Mob Hlwb Ntev Ua Kom Mob Hlwb Mob

Zoo Siab

• Ntsiab lus
• Yuav ua li cas yog leukemia?
• Mob leeg hu ua myeloid leukemia (CML) yog dab tsi?
• Dab tsi ua rau mob tus mob myeloid tawv nqaij (CML)?
• Leej twg ntxim yuav raug tus mob myeloid leukemia (ntev ntev) (CML)?
• Cov tsos mob ntawm tus mob hu ua myeloid leukemia zoo li cas (CML)?
• Yuav kuaj li cas thiaj paub tias yog tus mob myeloid leukemia (CML)?
• Dab tsi yog cov qib theem ntawm tus mob myeloid leukemia (CML)?
• Yuav kho tus mob myeloid leukemia li cas (CML)?

Ntsiab lus

Yuav ua li cas yog leukemia?

Ntshav ntshav yog ib lo lus rau cov qog nqaij hlav ntshav hauv cov ntshav. Mob leukemia pib nyob rau hauv cov nqaij tsim cov nqaij mos xws li hlwb pob txha. Koj cov hlwb pob txha ua rau cov qog ntshav uas yuav los tsim cov qe ntshav dawb, qe ntshav liab, thiab qe ua kom ntshav khov. Txhua hom ntawm tes muaj qhov haujlwm txawv:

• Cov qe ntshav dawb pab koj lub cev tawm tsam kev kis tus kab mob
• Cov ntshav liab xa cov pa oxygen los ntawm koj lub ntsws rau koj cov ntaub so ntswg thiab cov kabmob
• Platelets pab txhaws ua rau txhaws ntshav txhaws

Thaum koj muaj mob leukemia, koj tus hlwb pob txha ua rau muaj cov qe ntshav ntau heev. Qhov teeb meem no feem ntau tshwm sim nrog cov qe ntshav dawb. Cov hlwb txawv txav no ua rau koj cov pob txha pob txha thiab ntshav. Lawv cais tawm cov ntshav noj qab nyob zoo thiab ua rau nws nyuaj rau koj lub hlwb thiab ntshav ua lawv txoj haujlwm.

Mob leeg hu ua myeloid leukemia (CML) yog dab tsi?

Ntev ntshav mob mus ntev myeloid leukemia (CML) yog ib hom mob qog mob ntshav vwm ntev. "Ntev" txhais tau hais tias cov mob leukemia feem ntau mob qeeb dua. Hauv CML, hlwb pob txha ua rau muaj cov granulocytes txawv txav (ib hom qe ntshav dawb). Cov hlwb txawv txav no tseem hu ua blasts. Thaum cov qog ua haujlwm tsis zoo ua rau cov hlwb noj qab nyob zoo, nws tuaj yeem ua rau kis mob, ntshav liab, thiab los ntshav yoojyim. Cov qe ntshav uas tsis tu ncua tseem tuaj yeem kis tawm sab nraud cov ntshav mus rau lwm qhov ntawm lub cev.

CML feem ntau tshwm sim rau cov neeg laus thaum lossis nruab nrab hnub nyoog. Nws yog tsawg nyob rau hauv cov menyuam yaus.

Dab tsi ua rau mob tus mob myeloid tawv nqaij (CML)?

Cov neeg feem coob uas muaj CML muaj kev hloov caj ces hu ua Philadelphia chromosome. Nws tau hu qhov ntawd vim tias cov kws tshawb nrhiav hauv Philadelphia tshawb pom nws. Tib neeg ib txwm muaj 23 khub ntawm cov chromosomes hauv txhua lub cell. Cov chromosomes muaj koj cov DNA (cov khoom siv caj ces). Hauv CML, ib feem ntawm cov DNA los ntawm ib tug chromosome txav mus rau lwm tus chromosome. Nws txuas nrog qee qhov DNA nyob ntawd, uas tsim cov gene tshiab hu ua BCR-ABL. Cov keeb no ua rau koj cov leeg pob txha los ua cov protein tsis txaus. Cov protein no tso cai rau cov qe ntshav qog ua kom hlav tawm los ntawm kev tswj hwm.

Lub Philadelphia chromosome tsis dhau ntawm niam txiv mus rau menyuam. Nws tshwm sim thaum koj lub neej. Cov tsis paub yog vim li cas.

Leej twg ntxim yuav raug tus mob myeloid leukemia (ntev ntev) (CML)?

Nws yog ib qho nyuaj los twv seb leej twg yuav tau txais CML Muaj ob peb yam uas tuaj yeem ua rau koj txoj kev pheej hmoo:

• Hnub nyoog - koj txoj kev pheej hmoo nce zuj zus thaum koj laus zuj zus
• Tub los ntxhais - CML yog me ntsis ntau tshwm sim rau cov txiv neej
• Raug rau cov tshuaj tua hluav taws xob ntau

Cov tsos mob ntawm tus mob hu ua myeloid leukemia zoo li cas (CML)?

Qee zaum CML tsis ua rau cov tsos mob. Yog tias koj muaj tsos mob, lawv tuaj yeem suav nrog

• Zoo nkaus li nkees
• Poob phaus yam tsis paub tias yog vim li cas
• Hmo ntuj tawm hws
• Ua npaws
• Mob los yog ib qho kev xav ntawm tag nrho hauv qab cov tav ntawm sab laug

Yuav kuaj li cas thiaj paub tias yog tus mob myeloid leukemia (CML)?

