Psoriasis puas yog Autoimmune Disease?

Zoo Siab

• Txheej txheem cej luam
• Nkag siab txog cov kab mob autoimmune
• Hom mob autoimmune
• Psoriasis raws li tus kab mob autoimmune
• Cov kev kho mob uas muaj lub hom phiaj tiv thaiv lub cev
• Cov tshuaj laus dua
• Cov khoom siv roj ntsha
• TNF kev thaiv kev
• Tshiab zog roj ntsha
• Psoriasis thiab kev pheej hmoo rau lwm yam mob autoimmune
• Qhov kev xam pom yog

Txheej txheem cej luam

Psoriasis yog cov tawv nqaij mob uas pom muaj khaus liab ntawm daim tawv npog nrog lub ntsej muag nyiaj dawb. Nws yog ib tug mob mus ntev. Cov tsos mob tuaj yeem mus thiab mus, thiab tuaj yeem ua rau mob hnyav.

Psoriasis yog ib tug mob uas feem ntau, cuam tshuam yuav luag 3 feem pua ​​ntawm cov neeg nyob ntiaj teb. Kwv yees li 7.4 lab tus tib neeg hauv Asmeskas teb muaj psoriasis.

Qhov tseeb yog ua kom mob psoriasis tsis paub meej. Nws tau xav kom muaj kev sib txuas ntawm noob caj noob ces, ib puag ncig ib puag ncig, thiab koj muaj zog tiv thaiv.

Raws li kev tshawb fawb txog kev txhim kho hauv ob peb xyoos dhau los, psoriasis feem ntau tau cais raws li tus kabmob autoimmune. Qhov no txhais tau tias koj lub nruab zog tiv thaiv kab mob, hu ua T cell, ua tsis ncaj ncees lawm tawm tsam koj tus kheej daim tawv nqaij xoos raws li kev tawm tsam txawv teb chaws. Qhov no ua rau koj cov tawv nqaij ua kom tawg sai, ua rau muaj tus cwj pwm psoriasis tawv nqaij mob.

Tsis yog txhua tus kws tshawb nrhiav xav tias psoriasis mob autoimmune tsis zoo. Qee qhov pom zoo tias mob psoriasis yog qhov tiv thaiv kab mob-tiv thaiv kab mob. Tab sis lawv txoj kev xav yog tias psoriasis tshwm sim los ntawm cov noob cuam tshuam txawv txav ntawm cov kab mob ntawm daim tawv nqaij.

Nkag siab txog cov kab mob autoimmune

Feem ntau koj lub cev tiv thaiv kab mob paub koj lub hlwb thiab tsis tua lawv. Cov kab mob autoimmune yog thaum koj lub cev tsis muaj zog yuam kev tawm tsam cov hlwb noj qab haus huv zoo li lawv nyob sab nraud sab nraud tawm tsam koj lub cev.

Muaj ntau tshaj 100 hom kabmob autoimmune. Qee qhov kab mob autoimmune koom nrog tsuas yog ib feem ntawm koj lub cev - xws li koj cov tawv nqaij hauv psoriasis. Lwm tus yog cov hauv nruab ntug, koom nrog koj lub cev tag nrho.

Txhua qhov teeb meem autoimmune zoo li cas yog qhov lawv tshwm sim los ntawm kev sib xyaw ntawm cov noob caj noob ceg thiab ib puag ncig.

Raws nraim li cas cov caj ces thiab ib puag ncig hloov pauv ua rau ntau yam kabmob sib txawv yog lub ncauj lus ntawm kev tshawb fawb txuas ntxiv.

Txog tam sim no, dab tsi uas paub yog tias cov neeg muaj caj ces caj ces muaj txoj sia yuav muaj 2 txog 5 npaug ntawm kev muaj tus mob autoimmune zoo li cov neeg uas tsis muaj caj ces muaj mob.

Cov pab pawg ntawm cov noob koom nrog hu ua histocompatibility complex, hu ua HLA. HLA txawv rau txhua tus neeg.

Ib qho kev mob caj ces rau lub cev tiv thaiv kab mob kuj yuav khiav hauv tsev neeg, tab sis cov neeg hauv tsev neeg tej zaum yuav muaj teeb meem autoimmune sib txawv. Tsis tas li, yog tias koj muaj ib qho kev tsis zoo autoimmune, koj muaj feem ntau dua yuav dua lwm tus.

