Tus Sau: Gregory Harris
Hnub Kev Tsim: 9 Lub Plaub Hlis Ntuj 2021
Hloov Hnub: 18 Lub Kaum Ib Hli Ntuj 2024
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HER2 (Kev kuaj mob Cancer ntawm lub mis) - Tshuaj Kho Mob
HER2 (Kev kuaj mob Cancer ntawm lub mis) - Tshuaj Kho Mob

Zoo Siab

HER2 kuaj mob cancer mis yog dab tsi?

HER2 sawv cev rau tib neeg kev loj hlob kis tau tus kabmob receptor 2. Nws yog lub keeb tsim cov protein nyob rau txhua qhov chaw ntawm lub mis. Nws koom tes nrog kev loj hlob ntawm tes.

Cov noob yog qhov tseem ceeb ntawm caj ces, dhau ntawm koj niam thiab koj txiv. Nyob rau ntawm qee cov qog nqaij hlav, tshwj xeeb tshaj yog mob cancer mis, HER2 noob hloov pauv (hloov) thiab ua kom theej cov gene ntxiv. Thaum qhov no tshwm sim, HER2 noob ua HER2 protein ntau dhau lawm, ua rau lub hlwb sib faib thiab loj hlob sai heev.

Cov kabmob kheesxaws uas muaj HER2 protein ntau yog paub HER2-zoo. Cov qog noj ntshav uas muaj cov protein tsawg yog paub HER2-tsis zoo. Kwv yees li 20 feem pua ​​ntawm cov mis mob cancer mis yog HER2-zoo.

HER2 kuaj xyuas cov piv txwv ntawm cov qog nqaij hlav. Txoj kev nquag siv los kuaj cov qog nqaij hlav tawm yog:

  • Kev sim tshuaj Immunohistochemistry (IHC) ntsuas HER2 protein nyob rau sab nraud ntawm cov hlwb
  • Kev sim tshuaj fluorescence hauv situ hybridization (FISH) kuaj xyuas saib ntxiv rau HER2 gene

Ob txoj kev kuaj no tuaj yeem qhia saib koj puas muaj tus mob HER2-mob cancer. Cov kev kho mob tshwj xeeb kom HER2 zoo mob cancer mis yuav ua tau zoo.


Lwm lub npe: tib neeg epidermal kev loj hlob tau receptor 2, ERBB2 amplification, HER2 overexpression, HER2 / neu kev kuaj mob

Nws siv rau dab tsi?

Kev kuaj HER2 feem ntau yog siv los tshawb pom seb puas yog mob HER2. Nws kuj tseem siv qee zaum saib seb puas muaj mob qog noj tshuaj los kho lossis yog tias mob qog rov qab los tom qab kho.

Vim li cas kuv thiaj yuav tsum kuaj HER2 kuaj mob cancer mis?

Yog tias koj tau kuaj pom tias koj muaj mob qog noj mis, tej zaum koj yuav xav tau qhov kev kuaj no kom pom tias koj tus mob cancer HER2-zoo lossis HER2-tsis zoo. Yog koj twb tau txais kev kho mob HER2-zoo mob cancer mis, tej zaum koj yuav xav kuaj qhov no mus:

  • Tshawb nrhiav seb koj txoj kev kho mob puas ua haujlwm. Cov qib HER2 ib txwm yuav txhais tau tias koj tab tom kho mob. Qib siab txhais tau tias kev kho mob tsis ua haujlwm.
  • Kuaj seb puas muaj mob khees-xaws tau rov qab los tom qab kho tas.

Yuav muaj dab tsi tshwm sim thaum HER2 kuaj mob cancer mis?

