Tus Sau: Peter Berry
Hnub Kev Tsim: 19 Lub Xya Hli Ntuj 2021
Hloov Hnub: 13 Tau 2024
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All About Darzalex (daratumumab)
Daim Duab: All About Darzalex (daratumumab)

Zoo Siab

Darzalex yog dab tsi?

Darzalex yog cov tshuaj kws kho mob xaj. Nws tau siv los kho ntau yam mob myeloma, uas yog hom mob cancer uas cuam tshuam rau qee cov qe ntshav dawb hu ua plasma cell.

Darzalex muaj daratumumab. Qhov no yog hom tshuaj hu ua monoclonal antibody.

Darzalex tsis yog kev kho tshuaj. Nws yog hom kev tsom lub hom phiaj thiab qee zaum hu ua kev kho mob tshuaj tiv thaiv. Qhov no txhais tau hais tias Darzalex tau tsim los ua haujlwm nrog koj lub cev tiv thaiv kab mob (koj lub cev tiv thaiv tawm tsam kev kis mob).

Tus kws saib xyuas kev noj qab haus huv yuav muab Darzalex rau koj raws txoj leeg ntshav (IV) hauv koj tus kws kho mob lub chaw haujlwm lossis chaw kuaj mob. Txoj kev tso ntshav IV yog kev txhaj tshuaj rau hauv txoj hlab ntshav uas tau muab rau ncua sijhawm.

Nws siv li cas

Darzalex tuaj yeem muab tshuaj ib leeg lossis lwm yam tshuaj noj. Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo Darzalex siv los siv:

  • Rau cov neeg laus uas nyuam qhuav raug kuaj mob ntau myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho lub cev ntawm tes mob hlwb. (Nrog kev hloov kho lub qia hauv hlwb, koj tus kheej qia hlwb raug siv.) Hauv qhov xwm txheej no:
    • Darzalex tuaj yeem siv nrog cov tshuaj lenalidomide (Revlimid) thiab dexamethasone.
    • Darzalex kuj tseem siv tau nrog cov tshuaj bortezomib (Velcade), melphalan, thiab prednisone.
  • Rau cov neeg laus uas tau txais ib lossis ntau txoj kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis muaj ntau tus mob myeloma rov qab los. Hauv cov xwm txheej no, Darzalex siv nrog lenalidomide thiab dexamethasone.
  • Rau cov neeg laus uas tau txais ib lossis ntau dua yav dhau los ntau txoj kev kho tus mob myeloma. Hauv cov xwm txheej no, Darzalex siv nrog bortezomib thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais ob lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome, uas yog hom tshuaj. Hauv cov xwm txheej no, Darzalex siv nrog cov tshuaj pomalidomide (Pomalyst) thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais peb lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.
  • Hauv cov neeg laus uas tau sim cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob, tab sis cov tshuaj tsis ua haujlwm rau ntau yam mob myeloma. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.

Txij nkawm

Rau cov kev tshawb fawb soj ntsuam saib yuav ua li cas Darzalex tau siv los kho ntau yam mob myeloma, ib leeg thiab ua ke nrog lwm cov tshuaj tua kabmob kheesxaws.Cov kev tshawb fawb no hu ua MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, thiab SIRIUS. Cov kev tshawb fawb pom tau hais tias kev kho mob ntawm ntau yam mob myeloma zoo dua yog tias Darzalex tau ntxiv rau kev kho mob qog nqaij hlav txawv dua li cov kev kho mob no tau muab rau ib leeg. Yog xav paub cov ntaub ntawv ntau ntxiv txog ua haujlwm zoo, saib "Darzalex rau ntau tus mob myeloma" hauv qab no.


Darzalex feem ntau

Darzalex tsuas yog muaj raws li cov tshuaj muaj npe kev lag luam. Tamsis no nws tsis muaj cov ntawv ua tsis raug.

Darzalex muaj ib qho tshuaj txuam: daratumumab.

Cov tshuaj phiv Darzalex

Darzalex tuaj yeem ua rau mob hnyav los sis mob nyhav. Cov npe hauv qab no muaj qee qhov kev mob tshwm sim thaum yuav noj Darzalex. Daim ntawv teev npe no tsis suav tag nrho cov kev mob tshwm sim.

Yog xav paub cov ntaub ntawv ntau ntxiv txog qhov tshwm sim yuav tshwm sim ntawm Darzalex, tham nrog koj tus kws kho mob lossis kws muag tshuaj. Lawv tuaj yeem muab cov lus qhia rau koj txog kev yuav ua li cas nrog cov kev mob tshwm sim uas tuaj yeem thab.

Ntau cov kev mob tshwm sim

Cov kev mob tshwm sim heev ntawm Darzalex tuaj yeem suav nrog:

  • zoo nkaus li nkees
  • tsis muaj zog lossis tsis muaj zog
  • mob leeg pob txha (qwj)
  • xeev ntuav lossis ntuav
  • mob plab xws li mob raws plab lossis quav tawv
  • tsis qab los
  • teeb meem pw tsaug zog
  • ua npaws
  • ua daus no
  • txog siav siav lossis hnoos
  • kev ua pa sab saud, xws li mob khaub thuas
  • mob ntsws, ib hom mob ntsws
  • mob ib ce
  • txha los nraub qaum mob
  • kiv taub hau

Yog tias cov kev mob tshwm sim uas koj mloog zoo li mob hnyav dua lossis tsis txhob ploj mus, nrog koj tus kws kho mob lossis kws muag tshuaj tham.


Cov kev mob tshwm sim hnyav heev

Cov kev mob tshwm sim hnyav los ntawm Darzalex tsis tshua muaj, tab sis lawv tuaj yeem tshwm sim. Hu rau koj tus kws kho mob tam sim ntawd yog tias koj muaj kev phiv loj heev. Hu 911 yog koj tus mob hnov ​​lub neej tsis zoo lossis yog koj xav tias koj muaj mob xwm txheej kub ntxhov ceev.

Cov kev mob tshwm sim hnyav heev thiab lawv cov tsos mob tuaj yeem suav nrog cov hauv qab no:

  • Txoj kev lis ntshav cov tshuaj tiv thaiv, ib hom kev fab tshuaj. Cov tsos mob tuaj yeem suav nrog:
    • teeb meem ua pa
    • caj pas nruj
    • zoo nkaus li pom tob hau lossis kiv taub hau los ntawm cov ntshav qis
    • hnoos lossis hawb pob
    • los ntswg lossis txhaws ntswg
    • xeev ntuav lossis ntuav
    • ua daus no
    • ua npaws
    • mob taub hau
    • khaus
  • Kab mob ntsws, ib hom mob ntsws. Cov tsos mob tuaj yeem suav nrog:
    • hnoos tau hnoos qeev (hnoos qeev)
    • ua npaws thiab ua daus no
    • txog siav
    • mob hauv siab
  • Kab mob siab B, yog tias koj tau muaj yav tas los. Cov tsos mob tuaj yeem suav nrog:
    • kev nkees zuj zus
    • Qhov muag daj ntawm koj cov tawv nqaij lossis sab dawb ntawm koj lub qhov muag
  • Peripheral sensory neuropathy (puas qhov puas tsuaj uas ua rau tingling, loog, lossis mob). Cov tsos mob tuaj yeem suav nrog:
    • loog lossis tingling
    • mob mob
    • rhiab
    • tsis muaj zog hauv koj txhais tes lossis taw
  • Mob raum (o ntawm tes thiab taw). Cov tsos mob tuaj yeem suav nrog:
    • o ntawm caj npab lossis ceg
    • ncab tawv
    • daim tawv uas dents (qho to) thaum nias rau ob peb feeb

Lwm cov kev phiv loj heev, piav qhia ntxiv hauv qab no hauv “Cov ntsiab lus cuam tshuam,” suav nrog:


  • kev fab tshuaj tsis haum
  • thrombocytopenia, ntshav muaj ntshav tsawg, yog ib hom qe ntshav pab kom ntshav txhaws
  • neutropenia, qib qis ntawm neutrophils, uas yog ib hom qe ntshav dawb uas pab tua kab mob sib kis
  • mob yoov (mob pob hauv zos)

Sab sij huam cov ntsiab lus

Tej zaum koj yuav xav paub ntau npaum li cas tej kev mob tshwm sim nrog cov tshuaj no. Nov yog qee cov lus qhia txog kev mob tshwm sim loj heev cov tshuaj no yuav ua tau.

Kev fab tshuaj tiv thaiv

Ib yam li nrog rau cov tshuaj feem ntau, qee cov neeg tuaj yeem muaj kev fab tshuaj tom qab siv Darzalex. Nws tseem tsis tau paub meej npaum li cas tib neeg siv Darzalex muaj kev fab tshuaj tsis haum. Cov tsos mob ntawm kev txhaum fab hnyav tuaj yeem suav nrog:

  • tawv nqaij ua pob ua xua lossis khaus (ua pob khaus khaus ntawm koj cov tawv nqaij)
  • khaus
  • tso tawm (sov thiab liab nyob hauv koj cov tawv nqaij)
  • ua npaws

Ib qho kev txhaum fab hnyav dua yog muaj tsawg tab sis ua tau. Cov tsos mob ntawm kev txhaum fab hnyav tuaj yeem suav nrog:

  • o hauv koj cov tawv nqaij, feem ntau hauv koj daim tawv muag, daim di ncauj, tes, lossis ko taw
  • o ntawm koj tus nplaig, qhov ncauj, lossis caj pas
  • teeb meem ua pa

Hu rau koj tus kws kho mob tam sim ntawd yog tias koj muaj qhov kev txhaum fab hnyav rau Darzalex. Hu 911 yog koj tus mob hnov ​​lub neej tsis zoo lossis yog koj xav tias koj muaj mob xwm txheej kub ntxhov ceev.

Txoj kev lis ntshav cov tshuaj tiv thaiv

Darzalex muab cov tshuaj tso ntshav (IV) hauv koj tus kws kho mob chav kuaj mob lossis chaw kuaj mob. Qhov no yog kev txhaj tshuaj rau hauv cov leeg ntshav uas tau muab rau ncua sijhawm. Ib yam li nrog rau feem ntau cov tshuaj uas tau muab raws li IV Txoj kev lis ntshav, koj yuav muaj kev cuam tshuam tshuaj infusion tom qab tau txais Darzalex. (Kev sau ua ntshav yog ib hom kev tawm tsam ntawm txoj kev ua xua.)

Thaum cov kev tshawb fawb soj ntsuam, kev rov qab saib xyuas qhov mob tshwm sim hauv kwv yees li ib nrab ntawm txhua tus neeg kho nrog Darzalex Txoj kev lis ntshav. Feem ntau, cov kev tawm tsam tau tshwm sim thaum thawj qhov kev sib tw thiab muaj mob me. Feem ntau ntawm cov neeg uas tau txais Darzalex muaj kev tawm tsam thaum lossis 4 teev tom qab kawg ntawm kev ntuav ntshav. Cov kev mob tshwm sim yog tsis tshua tshwm sim nrog kev kho mob yav tom ntej. Hauv qhov kev tshawb fawb, cov neeg uas tau txais cov tshuaj noj uas tsis yog Darzalex tsis tau muab tshuaj rau hauv cov qauv ntawm infusions.

Yog tias koj muaj qhov tshaj tawm cov ntshav thaum mob sib khuav lossis mob hnyav, koj tus kws kho mob yuav ncua koj txoj kev lis ntshav los kho qhov tshuaj tiv thaiv. Lawv yuav tom qab ntawd rov pib qhov kev sib tw ntawm tus nqi qis dua (nrawm) yog li koj tau txais cov tshuaj qeeb dua. Yog tias koj qhov kev cuam tshuam tshuaj infusion muaj mob hnyav lossis anaphylactic (lub neej txoj sia), koj tus kws kho mob yuav tsum tsis kho kiag nrog Darzalex thiab pib kho mob kub ntxhov.

