Kev Tswj Cholesterol: PCSK9 Tus Tuav Pov Hwm thiab Statins
Zoo Siab
- Txog statins
- Lawv ua haujlwm li cas
- Cov hom
- Txog PCSK9 inhibitors
- Thaum lawv tau tshuaj
- Lawv ua haujlwm li cas
- Sab sij huam
- Txij nkawm
- Nqi
- Tham nrog koj tus kws kho mob
- Tham nrog koj tus kws kho mob
Taw qhia
Ze li ntawm 74 lab tus neeg Asmeskas muaj cov roj cholesterol siab, raws li tus. Txawm li cas los xij, tsawg dua li ib nrab tau txais kev kho mob rau nws. Qhov no ua rau lawv muaj kev pheej hmoo siab rau plawv nres thiab mob hlab ntsha tawg. Thaum kev tawm dag zog thiab kev noj qab haus huv zoo tuaj yeem pab tswj cov qib roj cholesterol, qee zaum yuav tau noj tshuaj.
Ob yam tshuaj uas tau siv los kho cov roj (cholesterol) siab heev yog cov statins thiab PCSK9 inhibitors. Statins yog qhov kev kho mob nrov uas tau muaj txij li xyoo 1980 los. PCSK9 inhibitors, ntawm qhov tod tes, yog hom tshiab ntawm cov tshuaj roj cholesterol. Lawv tau pom zoo los ntawm Food and Drug Administration xyoo 2015.
Thaum koj thiab koj tus kws kho mob txiav txim siab txog cov tshuaj roj cholesterol rau koj, koj yuav txiav txim siab txog qee yam xws li kev phiv, nqi, thiab ua tau hauj lwm zoo. Nyeem rau kom paub ntau ntxiv txog cov tshuaj no thiab seb ob hom sib piv li cas.
Txog statins
Statins yog ib hom tshuaj uas feem ntau siv los pab txo cov cholesterol. Yog tias koj muaj cov roj cholesterol siab lossis lwm yam kev phom sij ntawm lub plawv, koj tus kws kho mob yuav qhia kom koj pib noj cov tshuaj statin. Lawv feem ntau yog siv los ua thawj kab kev kho mob rau cov cholesterol. Qhov no txhais tau tias lawv yog thawj qhov kev kho mob uas koj tus kws kho mob yuav qhia.
Lawv ua haujlwm li cas
Statins ua hauj lwm los ntawm thaiv cov tshuaj hu ua HMG-CoA reductase. Qhov no yog qhov sib tov uas koj lub siab xav ua kom muaj cov cholesterol. Thaiv cov tshuaj no txo cov roj hauv koj lub siab ua. Statins tseem ua haujlwm los ntawm kev pab koj lub cev rov muab cov roj uas txhaws roj uas tau sib sau rau ntawm koj cov hlab ntsha. Xav paub ntau ntxiv, nyeem txog kev ua haujlwm statins.
Cov hom
Statins tuaj rau hauv daim ntawv ntawm cov ntsiav tshuaj lossis tshuaj ntsiav uas koj noj ntawm qhov ncauj. Niaj hnub no muaj ntau yam statins muaj nyob hauv Tebchaws Asmeskas. Lawv suav nrog:
- atorvastatin (Lipitor)
- fluvastatin (Lescol)
- lovastatin (Altoprev)
- pravastatin (Pravachol) Hmoob
- rosuvastatin (Crestor)
- simvastatin (Zocor)
- pitavastatin (Livalo)
Txog PCSK9 inhibitors
Statins tuaj yeem raug kho rau ntau tus neeg uas muaj roj cholesterol siab, tab sis PCSK9 inhibitors feem ntau yog kho rau qee hom neeg xwb. Vim tias statins tau nyob ntev dua, peb paub ntau ntxiv txog tias nws zoo li cas. PCSK9 inhibitors yog cov tshiab dua thiab yog li muaj cov ntaub ntawv muaj kev nyab xeeb tsawg dua ntev.
Tsis tas li, PCSK9 inhibitors yog kim heev piv rau statins.
PCSK9 inhibitors tau muab los ntawm txhaj tshuaj nkaus xwb. Muaj tsuas yog ob lub PCSK9 Tus Txheeb Khoom muaj nyob rau niaj hnub no hauv Tebchaws Meskas: Praluent (alirocumab) thiab Repatha (evolocumab).
Thaum lawv tau tshuaj
American College of Cardiology xav kom koj thiab koj tus kws kho mob txiav txim siab rau PCSK9 inhibitor tsuas yog tias:
- koj tau txiav txim siab muaj kev pheej hmoo siab rau cov teeb meem plawv plawv thiab koj cov roj (cholesterol) tsis yog tswj nrog statins lossis lwm cov tshuaj txo cov roj (cholesterol)
- koj muaj caj ces mob hu ua hib kev mob hypercholesterolemia, uas yog cov roj ntshav siab kawg
Ib qho ntawm ob yam no, PCSK9 inhibitors feem ntau yog tshuaj tom qab ob yam tshuaj noj tsis tau pab txo qis koj cov roj (cholesterol). Piv txwv li, koj tus kws kho mob yuav xub sau ntawv rau ib qho statin.Yog tias qhov ntawd tsis txo qis koj cov roj (cholesterol) kom txaus, koj tus kws kho mob yuav hais qhia ezetimibe (Zetia) lossis tshuaj hu ua bile acid resins. Piv txwv ntawm cov no suav nrog cholestyramine (Locholest), colesevelam (Welchol), lossis colestipol (Colestid).
Yog tias koj cov qib roj cholesterol tseem siab dhau tom qab siv hom tshuaj thib ob no, ces koj tus kws kho mob yuav qhia tus PCSK9 inhibitor.