Nws tsis tshua paub txog qee yam kev tshwj xeeb ib puag ncig uas ua rau muaj tus mob autoimmune rau ib tus neeg uas muaj kev mob caj ces rau lub cev tiv thaiv kab mob.

Hom mob autoimmune

Nov yog qee qhov teeb meem feem ntau autoimmune:

• tus kab mob celiac (ib qho tshuaj tiv thaiv rau gluten)
• ntshav qab zib hom 1
• cov mob hnyuv, nrog rau Crohn's
• lupus (mob hlwb lupus erythematosus, uas cuam tshuam rau daim tawv nqaij, raum, pob qij txha, hlwb, thiab lwm yam hauv nrog cev)
• rheumatoid mob caj dab (mob pob qij txha)
• Sjögren's syndrome (dryness hauv koj lub qhov ncauj, qhov muag, thiab lwm qhov chaw)
• vitiligo (poob ntawm cov xim tawv nqaij, uas ua rau cov tawv nqaij dawb)

Psoriasis raws li tus kab mob autoimmune

Feem coob ntawm cov kws tshawb fawb niaj hnub no ntseeg tias psoriasis yog tus kabmob autoimmune. Nws tau ntev tau paub tias lub cev tsis muaj zog koom nrog psoriasis. Tab sis qhov tseeb kiag li tsis tau muaj tseeb.

Nyob rau ob xyoo dhau los, kev tshawb fawb tau tsim tias cov caj ces thiab cov noob caj noob neeg cuam tshuam nrog psoriasis tau sib koom nrog paub autoimmune ntshawv siab. Kev tshawb fawb kuj tseem tsim tau hais tias cov tshuaj tiv thaiv kab mob yog cov kev kho mob tshiab rau tus mob psoriasis. Cov tshuaj no ua haujlwm los ntawm kev tiv thaiv cov kabmob tiv thaiv kev tawm tsam uas lub cev tsis muaj zog.

Kev tshawb fawb tseem niaj hnub ua txog lub luag haujlwm ntawm cov kabmob tiv thaiv kab mob T hauv psoriasis. Cov keeb ntshav yog lub zog tiv thaiv kab mob “tub rog” uas tawm tsam sib kis tau zoo. Thaum cov T cell ua haujlwm tsis zoo thiab tawm tsam cov tawv nqaij noj qab haus huv, lawv tso cov protein tshwj xeeb hu ua cytokines. Cov no ua rau cov tawv nqaij hlav ntau thiab ua rau koj cov tawv nqaij nto, uas ua rau muaj qhov nqaij ntuag ntshav nrog.

Ib tsab xov xwm 2017 tau tshaj tawm txog cov kev tshawb fawb tshiab uas tau qhia txog kev cuam tshuam ntawm cov kab mob T tshwj xeeb thiab interleukins uas twb paub tias muaj feem cuam tshuam hauv kev txhim kho ntawm tus mob psoriasis. Raws li paub ntau ntxiv, nws yuav dhau los ua cov hom phiaj tshuaj kho tshiab.

Cov kev kho mob uas muaj lub hom phiaj tiv thaiv lub cev

Kev kho mob psoriasis nyob ntawm seb hom thiab mob ntawm tus mob, koj cov kev noj qab haus huv dav, thiab lwm yam.

Ntawm no yog ntau yam kev kho mob uas lub hom phiaj tshwj xeeb hauv lub nruab zog tiv thaiv kab mob uas ua rau muaj mob. Cov no feem ntau siv thaum koj cov tsos mob psoriasis muaj mob hauj sim. Nco ntsoov tias cov tshuaj tshiab tshaj yog kim dua.

Cov tshuaj laus dua

Ob lub tshuaj laus laus tau siv los ua lub cev tiv thaiv tsis muaj zog thiab paub meej cov tsos mob psoriasis yog methotrexate thiab cyclosporine. Cov no yog ob qho tib si ua tau zoo, tab sis muaj cov kev mob tshwm sim thaum siv lub sijhawm ntev.