Txo txoj hauv kev muaj tshuaj tiv thaiv, koj tus kws kho mob yuav muab tshuaj ua ke rau koj. Ib mus rau peb teev ua ntej txhua lub Darzalex infusion, koj yuav tau txais:

  • corticosteroid (kom txo qis o)
  • antipyretic (los tiv thaiv lossis txo kub taub hau)
  • ib qho tshuaj antihistamine (los tiv thaiv lossis txo cov tsos mob ntawm kev tsis haum tshuaj)

Koj tseem tuaj yeem tau txais corticosteroid 1 hnub tom qab infusion kom tsis txhob ncua sijhawm. Tab sis yog tias koj twb tau noj cov tshuaj steroid xws li dexamethasone lossis prednisone, koj feem ntau yuav tsis xav tau qhov ntxiv steroid.

Yog tias koj muaj qhov tsis haum nrog Darzalex tom qab koj tawm ntawm koj tus kws kho mob lub chaw haujlwm lossis qhov chaw sau ntshav, hu rau koj tus kws kho mob tam sim ntawd. Hu 911 yog koj tus mob hnov ​​lub neej tsis zoo lossis yog koj xav tias koj muaj mob xwm txheej kub ntxhov ceev.

Ntshav mob rau cov ntshav

Darzalex tuaj yeem ua rau mob thrombocytopenia, uas yog qib qis ntawm koj cov platelets. (Cov no yog ib hom qe ntshav pab ua kom ntshav txhaws.) Cov tsos mob tuaj yeem suav nrog nqaij doog ntshav thiab los ntshav.

Hauv cov kev tshawb fawb soj ntsuam, kwv yees li 48% txog 90% ntawm cov neeg uas tau noj Darzalex lossis Darzalex nrog cov txheej txheem ntau tus mob myeloma tau muaj thrombocytopenia. Hauv kev sib piv, 58% rau 88% ntawm cov tib neeg uas nyuam qhuav muaj kev kho mob tseem muaj tus mob thrombocytopenia.

Darzalex tseem tuaj yeem ua rau neutropenia. Qhov no yog ib qho poob qis ntawm neutrophils, uas yog ib hom qe ntshav dawb uas pab tua kab mob sib kis. Cov tsos mob tuaj yeem suav nrog ua npaws thiab mob sib kis.

Hauv cov kev tshawb fawb soj ntsuam, kwv yees li 58% txog 95% ntawm cov neeg uas tau noj Darzalex lossis Darzalex nrog rau ntau tus txheej txheem myeloma kho tau neutropenia. Hauv kev sib piv, 40% mus rau 87% ntawm cov tib neeg uas nyuam qhuav muaj kev kho mob tseem muaj cov neutropenia.

Thaum koj kho Darzalex, koj tus kws kho mob yuav tshuaj xyuas koj cov ntshav txhaws thiab ntshav dawb. Lawv kuj yuav soj qab xyuas koj rau qhov uas doog ntshav, los ntshav, lossis kis tau mob. Yog tias koj muaj ib qho ntawm cov tsos mob no, qhia rau koj tus kws kho mob.

Mob muag

Thaum koj tab tom noj Darzalex, koj tuaj yeem tsim tus mob hu ua shingles (herpes zoster). Qhov no vim tias muaj ntau yam mob myeloma thiab tau txais ntau txoj kev kho mob myeloma tuaj yeem ua rau koj muaj feem kis mob yooj yim dua.

Thaum koj tau tus mob shingles, koj yuav muaj:

  • mob mob
  • tingling
  • khaus
  • xoo pob thiab tawm pob ntawm ib sab koj lub cev

Tus kab mob tib yam uas ua rau mob ntxaug kuj tuaj yeem ua mob qhua dej. Yog tias koj tau mob qhua maj yav dhau los, tus kab mob yuav tsis tawm hauv koj lub cev mus tom qab koj rov zoo los. Hloov, tus kab mob tsuas yog "mus pw tsaug zog" hauv koj cov hlab ntsha.

Tsis muaj leej twg paub tseeb vim li cas, tab sis tus kab mob tuaj yeem rov ua haujlwm lossis "sawv" nrog qee yam tshwm sim xws li lub cev tsis muaj zog tiv thaiv kab mob. (Koj muaj zog tiv thaiv koj lub cev tiv thaiv kab mob.)

Cov kev kho mob qog lossis mob qog noj ntshav tuaj yeem ua rau koj lub cev tsis muaj zog thiab rov qab kho tus mob herpes zoster tus kab mob. Thaum nws tsaug zog, nws qhia nws tus kheej tias yaug cov hloov tus kabmob qhua dej.

Hauv kev tshawb fawb hauv chaw kho mob, tus mob shingles tau tshaj tawm hauv 3% ntawm cov neeg uas tau kho nrog tsuas yog Darzalex. Hauv kev sib piv, tus mob pob tsuas tshwm sim hauv 2% rau 5% ntawm cov neeg uas tau noj Darzalex nrog kev siv tshuaj kho mob qog noj ntshav ntxiv.

Yog tias koj tau mob qhua maj los yog mob pob ntseg yav dhau los thiab noj Darzalex, koj tus kws kho mob tuaj yeem sau tshuaj rau noj los tiv thaiv kab mob. Hom tshuaj no tuaj yeem pab tiv thaiv tus mob txhawm rau txhim kho hauv koj lub cev. Koj yuav tsum tau siv tshuaj tua kab mob kho ua ntej dhau 1 lub lim tiam ntawm thawj zaug tau txais Darzalex. Tom qab ntawd koj yuav tsum noj nws ntxiv 3 lub hlis tom qab koj tau txais kev kho mob nrog Darzalex.

Mob ntsws o

Kev noj tshuaj Darzalex tuaj yeem coj koj los tsim kev mob ntsws uas hu ua mob ntsws. Qhov no vim tias yog tias koj muaj ntau yam mob myeloma, koj yuav kis tau tus mob yooj yim dua li cov neeg noj qab nyob zoo.

Hauv kev tshawb fawb hauv cov chaw kho mob, 11% mus rau 26% ntawm cov neeg uas tau siv Darzalex tsim cov mob ntsws. Qhov no piv rau 6% rau 14% ntawm cov neeg uas tau noj cov placebo (tsis muaj tshuaj kho).

Kab mob ntsws yog feem ntau tshaj tawm hais tias muaj mob hnyav. Txog li 4% ntawm cov neeg nyob thoob plaws txhua txoj kev tshawb fawb Darzalex yuav tsum tau tsum tsis txhob noj tshuaj vim tias mob ntsws. Kev tuag los ntawm kev mob ntsws yog qhov tsawg. Tab sis yog tias kev tuag tau tshwm sim, nws yog vim tias mob ntsws thiab mob sepsis (lub neej muaj kev phom sij txog kev kis tus kab mob).

Cov tsos mob ntawm mob ntsws muaj xws li:

  • hnoos tau hnoos qeev (hnoos qeev)
  • ua npaws thiab ua daus no
  • txog siav
  • mob hauv siab

Yog tias koj muaj cov tsos mob ntawm mob ntsws, qhia koj tus kws kho mob. Lawv yuav ncua koj koob tshuaj Darzalex los kho tus mob ntsws txheem. Hauv kev tshawb fawb hauv tsev kho mob, kwv yees li 1% mus rau 4% ntawm cov neeg uas tau siv Darzalex lossis tsuas yog kev kho mob qog noj ntshav yuav tsum tau txiav lawv cov tshuaj vim tias muaj mob ntsws ntau.

Tus nqi Darzalex

Ib yam li txhua yam tshuaj, cov nqi ntawm Darzalex tuaj yeem sib txawv. Txhawm rau nrhiav cov nqi tam sim no rau Darzalex hauv koj thaj chaw, txheeb xyuas WellRx.com. Tus nqi koj pom ntawm WellRx.com yog qhov koj tuaj yeem them yam tsis muaj kev pov hwm. Tus nqi tiag uas koj yuav them yuav nce nyob ntawm koj qhov kev tuav pov hwm thiab lub tsev muag tshuaj uas koj siv.

Koj txoj kev npaj fajseeb khomob yuav xav kom koj tau txais kev pom zoo uantej lawv yuav tsocai rau kev fajseeb khomob rau Darzalex. Qhov no txhais tau tias koj tus kws kho mob yuav tsum xa daim ntawv thov rau koj lub tuam txhab kev pov hwm kom lawv them rau cov tshuaj ntawd. Lub tuam txhab kev pov hwm yuav tshuaj xyuas qhov kev thov thiab qhia koj thiab koj tus kws kho mob paub yog tias koj txoj kev npaj yuav them rau Darzalex.

Yog tias koj tsis paub meej tias koj yuav tsum tau txais kev tso cai ua ntej rau Darzalex, tiv toj koj cov phiaj xwm kev pov hwm.

Kev pab nyiaj thiab kev tuav pov hwm

Yog tias koj xav tau kev pabcuam nyiaj txiag los them rau Darzalex, lossis yog koj xav tau kev pabcuam kom nkag siab txog koj cov nyiaj pov hwm kev tiv thaiv, muaj kev pab.

Janssen Biotech, Inc., tus tsim kom muaj Darzalex, muaj ib txoj haujlwm hu ua Janssen CarePath. Yog xav paub cov ntaub ntawv ntau ntxiv thiab saib seb koj puas tsim nyog tau txais kev txhawb nqa, hu 844-553-2792 lossis mus saib lub vev xaib website.

Darzalex dosage

Txoj kev noj tshuaj Darzalex uas koj tus kws kho mob tau sau ntawv yuav yog nyob ntawm ntau yam. Cov no suav nrog:

  • Yog tias koj tus mob nyuam qhuav raug kuaj los yog koj tau txais ib lossis ntau dua qhov kev kho tus mob myeloma yav dhau los
  • lwm txoj kev kho mob uas koj tau txais nrog Darzalex los kho ntau yam mob myeloma
  • lwm yam mob uas koj yuav muaj
  • phiv uas tsis ploj mus

Cov ntaub ntawv hauv qab no piav qhia ntau npaum li cas cov tshuaj uas feem ntau siv los yog ua kom siv. Koj tus kws kho mob yuav txiav txim siab muab qhov zoo tshaj plaws kom haum koj cov kev xav tau. Yuav kom tau txais txiaj ntsig zoo tshaj plaws ntawm qhov kev kho no, nws tseem ceeb heev uas koj yuav tsum mus rau tag nrho koj cov sij hawm teem tseg thiab tsis hla hnub.

Cov ntaub ntawv tshuaj thiab qhov ua tau zoo

Darzalex los ua cov tshuaj tov (sib tov ua kua) uas koj yuav tau txais yog hais tias yog txhaj rau. Txoj kev daws teeb meem yuav tsis muaj kob daj rau daj ntseg daj. Darzalex muaj nyob rau hauv ob qhov ntau thiab tsawg:

  • 100 mg / 5 mL hauv ib lub raj tshuaj ib leeg
  • 400 mg / 20 mL hauv ib lub raj tshuaj ib leeg

Tus kws saib xyuas kev noj qab haus huv yuav sib xyaw ib feem ntawm Darzalex nrog 0.9% sodium chloride (hom tshuaj ntsev dej). Tom qab ntawd lawv yuav muab cov tshuaj no rau koj los ntawm rab koob uas tau muab tso rau hauv txoj hlab ntshav. Qhov no yog hu ua tshuaj tso ntshav (IV) Txoj kev lis ntshav.

Feem ntau, koj tus kws kho mob yuav pib koj raws li kev pom zoo ntau npaum tab sis ntawm qib qis dua (nrawm) ntawm Txoj kev lis ntshav. Ua haujlwm dhau sijhawm, lawv yuav kho qhov kev sib tshuam mus rau tus nqi uas haum rau koj. Qhov no yuav yog nyob ntawm qhov kev cuam tshuam thaum ntsib koj.

Koj thawj zaug tshuaj ntawm Darzalex yuav siv sijhawm li 7 teev. Qhov no yog vim tias koj tus kws kho mob yuav siv tshuaj (maj mam muab rau koj) koj cov tshuaj maj mam mus rau hauv cov leeg ntshav. Nyob rau yav tom ntej, kev mob infusions yuav nyob ntev li 3 txog 5 teev vim tias koj yuav tau txais cov tshuaj sai dua. Tus kws kho mob yuav ib txwm saib xyuas koj lub sijhawm koj nyob ntawd.

