Kev kuaj CPK: nws yog vim li cas thiab vim li cas nws hloov lawm
Zoo Siab
Creatinophosphokinase, paub los ntawm acronym CPK lossis CK, yog ib qho enzyme uas ua rau cov leeg nqaij, lub hlwb thiab lub plawv, thiab nws ntau npaum li cas tau thov tshawb xyuas qhov ua tau rau cov kabmob no.
Piv txwv li kws kho mob tuaj yeem xaj kev kuaj mob no thaum tus neeg mus txog tom tsev kho mob yws yws ntawm kev mob hauv siab lossis kuaj xyuas seb puas muaj mob stroke lossis lwm yam mob uas cuam tshuam rau cov leeg nqaij, piv txwv.
Kev siv qhov tseem ceeb
Cov kev siv tseem ceeb rau creatine phosphokinase (CPK) yog 32 thiab 294 U / L rau txiv neej thiab 33 txog 211 U / L rau poj niam tab sis lawv tuaj yeem sib txawv raws qhov chaw kuaj ua qhov twg kuaj.
Dab tsi yog nws rau
Kev kuaj ntshav creatinophosphokinase (CPK) muaj txiaj ntsig zoo los pab kuaj xyuas cov kab mob xws li mob plawv, raum lossis mob ntsws, thiab lwm yam. Qhov enzyme no tau cais ua peb hom raws li nws qhov chaw nyob:
- CPK 1 lossis BB: Nws tuaj yeem pom hauv lub ntsws thiab lub hlwb, feem ntau;
- CPK 2 lossis MB: Nws yog pom hauv lub plawv mob thiab vim li ntawd tuaj yeem siv los ua kab cim infarction, piv txwv;
- CPK 3 lossis HLI: Nws muaj nyob hauv cov leeg nqaij thiab sawv cev 95% ntawm tag nrho cov creatine phosphokinases (BB thiab MB).
Qhov ntau npaum li cas ntawm txhua hom CK yog ua los ntawm ntau txoj kev kuaj raws li nws lub zog thiab raws li kev qhia kho mob. Thaum CPK ntau tau thov kom ntsuas qhov ntsuas infarction, piv txwv, CK MB yog ntsuas ntxiv rau lwm cov cim ntsuas mob, xws li myoglobin thiab troponin, feem ntau.
Tus CK MB tus nqi sib npaug los yog tsawg dua 5 ng / mL raug txiav txim siab ib txwm thiab nws qhov kev xav ntau yog feem ntau thaum muaj mob plawv. Cov theem ntawm CK MB feem ntau nce 3 mus rau 5 teev tom qab lub infarction, nce mus txog qhov siab kawg hauv 24 teev thiab tus nqi rov qab zoo li qub ntawm 48 mus rau 72 teev tom qab lub infarction. Txawm hais tias raug suav tias yog tus cim ntsuas plawv zoo, qhov ntsuas ntsuas ntawm CK MB rau kev kuaj mob infarction yuav tsum tau ua ke nrog troponin, feem ntau vim tias troponin cov nqi rov qab zoo li qub txog 10 hnub tom qab lub infarction, ua, yog li ntawd, ntau tshwj xeeb. Saib dab tsi troponin kuaj yog rau.
Dab tsi siab thiab qis CPK txhais tau tias
Ua rau kom muaj ntau ntxiv ntawm cov enzyme creatinophosphokinase yuav qhia tau tias:
High CPK | Qis Npaum Cas | |
CPK BB | Kev tiv thaiv kabmob, mob hlab ntsha tawg, mob qog hlwb, chua leeg, mob ntsws tsis ua haujlwm | -- |
CPK MB | Mob o, mob hauv siab, hluav taws xob, thaum lub plawv tsis ua haujlwm, phais plawv | -- |
MM CPK | Txhaws qhov kev raug mob, kev tawm dag zog lub cev, lub cev qoj ib ce ntev, siv cov tshuaj tsis raug cai, mob hauv lub cev, mob leeg, tom qab xaiv electromyography | Poob rau cov leeg nqaij, cachexia thiab kev noj haus tsis zoo |
TAG NRHO CPK | Kev haus dej haus cawv ntau dhau, vim siv cov tshuaj xws li amphotericin B, clofibrate, ethanol, carbenoxolone, halothane thiab succinylcholine tau muab tso ua ke, lom nrog barbiturates | -- |
Yuav kom ua qhov koob tshuaj ntawm CPK, kev yoo mov tsis yog qhov yuav tsum tau ua, thiab tej zaum yuav ua los yog tsis pom zoo los ntawm tus kws kho mob, txawm li cas los xij nws tseem ceeb kom tsis txhob ua lub cev qoj ib ce tsawg kawg 2 hnub ua ntej ua qhov kev ntsuas, vim tias qhov enzyme no yuav tau nce siab tom qab kev tawm dag zog vim. rau nws cov khoom siv los ntawm cov leeg, ntxiv rau ncua kev ncua ntawm cov tshuaj, xws li Amphotericin B thiab Clofibrate, piv txwv li, vim lawv tuaj yeem cuam tshuam cov txiaj ntsig sim.
Yog tias qhov kuaj xyuas raug thov rau lub hom phiaj los kuaj mob plawv, nws raug pom zoo tias kev sib raug zoo ntawm CPK MB thiab CPK raug ntsuas los siv cov qauv hauv qab no: 100% x (CK MB / CK tag nrho). Yog tias qhov txiaj ntsig ntawm kev sib raug zoo no ntau dua 6%, nws yog qhov qhia tias muaj kev raug mob rau lub siab nqaij, tab sis yog tias nws tsawg dua 6%, nws yog qhov taw qhia ntawm kev raug mob rau cov leeg pob txha, thiab tus kws kho mob yuav tsum tshawb xyuas qhov ua rau.