Kev kuaj HER2 feem ntau yuav tau ntsuas tus qauv nqaij hlav hauv ib txoj kev hu ua me me. Muaj peb lub ntsiab ntawm kev ua li no:


  • Kev siv rab koob xav tau koob hno, uas siv rab koob heev kom tshem tau cov hnoos qeev ntawm lub mis lossis kua dej tawm
  • Siv rab koob coj mus kuaj, uas siv ib rab koob loj dua los tshem tawm ib qho piv txwv
  • Kev phais me me, uas tshem tus qauv hauv cov hnub nyoog me, tus txheej txheem sab nraud

Kev siv rab koob zoo thiab cov koob txhaj tshuaj feem ntau suav nrog cov hauv qab no:

  • Koj yuav pw koj ib sab lossis zaum ntawm ib lub rooj kawm.
  • Tus kws kho mob yuav ntxuav qhov chaw biopsy thiab txhaj tshuaj loog kom koj thiaj li tsis hnov ​​mob thaum lub sijhawm ua haujlwm.
  • Thaum thaj chaw loog, tus kws kho mob yuav ntxiv rab koob xav tshuaj los yog rab koob hno rau hauv qhov chaw muab coj mus kuaj thiab hle cov hno lossis kua dej.
  • Koj tuaj yeem hnov ​​me ntsis thaum cov qauv rub tawm.
  • Yuav muab qhov siab mus rau qhov chaw me me kom txog rau thaum cov ntshav tawm plaws.
  • Koj tus kws kho mob yuav siv cov ntaub qhwv lub cev tsis huv ntawm qhov chaw me me.

Hauv kev phais me me, Tus kws phais yuav txiav me me rau hauv koj cov tawv nqaij kom tshem tawm txhua qhov lossis qee yam ntawm lub hauv siab menyuam yaus. Tej zaum yuav tau txiav me ntsis es yuav tsum tau phais yog tias siv tsis tau lub koob hno. Kev phais me me feem ntau suav cov hauv qab no.


  • Koj yuav tau pw ntawm lub rooj ua haujlwm. Qhov IV (tso dej kab) yuav muab tso rau hauv koj txhais caj npab lossis txhais tes.
  • Tej zaum koj yuav tau muab tshuaj, hu ua sedative, los pab koj so.
  • Koj yuav muab cov tshuaj loog hauv zos lossis ib puag ncig kom koj thiaj li tsis hnov ​​mob thaum ua haujlwm.
    • Rau cov tshuaj loog hauv ib cheeb tsam, tus kws kho mob yuav txhaj tshuaj qhov nqaij me me rau hauv qhov chaw mus loog.
    • Txog kev tso tshuaj kom tsaug zog, kws tshwj xeeb hu ua tshuaj loog yuav muab tshuaj rau koj yog li koj yuav tsis nco qab nyob hauv tus txheej txheem.
  • Thaum qhov chaw mos los loog lossis koj tsis nco qab lawm, tus kws phais yuav txiav ib qho me me rau hauv lub mis thiab tshem ib feem lossis tagnrho ib qho mob. Qee qhov nqaij mos nyob ib ncig ntawm lub qog kuj tseem yuav raug tshem tawm.
  • Qhov kev txiav hauv koj cov tawv nqaij yuav raug kaw nrog cov hlua khi lossis cov nplaum ib qho ntxiv.

Hom pawm me uas koj muaj yuav yog nyob ntawm ntau yam, nrog rau qhov loj thiab qhov chaw nyob ntawm cov qog. HER2 kuj tseem tuaj yeem ntsuas hauv kev ntsuas ntshav, tab sis kev kuaj ntshav rau HER2 tseem tsis tau muaj pov thawj tseem ceeb rau cov neeg mob feem ntau. Yog li nws tsis feem ntau pom zoo.

Tom qab koj cov nqaij coj mus kuaj tau lawm, nws yuav sim ua ib txoj hauv kev:

  • HER2 cov qib protein yuav ntsuas.
  • Cov qauv yuav raug saib xyuas rau cov ntawv luam ntxiv ntawm HER2 gene.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Koj yuav tsis tas npaj dab tsi tshwj xeeb yog tias koj tau txais tshuaj loog hauv zos (suav cov khoom siv ntawm qhov chaw). Yog tias koj tau txais tshuaj loog dav dav, koj yuav xav yoo mov (tsis noj los yog haus) rau ob peb teev ua ntej kev phais mob. Koj tus kws phais mob yuav muab cov lus qhia tshwj xeeb rau koj. Thiab, yog tias koj tab tom siv tshuaj loog lossis tshuaj loog ib txwm siv, nco ntsoov npaj ib tus neeg tsav koj lub tsev. Tej zaum koj yuav ua neeg khab theeb thiab tsis meej pem tom qab koj sawv ntawm qhov txheej txheem.