Tsuas tshuaj rau ntau myeloma

Darzalex yog kev kho mob ntawm nws tus kheej lossis nrog lwm yam kev kho mob qog nqaij hlav rau cov neeg laus uas muaj ntau yam mob myeloma. Qhov kev npaj khomob thiab sijhawm ntev npaum li cas yog tias koj nyuam qhuav raug kuaj pom lossis muaj kev khomob yav dhau los. Darzalex tsis tau kawm txog menyuam yaus.

Cov koob tshuaj pom zoo ntawm Darzalex yog 16 milligrams / kilogram (mg / kg) ntawm lub cev qhov hnyav raws li IV txoj kev lis ntshav. Piv txwv li, tus poj niam 110 phaus nyhav li 50 kg. Qhov ntawd txhais tau hais tias nws qhov pom zoo Darzalex koob tshuaj yuav yog 50 kg ntau zog txog 16 mg / kg, uas yog 800 mg.

Cov neeg laus uas nyuam qhuav raug kuaj mob ntau myeloma uas tsis tuaj yeem tsis tuaj yeem hloov qog hloov ntshav ntawm tes

Nrog autologous qia cell hloov khoom siv, koj tus kheej qia hlwb raug siv. Ib txoj kev kho mob yog Darzalex nrog lenalidomide (Revlimid) thiab dexamethasone. Cov kev xav noj ntau npaum li cas yog:

  • Lim tiam 1 txog 8: Ib koob tshuaj txhua lub lis piam (rau tag nrho ntawm yim zaug)
  • Lim tiam 9 txog 24: Ib koob tshuaj txhua 2 lub lis piam (rau tag nrho ntawm yim zaug)
  • Lub lim tiam 25 mus tom ntej: Ib koob tshuaj txhua 4 lub lis piam

Lwm txoj kev kho mob ntxiv yog Darzalex nrog bortezomib (Velcade), melphalan, thiab prednisone. Cov kev xav noj ntau npaum li cas yog:

  • Lim tiam 1 txog 6: Ib koob tshuaj txhua lub lis piam (rau tag nrho rau ntawm 6 koob tshuaj)
  • Lim tiam 7 txog 54: Ib koob tshuaj txhua 3 lub lis piam (rau tag nrho 16 koob)
  • Lub lim tiam 55 mus tom ntej: Ib koob tshuaj txhua 4 lub lis piam

Cov neeg laus uas tau txais ib lossis ntau qhov kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis muaj ntau tus mob myeloma rov qab los

Koj yuav tau txais Darzalex nrog lenalidomide thiab dexamethasone. Cov kev xav noj ntau npaum li cas yog:

  • Lim tiam 1 txog 8: Ib koob tshuaj txhua lub lis piam (rau tag nrho ntawm yim zaug)
  • Lim tiam 9 txog 24: Ib koob tshuaj txhua 2 lub lis piam (rau tag nrho ntawm yim zaug)
  • Lub lim tiam 25 mus tom ntej: Ib koob tshuaj txhua 4 lub lis piam

Cov neeg laus uas tau txais ib lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma

Koj yuav tau txais Darzalex nrog bortezomib thiab dexamethasone. Cov kev xav noj ntau npaum li cas yog:

  • Lim tiam 1 txog 9: Ib koob tshuaj txhua lub lis piam (rau tag nrho cuaj koob tshuaj)
  • Lim tiam 10 txog 24: Ib koob tshuaj txhua 3 lub lis piam (rau tag nrho tsib koob)
  • Lub lim tiam 25 mus tom ntej: Ib koob tshuaj txhua 4 lub lis piam

Cov neeg laus uas tau txais ob lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma, suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome

Koj yuav tau txais Darzalex nrog pomalidomide (Pomalyst) thiab dexamethasone. Cov kev xav noj ntau npaum li cas yog:

  • Lim tiam 1 txog 8: Ib koob tshuaj txhua lub lis piam (rau tag nrho ntawm yim zaug)
  • Lim tiam 9 txog 24: Ib koob tshuaj txhua 2 lub lis piam (rau tag nrho ntawm yim zaug)
  • Lub lim tiam 25 mus tom ntej: Ib koob tshuaj txhua 4 lub lis piam

Cov neeg laus uas tau txais peb lossis ntau tshaj yav dhau los ntau yam kev kho mob myeloma, suav nrog ib qho tshuaj tiv thaiv proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob, lossis tsis teb rau cov tshuaj tiv thaiv proteasome thiab cov tshuaj tiv thaiv immunomodulatory.

Koj yuav tau txais Darzalex nkaus xwb. Cov kev xav noj ntau npaum li cas yog:

  • Lim tiam 1 txog 8: Ib koob tshuaj txhua lub lis piam (rau tag nrho ntawm yim zaug)
  • Lim tiam 9 txog 24: Ib koob tshuaj txhua 2 lub lis piam (rau tag nrho ntawm yim zaug)
  • Lub lim tiam 25 mus tom ntej: Ib koob tshuaj txhua 4 lub lis piam

Txo txoj hauv kev muaj tshuaj tiv thaiv, koj tus kws kho mob yuav muab tshuaj ua ke rau koj. Ib mus rau peb teev ua ntej txhua lub Darzalex infusion, koj yuav tau txais:

  • corticosteroid (kom txo qis o)
  • antipyretic (los tiv thaiv los yog txo kub taub hau)
  • ib qho tshuaj antihistamine (los tiv thaiv lossis txo cov tsos mob ntawm kev fab tshuaj).

Koj tseem tuaj yeem tau txais corticosteroid 1 hnub tom qab infusion kom tsis txhob ncua sijhawm. Tab sis yog tias koj twb tau noj cov tshuaj steroid xws li dexamethasone lossis prednisone, koj feem ntau yuav tsis xav tau qhov ntxiv steroid.

Yog tias kuv plam koob tshuaj?

Yog tias koj tsis tau teem caij mus ntsib Darzalex infusion, hu rau koj tus kws kho mob tam sim ntawd mus teem sijhawm. Lawv yuav kho koj lub caij noj tshuaj kom paub tseeb tias koj tau txais cov naj npawb ntawm cov kev kho mob hauv lub sijhawm sijhawm.

Kuv puas yuav tau siv cov tshuaj no ntev?

Hauv kev tshawb fawb hauv kev kho mob, qhov nruab nrab lub sijhawm nws siv rau Darzalex pib ua haujlwm yog 1 hlis.

Txawm li cas los xij, koj yuav tau muab koj cov tshuaj rau ncua sijhawm ntev dua. Qhov no yuav yog nyob ntawm seb koj lub cev teb li cas rau Darzalex thiab yog tias koj ntau myeloma pib mob zuj zus.

Lub sijhawm ntawm kev kho mob kuj yuav yog nyob ntawm seb koj qhov mob ua ntau yam myeloma nyuam qhuav raug kuaj tshiab lossis yog tias koj tau txais kev kho yav tas los.

Darzalex rau ntau yam mob myeloma

Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo Darzalex rau kev kho mob ntawm ntau yam mob myeloma.

Qhov no yog ib hom mob cancer uas cuam tshuam rau qee cov qe ntshav dawb hu ua plasma cell. Plasma cell ua ib feem ntawm koj lub cev tiv thaiv kab mob thiab pab tua kab mob hauv koj lub cev. Hauv ntau lub myeloma, cov ntshav ntshav hloov mus rau ntau lub hlwb myeloma. Raws li ntau cov myeloma hlwb loj hlob thiab kis, lawv yuav khaws cov hlwb kom zoo thiab ua rau cov pob txha ncig lawv.

Darzalex raug pom zoo los siv:

  • Rau cov neeg laus uas nyuam qhuav raug kuaj mob ntau myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho lub cev ntawm tes mob hlwb. (Nrog kev hloov kho lub qia hauv hlwb, koj tus kheej qia hlwb raug siv.) Hauv qhov xwm txheej no:
    • Darzalex tuaj yeem siv nrog cov tshuaj lenalidomide (Revlimid) thiab dexamethasone.
    • Darzalex kuj tseem siv tau nrog cov tshuaj bortezomib (Velcade), melphalan, thiab prednisone.
  • Rau cov neeg laus uas tau txais ib lossis ntau txoj kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis muaj ntau tus mob myeloma rov qab los. Hauv cov xwm txheej no, Darzalex siv nrog lenalidomide thiab dexamethasone.
  • Rau cov neeg laus uas tau txais ib lossis ntau dua yav dhau los ntau txoj kev kho tus mob myeloma. Hauv cov xwm txheej no, Darzalex siv nrog bortezomib thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais ob lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome, uas yog hom tshuaj. Hauv cov xwm txheej no, Darzalex siv nrog cov tshuaj pomalidomide (Pomalyst) thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais peb lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.
  • Hauv cov neeg laus uas tau sim cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob tab sis tsis siv tshuaj ua haujlwm rau ntau yam mob myeloma. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.

Txij nkawm

Rau cov kev tshawb fawb soj ntsuam saib yuav ua li cas Darzalex tau siv los kho ntau yam mob myeloma ib leeg thiab ua ke nrog lwm cov tshuaj tua kabmob kheesxaws. Cov kev tshawb fawb no hu ua MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, thiab SIRIUS. Cov kev tshawb fawb pom tau hais tias kev kho kom zoo dua yog tias Darzalex ntxiv rau kev kho mob qog nqaij hlav ntau dua li cov kev kho mob no tau muab ib leeg.

Qhov MAIA kawm

Txoj kev tshawb nrhiav MAIA tau saib cov neeg nyuam qhuav raug kuaj mob nrog ntau tus mob myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho qog ntshav ntawm tes. Cov tib neeg tau txais kev kho mob qog mis ib qho qauv ntawm lenalidomide (Revlimid) thiab kev txhaj tshuaj qis-dexamethasone lossis kev kho tib yam ntxiv nrog Darzalex. Piv rau pab pawg kho mob niaj hnub, cov pab pawg Darzalex muaj qhov pheej hmoo tsawg ntawm 44% ntawm lawv cov myeloma mob heev dua lossis tuag taus.

Ntawm 42 lub hlis ntawm txoj kev tshawb no, ntau yam mob myeloma tsis mob loj dua rau cov neeg uas tau noj Darzalex nrog rau kev kho mob. Txog cov tib neeg uas nyuam qhuav txais kev kho mob, nws tau siv li 31.9 lub hlis ua ntej lawv ntau yam mob myeloma pib mob hnyav dua. Tus nqi teb tag yog 47.6% rau cov neeg kho nrog Darzalex thiab 24.9% rau cov neeg uas tau txais kev kho mob ib txwm. (Teb tiav txhais tau tias txhua yam mob cancer ploj tag thiab tsis muaj tus tsos mob ntawm kev kuaj sim, xoo duab, lossis kev kuaj mob.)

ALCYONE kawm

Qhov kev tshawb nrhiav ALCYONE tau saib cov neeg nyuam qhuav raug kuaj mob nrog ntau tus mob myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho pob qog ntshav ntawm tes. Cov neeg no tau txais kev kho mob cancer bortezomib (Velcade), melphalan, thiab prednisone lossis kev kho mob ntxiv rau Darzalex. Piv rau pab pawg kho mob niaj hnub, cov pab pawg Darzalex muaj qhov pheej hmoo 50% tsawg dua ntawm lawv cov myeloma mob heev dua lossis tuag taus.

Ntawm cov neeg uas tau txais kev kho mob Darzalex, 42.6% tau teb tiav. Qhov no tau muab piv rau 24.4% ntawm cov neeg uas tau txais kev kho mob tsuas yog qauv.

Qhov kev kawm POLLUX

Qhov kev kawm POLLUX tau saib cov neeg muaj ntau yam mob myeloma uas muaj tsawg kawg yog ib qho kev kho mob dhau los. Cov neeg tau coj cov kev kho mob lenalidomide thiab dexamethasone lossis kev kho tib yam ntxiv nrog Darzalex. Cov txiaj ntsig tau pom tias thaj tsam 91.3% ntawm cov tib neeg tau teb rau kev kho mob nrog Darzalex piv rau txog 74.6% ntawm cov neeg uas tau txais kev kho mob nkaus xwb.

Muab piv rau cov pab pawg kho mob niaj hnub, cov pab pawg kho nrog Darzalex muaj kev pheej hmoo tsawg dua 63% ntawm lawv cov myeloma ntau dua tuaj. Tom qab 13,5 lub hlis, 19% ntawm Darzalex pab pawg pom lawv ntau yam mob myeloma tsis zoo los yog lawv dhau mus. Qhov no tau muab piv rau 41% ntawm cov pawg kev kho mob.

