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Zoo Siab

BRAF kev kuaj mob yog dab tsi?

Kev kuaj mob BRAF nrhiav tau qhov hloov pauv, paub hu ua kev hloov pauv, hauv tus gene hu ua BRAF. Cov noob yog qhov tseem ceeb ntawm caj ces dhau los ntawm koj niam thiab koj txiv.

BRAF cov noob ua cov protein uas pab tswj kev loj hlob ntawm tes. Nws lub npe hu ua oncogene. Ib qho oncogene ua haujlwm zoo li lub roj nplua nuj ntawm lub tsheb. Nquag, muaj oncogene tig rau ntawm kev loj hlob ntawm tes raws li xav tau. Tab sis yog tias koj muaj BRAF hloov mus, nws zoo li lub rooj zaum roj av tau daig lawm, thiab tus gene yuav txwv tsis tau kom cov hlwb tawm tuaj. Kev tswj tsis tau cell ntau tuaj yeem ua mob qog noj ntshav.

Txoj kev hloov pauv BRAF tuaj yeem tau txais los ntawm koj niam koj txiv lossis tau dhau los hauv lub neej. Kev hloov pauv uas tshwm sim tom qab lub neej feem ntau tshwm sim los ntawm ib puag ncig lossis los ntawm kev ua yuam kev uas tshwm sim hauv koj lub cev thaum faib cov cell. Cov xeeb ntxwv BRAF uas muaj neeg muaj feem tsawg tsawg, tab sis lawv tuaj yeem ua rau muaj mob txaus ntshai.

Kis tau (tseem hu ua somatic) BRAF hloov pauv muaj ntau dua. Cov kev hloov pauv tau pom nyob hauv thaj tsam li ib nrab ntawm txhua tus neeg mob melanoma, uas yog hom mob cancer rau ntawm daim tawv nqaij ntau tshaj plaws. Kev hloov pauv BRAF feem ntau kuj pom muaj nyob rau lwm yam kev cuam tshuam thiab ntau hom mob cancer, suav nrog cov qog nqaij hlav nyuv, lub qog, thiab zes qe menyuam. Cov kabmob uas muaj kev hloov pauv BRAF muaj feem ntau yuav hnyav dua li cov tsis muaj kev sib hloov.


Lwm lub npe: BRAF noob hloov pauv, Melanoma, BRAF V600 hloov pauv, cob

Nws siv rau dab tsi?

Qhov kev ntsuam xyuas no feem ntau siv los nrhiav BRAF hloov pauv hauv cov neeg mob melanoma lossis lwm yam qog nqaij hlav BRAF. Qee hom tshuaj tua kab mob cancer tshwj xeeb tshaj yog rau cov neeg uas muaj BRAF hloov. Cov tshuaj tib yam tsis zoo thiab qee zaum txaus ntshai rau cov neeg uas tsis muaj kev sib hloov.

Kev kuaj ntshav BRAF kuj tseem siv tau los saib seb koj puas yuav muaj feem yuav mob qog noj ntshav raws keeb kwm tsev neeg thiab / lossis koj li keeb kwm kev noj qab haus huv.

Vim li cas kuv thiaj li xav tau BRAF kev kuaj mob?

Koj yuav tsum tau kuaj BRAF yog tias koj tau tshawb pom tias muaj mob melanoma lossis lwm yam mob qog noj ntshav. Paub seb koj puas muaj kev hloov pauv tuaj yeem pab koj tus kws kho mob tau sau ntawv rau txoj kev kho mob.

Koj tseem yuav xav tau qhov kev ntsuas no kom pom tias koj muaj feem ntau yuav ua mob qog nqaij hlav cancer. Tej yam txaus ntshai xam nrog rau tsev neeg keeb kwm muaj mob qog noj ntshav thiab / lossis muaj mob qog noj ntshav thaum tseem yau. Lub hnub nyoog tshwj xeeb yog nyob ntawm hom mob qog noj ntshav.


Yuav muaj dab tsi tshwm sim thaum kuaj BRAF?