Lawv ua haujlwm li cas
PCSK9 inhibitors tuaj yeem siv ntxiv rau los yog siv cov statins. Cov tshuaj no ua haujlwm txawv. PCSK9 inhibitors tsom lub protein nyob hauv daim siab hu ua proprotein convertase subtilisin kexin 9, lossis PCSK9. Los ntawm kev txo cov nyiaj ntawm PCSK9 hauv koj lub cev, PCSK9 inhibitors tso cai rau koj lub cev tshem cov roj cholesterol kom zoo dua.
Sab sij huam
Statins thiab PCSK9 inhibitors tuaj yeem ua rau txhua qhov mob sib khuav me thiab loj dua, thiab cov teebmeem no sib txawv ntawm cov tshuaj.
| Statins | PCSK9 inhibitors | |
| Me me kev tshwm sim | • cov leeg thiab leeg mob • xeev siab • mob plab • cem quav • mob taub hau | • o ntawm thaj chaw txhaj tshuaj • mob ntawm koj ceg lossis leeg • nkees nkees |
| Cov kev mob tshwm sim hnyav heev | • mob siab • cov ntshav qabzib ntau ntau • qhov feem ntau ntawm cov ntshav qab zib hom 2 ntau dua • cov teeb meem kev txawj ntse (hlwb) • cov leeg ua rau cov leeg mob rhabdomyolysis | • mob ntshav qab zib • teeb meem mob siab • raum muaj teeb meem • dementia |
Txij nkawm
Statins tau pom tias cov roj (cholesterol) tsawg hauv ntau tus neeg. Lawv tau siv txij li 1980s thiab lawv cov kev cuam tshuam tau kawm hauv ntau txhiab tus neeg uas tau siv statins los tiv thaiv kev mob plawv thiab mob stroke.
Hauv kev sib piv, PCSK9 inhibitors tau pom zoo tsis ntev los no, yog li cov ntaub ntawv kev tiv thaiv kev nyab xeeb nyob ntev ntev yuav tsis zoo. Tseem PCSK9 inhibitors yog qhov muaj txiaj ntsig zoo rau qee tus neeg.Ib txoj kev tshawb nrhiav tau qhia tias lwmrocumab txo cov qib roj cholesterol yog 61 feem pua. Nws kuj tseem txo txoj kev pheej hmoo ntawm cov hlab plawv xws li mob plawv nres thiab mob ntshav nce hlwb. Lwm qhov kev tshawb pom pom cov txiaj ntsig zoo sib xws nrog evolocumab.
Nqi
Statins muaj ntau hom npe thiab hom qauv. Generics feem ntau raug nqi tsawg dua hom qauv, yog li cov statins tuaj yeem pheej yig.
PCSK9 inhibitors yog qhov tshiab, yog li lawv tsis muaj cov qauv siv feem ntau tseem muaj. Vim li no, lawv kim dua cov statins. Tus nqi ntawm PCSK9 inhibitors tuaj yeem tshaj $ 14,000 toj xyoo. Ib qho ntxiv, kom muaj tus nqi no los ntawm koj qhov kev pov hwm, koj yuav tsum poob rau hauv ib ntawm ob pawg tau pom zoo siv rau PCSK9 inhibitors. Yog tias koj tsis haum rau ib qho ntawm cov pawg ntawd, koj yuav raug them nyiaj rau PCSK9 inhibitor koj tus kheej.
Tham nrog koj tus kws kho mob
Statins thiab PCSK9 inhibitors yog qhov tseem ceeb hauv kev siv tshuaj hauv kev kho cov qib roj siab siab. Thaum ob hom tshuaj no pab txo qis cov roj cholesterol, muaj qee qhov sib txawv. Cov lus hauv qab no qhia txog qhov sib txawv ntawm ib nrais muag.
| Statins | PCSK9 inhibitors | |
| Xyoo muaj | 1987 | 2015 |
| Daim ntawv thov tshuaj | ntsiav tshuaj noj los ntawm qhov ncauj | txhaj tshuaj nkaus xwb |
| Caw rau | cov neeg muaj roj cholesterol siab | cov neeg muaj cov roj (cholesterol) siab uas ua tau raws li ob qho tseem ceeb |
| Feem ntau cov kev mob tshwm sim | leeg mob, mob taub hau, thiab teeb meem plab zom mov | txhaj tshuaj ntawm qhov chaw o, nqua los yog mob leeg, thiab nkees |
| Nqi | pheej yig dua | kim |
| Muaj ntau yam | generics muaj | tsis muaj generics muaj |
Tham nrog koj tus kws kho mob
Yog tias koj muaj cov roj (cholesterol) siab thiab xav tias cov tshuaj no yuav zoo rau koj, koj thawj kauj ruam yuav tsum nrog koj tus kws kho mob tham. Lawv tuaj yeem qhia koj ntau ntxiv txog cov tshuaj no thiab lwm txoj kev kho mob. Qee cov lus nug los tham nrog koj tus kws kho mob tej zaum yuav yog:
- Cov tshuaj puas yog kauj ruam txuas ntxiv rau kuv hauv kev tswj hwm kuv cov cholesterol siab?
- Kuv puas ua raws li ob qho qauv rau cov neeg tuaj yeem kho mob PCSK9 inhibitors?
- Kuv Puas Nrog Cuam Tham Nrog Tus Kws lipid?
- Kuv puas yuav tsum pib ua kev tawm dag zog los pab tswj kuv cov cholesterol?
- Koj tuaj yeem xa kuv mus rau ib tus kws qhia noj zaubmov kom pab kuv tswj kuv kev noj zaub mov kom zoo?
Txiv Nom