CASTOR kawm

Txoj kev tshawb CASTOR kuj tau saib cov neeg muaj ntau yam mob myeloma uas tau muaj kev kho mob tsawg kawg ib zaug. Cov neeg tau coj los kho tus mob bortezomib thiab dexamethasone lossis kev kho tib yam ntxiv nrog Darzalex. Cov txiaj ntsig tau zoo ib yam li POLLUX txoj kev tshawb no. Txog 73.9% ntawm cov neeg muaj teb rau kev kho nrog Darzalex piv rau kwv yees li 59.9% ntawm cov neeg uas tau txais kev kho mob tsuas yog qauv.

Piv rau cov qauv kev kho mob, kev kho mob Darzalex tau txuas rau 61% qis dua ntawm tus mob myeloma pheej mob heev lossis tuag taus. Cov neeg coj Darzalex kuj tseem tuaj yeem nyob hauv kev zam dua ntev. (Kev tshem tawm txhais tau tias tus kabmob kis mus rau qog qeeb qeeb.)

Txoj kev tshawb no EQUULEUS

Qhov kev tshawb nrhiav EQUULEUS ntsia ntawm 103 tus neeg uas muaj ntau tus mob myeloma uas yav tas los tau kho txog plaub zaug rau lawv ntau yam mob myeloma. Cov neeg no twb tau txais ob hom kev kho mob: ib qho tshuaj tiv thaiv proteasome thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Txhua tus hauv qhov kev tshawb fawb tau coj tus qauv kev kho mob ntawm pomalidomide (Pomalyst) thiab dexamethasone ntxiv rau Darzalex. Lub hom phiaj tseem ceeb ntawm txoj kev tshawb no yog kom pom tias muaj pes tsawg leej neeg kho rau kev kho mob.

Tshaj tag nrho, qhov kev kho mob pib ua haujlwm nyob rau thaj tsam li 1 hlis hauv neeg feem coob. Cov kev kho mob ua haujlwm rau thaj tsam li ntawm 13.6 lub hlis. Ntau qhov mob myeloma los ntawm 90% lossis ntau dua hauv 42% ntawm cov neeg. Qee tus neeg txawm tias tsis muaj mob qog nqaij hlav ntxiv thaum kawg ntawm kev tshawb fawb.

Txoj kev tshawb kawm SIRIUS

Txoj kev tshawb nrhiav SIRIUS saib txog 106 cov neeg uas muaj ntau hom mob myeloma uas mob hnyav thiab tau txais qhov nruab nrab ntawm tsib cov kev kho mob dhau los. Txhua tus neeg hauv txoj kev tshawb fawb tau muab tsuas yog Darzalex. Lub hom phiaj tseem ceeb ntawm txoj kev tshawb no yog kom pom tias muaj pes tsawg leej neeg kho rau kev kho mob.

Tag nrho, 31 tus neeg uas tau txais Darzalex muaj lawv cov kev mob ntau dua myeloma tsawg dua. Kwv yees li 64.8% ntawm cov neeg uas siv Darzalex hauv txoj kev tshawb fawb no muaj sia nyob tsawg kawg 12 lub hlis.

Txo txoj hauv kev muaj qhov tsis haum tshwm sim, cov neeg nyob hauv txhua qhov kev tshawb fawb no tau muab tshuaj sib xyaw ua ke. Ib mus rau peb teev ua ntej txhua txhua Txoj Kev Lom Zem Darzalex, lawv tau txais:

  • corticosteroid (kom txo qis o)
  • antipyretic (los tiv thaiv los yog txo kub taub hau)
  • ib qho tshuaj antihistamine (los tiv thaiv lossis txo cov tsos mob ntawm kev tsis haum tshuaj)

Tej zaum lawv tseem yuav tau txais corticosteroid 1 hnub tom qab infusion kom tsis txhob ncua sijhawm. Tab sis yog tias cov neeg twb tau noj cov tshuaj steroid xws li dexamethasone lossis prednisone, lawv feem ntau tsis xav tau qhov kev txhawb ntxiv steroid.

Darzalex rau lwm yam mob

Ntxiv rau ntau yam mob myeloma, Darzalex tseem tab tom kawm ua kev kho mob rau immunoglobulin teeb ci amyloidosis.

Darzalex rau immunoglobulin teeb cov saw amyloidosis (hauv qab)

Immunoglobulin lub teeb saw amyloidosis (AL) yog ib yam mob uas muaj qee cov protein hu ua cov saw teeb tsim nyob hauv koj cov leeg hauv koj lub cev. Feem ntau, koj lub plawv, raum, spleen, thiab nplooj siab raug cuam tshuam. Cov protein ntau ua rau tuaj yeem ua kom puas thiab ua rau cov kabmob no ua tsis tiav.

Darzalex tsis yog FDA pom zoo kho AL. Txawm li cas los xij, muaj qee txoj kev tshawb fawb tsawg uas siv Darzalex off-label los kho tus mob no. (Kev siv daim ntawv lo yog daim ntawv tso tawm yog thaum siv yeeb tshuaj uas raug pom zoo los kho ib qho mob los siv rau kev kho mob sib txawv.)

Hauv ib txoj kev tshawb nrhiav, Darzalex tau muab rau cov neeg mob AL uas muaj, qhov nruab nrab, tau txais peb yam kev kho mob uas tsis ua haujlwm. Darzalex tsim tawm yuav luag tiav lossis teb tau tiav hauv 76% ntawm cov neeg uas tau noj cov tshuaj. (Teb tiav txhais tau tias txhua tus kabmob ploj mus thiab tsis muaj tus kabmob ntawm kev kuaj ntshav, xoo hluav taws xob, kev kuaj mob hauv tsev kuaj mob.) Cov neeg no muaj cov kev mob tshwm sim zoo ib yam li cov kev cia siab hauv cov neeg uas coj Darzalex los kho ntau tus mob myeloma. Hauv lwm cov ntawv ceeb toom, Darzalex tau txais txiaj ntsig zoo los kho AL thiab txhim kho lub neej zoo ntawm cov neeg uas tau siv tshuaj.

Muaj ntau cov kev kawm ntxiv los ua pov thawj tias Darzalex ua haujlwm zoo thiab muaj kev nyab xeeb thaum siv nrog cov neeg mob AL. Txog thaum ntawd, cov kws tshawb nrhiav yuav siv Darzalex rau cov neeg uas muaj AL uas tsis muaj kev xaiv ua ntej, FDA-pom zoo kev kho mob sab laug.

Darzalex siv nrog lwm yam tshuaj rau ntau yam mob myeloma

Darzalex yog tshuaj los ntawm nws tus kheej lossis nrog lwm yam kev kho mob cancer rau cov neeg laus uas muaj ntau tus mob myeloma. Qhov kev npaj khomob thiab sijhawm ntev npaum li cas yog tias koj nyuam qhuav raug kuaj pom lossis muaj kev khomob yav dhau los.

Darzalex raug pom zoo kom siv nrog rau:

  • lenalidomide (Revlimid) thiab dexamethasone rau cov neeg laus uas tau kuaj pom muaj ntau yam mob myeloma uas tsis tuaj yeem tsis tuaj yeem hloov qog cell qog hloov. (Nrog kev hloov khoom siv qia ua cell, koj tus kheej qia hlwb raug siv.)
  • lenalidomide thiab dexamethasone hauv cov neeg laus uas tau txais ib lossis ntau qhov kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis uas muaj ntau tus mob myeloma rov qab los.
  • bortezomib (Velcade), melphalan, thiab prednisone rau cov neeg laus uas nyuam qhuav raug tus mob ntau yam mob myeloma uas tsis tuaj yeem txais cov mob qog nqaij hlav hloov.
  • bortezomib thiab dexamethasone hauv cov neeg laus uas tau txais ib lossis ntau dua qhov kev kho tus mob myeloma yav dhau los.
  • pomalidomide (Pomalyst) thiab dexamethasone hauv cov neeg laus uas tau txais ob lossis ntau tshaj yav dhau los ntau cov kev kho mob myeloma. Cov kev kho mob no yuav tsum muaj lenalidomide thiab ib qho tshuaj tiv thaiv proteasome.

Rau cov kev tshawb fawb soj ntsuam saib yuav ua li cas Darzalex tau siv los kho ntau yam mob myeloma, ib leeg thiab ua ke nrog lwm cov tshuaj tua kabmob kheesxaws. Cov kev tshawb fawb no hu ua MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, thiab SIRIUS. Cov kev tshawb fawb pom tau hais tias kev kho mob ntawm ntau yam mob myeloma zoo dua yog tias Darzalex tau ntxiv rau kev kho mob qog nqaij hlav txawv dua li cov kev kho mob no tau muab rau ib leeg. Yog xav paub ntxiv txog cov kev tshawb fawb no, thov saib hauv seem "Darzalex rau ntau tus mob myeloma" saum toj no.

Xaiv rau Darzalex

Lwm cov tshuaj muaj nyob uas tuaj yeem kho ntau yam mob myeloma. Qee tus kuj yuav zoo dua rau koj dua li lwm tus. Yog tias koj xav paub txog lwm txoj kev xaiv los ntawm Darzalex, tham nrog koj tus kws kho mob kom paub ntxiv txog lwm cov tshuaj uas yuav ua haujlwm zoo rau koj.

Hauv qab no yog cov npe tshuaj uas tau pom zoo los ntawm National Comprehensive Cancer Network cov txheej txheem rau kev kho ntau yam mob myeloma:

  • Kws khomob siv tshuaj, xws li:
    • bendamustine (Bendeka lossis Treanda)
    • cisplatin
    • cyclophosphamide (Cytoxan)
    • doxorubicin (Doxil)
    • etoposide (Etopophos)
    • melphalan (Alkeran)
  • Proteasome inhibitors, xws li:
    • bortezomib (Velcade)
    • carfilzomib (Kyprolis)
    • ixazomib (Ninlaro)
  • Cov kab mob monoclonal, xws li:
    • elotuzumab (Empliciti)
  • Keeb kwm deacetylase inhibitors, xws li:
    • panobinostat (Farydak)
  • Immunomodulators, xws li:
    • lenalidomide (Revlimid)
    • pomalidomide (Pomalyst)
    • thalidomide (Thalomid)
  • Corticosteroids, xws li:
    • dexamethasone (Decadron)

Nco tseg: Qee cov tshuaj teev rau ntawm no tuaj yeem siv daim ntawv lo npe coj los kho ntau tus mob myeloma.

Darzalex vs. Empliciti

Tej zaum koj yuav xav li cas Darzalex piv rau lwm cov tshuaj uas tau sau tseg rau kev siv zoo sib xws. Ntawm no peb saib yuav ua li cas Darzalex thiab Empliciti zoo ib yam thiab txawv.

Txog

Darzalex muaj daratumumab, thaum Empliciti muaj elotuzumab. Ob lub Darzalex thiab Empliciti yog koom nrog ib chav kawm ntawm cov tshuaj hu ua monoclonal antibodies. (Ib chav kawm ntawm cov tshuaj yog ib pawg tshuaj uas ua haujlwm zoo ib yam.) Ob leeg Darzalex thiab Empliciti suav tias yog cov hom phiaj kho rau ntau tus mob myeloma.

Kev Siv

Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo ob leeg Darzalex thiab Empliciti los kho ntau tus mob myeloma.

Darzalex raug pom zoo los siv:

  • Rau cov neeg laus uas nyuam qhuav raug kuaj mob ntau myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho lub cev ntawm tes mob hlwb. (Nrog kev hloov kho lub qia hauv hlwb, koj tus kheej qia hlwb raug siv.) Hauv qhov xwm txheej no:
    • Darzalex tuaj yeem siv nrog cov tshuaj lenalidomide (Revlimid) thiab dexamethasone.
    • Darzalex kuj tseem siv tau nrog cov tshuaj bortezomib (Velcade), melphalan, thiab prednisone.
  • Rau cov neeg laus uas tau txais ib lossis ntau txoj kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis muaj ntau tus mob myeloma rov qab los. Hauv cov xwm txheej no, Darzalex siv nrog lenalidomide thiab dexamethasone.
  • Rau cov neeg laus uas tau txais ib lossis ntau dua yav dhau los ntau txoj kev kho tus mob myeloma. Hauv cov xwm txheej no, Darzalex siv nrog bortezomib thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais ob lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome, uas yog hom tshuaj. Hauv cov xwm txheej no, Darzalex siv nrog cov tshuaj pomalidomide (Pomalyst) thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais peb lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.
  • Hauv cov neeg laus uas tau sim cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob tab sis tsis siv tshuaj ua haujlwm rau ntau yam mob myeloma. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.