Kev kuaj ntshav ntawm BRAF feem ntau tau ua nyob rau hauv tus txheej txheem hu ua qog nqaij hlav. Lub sijhawm txiav me me, cov kws kho mob yuav tshem tawm ib qho nqaij me me los ntawm kev txiav lossis khawb tawv nqaij lub ntsej muag. Yog tias koj tus kws kho mob xav kuaj qog nqaij hlav hauv koj lub cev, nws yuav siv ib rab koob tshwj xeeb los thim qhov hnoos qeev.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Koj feem ntau tsis tas yuav npaj tshwj xeeb rau kev xeem BRAF.

Puas muaj kev pheej hmoo rau kev kuaj?

Tej zaum koj yuav muaj nqaij me me los ntshav los ntawm qhov nqaij me. Koj kuj tseem yuav muaj kev tsis xis nyob me ntsis rau ntawm qhov chaw ib hnub lossis ob hnub.

Cov txiaj ntsig li cas?

Yog tias koj muaj tus mob melanoma lossis lwm hom mob qog nqaij hlav, thiab cov txiaj ntsig pom tias koj muaj BRAF hloov pauv, koj tus kws kho mob tuaj yeem sau tshuaj rau cov tshuaj uas tsim los ua kom muaj kev sib hloov. Cov tshuaj no tuaj yeem ua tau zoo dua li lwm txoj kev kho mob.

Yog tias koj muaj mob melanoma lossis lwm yam mob qog nqaij hlav, thiab cov txiaj ntsig tau qhia koj tsis txhob muaj kev sib hloov, koj tus kws kho mob yuav sau ntawv tawm ntau hom tshuaj los kho koj tus mob qog noj ntshav.


Yog tias koj tsis tau kuaj pom tias mob qog nqaij hlav cancer thiab koj cov txiaj ntsig tau pom tias koj muaj BRAF caj ces hloov, nws yog tsis muaj txhais tau tias koj muaj mob qog noj ntshav, tab sis koj muaj feem yuav mob khees xaws. Tab sis kev kuaj kheesxaws ntau dhau, xws li kuaj daim tawv nqaij tuaj yeem txo koj qhov kev pheej hmoo. Thaum kuaj daim tawv, tus kws saib xyuas kev noj qab haus huv yuav ua tib zoo saib daim tawv nqaij ntawm koj lub cev tag nrho kom kuaj seb puas yog moles thiab lwm yam kev loj hlob ntxiv.

Tham nrog koj tus kws kho mob txog lwm cov kauj ruam uas koj tuaj yeem ua los txo koj txoj kev pheej hmoo.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv uas kuv xav paub txog kev kuaj mob BRAF?

Koj tuaj yeem hnov ​​koj tus kws kho mob tham txog kev hloov pauv V600E. Muaj ntau hom kev sib txawv ntawm BRAF hloov pauv. V600E yog qhov feem ntau siv ntau yam ntawm BRAF hloov pauv.