Puas muaj kev pheej hmoo rau kev kuaj?

Tej zaum koj yuav muaj nqaij me me los ntshav los ntawm qhov nqaij me. Qee zaum tus xaib tau kis. Yog tias qhov ntawd tshwm sim, koj yuav raug kho nrog tshuaj tua kab mob. Kev phais me me yuav ua rau mob ntxiv thiab tsis xis nyob. Koj tus kws kho mob yuav pom zoo lossis sau ntawv yuav tshuaj los pab koj kom koj xis nyob.

Txoj kev kuaj ntshav muaj feem me me. Koj yuav muaj mob me lossis doog ntshav ntawm qhov chaw tso rab koob, tab sis feem ntau cov tsos mob ploj mus sai.

Cov txiaj ntsig li cas?

Yog tias qib HER2 muaj protein ntau dua li ib txwm lossis ib daim ntawv luam ntawm tus HER2 pom, nws yuav txhais tau tias koj muaj tus kabmob HER2-zoo. Yog tias koj cov txiaj ntsig tau qhia tias muaj HER2 protein npaum li cas los yog tus naj npawb ib txwm muaj HER2 noob, koj yuav muaj tus kab mob HER2-tsis mob cancer.

Yog tias koj cov txiaj ntsig tsis tau pom meej lossis tsis zoo, koj yuav tau rov qab ua dua, siv ib qho qauv qog txawv lossis siv cov qauv ntsuas sib txawv. Feem ntau, IHC (kuaj cov HER2 protein) ua ntej, tom qab los ntawm FISH (kuaj ntxiv rau cov ntawv theej ntawm cov gene). Kev kuaj IHC tsis pheej yig dua thiab muab cov txiaj ntsig tau sai dua li FISH. Tab sis cov kws paub mis feem ntau xav tias kev tshuaj ntsuam FISH yog qhov tseeb dua.

Cov kev kho mob rau tus mob HER2 zoo mob cancer mis tuaj yeem ua rau mob qog nqaij hlav cancer, nrog rau kev phiv heev. Cov kev kho no tsis muaj txiaj ntsig zoo hauv HER2-mob qog noj ntshav.

Yog tias koj tau mus kho tus mob HER2-zoo mob cancer, cov txiaj ntsig ib txwm yuav txhais tau tias koj tau txais kev kho mob. Cov txiaj ntsig tau qhia pom ntau dua cov nyiaj tau ib txwm txhais tau tias koj qhov kev kho mob tsis ua haujlwm, lossis tias tus kabmob kheesxaws tau rov qab los tom qab kho tas.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv Kuv yuav tsum paub txog HER2 kuaj mob cancer mis?

Txawm hais tias nws pom muaj ntau rau cov poj niam, mob cancer mis, suav nrog HER2-zoo mob cancer mis, tuaj yeem cuam tshuam rau txiv neej. Yog tus txiv neej raug kuaj mob qog noj ntshav mis, yuav kuaj tus mob HER2.

Ib qho ntxiv, tus txiv neej thiab poj niam yuav tau kuaj HER2 yog tias lawv muaj qee yam mob khees xaws hauv lub plab thiab txoj hlab pas. Cov qog nqaij hlav no qee zaum muaj HER2 protein ntau thiab yuav teb zoo los kho HER2-kho mob cancer zoo.