Empliciti raug pom zoo los siv:

  • Hauv cov neeg laus uas tau txais ib mus rau peb qhov kev kho mob yav dhau los rau lawv ntau yam mob myeloma. Empliciti yog siv nrog lenalidomide (Revlimid) thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais tsawg kawg ob zaug kev kho mob yav dhau los uas suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome. Empliciti yog siv nrog pomalidomide (Pomalyst) thiab dexamethasone.

Feem ntau, Empliciti raug muab yog tias koj ntau myeloma tau rov qab los tom qab lwm yam kev kho mob.

Cov ntaub ntawv tshuaj thiab kev tswj hwm

Ob leeg Darzalex thiab Empliciti raug muab raws li kev tso dej (IV) Txoj kev lis ntshav. Qhov no yog kev txhaj tshuaj uas tau txuas nrog maj mam dhau lub sij hawm dhau los ntawm rab koob uas tau muab tso rau hauv koj txoj hlab ntsha.

Rau Darzalex

Darzalex los ua cov tshuaj tov (sib tov ua kua) uas koj yuav tau txais yog hais tias yog txhaj rau. Txoj kev daws teeb meem yuav tsis muaj xim rau daj ntseg. Cov tshuaj muaj nyob rau hauv ob qhov ntau thiab tsawg:

  • 100 mg / 5 mL hauv ib lub raj tshuaj ib leeg
  • 400 mg / 20 mL hauv ib lub raj tshuaj ib leeg

Txo txoj hauv kev muaj tshuaj tiv thaiv, koj tus kws kho mob yuav muab tshuaj ua ke rau koj. Ib mus rau peb teev ua ntej txhua lub Darzalex infusion, koj yuav tau txais:

  • corticosteroid kom tsis txhob o
  • tshuaj tua kabmob los tiv thaiv lossis txo qhov kub taub hau
  • cov tshuaj antihistamine los tiv thaiv lossis txo cov tsos mob ntawm kev fab tshuaj

Koj tseem tuaj yeem tau txais corticosteroid 1 hnub tom qab infusion kom tsis txhob ncua sijhawm. Tab sis yog tias koj twb tau noj cov tshuaj steroid xws li dexamethasone lossis prednisone, koj feem ntau yuav tsis xav tau qhov ntxiv steroid.

Rau Empliciti

Empliciti los ua lub hmoov dawb tawm-dawb. Tus kws kho mob yuav muab cov tshuaj no coj los tov nrog rau qhov muab txhaj tshuaj rau koj. Empliciti muaj nyob rau hauv ob qho kev ua tau zoo:

  • 300 mg rau hauv ib lub raj tshuaj ib zaug
  • 400 mg nyob hauv ib leeg-koob vial

Txo txoj hauv kev muaj tshuaj tiv thaiv, koj tus kws kho mob yuav muab tshuaj ua ke rau koj. Li ntawm 45 txog 90 feeb ua ntej ib qho Empliciti infusion, koj yuav tau txais:

  • Acetaminophen txhawm rau tiv thaiv los yog txo qhov kub taub hau
  • diphenhydramine (Benadryl) txhawm rau tiv thaiv lossis txo cov tsos mob ntawm kev fab tshuaj
  • ranitidine los tiv thaiv lossis txo cov tsos mob ntawm kev fab tshuaj
  • dexamethasone kom txo qhov o

Phiv thiab txaus ntshai

Darzalex thiab Empliciti ob leeg muaj cov tshuaj uas ua haujlwm zoo ib yam. Yog li, ob hom tshuaj ua rau muaj kev phiv zoo heev. Hauv qab no yog cov piv txwv ntawm cov kev mob tshwm sim no.

Ntau cov kev mob tshwm sim

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim ntau dua uas tuaj yeem tshwm sim nrog Darzalex, nrog Empliciti, lossis nrog ob qho tshuaj (thaum noj ib leeg).

  • Yuav tshwm sim nrog Darzalex:
    • tsis muaj zog
    • lub cev mob los yog mob txha
    • xeev siab
    • teeb meem pw tsaug zog
    • mob ntsws, ib hom mob ntsws
    • kiv taub hau
  • Yuav tshwm sim nrog Empliciti:
    • ntshav siab
    • mob mob hauv koj txhais tes lossis txhais ceg * *
  • Muaj peev xwm tshwm sim nrog ob leeg Darzalex thiab Empliciti:
    • zoo nkaus li nkees lossis tsis muaj lub zog
    • mob plab xws li mob raws plab lossis quav tawv
    • tsis qab los
    • ua npaws
    • ua daus no
    • txog siav siav lossis hnoos
    • cov kab mob sab sauv yog khaub thuas
    • mob leeg pob txha (qwj)
    • ntuav
    • peripheral edema, uas yog o ntawm tes thiab taw

** Thaum Empliciti yog siv nrog lenalidomide ntxiv rau dexamethasone

Cov kev mob tshwm sim hnyav heev

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim loj uas tuaj yeem tshwm sim nrog Darzalex, nrog Empliciti, lossis nrog ob qho tshuaj (thaum noj ib leeg).

  • Yuav tshwm sim nrog Darzalex:
    • thrombocytopenia, ntshav muaj ntshav tsawg, yog ib hom qe ntshav pab kom ntshav txhaws
    • neutropenia, qib qis ntawm neutrophils, uas yog ib hom qe ntshav dawb uas pab tua kab mob sib kis
    • mob yoov (mob pob hauv zos)
  • Yuav tshwm sim nrog Empliciti:
    • cov qog nqaij hlav tshiab
    • teeb meem mob siab
  • Muaj peev xwm tshwm sim nrog ob leeg Darzalex thiab Empliciti:
    • Txoj kev lis ntshav tshwm sim
    • mob ntsws, ib hom mob ntsws
    • peripheral sensory neuropathy, ib yam kev puas ntsoog uas ua rau khaus, tawv, lossis mob

Txij nkawm

Darzalex thiab Empliciti muaj cov kev tso cai siv FDA sib txawv, tab sis nkawd ob leeg siv los kho ntau tus mob myeloma rau cov neeg laus.

Cov tshuaj no tsis tau muab piv rau qhov kev tshawb fawb tiag tiag (hu ua kev tshawb fawb-hauv taub hau). Txawm li cas los xij, kev tshuaj xyuas 13 qhov kev tshawb fawb soj ntsuam ntawm Darzalex thiab Empliciti tau pom tias ob qho tshuaj ua tau zoo hauv kev ncua kev mob (zuj zus ntxiv) ntawm ntau yam mob myeloma.

Rau cov tib neeg uas muaj ntau tus mob myeloma tau rov qab los yog pheej loj ntxiv txawm tias tom qab ntau yam kev kho mob, National Comprehensive Cancer Network cov lus qhia pom zoo Darzalex ua ntej. Yog tias Darzalex tsis ua haujlwm, kev kho mob nrog Empliciti yog lwm txoj kev xaiv.

Cov nqi

Darzalex thiab Empliciti yog ob hom tshuaj muaj npe. Tam sim no tsis muaj cov ntaub ntawv tsis tseem ceeb ntawm ib yam yeeb tshuaj. Cov tshuaj muaj npe lag luam feem ntau raug nqi ntau dua li cov generics.

Raws li kev kwv yees nyob rau WellRx.com, Darzalex feem ntau raug nqi tsawg dua Empliciti. Tus nqi tiag uas koj yuav them rau cov tshuaj yog nyob ntawm koj qhov kev fajseeb npaj nyiaj txiag thiab koj qhov chaw nyob.

Darzalex vs. Kyprolis

Zoo li Empliciti (saum toj no), cov tshuaj Kyprolis tau siv zoo ib yam li Darzalex. Tam sim no saib seb Darzalex thiab Kyprolis zoo ib yam thiab txawv.

Txog

Darzalex muaj daratumumab, thaum Kyprolis muaj carfilzomib. Ob qho tshuaj yog txiav txim siab tsom cov kev kho rau ntau tus mob myeloma. Txawm li cas los xij, cov tshuaj yuav nyob hauv cov chav kawm sib txawv ntawm cov tshuaj. (Ib chav kawm ntawm cov tshuaj yog ib pawg tshuaj uas ua haujlwm zoo ib yam.) Darzalex yog ib hom tshuaj hu ua monoclonal antibody. Kyprolis yog ib hom tshuaj uas hu ua proteasome inhibitor.

Kev Siv

Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo Darzalex siv los siv:

  • Rau cov neeg laus uas nyuam qhuav raug kuaj mob ntau myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho lub cev ntawm tes mob hlwb. (Nrog kev hloov kho lub qia hauv hlwb, koj tus kheej qia hlwb raug siv.) Hauv qhov xwm txheej no:
    • Darzalex tuaj yeem siv nrog cov tshuaj lenalidomide (Revlimid) thiab dexamethasone.
    • Darzalex kuj tseem siv tau nrog cov tshuaj bortezomib (Velcade), melphalan, thiab prednisone.
  • Rau cov neeg laus uas tau txais ib lossis ntau txoj kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis muaj ntau tus mob myeloma rov qab los. Hauv cov xwm txheej no, Darzalex siv nrog lenalidomide thiab dexamethasone.
  • Rau cov neeg laus uas tau txais ib lossis ntau dua yav dhau los ntau txoj kev kho tus mob myeloma. Hauv cov xwm txheej no, Darzalex siv nrog bortezomib thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais ob lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome, uas yog hom tshuaj. Hauv cov xwm txheej no, Darzalex siv nrog cov tshuaj pomalidomide (Pomalyst) thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais peb lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.
  • Hauv cov neeg laus uas tau sim cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob tab sis tsis siv tshuaj ua haujlwm rau ntau yam mob myeloma. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.

Kyprolis yog FDA pom zoo siv:

  • Hauv cov neeg laus uas tau txais ib mus rau peb qhov kev kho mob yav dhau los rau lawv ntau yam mob myeloma. Kyprolis yog siv nrog dexamethasone los yog nrog lenalidomide thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais ib lossis ntau qhov kev kho mob dhau los rau lawv ntau yam mob myeloma. Kyprolis yog siv los ntawm nws tus kheej.

Cov ntaub ntawv tshuaj thiab kev tswj hwm

Ob leeg Darzalex thiab Kyprolis raug muab raws li kev tso ntshav (IV) Txoj kev lis ntshav. Qhov no yog kev txhaj tshuaj uas tau txuas nrog maj mam dhau sijhawm los ntawm rab koob uas tau muab tso rau hauv koj txoj hlab ntsha.

Rau Darzalex

Darzalex los ua cov tshuaj tov (sib tov ua kua) uas koj yuav tau txais yog hais tias yog txhaj rau. Txoj kev daws teeb meem yuav tsis muaj xim rau daj ntseg. Cov tshuaj muaj nyob rau hauv ob qhov ntau thiab tsawg:

  • 100 mg / 5 mL hauv ib lub raj tshuaj ib leeg
  • 400 mg / 20 mL hauv ib lub raj tshuaj ib leeg

Txo qhov muaj feem ntawm qhov kev tawm tsam txoj kev nqus, koj tus kws kho mob yuav muab tshuaj ua ke rau koj. tshuaj. Ib mus rau peb teev ua ntej txhua lub Darzalex infusion, koj yuav tau txais:

  • corticosteroid kom tsis txhob o
  • tshuaj tua kabmob los tiv thaiv lossis txo qhov kub taub hau
  • cov tshuaj antihistamine los tiv thaiv lossis txo cov tsos mob ntawm kev fab tshuaj

Koj tseem tuaj yeem tau txais corticosteroid 1 hnub tom qab infusion kom tsis txhob ncua sijhawm. Tab sis yog tias koj twb tau noj cov tshuaj steroid xws li dexamethasone lossis prednisone, koj feem ntau yuav tsis xav tau qhov ntxiv steroid.

