cov tsos mob. Nws tsis yog qhov zoo uas yuav tau nyob twj ywm rau cov tshuaj steroids mus sij hawm ntev, vim tias lawv tuaj yeem tsim teeb meem zoo li ntshav qab zib, nce phaus, kis mob, thiab pob txha poob.

Cov tshuaj tiv thaiv kab mob ntshav

Cov tshuaj no tuaj yeem tiv thaiv koj lub cev kom tiv thaiv nws los ntawm kev ua rau o. Koj tuaj yeem pib noj ib qho ntawm cov tshuaj no yog tias aminosalicylates tsis tau pab koj li cov tsos mob. Piv txwv ntawm cov tshuaj tiv thaiv kev tiv thaiv muaj xws li:

• azathioprine (Azasan)
• 6-mercaptopurine (6MP) (Purinethol)
• cyclosporine (Sandimmune, Neoral, lwm tus)

TNF blockers

TNF blockers yog ib hom tshuaj siv roj ntsha. Cov khoom siv roj ntsha yog tsim los ntawm cov roj ntsha muaj roj los yog lwm cov tshuaj ntuj. Lawv ua rau qee qhov tshwj xeeb ntawm koj lub nruab zog tiv thaiv kab mob uas ua rau muaj mob.

Anti-TNF tshuaj tiv thaiv cov tshuaj tiv thaiv kab mob hauv lub cev hu ua qog necrosis factor (TNF) uas ua rau mob o. Lawv tuaj yeem pab cov neeg muaj mob-rau-hnyav UC uas lawv cov tsos mob tsis tau zoo dua thaum siv lwm cov tshuaj.

TNF blockers suav nrog:

• adalimumab (Humira)
• golimumab (Simponi)
• infliximab (Nco)
• vedolizumab (Entyvio)

Kev phais mob

Yog txoj kev khomob uas koj tau sim tsis tau tswjhwm koj cov tsos mob lossis tsis ua haujlwm, tej zaum koj yuav raug phais. Tus txheej txheem hu ua proctocolectomy tshem tawm txoj hnyuv thiab lub qhov quav tag nrho kom tiv thaiv kev mob ntxiv.

Tom qab phais tas, koj yuav tsis muaj kab mob los khaws cov khib nyiab. Koj tus kws phais yuav tsim lub hnab sab nraum koj lub cev hu ua ileostomy, lossis hauv koj lub cev los ntawm qee qhov ntawm koj txoj hnyuv (ileum).

Kev phais mob yog ib qho tseem ceeb, tab sis nws yuav pab txo cov tsos mob ntawm UC.

Cov tshuaj tshiab

Ob peb xyoos dhau los, qee qhov kev kho mob UC tshiab tau tshwm sim.

Tofacitinib (Xeljanz)

Xeljanz belongs rau chav kawm ntawm cov tshuaj hu ua Janus kinase (JAK) inhibitors. Cov tshuaj no thaiv cov enzyme JAK, uas ua kom cov hlwb ntawm lub cev tiv thaiv kab mob los ua kom muaj mob o.

Xeljanz tau pom zoo txij li xyoo 2012 los kho kev mob caj dab (RA), thiab txij li xyoo 2017 los kho tus mob psoriatic mob caj dab (PsA). Xyoo 2018, FDA tseem pom zoo nws kho cov neeg uas muaj mob-rau-hnyav UC uas tsis tau teb rau TNF blockers.

Cov tshuaj no yog thawj zaug hauv lub qhov ncauj ntev rau kev kho mob hnyav-rau-hnyav UC. Lwm yam tshuaj xav tau kev sib sau lossis txhaj tshuaj. Cov kev mob tshwm sim los ntawm Xeljanz suav nrog kev muaj zog, mob taub hau, raws plab, mob khaub thuas, tawm pob, thiab tawm pob.

Biosimilars

Biosimilars yog cov chav kawm tshiab ntawm cov tshuaj uas tsim los ua ntsi xws li cov teebmeem ntawm kev lom neeg. Zoo li kev ua roj ntsha, cov tshuaj no tsom cov muaj zog tiv thaiv kab mob protein uas ua rau kom mob.

Biosimilars ua haujlwm zoo ib yam li cov roj ntsha, tab sis lawv yuav raug nqi tsawg dua. Plaub tus tsiaj ntawv tau ntxiv rau tom kawg ntawm lub npe los pab kom paub qhov txawv ntawm cov tshuaj biosimilar los ntawm cov thawj biologic.

FDA tau pom zoo ob peb biosimilars rau UC hauv ob peb lub xyoo dhau los, suav nrog:

• infliximab-abda (Renflexis)
• infliximab-dyyb (Inflectra)
• infliximab-qbtx (Ixifi)
• adalimumab-adbm (Cyltezo)
• adalimumab-atto (Amjevita)

Cov kev kho mob hauv kev tshawb nrhiav

Cov kws tshawb nrhiav tshawb nrhiav txog txoj hauv kev zoo dua los tswj UC. Nov yog qee qhov kev kho mob tshiab tshiab hauv kev tshawb xyuas.

Fecal hloov

Kev hloov quav quav, lossis tso quav, yog qhov txheej txheem sim uas coj cov kab mob zoo los ntawm tus neeg pub quav mus rau txoj hnyuv laus ntawm tus neeg uas mob UC.Lub tswv yim tuaj yeem mloog tsis pom, tab sis cov kab mob zoo pab kho kev puas tsuaj los ntawm UC thiab rov qab muaj kev noj qab haus huv ntawm cov kab mob hauv lub plab.

Qia cell kho

Qia qog yog cov qog yau uas loj hlob mus rau txhua yam ntawm cov hlwb thiab cov nqaij hauv peb lub cev. Lawv muaj lub peev xwm los kho txhua yam kev puas tsuaj yog tias peb tau siv thiab siv kom raug. Hauv UC, cov qia hlwb yuav hloov txoj kev tiv thaiv kab mob hauv ib txoj hauv kev uas pab txo qis kev mob thiab kho kev puas tsuaj.

Cov chaw kuaj mob

Cov kws kho mob muaj ntau yam kev kho mob rau UC dua li ua ntej. Txawm hais tias muaj ntau yam tshuaj, muaj qee tus neeg muaj teeb meem nrhiav ib qho uas ua haujlwm rau lawv.

Cov kws tshawb nrhiav yeej niaj hnub kawm txoj kev kho tshiab hauv kev sim tshuaj. Koom nrog ib qho ntawm cov kev tshawb fawb no tuaj yeem ua rau koj nkag mus siv tshuaj ua ntej nws muaj rau cov pej xeem. Nug tus kws kho mob uas saib xyuas koj li UC yog tias kev sim tshuaj rau thaj chaw koj nyob yuav zoo rau koj.

Nqa Nyiaj

Qhov kev xam pom rau cov neeg uas muaj UC yuav zoo dua li niaj hnub no, ua tsaug rau cov tshuaj tshiab uas tuaj yeem txo qhov mob hnyuv. Yog tias koj tau sim tshuaj thiab nws tsis pab koj, paub tias lwm txoj kev xaiv tuaj yeem txhim kho koj tus mob. Ua siab ntev, thiab ua haujlwm zoo nrog koj tus kws kho mob txhawm rau nrhiav kev kho uas thaum kawg ua haujlwm rau koj.