Ua tim khawv

  1. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Melanoma Cov Nqaij Tawv Rog; [hais 2018 2018 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/melanoma-skin-cancer.html
  2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Oncogenes thiab qog suppressor noob; [kho tshiab 2014 Jun 25; hais 2018 Jul 10]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-Suppressor-genes.html
  3. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Cov Hom Phiaj Kho rau Melanoma Cov Mob Qog Nqaij; [kho tshiab 2018 Jun 28; hais 2018 Jul 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
  4. Cancer.Net [Is Taws Nem]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Kev Tshuaj Ntsuas Genetic rau Cov Kab Mob Cancer; 2017 Jul [hais 2018 2018 10]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.net/navigating-cancer- zov/cancer-basics/genetics/genetic-testing-cancer-risk
  5. Cancer.Net [Is Taws Nem]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005–2018. Nkag Siab Kev Kho Mob Rau Lub Hom Phiaj; 2018 Tsib Hlis [2018 2018 2018 10]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
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  7. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C: Koom Haum Asmeskas rau Chaw Kuaj Mob; c2001–2018. Txaij Nraum; [kho tshiab 2017 Jul 10; hais 2018 Jul 10]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/glossary/biopsy
  8. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .: Koom Haum Asmeskas Rau Chaw Kuaj Mob; c2001–2018. Kev tshuaj ntsuam caj ces rau Hom Phiaj Kho Mob; [kho tshiab 2018 Jul 10; hais 2018 Jul 10]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
  9. Mayo Clinic: Mayo Medical Laboratories [Is Taws Nem]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1995–2018. Test ID: BRAFT: BRAF Qhov Kev Ntsuam Xyuas Kev Tshawb Fawb (V600E), Qhov Cuam Tshuam: Soj Ntsuam thiab Txhais Lus; [hais 2018 2018 10]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
  10. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Kev Tshuaj Ntsuam Xaj rau Kab Mob Cancer Ntshav Tes Taw; [hais 2018 2018 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
  11. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI phau ntawv txhais lus ntawm Cancer Cov Lus Cog Tseg: BRAF gene; [hais 2018 2018 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
  12. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI phau ntawv txhais lus ntawm Cov Lus Cog Tseg Cancer: BRAF (V600E) hloov pauv; [hais 2018 2018 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
  13. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI Lus Txhais ntawm Cancer Cov Lus Cog Tseg: noob; [hais 2018 2018 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
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  15. NIH Lub Tebchaws Asmeskas Cov Tsev Kuaj Tshuaj (Genetics) Hauv Tsev [Hauv Is Taws Nem]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; BRAF gene; 2018 Jul 3 [raug nplua 2018 Jul 10]; [txog 3 ntxaij]. Muaj los ntawm: https://ghr.nlm.nih.gov/gene/BRAF
  16. NIH Lub Tebchaws Asmeskas Cov Tsev Kuaj Tshuaj (Genetics) Hauv Tsev [Hauv Is Taws Nem]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Lub cev hloov pauv tau zoo li cas thiab kev hloov pauv muaj li cas ?; 2018 Jul 3 [raug nplua 2018 Jul 10]; [txog 3 ntxaij]. Muaj los ntawm: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
  17. Kev Tshawb Nrhiav Yeeb Yam [Internet]. Kev Tshawb Nrhiav Yeeb Yam; c2000–2017. Cov Chaw Xeem: Melanoma, BRAF V600 Kev Sib Koom Tes, Cobas: Cov Lus Txhais; [hais 2018 2018 10]; [txog 4 ntxaij]. Muaj los ntawm: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
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  20. UW Kev Noj Qab Haus Huv [Is Taws Nem]. Madison (WI): University of Wisconsin Cov Tsev Kho Mob thiab Chaw Kho Mob; c2018. Cov Ntaub Ntawv Kev Noj Qab Haus Huv: Kev Kuaj Ib Ce ntawm daim tawv nqaij rau Kev Mob Cancer Ntawm Daim tawv nqaij: Kuaj xyuas ib txwm; [kho tshiab 2017 Tsib Hlis 3; hais 2018 Jul 18]; [txog 2 ntxaij]. Muaj los ntawm: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
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  22. UW Health: American Family Cov Menyuam Lub Tsev Kho Mob [Is Taws Nem]. Madison (WI): University of Wisconsin Cov Tsev Kho Mob thiab Chaw Kho Mob; c2018. Cov Menyuam Txoj Kev Noj Qab Haus Huv: Biopsy; [hais 2018 2018 10]; [txog 3 ntxaij]. Muaj los ntawm: https://www.uwhealthkids.org/kidshealth/en/parents/biopsy.html/
  23. Zial J, Hui P. BRAF hloov coj mus kuaj hauv chaw kho mob. Tus Kws Paub Txog Rev Mol Diagn [Internet]. 2012 Mar [hais 2018 2018 10]; 12 (2): 127–38. Muaj los ntawm: https://www.ncbi.nlm.nih.gov/pubmed/22369373

Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.

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