Txog Kyprolis

Kyprolis los hauv lub ncuav mog qab zib lossis hmoov tsim ib koob tshuaj ib leeg. Nws tawm hauv peb lub zog: 10 mg, 30 mg, thiab 60 mg.

Txo txoj hauv kev muaj qhov hnoos qeev, koj tus kws kho mob yuav muab ib qho tshuaj steroid rau koj. Koj yuav tau txais cov tshuaj steroid 30 feeb txog 4 teev ua ntej koj Kyprolis infusion. Tab sis yog tias koj twb tau noj steroid xws li dexamethasone, koj tus kws kho mob tsis tas yuav muab koj cov tshuaj ntxiv.

Phiv thiab txaus ntshai

Darzalex thiab Kyprolis tuaj yeem ua rau phiv zoo heev. Hauv qab no yog cov piv txwv ntawm cov kev mob tshwm sim no.

Ntau cov kev mob tshwm sim

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim ntau dua uas tuaj yeem tshwm sim nrog Darzalex, nrog Kyprolis, lossis nrog ob hom tshuaj (thaum noj ib leeg).

  • Yuav tshwm sim nrog Darzalex:
    • tsis muaj zog lossis tsis muaj zog
    • mob ntsws, ib hom mob ntsws
    • lub cev mob los yog mob txha
  • Yuav tshwm sim nrog Kyprolis:
    • cov ntshav liab tsawg hauv lub cev suav
    • cov qe ntshav dawb tsawg
    • teeb meem ua pa
    • tsawg dua cov poov tshuaj theem
  • Muaj peev xwm tshwm sim nrog ob leeg Darzalex thiab Kyprolis:
    • mob leeg pob txha (qwj)
    • teeb meem pw tsaug zog
    • zoo nkaus li nkees
    • mob plab xws li mob raws plab lossis quav tawv
    • ua npaws
    • ua daus no
    • txog siav
    • hnoos
    • kev ua pa sab saud, xws li mob khaub thuas
    • xeev ntuav lossis ntuav
    • tsis qab los
    • peripheral edema, uas yog o ntawm tes thiab taw
    • kiv taub hau

Cov kev mob tshwm sim hnyav heev

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim loj uas tuaj yeem tshwm sim nrog Darzalex, nrog Kyprolis, lossis nrog ob yam tshuaj (thaum noj ib leeg).

  • Yuav tshwm sim nrog Darzalex:
    • neutropenia, qib qis ntawm neutrophils, uas yog ib hom qe ntshav dawb uas pab tua kab mob sib kis
    • mob yoov (mob pob hauv zos)
    • peripheral sensory neuropathy, ib yam kev puas ntsoog uas ua rau khaus, tawv, lossis mob
  • Yuav tshwm sim nrog Kyprolis:
    • mob ntsws xws li los ntshav, ntshav txhaws, o, lossis mob rau hauv lub ntsws
    • kev mob plawv lossis lub plawv tsis ua haujlwm
    • daim siab ua teeb meem, xws li nce ntxiv hauv qib ntawm daim siab ua haujlwm lossis lub siab ua haujlwm
    • raum tsis ua hauj lwm
    • mob qog mob syys, ib qho mob uas cov qog nqaij hlav cancer tuag sai thiab cov ntsiab lus nchuav mus rau hauv koj cov ntshav
    • posterior hlws rov qab encephalopathy syndrome, ib tug kab mob ntawm cov leeg nyob hauv lub hlwb
    • ntshav siab
    • pulmonary hypertension, uas yog cov ntshav siab hauv cov ntsws
    • ntshav txhaws
    • cov teeb meem ntshav los tsis xwm yeem xws li los ntshav hauv plab, ntsws, lossis lub hlwb
  • Muaj peev xwm tshwm sim nrog ob leeg Darzalex thiab Kyprolis:
    • Txoj kev lis ntshav tshwm sim
    • thrombocytopenia, ntshav muaj ntshav tsawg, yog ib hom qe ntshav pab kom ntshav txhaws
    • mob ntsws, ib hom mob ntsws

Txij nkawm

Darzalex thiab Kyprolis muaj kev siv FDA sib txawv, tab sis nkawd ob leeg siv los kho ntau yam mob myeloma.

Kev siv Darzalex thiab Kyprolis rau ntau yam mob myeloma tsis tau muab piv rau hauv cov kev tshawb fawb soj ntsuam. Txawm li cas los xij, kev tshawb fawb tau pom ob qho Darzalex thiab Kyprolis kom muaj txiaj ntsig zoo rau kev kho ntau yam mob myeloma.

Cov kws tshawb nrhiav tau tam sim no kawm txog kev siv ob lub tshuaj ua ke nrog dexamethasone los kho hom mob qog nqaij hlav no. Cov txiaj ntsig tau pom tias cov tib neeg uas twb tau kho ntau tus mob myeloma tau teb tau zoo rau cov kev kho mob sib xyaw ua ke. Tab sis ntau cov kev ntsuam xyuas ntxiv yog xav tau ua ntej FDA tuaj yeem pom zoo kev kho ua ke ntawm Darzalex thiab Kyprolis rau ntau yam mob myeloma.

Cov nqi

Darzalex thiab Kyprolis yog ob hom tshuaj muaj npe. Tam sim no tsis muaj cov ntaub ntawv tsis tseem ceeb ntawm ib yam yeeb tshuaj. Cov tshuaj muaj npe lag luam feem ntau raug nqi ntau dua li cov generics.

Raws li kev kwv yees nyob rau WellRx.com, Darzalex feem ntau raug nqi tsawg dua Kyprolis. Tus nqi tiag uas koj yuav them rau ib qho tshuaj twg yog nyob ntawm koj qhov kev fajseeb npaj nyiaj txiag thiab koj qhov chaw nyob.

Yuav ua li cas Darzalex ua haujlwm

Ntau hom mob myeloma yog mob qog ntshav uas pib nyob rau hauv ib hom qe ntshav dawb hu ua plasma cell. Plasma cell ua ib feem ntawm koj lub cev tiv thaiv kab mob thiab pab tua kab mob hauv koj lub cev.

Qee zaum cov kev hloov hauv koj cov noob, hu ua kev sib hloov, tuaj yeem hloov cov hlwb noj qab haus huv ua rau cov qog noj ntshav. (Cov noob keeb kwm yog cov txheej qhia uas pab tswj txoj kev koj lub hlwb loj hlob thiab kev coj zoo). Thaum cov ntshav hlwb hloov mus rau ntau lub hlwb myeloma, lawv pib txhim kho cov pob txha pob txha (hauv sab hauv ntawm koj cov pob txha). Raws li ntau cov myeloma hlwb loj hlob thiab kis, lawv tuaj yeem faib tawm cov hlwb zoo thiab ua rau cov pob txha nyob ib puag ncig lawv.

Darzalex yog cov tshuaj tsim los ntawm cov txiv neej hu ua monoclonal antibody. (Cov tshuaj monoclonal yog cov protein nyob hauv koj lub cev tiv thaiv kab mob. Nws tau tsim los tua thiab tua qee qhov ntawm qog nqaij hlav cancer.)

Thaum cov cell ntshav tig mus rau ntau lub hlwb myeloma, lawv txhim kho cov protein ntau hu ua CD38 ntawm lawv qhov chaw. Cov kab mob monoclonal antibody Darzalex ua haujlwm los ntawm kev ua kom muaj protein ntau CD38 rau ntawm ntau lub myeloma ntawm tes. Los ntawm kev ua qhov no, Darzalex ncaj qha tua lossis pab koj muaj zog tiv thaiv kev ua kom puas rau ntau tus hlwb myeloma.

Yuav siv sijhawm ntev npaum li cas ua haujlwm?

Hauv kev tshawb fawb hauv kev kho mob, qhov nruab nrab lub sijhawm nws coj Darzalex los pib ua haujlwm yog 1 hlis. Txawm li cas los xij, koj yuav tau muab koj cov tshuaj rau ncua sijhawm ntev dua. Qhov no nyob ntawm seb koj lub cev teb rau Darzalex li cas thiab yog tias koj ntau myeloma pib mob zuj zus. Lub sijhawm ntawm kev kho mob kuj tseem yog nyob ntawm yog tias koj ntau yam mob myeloma nyuam qhuav raug kuaj tshiab lossis yog tias koj twb tau txais kev kho mob yav dhau los.

Darzalex thiab cawv

Tsis muaj kev paub txog kev sib cuam tshuam ntawm Darzalex thiab dej cawv. Tab sis nws raug nquahu kom koj tsis txhob haus cawv thaum noj Darzalex. Qhov no yuav tsum tau ua nrog ntev npaum li cas nws thiaj li yuav tau txais cov tshuaj.

Darzalex yog muab raws li kev tso ntshav (IV) Txoj kev lis ntshav. Qhov no yog kev txhaj tshuaj rau hauv cov leeg ntshav uas tau muab rau ncua sijhawm. Kev ua txhaum cai ntawm Darzalex tuaj yeem ntev li 3 txog 7 teev. Yog li nws yog ib qho tseem ceeb kom nyob twj ywm hydrated ua ntej thiab thaum lub sijhawm koj lub hnoos qeev. Cov dej cawv muaj peev xwm ua rau koj lub cev qhuav dej, yog li tsis txhob haus cawv thaum noj Darzalex.

Yog tias koj muaj lus nug txog cawv thiab Darzalex, nug koj tus kws kho mob.

Darzalex kev sib cuam tshuam

Ua ntej noj cov tshuaj Darzalex, nco ntsoov qhia koj tus kws kho mob thiab kws muag tshuaj txog txhua yam tshuaj noj, yuav tom kiab khw, thiab lwm yam tshuaj uas koj noj. Kuj tseem qhia rau lawv txog cov vitamins, tshuaj ntsuab, thiab tshuaj siv uas koj siv. Sib qhia cov ntaub ntawv no tuaj yeem pab koj kom tsis txhob muaj kev cuam tshuam.

Yog tias koj muaj lus nug txog kev sib txuam nrog tshuaj uas yuav cuam tshuam koj, nug koj tus kws kho mob lossis kws muag tshuaj.

Darzalex thiab kev sim ntsuas

Noj Darzalex tuaj yeem hloov cov kev tshwm sim los ntawm qee yam kev sim hauv chaw kuaj.

Ntshav hom ntshav yuam kev

Yog tias koj noj cov Darzalex thiab kuaj ntshav kom phim rau koj cov ntshav, cov txiaj ntsig yuav tsis muaj tseeb. Cov teeb meem ntawm cov ntawv no tuaj yeem dhau mus txog 6 lub hlis tom qab koj tau txais kev tso cai kawg ntawm Darzalex.

Darzalex ua haujlwm los ntawm kev ua ke nrog CD38 protein rau saum npoo ntawm ntau myeloma cell thiab ua kom cov protein tsis zoo. Qee zaum cov qe ntshav liab tuaj yeem muaj cov protein CD38 rau lawv. Darzalex tuaj yeem sib kis tau nws tus kheej rau CD38 protein rau ntawm cov ntshav liab hloov chaw ntawm ntau lub myeloma cell. Thaum qhov no tshwm sim, nws hloov txoj kev ntawm lub qe ntshav liab "saib" rau kev kuaj ntshav. Txawm li cas los xij, Darzalex yuav tsis cuam tshuam koj cov ntshav hom.

Txhawm rau zam kom tsis txhob raug cov ntshav yuam kev, koj tus kws kho mob yuav kuaj koj cov ntshav ua ntej koj thawj koob tshuaj Darzalex. Lawv yuav ua qhov no yog tias koj xav tau ntshav ntxiv rau yav tom ntej.

Yuav ua li cas Darzalex raug muab

Txhawm rau kom tau txais koj cov koob tshuaj ntawm Darzalex, koj yuav tsum mus rau koj tus kws kho mob lub chaw haujlwm lossis chaw saib xyuas mob ntshav. Cov tshuaj tawm los ua kua (dej sib tov). Tus kws saib xyuas kev noj qab haus huv yuav sib xyaw Darzalex nrog 0.9% sodium chloride (hom tshuaj ntsev dej). Tom qab ntawd lawv yuav muab cov tshuaj no rau koj raws sijhawm dhau los ntawm rab koob uas tau muab tso rau hauv txoj hlab ntshav. Qhov no yog hu ua tshuaj tso ntshav (IV) Txoj kev lis ntshav. Tej zaum koj yuav tau txais Darzalex los ntawm nws tus kheej lossis nrog lwm yam kev kho mob.

