HER2-positive vs. HER2-Tsis Zoo Cancer Mis: Nws Yog Dab Tsi Rau Kuv?

Zoo Siab

• HER2 li cas?
• HER2-zoo txhais li cas?
• HER2-negative txhais li cas?
• Kev xeem rau HER2
• Kho HER2-zoo mob cancer mis
• Outlook

Txheej txheem cej luam

Yog tias koj lossis ib tug neeg hlub tau kuaj mob cancer mis, tej zaum koj twb hnov ​​lo lus "HER2." Tej zaum koj yuav xav paub qhov txhais tau tias muaj HER2-zoo lossis HER2-tsis zoo mob cancer mis.

Koj li xwm txheej HER2, nrog rau koj kev mob qog noj ntshav cancer, pab txiav txim cov kab mob ntawm koj mob cancer mis. Koj HER2 xwm txheej tseem tuaj yeem pab txiav txim seb tus mob qog noj ntshav ntau npaum li cas. Koj tus kws kho mob yuav siv cov ntaub ntawv no los ntsuas koj cov kev kho mob.

Xyoo tsis ntev los no, tau muaj kev txhim kho ntau yam nyob rau hauv kev kho mob HER2-zoo mob cancer mis. Qhov no tau ua rau pom kev pom zoo rau cov neeg uas muaj hom kabmob no.

HER2 li cas?

HER2 sawv cev rau tib neeg kev loj hlob los ntawm tus kab mob receptor 2. HER2 cov roj ntsha muaj nyob ntawm cov qe ntshav ua haujlwm. Lawv tau koom nrog txoj kev loj hlob ntawm tes zoo tab sis tuaj yeem dhau los ua tus "hnyav dhau." Qhov no txhais tau hais tias theem ntawm cov protein muaj ntau dua li ib txwm.

HER2 tau tshawb pom xyoo 1980s. Cov kws tshawb nrhiav tau txiav txim tias qhov muaj HER2 protein ntau yuav ua rau mob cancer loj hlob thiab kis tau sai. Qhov kev tshawb pom no tau coj los tshawb fawb txog yuav ua li cas qeeb lossis hloov kev loj hlob ntawm cov qog nqaij hlav cancer no.

HER2-zoo txhais li cas?

HER2-zoo lub mis mob qog mis muaj peev xwm ua tau ntau ntawm HER2 cov protein ntau. Qhov no tuaj yeem ua rau lub hlwb muaj zog sai dua qhov qub. Kev yug me nyuam ntev dhau lawm yuav ua rau muaj tus mob cancer mis sai uas yuav kis tau.

Kwv yees li 25 feem pua ​​ntawm cov neeg mob cancer mis yog HER2-zoo.

Hauv 20 xyoo dhau los, tau muaj kev txhim kho tseem ceeb hauv cov kev kho mob rau HER2-zoo mob cancer mis.

HER2-negative txhais li cas?

Yog tias cov qog mis mob cancer mis tsis muaj qib HER2 ua haujlwm tsis txawv txav, ces tus mob cancer mis saib xyuas yog HER2-tsis zoo. Yog tias koj mob cancer yog HER2-tsis zoo, nws kuj tseem muaj estrogen- lossis progesterone-zoo. Seb puas los yog tsis cuam tshuam rau koj cov kev kho mob.

Kev xeem rau HER2

Kev ntsuam xyuas uas tuaj yeem txiav txim siab HER2 muaj xws li:

• txhaj tshuaj tiv thaiv kabmob (IHC)
• hauv situ hybridization (ISH) xeem

Muaj ob peb yam sib txawv ntawm IHC thiab ISH cov kev ntsuam xyuas pom zoo los ntawm Food and Drug Administration. Nws yog ib qho tseem ceeb los ntsuas rau kev ua siab ncaj ntawm HER2 vim tias qhov tshwm sim yuav txiav txim siab seb koj puas tau txais txiaj ntsig los ntawm qee yam tshuaj.

Kho HER2-zoo mob cancer mis

Rau ntau tshaj 30 xyoo, cov kws tshawb nrhiav tau kawm txog HER2-mob cancer mis thiab cov hau kev los kho nws. Cov tshuaj tiv thaiv tau hloov pauv tam sim no qhov kev pom ntawm theem 1 mus rau 3 lub mis mob qog mis los ntawm qhov tsis zoo mus rau qhov zoo.

Lub hom phiaj tshuaj trastuzumab (Herceptin), thaum siv nyob rau hauv tandem nrog kev siv tshuaj kho mob, tau txhim kho qhov pom ntawm cov neeg uas muaj HER2-zoo mob cancer mis.

Ib qho ua ntej tshaj tawm tias kev sib txuam ua ke ntawm kev kho mob ua rau qeeb HER2-zoo mob cancer mis zoo dua li kev kho mob ib leeg. Txog qee leej, kev siv tshuaj Herceptin nrog kev siv tshuaj tua kab mob tau ua rau muaj kev zam ntev ntev.

Ntau cov kev tshawb fawb tsis ntev los no tau txuas ntxiv tau qhia tias kev kho mob nrog Herceptin ntxiv rau kev kho cov tshuaj kho mob tau kho kom pom tseeb rau cov neeg muaj tus mob HER2 zoo mob cancer mis. Nws feem ntau yog siv los kho tus mob HER2 kom zoo mob cancer mis.

Qee qhov xwm txheej, pertuzumab (Perjeta) yuav raug ntxiv nyob rau hauv kev sib xyaw nrog Herceptin. Qhov no tej zaum yuav pom zoo rau HER2-zoo mob qog mis hlav cancer muaj qhov muaj kev pheej hmoo ntau dua, zoo li theem 2 thiab siab dua, lossis rau cov qog nqaij hlav uas kis mus rau cov qog ntshav.

Neratinib (Nerlynx) yog lwm yam tshuaj uas tuaj yeem pom zoo tom qab kho nrog Herceptin nyob rau hauv rooj plaub uas muaj kev pheej hmoo siab yuav rov ua dua.

Rau HER2-zoo lub mis mob qog mis uas tseem yog estrogen- thiab progesterone-zoo, kev kho nrog kev kho tshuaj hormones kuj tseem pom zoo. Lwm txoj kev kho mob HER2-muaj kev kho mob rau cov neeg muaj mob qog siab lossis mob cancer mis ntau dua.

Outlook

Yog tias koj tau txais kev kuaj mob tus kabmob kheesxaws mis uas tsis zoo, koj tus kws khomob yuav kuaj seb koj qhov mob cancer HER2 zoo li cas. Cov txiaj ntsig ntawm kev sim yuav txiav txim siab cov kev xaiv zoo tshaj plaws los kho koj tus mob qog noj ntshav.

Kev tsim kho tshiab hauv kev kho mob HER2-zoo mob cancer mis tau txhim kho kev pom zoo rau cov neeg muaj tus mob no. Kev tshawb nrhiav tseem tab tom kho rau cov kev kho mob tshiab, thiab cov kev pom zoo rau cov neeg muaj mob cancer mis yog pheej txhim kho.

Yog tias koj tau kuaj pom tus mob HER-mob cancer mis, kawm txhua yam koj tuaj yeem ua tau thiab tham siab txog koj cov lus nug nrog koj tus kws kho mob.