Koj tus kws kho mob yuav siv ntau cov cuab yeej los kuaj CML:

• Kev soj ntsuam lub cev
• Keeb kwm kev kho mob
• Kev kuaj ntshav, xws li ua kom tiav cov ntshav suav (CBC) nrog qhov sib txawv thiab cov ntshav kuaj cov chemical ntshav. Kev kuaj ntshav cov ntshav yuav ntsuas seb cov tshuaj sib txawv hauv cov ntshav, nrog rau cov electrolytes, cov rog, cov protein, piam thaj (piam thaj), thiab enzymes. Cov kev kuaj ntshav ntshav tshwj xeeb suav nrog kev teeb txheeb metabolic vaj huam sib luag (BMP), cov vaj huam sib luag metabolic vaj huam sib luag (CMP), kev tshuaj xyuas lub raum, kuaj ntshav lub siab, thiab lub ntsuas hluav taws xob.
• Kuaj pob txha ua pob. Nws muaj ob hom kev loj - kev mob siab rau pob txha thiab pob txha mos. Ob qhov kev ntsuam xyuas muaj feem cuam tshem ib qho qauv ntawm cov leeg pob txha thiab pob txha. Cov hnoos qeev raug xa mus rau ib qhov chaw kuaj sim.
• Kev tshuaj ntsuam caj ces kom saib cov gene thiab cov chromosome pauv, suav nrog kev sim mus saib Philadelphia chromosome

Yog tias koj tau kuaj pom tias muaj CML, koj tuaj yeem muaj lwm yam kev kuaj ntxiv xws li kev soj ntsuam duab los saib seb puas muaj mob cancer kis.

Dab tsi yog cov qib theem ntawm tus mob myeloid leukemia (CML)?

CML muaj peb ntu. Cov theem nyob ntawm qhov ntau npaum li cas CML tau loj hlob lossis sib kis:

• Cov theem mob ntev, uas tsawg dua 10% ntawm cov hlwb nyob rau hauv cov ntshav thiab cov pob txha pob txha yog cov hlwb tawg (hlwb hlav ntshav). Feem ntau cov neeg tau kuaj mob nyob rau theem no, thiab ntau tus neeg tsis muaj tsos mob. Cov qauv kev kho mob feem ntau pab nyob rau theem no.
• Ua kom tiav cov qib, 10% mus rau 19% ntawm cov hlwb nyob rau hauv cov ntshav thiab cov pob txha pob txha yog cov hlwb tawg. Hauv theem no, tib neeg feem ntau muaj cov tsos mob thiab tus txheej txheem kho yuav tsis ua haujlwm zoo li hauv ntu mob ntev.
• Blastic theem, qhov twg 20% ​​lossis ntau dua ntawm cov kabmob hauv cov ntshav lossis hlwb pob txha yog qhov tawg hlwb. Lub tshuab tawg tau kis mus rau lwm cov nqaij thiab kabmob. Yog tias koj muaj qhov nkees nkees, kub cev, thiab qhov hnoos qeev loj dua thaum lub caij blastic, nws hu ua qhov teeb meem tawg. Cov qib no nyuaj los kho.

Yuav kho tus mob myeloid leukemia li cas (CML)?

Muaj ntau txoj kev kho rau CML:

• Cov hom phiaj kho, uas siv cov tshuaj lossis lwm yam tshuaj tua cov qog nqaij hlav cancer tshwj xeeb uas tsis tshua muaj kev phom sij rau cov kab mob hauv lub cev. Rau CML, cov tshuaj yog tyrosine kinase inhibitors (TKIs). Lawv thaiv cov kabmob tyrosine kinase, uas yog ib qho enzyme uas ua rau koj cov hlwb pob txha ua rau tawg ntau dhau.
• Kws khomob
• Kev Txhaj Tshuaj Tiv Thaiv
• Kev siv tshuaj ntau ntxiv nrog cov qog hloov qog
• Pub nyiaj lymphocyte Txoj Kev lis ntshav (DLI). DLI yog kev kho mob uas yuav siv tom qab hloov qia ntawm tes. Nws koom nrog muab koj qhov ntshav (rau hauv koj cov hlab ntshav) ntawm cov lymphocytes kom muaj txiaj ntsig zoo los ntawm cov qog cell hloov ntshav pub. Lymphocytes yog ib hom qe ntshav dawb. Cov lymphocytes pub dawb no yuav tua cov qog nqaij hlav cancer uas tseem tshuav ntxiv mus.
• Kev phais kom tshem tawm tus po (splenectomy)

Cov kev kho mob twg koj tau txais yuav nyob ntawm theem uas koj nyob hauv, koj hnub nyoog, koj li kev noj qab haus huv tag nrho, thiab lwm yam. Thaum cov cim thiab cov tsos mob ntawm CML txo qis lossis tau ploj mus, nws hu ua kev zam txim. Lub CML tuaj yeem rov qab los tom qab kev zam tawm, thiab koj yuav tsum tau kho ntau dua.

NIH: Lub Tsev Haujlwm Cancer Hauv Tebchaws