Calcinosis Cutis

Zoo Siab

• Hom ntawm calcinosis cutis
• Cov tsos mob ntawm calcinosis cutis
• Ua rau ntawm calcinosis cutis
• Dystrophic calcification
• Metastatic calcification
• Idiopathic calcification
• Iatrogenic calcification
• Calciphylaxis
• Hauv kev sib xyaw nrog scleroderma
• Kev kuaj mob ntawm calcinosis cutis
• Kev kho mob ntawm calcinosis cutis
• Tshuaj
• Kev phais mob
• Lwm yam kev kho mob
• Outlook rau calcinosis cutis

Txheej txheem cej luam

Calcinosis cutis yog kev tsub zuj zuj ntawm calcium ntsev muaju hauv koj cov tawv nqaij. Cov calcium calcium yog cov tawv tawv uas tsis yaj. Cov duab thiab qhov loj me ntawm qhov txhab txhab sib txawv.

Qhov no yog qhov tsis tshua muaj tshwm sim uas muaj ntau yam ua rau. Cov no yog kis los ntawm kev kis mob thiab raug mob rau cov kab mob xws li lub raum tsis ua haujlwm.

Feem ntau calcinosis cutis tsis muaj cov tsos mob. Tab sis qee qhov xwm txheej, nws tuaj yeem mob heev. Cov kev kho mob yog muaj, suav nrog kev phais mob, tab sis cov qhov txhab calcium yuav rov muaj dua.

Hom ntawm calcinosis cutis

Muaj tsib subtypes ntawm calcinosis cutis:

• Dystrophic calcification. Qhov no yog hom feem ntau ntawm cov calcinosis. Nws tshwm sim qhov twg ntawm daim tawv nqaij tau raug mob los yog kub. Nws tsis hais txog qib calcium uas ntau ntau los yog phosphorus hauv lub cev.
• Metastatic calcification. Qhov no tshwm sim hauv cov neeg uas muaj calcium thiab phosphorus qib siab tsis sib thooj.
• Idiopathic calcification. Qhov no hom ntawm calcinosis cutis tsis muaj qhov ua rau pom tseeb. Nws feem ntau tshwm sim hauv ib thaj chaw ntawm lub cev nkaus xwb.
• Iatrogenic calcification. Hom calcinosis cutis no tshwm sim los ntawm txheej txheem kev kho mob lossis kev kho mob, feem ntau ua yuam kev. Piv txwv, cov menyuam yug tshiab tuaj yeem muaj iatrogenic calcification ntawm pob taws, ua los ntawm pob taws txhaws coj los ntshav.
• Calciphylaxis. Qhov tsawg thiab mob hnyav hom calcinosis cutis no feem ntau yog tshwm sim rau cov neeg muaj lub raum tsis ua haujlwm, tau txais lub raum, lossis ua rau lim ntshav. Nws cuam tshuam cov hlab ntshav hauv daim tawv nqaij lossis roj txheej.Cov calcium thiab qib ntsev hauv lub cev yog qhov txawv txav.

Cov tsos mob ntawm calcinosis cutis

Cov tsos thiab qhov chaw ntawm calcinosis cutis nyob ntawm seb qhov pib. Cov qhov txhab feem ntau nyuaj, tawv-daj ua pob nyob rau ntawm daim tawv nqaij. Lawv pib qeeb thiab sib txawv raws qhov loj me.

Lub qhov txhab txhab yuav tsis muaj tsos mob, lossis nws yuav ua tau mob hnyav, mob, lossis ua pa tawm ntawm cov tshuaj dawb. Muaj qee zaus, qhov txhab ua paug tuaj yeem tuag taus.

Ntawm no yog thaj chaw uas qhov txhab feem ntau tshwm sim hauv txhua qhov subtypes ntawm calcinosis cutis:

• Dystrophic calcification. Cov pob no tshwm sim nyob rau thaj tsam ntawm cov nqaij mob. Tej qhov chaw yog forearms, lauj tshib, ntiv tes, thiab hauv caug. Nrog mob lupus, qhov txhab tshwm sim ntawm tes thiab taw, pob tw, thiab hauv qab lupus txhab.
• Metastatic calcification. Cov pob muaj nyob ua ke ib ncig ntawm cov pob qij txha: hauv caug, lauj tshib, los yog xub pwg. Tej zaum lawv yuav tuaj yeem ua thaj chaw hauv nruab nrog cev, xws li ntsws, raum, hlab ntshav, lossis lub plab. Cov tawv nqaij nyob ib ncig ntawm cov pob qij txha tuaj yeem txwv txoj kev txav chaw raws li daim tawv nqaij tawv.
• Idiopathic calcification. Qhov no feem ntau cuam tshuam tsuas yog ib cheeb tsam ntawm lub cev. Nws tuaj yeem tshwm sim puag ncig ntawm cov pob qij txha loj, txhaws viav vias, lub taub hau, ob lub mis, chaw mos, rab qau, lossis txhais tes thiab taw. Hauv cov menyuam yaus nws yuav yog ntawm ntsej muag. Cov qhov txhab txhab ntawd yuav tso tawm dawb.
• Iatrogenic calcification. Lub qhov txhab tshwm ntawm thaj chaw kho mob lossis kho txheej txheem uas tho qhov tawv nqaij.
• Calciphylaxis. Cov tawv nqaij mob feem ntau nyob ntawm ceg lossis pob tw, tshwj xeeb tshaj yog cov roj ntsha xws li mis, pob tw, thiab lub plab. Lub qhov txhab txhab pom thiab mob. Lawv tuaj yeem ua mob ua kiav txhab uas tsis zoo, lossis lawv tuaj yeem tsim kev lom zem. Lub qhov txhab yuav nrog lwm cov tsos mob, xws li nkees thiab qaug zog.

Ua rau ntawm calcinosis cutis

Calcinosis cutis yog qhov tsis tshua muaj tab sis muaj ntau yam ua rau, nyob ntawm seb lub subtype:

Dystrophic calcification

Feem ntau, kev puas tsuaj ntawm cov nqaij mos ua rau cov ntsev phosphate cov roj ntsha tso tawm los ntawm kev mob hlwb tuag uas tom qab ntawd calcify, sib sau cov ntsev calcium. Cov ntaub so ntswg cov ntaub ntawv tuaj yeem los ntawm:

• kis tau tus mob
• hlav hlav
• pob txuv
• mob tiv thaiv cov nqaij mob xws li mob lupus, mauj tshuaj sclerosis, lossis mob dermatomyositis

Metastatic calcification

Thaum lub cev cov calcium phosphate yog siab tsis txaus, nws ua cov ntsev calcium uas ua rau cov hnoos qeev ntawm daim tawv nqaij. Cov ua rau muaj qhov tsis txaus ntseeg ntawm cov calcium thiab phosphate yog:

• mob raum tsis ua hauj lwm (qhov tshwm sim feem ntau)
• ntau dhau ntawm cov vitamin D
• hyperparathyroidism (kev nthuav dav parathyroid caj pas ua haujlwm ntau dua cov thyroid hormones)
• sarcoidosis (ib pawg ntawm cov qe ntshav ua nyob rau hauv lub ntsws, cov qog ntshav, tawv nqaij, thiab lwm qhov hauv lub cev)
• mis-alkali syndrome (ntau cov calcium los ntawm cov zaub mov lossis antacids)
• cov kab mob pob txha, xws li Tus Kab Mob Paget

Idiopathic calcification

Tsis zoo li thawj ob hom calcinosis cutis, idiopathic calcification tshwm sim tsis muaj qhov hauv qab cov ntaub so ntswg puas thiab tsis muaj qhov txawv txav ntawm calcium lossis phosphorus. Idiopathic txhais tau tias "tsis paub tias yog vim li cas." Nws muaj peb hom:

• tsev neeg nodules, uas feem ntau tshwm sim hauv cov hluas tsis muaj mob lossis cov menyuam yaus me
• subepidermal nodules, uas tshwm sim hauv qab daim tawv nqaij
• nodules ntawm daim tawv nqaij

Iatrogenic calcification

Qhov ua rau ntawm iatrogenic calcification yog cov txheej txheem kho mob uas ua yuam kev ua rau cov ntsev calcium tso nyiaj raws li kev phiv. Tus txheej txheem rau qhov no tsis tau paub. Qee cov txheej txheem koom nrog yog:

• kev tswj hwm ntawm cov kev daws teeb meem muaj cov tshuaj calcium thiab ntsev
• kev tiv thaiv ntev nrog cov calcium calcium chloride electrode muab tshuaj txhuam thaum lub sijhawm electroencephalograph lossis electromyograph
• Tso cov tshuaj calcium gluconate, calcium chloride, thiab para-aminosalicylic acid hauv kev kho mob ntsws qhuav
• luj taws hauv cov menyuam tshiab

Calciphylaxis

Qhov ua rau ntawm calciphylaxis tseem tsis tau paub meej. Nws muaj tsawg heev, txawm hais tias qee qhov cuam tshuam cuam tshuam feem ntau muaj:

• mob raum tsis ua hauj lwm
• rog dhau
• mob ntshav qab zib
• hyperparathyroidism

Hauv kev sib xyaw nrog scleroderma

Calcinosis cutis feem ntau tshwm sim nrog cov kab mob sclerosis (scleroderma). Nws pom muaj tshwj xeeb hauv cov kev mob ntawm qee yam kabmob me me, paub tias yog qhov ua kom mob nqaij mob tsawg (CREST).