Koj tus kws kho mob yuav txiav txim siab Darzalex ntau npaum li cas rau koj raws li koj qhov hnyav thiab koj hom phiaj xwm kho mob tshwj xeeb. Tus kws kho mob yuav ib txwm saib xyuas koj lub sijhawm thaum lub sijhawm ntawd.

Thaum twg mam coj

Koj tus kws kho mob yuav txiav txim siab raws lub sijhawm ntawm kev siv tshuaj thiab ntau npaum li cas koj xav tau. Qhov no yuav ua raws seb koj puas noj Darzalex ib leeg lossis nrog lwm cov kev kho mob. Nug koj tus kws kho mob kom pom zoo hnub thiab sijhawm zoo tshaj plaws kom tau txais koj txoj kev lom zem raws li koj niaj hnub ua.

Yuav ua li cas feem ntau koj tau Darzalex thiab qhov ntev ntawm lub sij hawm ntawm Txoj kev lis ntshav yuav txo lub sij hawm. Koj thawj zaug tshuaj ntawm Darzalex yuav siv sijhawm li 7 teev. Nov yog vim tias koj tus kws kho mob yuav siv tshuaj kom qeeb rau hauv koj cov leeg. Txoj kev kho mob yav tom ntej yuav siv sijhawm tsawg dua thiab siv sijhawm ntev li 3 txog 5 teev vim tias koj yuav tau txais cov tshuaj sai dua.

Noj cov Darzalex nrog zaub mov

Darzalex Txoj kev lis ntshav lub sijhawm tuaj yeem muaj li 3 txog 7 teev, nyob ntawm koj txoj kev npaj khomob. Yog li ntawv nws yog ib lub tswv yim zoo uas koj npaj nrog khoom noj txom ncauj thiab haus dej yog tias nws tsis ua li cas nrog koj tus kws kho mob.

Darzalex thiab cev xeeb tub

Darzalex tsis tau kawm txog poj niam cev xeeb tub lossis tsiaj. Tab sis Darzalex yog cov tshuaj monoclonal antibody, uas yog hom tshuaj uas muaj lub hom phiaj mob hlwb. Thiab cov kab mob monoclonal tau paub kom hla lub cev. (Lub tsev me nyuam yog ib yam khoom hauv nruab nrog cev ntawm koj lub cev xa cov khoom tuaj ntawm koj lub cev mus rau koj tus menyuam.)

Raws li txoj haujlwm Darzalex ua haujlwm, cov tshuaj yuav ua rau pob txha tsis muaj zog hauv menyuam mos hauv plab. Nws kuj tseem yuav txo tau cov ntshav thiab cov qe ntshav tsis muaj zog uas cov menyuam loj hlob.

Ua ntej koj pib noj cov tshuaj Darzalex, nco ntsoov qhia koj tus kws kho mob yog tias koj cev xeeb tub, cev xeeb tub, lossis npaj yuav cev xeeb tub.

Darzalex nrog lenalidomide lossis pomalidomide

Qee zaum Darzalex qee zaum noj nrog cov tshuaj hu ua lenalidomide (Revlimid) lossis pomalidomide (Pomalyst) rau ntau yam mob myeloma. Lenalidomide thiab pomalidomide ob qho tib si muaj lub thawv ceeb toom * rau kev mob hnyav thiab ua rau muaj mob rau lub neej. Yog tias koj yog poj niam thiab koj tus kws kho mob sau ntawv rau Darzalex nrog lenalidomide lossis pomalidomide, koj yuav tsum tsis txhob xeeb tub:

  • rau tsawg kawg 4 lub lis piam ua ntej pib kev kho mob
  • hos kev kho mob
  • lub sijhawm kho mob ib pliag
  • tsawg kawg 4 lub lis piam tom qab nres lenalidomide lossis pomalidomide

Yog tias koj muaj lus nug txog kev noj Darzalex, lenalidomide, lossis pom invalidomide thaum cev xeeb tub, tham nrog koj tus kws kho mob.

Darzalex thiab tshuaj yug me nyuam

Yog tias muaj lub caij nyoog koj tuaj yeem cev xeeb tub, nws raug nquahu kom koj siv tshuaj tswj tsis pub muaj menyuam thaum noj Darzalex. Koj yuav tsum siv cov kev tswj tsis pub muaj menyuam tom qab 3 hlis tom qab koj cov tshuaj Darzalex tiav lawm. Qhov no vim tias cov tshuaj tuaj yeem nyob hauv koj lub cev rau lub sijhawm luv luv tom qab koj tsum tsis noj nws.

Yog tias koj yog tus txiv neej thiab nyiam sib deev nrog poj niam, yuav muaj lub caij nyoog kom cev xeeb tub. Xav txog kev siv txoj hauv kev tiv thaiv kom tsis txhob muaj menyuam, xws li siv hnab looj, txawm hais tias koj tus khub kev sib deev tseem siv los tswj kom tsis txhob muaj menyuam.

Darzalex nrog lenalidomide lossis pomalidomide

Muaj qee kis, koj tuaj yeem noj nrog Darzalex nrog cov tshuaj hu ua lenalidomide (Revlimid) lossis pomalidomide (Pomalyst). Yog tias koj yog poj niam thiab tau noj tshuaj Darzalex nrog lenalidomide lossis pomalidomide, koj yuav tsum pom zoo siv ob hom kev tswj tsis pub muaj menyuam. Koj yuav tsum tau pib siv kev tswj tsis pub muaj tsawg kawg 4 lub lis piam ua ntej koj pib kho nrog cov tshuaj. Siv kev tswj kom tsis txhob muaj menyuam thaum noj cov tshuaj Darzalex thiab lenalidomide lossis pomalidomide, thiab thaum lub sijhawm ncua kev kho mob. Koj yuav tsum tau siv kev tswj tsis pub muaj tsawg kawg 4 lub lis piam tom qab koj tsum tsis noj lenalidomide lossis pomalidomide.

Lenalidomide thiab pomalidomide tuaj yeem nkag mus rau tib neeg cov phev. Yog li txhua tus txiv neej yuav tsum siv hnab looj lossis hnab looj tes thaum muaj kev sib deev nrog tus poj niam tuaj yeem cev xeeb tub. Cov txiv neej yuav tsum siv tus qauv no tiv thaiv tsis pub muaj menyuam nyob rau tib lub sijhawm uas lawv tus khub yog noj tshuaj tiv thaiv tsis pub muaj menyuam.

Yog tias koj tau sib deev thiab koj lossis koj tus khub muaj peev xwm cev xeeb tub, tham nrog koj tus kws kho mob. Lawv tuaj yeem pab koj txiav txim siab txog qhov xav tau tshuaj yug me nyuam thaum koj siv Darzalex.

Darzalex thiab pub niam mis

Nws tsis paub yog tias Darzalex tuaj yeem nkag mus rau niam mis lossis cov tshuaj yuav cuam tshuam licas rau cov kua mis. Nws tseem tsis tau paub yog tias Darzalex tuaj yeem cuam tshuam cov menyuam noj niam mis.

Darzalex nrog lenalidomide lossis pomalidomide

Muaj qee kis, koj tuaj yeem noj nrog Darzalex nrog cov tshuaj hu ua lenalidomide (Revlimid) lossis pomalidomide (Pomalyst). Yog tias koj yog tus poj niam uas pub mis niam, koj yuav tsum tsis txhob siv lenalidomide lossis pomalidomide. Tsis paub meej yog tias cov tshuaj no tuaj yeem nkag rau hauv niam cov kua mis thiab ua rau koj tus menyuam mob.

Yog tias koj xav pub mis niam rau koj tus menyuam thiab tab tom xav txog kev noj Darzalex, nrog koj tus kws kho mob tham. Lawv tuaj yeem qhia koj txog qhov zoo thiab kev pom zoo ntawm kev siv cov tshuaj no thaum pub niam mis.

Cov lus nug nquag nug txog Darzalex

Nov yog cov lus teb rau qee cov lus nug nquag nug txog Darzalex.

Vim li cas kuv thiaj li yuav tsum tau noj cov tshuaj steroids thiab lwm yam tshuaj noj thaum kuv cov sijhawm teem rau Darzalex infusions?

Thaum koj tau txais Darzalex, koj tuaj yeem ua xua. Txhawm rau tiv thaiv qhov no, koj tus kws kho mob yuav muab cov tshuaj hu ua corticosteroids thiab lwm yam tshuaj.

Tus kws saib xyuas kev noj qab haus huv yuav muab Darzalex rau koj raws txoj leeg ntshav (IV) hauv koj tus kws kho mob lub chaw haujlwm lossis chaw kuaj mob. Qhov no yog kev txhaj tshuaj rau hauv cov leeg ntshav uas tau muab rau ncua sijhawm. Ib mus rau peb teev ua ntej txhua lub Darzalex infusion, koj feem ntau yuav tau txais cov tshuaj hauv qab no:

  • corticosteroid (kom txo qis o)
  • antipyretic (los tiv thaiv lossis txo kub taub hau)
  • ib qho tshuaj antihistamine (los tiv thaiv lossis txo cov tsos mob ntawm kev tsis haum tshuaj)

Koj tseem tuaj yeem tau txais corticosteroid 1 hnub tom qab infusion kom tsis txhob ncua sijhawm. Tab sis yog tias koj twb tau noj cov tshuaj steroid xws li dexamethasone lossis prednisone, koj feem ntau yuav tsis xav tau qhov ntxiv steroid.

Yog tias koj muaj lus nug txog ib qho tshuaj twg uas muab nrog Darzalex infusions, nug koj tus kws kho mob.

Kuv puas tuaj yeem tau tsav kuv tus kheej hauv tsev tom qab kuv Darzalex infusion?

Nws tsis raug pom zoo. Qhov no yog vim nws nquag ua rau nkees nkees tom qab qhov infusion lossis txawm tias muaj qhov tsis haum. (Saib “Kev qhia txog Txoj kev lis ntshav” hauv seem “Cov lus qhia txog sab nraud” kom paub ntau ntxiv.) Yog li kom muaj kev nyab xeeb, muaj ib tus hauv koj tsev neeg, cov phooj ywg, lossis cov neeg saib xyuas xa koj mus thiab los ntawm koj qhov kev teem sijhawm sib ntsib.

Ua tib zoo saib koj txoj kev xav zoo li cas tom qab koj nqus koj tus mob thiab khaws koj qhov tsos mob ntawm koj cov tsos mob. Qhov no tuaj yeem pab koj txiav txim siab yog tias koj tuaj yeem tsav koj tus kheej, yog tias koj xav tau.

Yog tias koj tsis tuaj yeem nrhiav tus tsav, Janssen Biotech, Inc., tus tsim khoom ntawm Darzalex, tuaj yeem pab tau. Koj tuaj yeem tham nrog Janssen CarePath tus kws tuav ntaub ntawv txog kev mus thiab thaum tau teem caij thiab tau txais kev pabcuam nrog tus nqi taug kev. Xav paub ntau ntxiv, hu 844-553-2792 lossis mus saib hauv Darzalex lub vev xaib.

Kuv puas tuaj yeem siv Darzalex yog tias kuv muaj cov mob pob ntseg?

Yog lawm, koj tuaj yeem siv Darzalex yog tias koj muaj tus mob hu ua shingles. Tab sis ua ntej koj yuav noj Darzalex, nws yog ib qho tseem ceeb uas yuav tau qhia koj tus kws kho mob yog tias koj tau mob pob ntseg lossis mob qhua qhua. (Tus kab mob tib yam uas ua rau mob voos tuaj yeem ua rau mob qhua taum tau.)

Yog tias koj tau mob qhua maj yav dhau los, tus kab mob yuav tsis tawm hauv koj lub cev mus tom qab koj rov zoo los. Hloov, tus kab mob tsuas yog "mus pw tsaug zog" hauv koj cov hlab ntsha.

