Antineutrophil Cytoplasmic Antibodies (ANCA) Kev Ntsuas

Zoo Siab

• Qhov tshuaj tiv thaiv antineutrophil cytoplasmic antibodies (ANCA) yog dab tsi?
• Nws siv rau dab tsi?
• Vim li cas kuv thiaj li xav tau ANCA kuaj?
• Muaj dab tsi tshwm sim thaum ANCA kuaj?
• Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?
• Puas muaj kev pheej hmoo rau kev kuaj?
• Cov txiaj ntsig li cas?
• Puas muaj lwm yam ntxiv uas kuv xav paub txog qhov kev kuaj ANCA?
• Ua tim khawv

Qhov tshuaj tiv thaiv antineutrophil cytoplasmic antibodies (ANCA) yog dab tsi?

Txoj kev kuaj no nrhiav cov tshuaj tiv thaiv antineutrophil cytoplasmic antibodies (ANCA) hauv koj cov ntshav. Tshuaj tua kab mob yog cov protein ua kom koj lub cev tiv thaiv kab mob sib kis cov tshuaj txawv teb chaws xws li kab mob thiab kab mob. Tab sis ANCAs tawm tsam cov hlwb noj qab haus huv hu ua neutrophils (hom ntshav dawb) los ntawm kev ua txhaum. Qhov no tuaj yeem ua rau qhov kev tsis txaus siab hu ua autoimmune vasculitis. Txoj hlab vas vas kiag ua rau lub hlwb thiab o ntawm cov hlab ntshav.

Cov hlab ntshav xa cov ntshav los ntawm koj lub plawv mus rau koj cov plab hnyuv siab raum, cov ntaub so ntswg, thiab lwm lub tshuab, thiab rov qab los dua. Hom hlab ntsha muaj hlab ntsha, leeg ntshav, thiab hlab ntsha. Kev o nyob rau hauv cov hlab ntshav tuaj yeem ua rau muaj mob loj. Teeb meem sib txawv nyob ntawm seb cov hlab ntsha thiab lub cev raug cuam tshuam li cas.

Muaj ob qho tseem ceeb ntawm ANCA. Txhua lub hom phiaj tshwj cov protein nyob hauv cov qe ntshav dawb:

• pANCA, uas lub hom phiaj yog protein hu ua MPO (myeloperoxidase)
• cANCA, uas lub hom phiaj muaj protein hu ua PR3 (proteinase 3)

Qhov ntsuas tuaj yeem tuaj yeem qhia tau tias koj muaj ib lossis ob hom tshuaj tiv thaiv. Qhov no tuaj yeem pab koj tus kws kho mob txheeb xyuas thiab kho koj cov kev mob.

Lwm lub npe: Cov tshuaj tiv thaiv ANCA, cANCA pANCA, koob tshuaj tiv thaiv cytoplasmic neutrophil, ntshav ntshiab, anticytoplasmic autoantibodies

Nws siv rau dab tsi?

Kev kuaj ANCA feem ntau siv los tshawb xyuas seb koj puas muaj hom mob autoimmune vasculitis. Nws muaj ntau hom kev tsis meej no. Lawv txhua tus ua rau o thiab o ntawm cov hlab ntshav, tab sis txhua hom cuam tshuam rau cov hlab ntsha sib txawv thiab qhov chaw ntawm lub cev. Hom mob autoimmune vasculitis muaj xws li:

• Granulomatosis nrog polyangiitis (GPA), yav dhau los hu ua Wegener's disease. Feem ntau nws cuam tshuam rau lub ntsws, lub raum, thiab tej yam ua txhaum.
• Kab mob ntsig txog me me (MPA). Qhov kev tsis zoo no yuav cuam tshuam rau ntau yam kabmob hauv lub cev, suav nrog lub ntsws, raum, lub paj hlwb, thiab daim tawv.
• Eosinophilic granulomatosis nrog polyangiitis (EGPA), yav tas los hu ua Churg-Strauss syndrome. Qhov kev tsis zoo no feem ntau cuam tshuam rau daim tawv nqaij thiab lub ntsws. Nws feem ntau ua rau hawb pob.
• Polyesteritis nodosa (PAN). Qhov kev tsis zoo no feem ntau cuam tshuam rau lub siab, ob lub raum, tawv nqaij, thiab lub hauv nruab nrog poob siab.

