Dab tsi yog mosaicism thiab nws cov txiaj ntsig tseem ceeb

Zoo Siab

• Cov qauv tseem ceeb
• Qhov tshwm sim ntawm mosaicism

Mosaicism yog lub npe muab rau ib hom kev hloov caj ces thaum lub sij hawm txhim kho lub embryo sab hauv lub tsev menyuam, uas tus neeg pib muaj 2 yam khoom keeb kwm sib txawv, ib qho yog tsim los ntawm kev sib tshuam ntawm lub qe nrog cov phev ntawm niam txiv , thiab lwm qhov uas tshwm sim vim kev sib hloov ntawm lub cell nyob rau hauv chav kawm ntawm txoj kev loj hlob ntawm lub embryo.

Yog li, tus neeg yuav tsim kho cov hlwb sib xyaw, nrog cov feem pua ​​ntawm cov hlwb ib txwm thiab lwm feem pua ​​ntawm cov hlwb nrog kev hloov pauv, raws li pom hauv daim duab hauv qab no:

Cov qauv tseem ceeb

Mosaicism tshwm sim thaum ib qho kev sib hloov tshwm sim hauv lub hlwb embryo, feem ntau poob lossis theej tawm ntawm cov chromosome, uas ua rau tus neeg txhim kho nws lub cev nrog 2 hom hlwb, thiab 2 hom keeb caj ces. Qhov kev hloov pauv tuaj yeem yog ntawm 2 hom:

• Lub cev xeeb ntxwv lossis Gonadal: cuam ​​tshuam cov phev lossis cov qe, nrog rau kev hloov pauv tuaj yeem kis tau rau menyuam yaus. Qee cov piv txwv ntawm cov kab mob tshwm sim los ntawm kev hloov pauv ntawm cov kab mob hauv cov kab mob yog Turner tus mob, tsis txaus ntseeg osteogenesis thiab Duchenne leeg mob cov leeg nqaij;
• Kev Sib Koom Tes: cov keeb ntshav uas nyob rau lwm qhov ntawm lub cev muaj qhov hloov pauv no, txawm hais tias tus neeg ntawd yuav hloov kho lub cev los ntawm nws. Yog li, lub cev kev qhia ntawm kev hloov pauv nyob ntawm seb qhov twg thiab muaj pes tsawg lub hlwb hauv lub cev tau cuam tshuam. Somatic mosaicism tuaj yeem sib kis ntawm niam txiv mus rau menyuam yaus, thiab qee qhov piv txwv ntawm cov kabmob tshwm sim yog Down's syndrome thiab neurofibromatosis.

Mixed mosaicism, ntawm qhov tod tes, tshwm sim thaum tus neeg muaj ob hom mosaicism, ob qho tib si germinative thiab somatic.

Mosaicism txawv ntawm qhov chimerism nyob rau hauv uas, hauv qhov xwm txheej no, cov embryo cov khoom siv caj ces yog theej tawm los ntawm kev sib txuas ntawm 2 cov embryos sib txawv, uas dhau los ua ib qho. Kawm paub ntau ntxiv txog cov xwm txheej no hauv chimerism.

Qhov tshwm sim ntawm mosaicism

Txawm hais tias muaj ntau qhov kev tshwm sim ntawm mosaicism tsis ua rau cov tsos mob lossis kev rau txim rau kev noj qab haus huv ntawm tus neeg, qhov xwm txheej no tuaj yeem ua rau pom qhov tshwm sim ntawm ntau qhov kev cuam tshuam thiab kab mob rau tus neeg nqa khoom, thiab qee qhov piv txwv yog:

• Ntxias mus rau mob qog noj ntshav;
• Hloov kev loj hlob;
• Ntxias mus rau qhov raug qau tshem tawm;
• Hloov pauv txawv xim hauv daim tawv nqaij;
• Oter heterochromia, nyob rau hauv uas tus neeg muaj peev xwm muaj ib lub qhov muag ntawm txhua xim;
• Down mob;
• Turner syndrome;
• Osteogenesis imperfecta;
• Duchenne npag dystrophy;
• McCune-Albright syndromes;
• Cov Kab Mob Pallister-Killian;
• Proteus mob siab.

Tsis tas li ntawd, nws tau pom tias mosaicism nce cov kev xav ua rau cov kab mob neurological degenerative, xws li Alzheimer lossis Parkinson, piv txwv.