Ib qho kwv yees ntawm cov neeg muaj mob CREST yuav mob calcinosis cutis tom qab.

Cov qhov txhab tshwm feem ntau tshwm sim ncig ntawm cov ntiv tes thiab lub luj tshib thiab yuav tawg qhib thiab to ib txheej khoom dawb dawb.

Kev kuaj mob ntawm calcinosis cutis

Kev txiav txim siab seb hom calcinosis cutis koj muaj yog qhov tseem ceeb hauv kev txiav txim siab txoj kev kho mob uas tsim nyog. Koj tus kws kho mob yuav tshuaj xyuas koj thiab coj koj li keeb kwm kev kho mob thiab nug koj txog cov tsos mob ntawm koj.

Tus kws kho mob tej zaum yuav xaj ntau qhov kev kuaj sim los txiav txim siab qhov pib ua rau koj tus mob calcinosis cutis:

• kev ntsuam xyuas ntshav seb koj cov calcium thiab phosphate qib siab tsis txaus, txhawm rau nrhiav cov cim rau lupus thiab cov qog ua haujlwm, thiab los txiav txim siab txog qhov tsis txaus parathyroid thiab vitamin D
• kev ntsuas metabolic los txiav tawm teeb meem lub raum
• Kev xoo hluav taws xob, CT scans, lossis pob txha scans (scintigraphy) kom saib qhov kev ntsuas ntawm qhov ntev
• qhov txhab ntawm qhov txhab
• lwm yam tshwj xeeb kev kuaj mob txhawm rau kuaj pom dermatomyositis (mob o) thiab mis-alkali syndrome

Lub thev naus laus zis tshiab nyob hauv txoj kev txhim kho rau cov txiaj ntsig pabcuam kev txheeb xyuas tau ua kom tsis muaj kev vibrational tsom iav. Cov txheej txheem kev kuaj mob no siv plaub zaug sib pauv infrared (FT-IR) lossis Raman spectroscopic tsom. Nws nrawm pom cov tshuaj lom neeg muaj pes tsawg leeg ntawm cov calcinosis cutis lesions. Nws kuj tuaj yeem twv tau tus neeg mob.

Kev kho mob ntawm calcinosis cutis

Kev kho rau calcinosis cutis nyob ntawm tus kab mob hauv qab los yog vim li cas.

Tshuaj

Muaj ntau hom tshuaj tuaj yeem sim kho qhov mob txhab, tab sis lawv txoj kev ua tiav tau dhau los.

Rau cov mob txhab me, cov tshuaj uas muaj:

• warfarin
• ceftriaxone
• Tso tshuaj immunoglobulin (IVIG)

Rau cov qhov txhab txhab loj, cov tshuaj muaj xws li:

• diltiazem
• bisphosphonates
• probenecid
• aluminium hydroxide

Kev tshawb nrhiav xyoo 2003 tau tshaj tawm tias qhov tshuaj tiv thaiv minocycline tsawg kawg yog siv tau los txo qhov mob thiab qhov mob ntawm qhov mob txhab rau cov neeg muaj CREST syndrome. Cov tshuaj sodium thiosulfate kuj tseem siv tau.

Kev phais mob

Yog tias koj qhov txhab txhab mob, mob ntau zaus, lossis ua tsis tau haujlwm zoo, koj tus kws kho mob yuav hais kom phais. Tab sis cov txhab tawm yuav rov tshwm sim tom qab phais tas. Nws raug nquahu tias kev phais mob pib nrog ib qho me me ntawm qhov txhab.

Lwm yam kev kho mob

Kev kho mob tshiab yog hematopoietic qia cell hloov (HSCT), uas hloov cov neeg cov ntshav tsim. Qhov no tau siv los kho qee qhov mob autoimmune.

Txoj kev kho laser thiab thev naus laus zis sib zog (kev kho mob ultrasound siv los tawg lub raum pob zeb) kuj yog kev kho mob.

Outlook rau calcinosis cutis

Qhov pom ntawm calcinosis cutis nyob ntawm nws tus mob hauv qab los yog qhov ua rau, thiab qhov mob hnyav ntawm koj qhov txhab. Kev kho tam sim no tuaj yeem pab tau, thiab cov kev kho mob tshiab tau tsim kho. Tham nrog koj tus kws kho mob txog kev daws koj cov tsos mob thiab kho lub hauv paus ntawm qhov teeb meem.