Kev tshuaj ntsuam ANCA kuj tseem siv tau los saib xyuas kev kho mob ntawm cov kev tsis zoo no.

Vim li cas kuv thiaj li xav tau ANCA kuaj?

Koj tus kws kho mob yuav yuam kom kuaj ANCA yog tias koj muaj cov tsos mob ntawm tus mob autoimmune vasculitis. Cov tsos mob muaj xws li:

• Ua npaws
• Nkees
• Lub cev yuag
• Mob thiab / lossis mob ib ce

Koj cov tsos mob kuj yuav cuam tshuam rau ib lossis ntau cov kabmob hauv koj lub cev. Cov kab mob uas nquag muaj nrog thiab cov tsos mob uas lawv ua rau muaj xws li:

• Ob lub qhov muag
  • Liab
  • Qhov muag plooj
  • Tsis pom kev
• Pob Ntseg
  • Lub pob ntseg hauv pob ntseg (tinnitus)
  • Hnov tsis hnov ​​lus
• Kev txhaum
  • Sinus mob
  • Los ntswg
  • Ntswg ntshav
• Daim tawv nqaij
  • Pob tw
  • Cov qhov txhab lossis mob txhab, yog ib hom mob sib sib zog nqus uas maj mam kho thiab / lossis rov qab los
• Lub ntsws
  • Hnoos
  • Teeb meem ua pa
  • Kev mob hauv siab
• Raum
  • Cov ntshav hauv cov zis
  • Ua npuas ncauj zis, uas yog tshwm sim los ntawm cov protein nyob hauv cov zis
• Kev tswj hwm leeg
  • Loog thiab tingling nyob rau ntau qhov chaw ntawm lub cev

Muaj dab tsi tshwm sim thaum ANCA kuaj?

Tus kws kho mob yuav kuaj ntshav ntawm txoj hlab ntshav hauv koj txhais caj npab, siv rab koob me me. Tom qab cov koob raug tso nkag, cov ntshav me me yuav raug sau rau hauv lub khob kuaj lossis vial. Koj tuaj yeem hnov ​​me ntsis thaum cov koob nkag mus lossis tawm. Qhov no feem ntau yuav siv sijhawm tsawg dua tsib feeb.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Koj tsis tas yuav muaj kev npaj tshwj xeeb rau qhov kev ntsuas ANCA.

Puas muaj kev pheej hmoo rau kev kuaj?

Txoj kev kuaj ntshav muaj feem me me. Koj yuav muaj mob me lossis doog ntshav ntawm qhov chaw tso rab koob, tab sis feem ntau cov tsos mob ploj mus sai.

Cov txiaj ntsig li cas?

Yog tias koj cov txiaj ntsig tau tsis zoo, nws txhais tau tias koj cov kev mob tshwm sim tej zaum tsis yog vim autoimmune vasculitis.

Yog tias koj cov txiaj ntsig tau zoo, nws yuav txhais tau tias koj muaj tus mob autoimmune vasculitis. Nws kuj tuaj yeem qhia tau yog tias pom cANCAs lossis pANCAs. Qhov no tuaj yeem pab txiav txim siab txog hom vasculitis uas koj muaj.

Tsis hais hom twg ntawm cov tshuaj tiv thaiv tau pom, koj yuav xav tau kev sim ntxiv, hu ua biopsy, kom paub meej cov mob. Txoj kev kuaj me me yog ib qho txheej txheem uas tshem ib qho hnoos qeev me me lossis cov cell mus kuaj. Koj tus kws saib xyuas kev noj qab haus huv kuj tuaj yeem hais kom kuaj ntxiv los ntsuas ntsuas ANCA hauv koj cov ntshav.

Yog tias koj tab tom kho tus kab mob autoimmune vasculitis, koj cov txiaj ntsig yuav qhia tau tias qhov kev kho koj puas ua haujlwm.