Tsis muaj leej twg paub tseeb vim li cas, tab sis tus kab mob tuaj yeem rov ua haujlwm lossis "sawv" nrog qee yam tshwm sim xws li lub cev tsis muaj zog tiv thaiv kab mob. (Koj muaj zog tiv thaiv koj lub cev tiv thaiv kab mob.)

Cov kev kho mob qog noj ntshav xws li Darzalex tuaj yeem ua rau koj lub cev tsis muaj zog thiab rov tua tus kab mob. Thaum nws tsaug zog, nws qhia nws tus kheej tias yaug cov hloov tus kabmob qhua dej.

Yog li yog tias koj muaj mob pob zeb los yog mob qhua dej, koj tus kws kho mob yuav sau cov tshuaj tua kab mob los tiv thaiv tus mob pob ntseg kom txhob rov mob ntxiv nyob rau hauv koj lub cev. Koj yuav tsum tau siv tshuaj tua kab mob kho ua ntej dhau 1 lub hlis txij li hnub pib noj Darzalex. Tom qab ntawd koj yuav tsum noj tshuaj tiv thaiv kab mob tshuaj tiv thaiv rau 3 lub hlis tom qab koj ua tiav cov kev kho mob nrog Darzalex.

Yog tias koj tsis paub meej tias koj puas muaj mob pob ntseg lossis ua qoob, nrog koj tus kws kho mob tham.

Puas yog Darzalex kho tau ntau yam mob myeloma?

Tamsis no, tsis muaj tshuaj kho tau ntau yam mob myeloma. Tab sis dab tsi Darzalex tuaj yeem ua tau yog txhim kho koj qhov zoo thiab lub neej ntev, nyob ntawm koj qhov kev kuaj mob. Koj tus kws kho mob tuaj yeem qhia koj ntxiv.

Kev ceev faj Darzalex

Ua ntej noj cov Darzalex, nrog koj tus kws kho mob tham txog koj li kev noj qab haus huv keeb kwm. Darzalex tej zaum yuav tsis zoo rau koj yog tias koj muaj qee yam mob lossis lwm yam cuam tshuam koj txoj kev noj qab haus huv. Cov no suav nrog:

  • Kab mob siab B. Yog tias koj muaj kab mob siab B lossis muaj nws yav dhau los, kev noj tshuaj Darzalex tuaj yeem ua rau nws rov ua haujlwm dua. Ua ntej koj pib noj cov Darzalex, koj tus kws kho mob yuav kuaj koj txog kab mob siab B. Lawv kuj tuaj yeem kuaj koj tom qab koj tau tso tshuaj kho. Cov tsos mob ntawm tus kab mob siab B muaj xws li ua rau nkees zuj zus tuaj, thiab cov xim daj ntawm koj cov tawv nqaij thiab dawb ntawm koj lub qhov muag. Yog tias koj pom cov tsos mob no, qhia rau koj tus kws kho mob.
  • Mob muag. Thaum koj tab tom noj Darzalex, koj tuaj yeem tsim tus mob hu ua shingles. Tus kab mob tib yam uas ua rau mob ntxaug kuj tuaj yeem ua mob qhua dej. Yog li yog tias koj tau mob qhua maj los yog mob yuag yav dhau los thiab tab tom noj Darzalex, koj tus kws kho mob yuav sau ntawv muab tshuaj rau noj los tiv thaiv kab mob. Hom tshuaj no tuaj yeem pab tiv thaiv tus mob txhawm rau txhim kho hauv koj lub cev.
  • Kab Mob Hlwb Mob Hlwb Ntev (COPD). Yog tias koj muaj keeb kwm ntawm kev ua tsis taus pa hu ua mob ntsws ntsws (COPD), qhia rau koj tus kws kho mob ua ntej koj pib noj cov tshuaj Darzalex. Lawv yuav muab cov tshuaj nqus pa pab koj ua pa yooj yim dua thiab corticosteroids kom pab txo qhov o ntawm koj lub ntsws.
  • Cev xeeb tub. Darzalex tsis tau kawm txog cov poj niam cev xeeb tub. Tab sis nws yog hom tshuaj uas tuaj yeem hla cov txiaj ntsig. (Lub cev yog ib qho khoom hauv nruab nrog koj lub cev uas xa zaub mov ntawm koj lub cev mus rau koj tus menyuam.) Yog xav paub ntxiv, thov saib tshooj "Darzalex thiab cev xeeb tub" saum toj no.
  • Kev pub niam mis. Nws tsis paub yog tias nws muaj kev nyab xeeb rau kev pub niam mis thaum noj Darzalex. Yog xav paub ntau ntxiv, thov saib hauv seem “Darzalex thiab pub mis niam” sab saud.

Qhia koj tus kws kho mob yog tias koj muaj ib qho ntawm cov mob no thaum lossis tom qab kho nrog Darzalex.

Nco tseg: Yog xav paub ntxiv txog cov kev cuam tshuam zoo ntawm Darzalex, saib tshooj "Darzalex Side Effects" saud.

Cov ntaub ntawv tshaj lij rau Darzalex

Cov ntaub ntawv hauv qab no yog muab rau cov kws kho mob thiab lwm tus kws kho mob.

Cov Khoom Qhia

Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo thiab taw qhia Darzalex rau kev siv:

  • Rau cov neeg laus uas nyuam qhuav raug kuaj mob ntau myeloma uas tsis tuaj yeem tsis tuaj yeem hloov kho lub cev ntawm tes mob hlwb. (Nrog kev hloov kho lub qia hauv hlwb, koj tus kheej qia hlwb raug siv.) Hauv qhov xwm txheej no:
    • Darzalex tuaj yeem siv nrog cov tshuaj lenalidomide (Revlimid) thiab dexamethasone.
    • Darzalex kuj tseem siv tau nrog cov tshuaj bortezomib (Velcade), melphalan, thiab prednisone.
  • Rau cov neeg laus uas tau txais ib lossis ntau txoj kev kho mob yav dhau los uas tsis ua haujlwm zoo lossis muaj ntau tus mob myeloma rov qab los. Hauv cov xwm txheej no, Darzalex siv nrog lenalidomide thiab dexamethasone.
  • Rau cov neeg laus uas tau txais ib lossis ntau dua yav dhau los ntau txoj kev kho tus mob myeloma. Hauv cov xwm txheej no, Darzalex siv nrog bortezomib thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais ob lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog lenalidomide thiab ib qho tshuaj tiv thaiv proteasome, uas yog hom tshuaj. Hauv cov xwm txheej no, Darzalex siv nrog cov tshuaj pomalidomide (Pomalyst) thiab dexamethasone.
  • Hauv cov neeg laus uas tau txais peb lossis ntau dua yav dhau los ntau txoj kev kho mob myeloma uas suav nrog cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.
  • Hauv cov neeg laus uas tau sim cov tshuaj proteasome inhibitor thiab cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob tab sis tsis siv tshuaj ua haujlwm rau ntau yam mob myeloma. Hauv qhov xwm txheej no, Darzalex tau siv los ntawm nws tus kheej.

Mechanism ntawm kev ua

Darzalex yog cov tshuaj monoclonal antibody thiab tiv thaiv lossis rhuav tshem qog cell loj hlob ntawm ntau cov hlwb myeloma. Thaum cov ntshav hlwb hloov mus rau ntau cov qe ntshav myeloma, lawv muaj cov qe protein ntau hu ua CD38. Darzalex lub hom phiaj thiab txuas nws tus kheej rau cov roj ntsha CD38 no. Los ntawm cov txheej txheem tiv thaiv kab mob thiab ncaj qha rau cov qog ua haujlwm, Darzalex inhibits kev loj hlob ntawm ntau lub hlwb myeloma thiab pib txoj kev ua haujlwm ntawm apoptosis (kev tuag ntawm tes).

Pharmacokinetics thiab cov metabolism

Tsis muaj qhov sib txawv tseem ceeb hauv cov chaw muag tshuaj ntawm Darzalex li kev kho mob lossis kev kho mob sib xyaw tau pom raws li cov neeg muaj mob.

Ua raws li kev pom zoo ntawm cov tshuaj pom zoo ntawm Darzalex ib leeg lossis los ntawm kev sib xyaw ua ke, kev noj tshuaj ntshav ntawm Darzalex yuav luag peb zaug dua thaum kawg ntawm kev noj tshuaj txhua lub limtiam hauv kev sib piv rau thawj koob tshuaj.

Kev txhaj thawj koob tshuaj Darzalex ua rau muaj ntshav ntau dua li ib tus neeg tau txais thawj thawj koob tshuaj. Txawm li cas los xij, cov peaks zoo sib xws thiab troughs ntawm cov ntshav siab tau pom thiab kwv yees tom qab tau txais koob tshuaj thib ob rau lub lim tiam 1, hnub 2 ntawm kev kho mob.

Thaum Darzalex tau muab rau ib leeg, qhov ntshav siab (ntshav khov) nce mus txog li 5 lub hlis mus rau hauv kev noj tshuaj txhua 4 lub lis piam (los ntawm 21 lub lis piam). Hauv lub xeev khov kho, Darzalex txhais tau tias kev sib xyaw ua ke ntau rau cov ntshav siab tshaj yog 1,6.

Faib:

  • monotherapy: 4.7 ± 1.3 L
  • kev sib txuas ua ke: 4.4 ± 1.5 L

Ib nrab-lub neej tshem tawm rau kev kho mob monotherapy thiab kev sib txuas ua ke yog 18 ± 9 hnub. Kev tshem tawm Darzalex txo qis nrog kev nce siab thiab nrog kev noj tshuaj ntau. Kev tshem tawm tau kwv yees yog 171.4 ± 95.3 mL / hnub. Raws li lub cev hnyav nce, qhov ntim ntawm kev faib tawm thiab tus nqi uas Darzalex tshem tawm ntawm lub cev nce.

Cov Yuav Tsum Tau Ua

Darzalex yog contraindicated nyob rau hauv cov neeg mob uas muaj keeb kwm ntawm kev phiv tshuaj hnyav rau daratumumab lossis ib qho tshwj xeeb tshaj tawm ntawm cov tshuaj qauv. Cov mob loj dua ntawm neutropenia, thrombocytopenia, lossis kev rov ua kauv vim qhov kev kho mob yuav ua rau Darzalex raug txwv lossis nres ib ntus.

Cia

Darzalex yuav tsum khaws cia hauv tub yees ntawm 36 ° F txog 46 ° F (2 ° C txog 8 ° C).

Tsis txhob tshee lossis khov rau Darzalex. Cov tshuaj yuav tsum tau tiv thaiv los ntawm lub teeb. Darzalex tsis muaj ib yam tshuaj noj kom zoo.

Tsis lees paub: Cov Xov Xwm Kho Mob Niaj Hnub no tau ua txhua yam kom paub tseeb tias txhua yam ntaub ntawv yog qhov tseeb, raug, thiab dhau-hnub. Txawm li cas los xij, cov kab lus no yuav tsum tsis txhob siv los hloov chaw rau qhov kev paub thiab kev paub ntawm tus neeg muaj ntawv tso cai kho mob. Koj yuav tsum tau sab laj nrog koj tus kws kho mob lossis lwm tus kws saib xyuas kev noj qab haus huv ua ntej noj tshuaj. Cov ntaub ntawv tshuaj muaj nyob ntawm no yuav raug hloov thiab tsis yog npaj rau txhua txoj kev siv, cov lus qhia, kev ceev faj, ceeb toom, kev cuam tshuam nrog tshuaj, kev fab tshuaj, lossis muaj kev cuam tshuam tsis zoo. Qhov tsis muaj lus ceeb toom lossis lwm cov ntaub ntawv rau kev muab tshuaj tsis qhia tias kev sib txuam tshuaj lossis tshuaj muaj kev nyab xeeb, siv tau, lossis tsim nyog rau txhua tus neeg mob lossis txhua qhov siv tshwj xeeb.

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Dab Tsi Yog Nonvalvular Atrial Fibrillation?

Txheej txheem cej luamAtrial fibrillation (AFib) yog lo lu kho mob rau kev mob plawv t i xwm yeem. Muaj ntau yam t hwm im ntawm AFib. Cov no uav nrog cov kab mob plawv, ua qhov t i xwm yeem ntawm tu ...