Cov khoom siv roj ntsha

TNF kev thaiv kev

Ib qho tshuaj yeeb tshuaj tsis ntev los no tsom rau cov tshuaj uas ua rau mob hu ua qog ua hlav hlav (TNF). TNF yog cytokine ua los ntawm cov kab mob tiv thaiv kab mob xws li T cell. Cov tshuaj tshiab no hu ua TNF kev thaiv kev.

Anti-TNF tshuaj muaj txiaj ntsig zoo, tab sis tsawg dua li cov roj tshiab. TNF antagonist tshuaj suav nrog:

• adalimumab (Humira)
• etanercept (Enbrel)
• infliximab (Nco)
• certolizumab pegol (Cimzia)

Tshiab zog roj ntsha

Ntau cov neeg siv biologics tau txheeb thiab tiv thaiv tshwj xeeb T cell thiab interleukin pathways koom nrog rau psoriasis. Peb lub biologics uas phiaj IL-17 tau pom zoo txij li xyoo 2015:

• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)

Lwm cov tshuaj txhawm rau txhawm rau txhawm rau txhawm rau thaiv lwm txoj kev ua haujlwm (I-23 thiab IL-12):

• ustekinuman (Stelara) (IL-23 thiab IL-12)
• guselkumab (Tremfya) (IL-23)
• tildrakizumab-asmn (Ilumya) (IL-23)
• risankizumab-rzaa (Skyrizi) (IL-23)

Cov roj ntsha no tau ua pov thawj tias muaj kev nyab xeeb thiab tau txais txiaj ntsig zoo.

Psoriasis thiab kev pheej hmoo rau lwm yam mob autoimmune

Muaj ib tus kabmob autoimmune xws li psoriasis tso koj rau kev tsim lwm yam kabmob autoimmune. Txoj kev pheej hmoo yuav nce ntxiv yog tias koj psoriasis mob hnyav.

Cov pab pawg ntawm cov noob uas ua rau koj los tsim kho qhov mob autoimmune yog qhov zoo sib xws nyob rau ntau hom kab mob autoimmune. Qee qhov txheej txheem o thiab cov xwm txheej ib puag ncig kuj zoo ib yam.

Lub ntsiab autoimmune cuam tshuam nrog psoriasis yog:

• psoriatic mob caj dab, uas cuam tshuam 30 rau 33 feem pua ​​ntawm cov neeg uas muaj mob caj dab
• rheumatoid mob caj dab
• mob celiac
• Crohn's kab mob thiab lwm yam hnyuv mob
• ntau yam sclerosis
• lupus (cov kab mob lupus erythematosus lossis SLE)
• autoimmune lub qog tus kab mob
• Sjögren's syndrome
• cov plaub hau tsis zoo nkauj ploj (alopecia areata)
• qog pemphigoid

Nrog nrog psoriasis yog nrog mob rheumatoid kev mob caj dab.

Kev sib raug zoo ntawm tus mob psoriasis rau lwm cov kab mob autoimmune yog lub ncauj lus ntawm kev kawm tshawb fawb tsis tu ncua. Kuj tseem tau kawm yog kev koom nrog tus mob psoriasis thiab nrog kev tuag ntau dua los ntawm cov kab mob no.

Qhov kev xam pom yog

Txoj kev xam pom rau cov neeg muaj psoriasis zoo heev. Tus mob no yuav kho tsis tau kom zoo, tab sis kev kho tam sim no feem ntau tuaj yeem tswj hwm tus mob.

Cov kev tshawb fawb kho mob txuas ntxiv mus tshawb pom ntau yam tshwj xeeb txog cov ua rau mob psoriasis thiab lwm yam kev tiv thaiv kab mob autoimmune. Cov kev tshawb pom tshiab no yuav pab tsim kho cov tshuaj tshiab uas tshwj xeeb tsom thiab thaiv txoj kev mob.

Piv txwv li, ntau ntau yam tshuaj tshiab tsom rau interleukin-23 tam sim no tau nyob hauv kev sim tshuaj. Lwm txoj hauv kev tshiab yog yuav tuaj tawm ntawm kev tshawb fawb txuas ntxiv txog tus kabmob muaj lub cev tsis haum nyob rau hauv dav dav.

Tham nrog koj tus kws kho mob txog kev koom tes hauv kev sim tshuaj txuas ntxiv thiab txog kev tsim kho tshiab. Koj kuj tseem xav koom nrog kev koom tes hauv online psoriasis / PsA pab pawg.