Yog koj muaj lus nug txog koj cov txiaj ntsig, nrog koj tus kws kho mob tham.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv uas kuv xav paub txog qhov kev kuaj ANCA?

Yog tias koj cov txiaj ntsig ANCA qhia tau tias koj muaj tus mob autoimmune vasculitis, muaj ntau txoj hauv kev los kho thiab tswj tus mob. Cov kev kho mob yuav suav nrog tshuaj, kev kho mob uas tshem tawm ANCAs ib ntus ntawm koj cov ntshav, thiab / lossis phais.

Ua tim khawv

1. Allina Kev Noj Qab Haus Huv [Is Taws Nem]. Minneapolis: Allina Kev Noj Qab Haus Huv; C-ANCA ntsuas; [hais tawm 2019 Tsib Hlis 3]; [txog 3 ntxaij]. Muaj los ntawm: https://account.allinahealth.org/library/content/49/150100
2. Allina Kev Noj Qab Haus Huv [Is Taws Nem]. Minneapolis: Allina Kev Noj Qab Haus Huv; P-ANCA ntsuas; [hais tawm 2019 Tsib Hlis 3]; [txog 3 ntxaij]. Muaj los ntawm: https://account.allinahealth.org/library/content/49/150470
3. Cleveland Clinic [Hauv Is Taws Nem]. Cleveland (OH): Cleveland Clinic; c2019. Ceg Ceg thiab Mob Pob Ntse; [hais tawm 2019 Tsib Hlis 3]; [txog 3 ntxaij]. Muaj los ntawm: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C: Koom Haum Asmeskas rau Chaw Kuaj Mob; c2001–2019. Tshuaj tiv thaiv ANCA / MPO / PR3; [kho tshiab 2019 Apr 29; raug nplua 2019 Tsib Hlis 3]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .: Koom Haum Asmeskas Rau Chaw Kuaj Mob; c2001–2019. Txaij Nraum; [kho tshiab 2017 Jul 10; raug nplua 2019 Tsib Hlis 3]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/glossary/biopsy
6. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .: Koom Haum Asmeskas Rau Chaw Kuaj Mob; c2001–2019. Vasculitis; [kho tshiab 2017 Sep 8; raug nplua 2019 Tsib Hlis 3]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-txuam Me-Vessel Vasculitis. Am Nkaub Tus Kws Kho Mob [Internet]. 2002 Lub Plaub Hlis Tim 15 [txheeb 2019 Tsib Hlis 3]; 65 (8): 1615–1621. Muaj los ntawm: https://www.aafp.org/afp/2002/0415/p1615.html
8. Mayo Clinic Lub Chaw Kuaj Mob [Internet]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1995–2019. Test ID: ANCA: Cytoplasmic Neutrophil Antibodies, Ntshav: Kho mob thiab Sib; [hais tawm 2019 Tsib Hlis 3]; [txog 4 ntxaij]. Muaj los ntawm: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. Teb Chaws Lub Plawv, Lub Ntsws, thiab Koom Haum Ntshav [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Kuaj ntshav; [hais tawm 2019 Tsib Hlis 3]; [txog 3 ntxaij]. Muaj los ntawm: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. Teb Chaws Lub Plawv, Lub Ntsws, thiab Koom Haum Ntshav [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Vasculitis; [hais tawm 2019 Tsib Hlis 3]; [txog 2 ntxaij]. Muaj los ntawm: https://www.nhlbi.nih.gov/health-topics/vasculitisitis
11. Radice A, Sinico RA. Tshuaj Antineutrophil Cytoplasmic Antibodies (ANCA). Autoimmunity [Internet]. 2005 Feb [hais tawm 2019 Tsib Hlis Tim 3]; 38 (1): 93–103. Muaj los ntawm: https://www.ncbi.nlm.nih.gov/pubmed/15804710
12. Chaw UNC raum [Is Taws Nem]. Chapel Hill (NC): Chaw UNC raum; c2019. ANCA Vasculitis; [kho tshiab 2018 Sep; raug nplua 2019 Tsib Hlis 3]; [txog 3 ntxaij]. Muaj los ntawm: https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/anca-vasculitis

Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.