Ua tim khawv

  1. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Kev Siv Tshuab Zais Me nyuam (hloov kho 2017 Oct 9; hais 2018 Aug 11]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/breast-cancer/ Screening-tests-and-early-detection/breast-biopsy.html
  2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Tus Kab Mob Khees Xaws HER2 xwm txheej [kho tshiab 2017 Sep 25; hais 2018 Aug 11]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-her2-status.html
  3. Breastcancer.org [Hauv Is Taws Nem]. Ardmore (PA): Breastcancer.org; c2018. HER2 xwm txheej [kho tshiab 2018 Feb 19; hais 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.breastcancer.org/symcepts/diagnosis/her2
  4. Cancer.net [Internet]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Tus Kab Mob Khees Xawj: Kev Tshuaj Ntsuam Xyuas; 2017 Lub Plaub Hlis [hais 2018 2018 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.net/cancer-types/breast-cancer/diagnosis
  5. Cancer.net [Internet]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Mob Cancer Mis: Taw qhia; 2017 Lub Plaub Hlis [hais 2018 2018 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.net/cancer-types/breast-cancer/introduction
  6. Johns Hopkins Tshuaj Kho Mob [Internet]. Tsev Kawm Ntawv Johns Hopkins University; Lub Tsev Saib Xyuas Kev Noj Qab Haus Huv: Cancer Mis: Qeb thiab Qib [muab 2018 2018 11; [txog 3 ntxaij]. Muaj los ntawm: https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/breast_health/breast_cancer_grades_and_stages_34,8535-1
  7. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .; Cov Koom Haum Asmeskas rau Chaw Kho Mob Soj Ntsuam; c2001–2018. HER2 [hloov tshiab 2018 Jul 27; hais 2018 Aug 11]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/tests/her2
  8. Mayo Clinic [Internet]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1998–2018. Raug Txom Nyem Ntawm Lub Mis: Txog 2018 Mar 22 [raug nplua 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.mayoclinic.org/tests-procedures/breast-biopsy/about/pac-20384812
  9. Mayo Clinic [Internet]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1998–2018. General Kev Ua Tsaug Zog: Txog; 2017 Dec 29 [raug nplua 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.mayoclinic.org/tests-procedures/anesthesia/about/pac-20384568
  10. Mayo Clinic [Internet]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1998–2018. HER2-zoo mob cancer mis: nws yog dab tsi ?; 2018 Mar 29 [raug nplua 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.mayoclinic.org/breast-cancer/expert-answers/faq-20058066
  11. Mayo Clinic: Mayo Medical Laboratories [Is Taws Nem]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1995–2018. Test ID: HERDN: HER2, Mis, DCIS, Quantitative Immunohistochemistry, Los Ntawm Txhais Tes Tsis Reflex: Soj Ntsuam thiab Txhais Lus [hais 2018 Aug 11]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/71498
  12. MD Anderson Cancer Center [Is Taws Nem]. University of Texas MD Anderson Cancer Center; c2018. Tus Kab Mob Khees Xob [Hais Txog 2018 Aug 11]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mdanderson.org/cancer-types/breast-cancer.html
  13. Memorial Sloan Kettering Cancer Center [Internet]. New York: Memorial Sloan Kettering Cancer Center; c2018. Qhov Koj Yuav Tsum Tau Paub Txog Kab Mob Hlawv Mis; 2016 Oct 27 [raug nplua 2018 Aug 11]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mskcc.org/blog/what-you-should-know-about-metastatic-breast
  14. Merck Los Ntawm Cov Neeg Siv Khoom Siv [Internet]. Kenilworth (NJ): Merck & Co., Inc .; c2018. Tus Kab Mob Khees Xob [Hais Txog 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.merckmanuals.com/home/women-s- health-issues/breast-disorders/breast-cancer
  15. Lub Teb Chaws Cancer Mis Foundation [Is Taws Nem]. Frisco (TX): Lub Tebchaws Cancer Cancer Foundation Inc .; c2016. Kev kuaj sim [hais tawm 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.nationalbreastcancer.org/breast-cancer-lab-tests
  16. Teb Chaws Lub Plawv, Lub Ntsws, thiab Koom Haum Ntshav [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Kuaj ntshav [cited 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.nhlbi.nih.gov/health-topics/blood-tests
  17. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI phau ntawv txhais lus ntawm Cancer Cov Lus Cog Tseg: gene [hais 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
  18. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI Lus Txhais ntawm Cancer Cov Lus Cog Tseg: HER2 kuaj [muab 2018 Aug 11]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=HER2
  19. University of Rochester Medical Center [Internet]. Rochester (NY): Tsev kawm qib siab Rochester Medical Center; c2018. Cov Ntawv Qhia Txog Kev Noj Qab Haus Huv: HER2 / neu [raug nplua 2018 Aug 11]; [txog 2 ntxaij].Muaj los ntawm: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=her2neu

Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.

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