Elexacaftor, Tezacaftor, thiab Ivacaftor

Zoo Siab

• Ua ntej noj ntawm kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor,
• Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor tuaj yeem ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor yog siv los kho qee yam mob cystic fibrosis (mob inborn uas ua rau muaj teeb meem nrog kev ua pa, plab zom mov, thiab rov tsim dua tshiab) hauv cov laus thiab menyuam hnub nyoog 12 xyoos thiab laus dua. Nws yuav tsum tau siv rau hauv cov neeg muaj qee yam caj ces tsim nkaus xwb. Koj tus kws kho mob yuav kom kuaj ntshav los pab txiav txim seb cov tshuaj no puas zoo rau koj. Elexacaftor thiab tezacaftor yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua cystic fibrosis transmembrane conductance regulator (CFTR) correctors. Ivacaftor yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Cov tshuaj no ua haujlwm los ntawm kev txhim kho lub luag haujlwm ntawm cov protein nyob hauv lub cev kom txo qis txhim kho cov hnoos qeev hauv lub ntsws thiab txhim kho lwm cov tsos mob cystic fibrosis.

Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor tuaj ua cov ntsiav tshuaj los noj ntawm qhov ncauj. Txhua koob tshuaj txhua hnub muaj ntau hom ntsiav tshuaj: ib ntsiav tshuaj yog kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor thiab lwm lub ntsiav tshuaj yog ivacaftor. Siv elexacaftor, tezacaftor, thiab ivacaftor (2 lub txiv kab ntxwv) txhua tag kis sawv ntxov nrog cov khoom noj muaj roj thiab ivacaftor (1 ntsiav tshuaj xiav) txhua hmo nrog rau cov khoom noj muaj roj, 12 teev sib nrug. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj cov tshuaj no raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov ntsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv.

Siv kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor nrog cov khoom noj muaj roj xws li qe, butter, txiv ntoo, txiv laum huab xeeb, cheese pizza, thiab tag nrho cov khoom noj mis nyuj (xws li mis nyuj, cheese, thiab yogurt). Tham nrog koj tus kws kho mob txog lwm cov zaub mov muaj roj los noj nrog cov tshuaj no.

Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor ua haujlwm los tswj cystic fibrosis, tab sis nws tsis kho nws.Txuas ntxiv noj cov tshuaj no txawm hais tias koj twb xis neej. Tsis txhob tsum tsis txhob noj cov tshuaj no yam tsis tau tham nrog koj tus kws kho mob.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj ntawm kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor,

• qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj muaj kev fab tshuaj rau elexacaftor, tezacaftor, thiab ivacaftor lwm yam tshuaj noj, lossis ib qho twg hauv cov tshuaj hauv elexacaftor, tezacaftor, thiab ivacaftor ntsiav tshuaj. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov ntawv yuav tshuaj, cov vitamins, khoom noj khoom haus muaj txiaj ntsig zoo, koj noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: qee yam tshuaj tua kab mob xws li clarithromycin (Biaxin, hauv PrevPac) thiab erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin); qee yam antifungals xws li fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), thiab voriconazole (Vfend); cov tshuaj ua kom ntshav qab zib (statins) xws li atorvastatin (Lipitor, hauv Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pravastatin (Pravachol), rosuvastatin (Crestor), thiab simvastatin (Zocor, hauv Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Afinitor, Zortress); glimepiride (Amaryl); glipizide (Glucotrol); glyburide (Mob Ntshav Qab Zib); tshuaj tiv thaiv cev xeeb tub (tshuaj txwv, thaj ua rau thaj, pleev ib ce, lossis hno); qee cov tshuaj rau qaug dab peg xws li carbamazepine (Carbatrol, Epitol, Tegretol, lwm tus), phenobarbital, thiab phenytoin (Dilantin, Phenytek); cais pawg; rov ua dua tshiab; rifabutin (Mycobutin); rifampin (Rifadin, hauv Rifamate, hauv Rifater, Rimactane); sirolimus (Rapamune); tacrolimus (Astagraf, Prograf), lossis warfarin (Coumadin, Jantoven). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog elexacaftor, tezacaftor, lossis ivacaftor, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias cov uas tsis tshwm hauv cov npe no.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort. Koj tus kws kho mob yuav qhia koj kom tsis txhob coj St. John lub wort thaum noj tshuaj sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor.
• qhia rau koj tus kws kho mob yog tias koj muaj lossis tau muaj mob siab lossis mob raum.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor, hu rau koj tus kws kho mob.
• koj yuav tsum paub tias cov tshuaj no tuaj yeem ua rau koj tsaug zog. Tsis txhob tsav tsheb los sis siv lub tshuab ua haujlwm kom txog thaum koj paub tias cov tshuaj no cuam tshuam rau koj li cas.

Tsis txhob noj txiv kab ntxwv qaub lossis haus cov txiv kab ntxwv kua txiv thaum noj cov tshuaj no.

Yog tias koj nco qab noj thaum sawv ntxov los sis yav tsaus ntuj tsis dhau 6 teev ntawm lub sijhawm uas koj tau teem caij mus noj, noj cov tshuaj uas ploj lawm tam sim ntawd nrog ib qho khoom noj muaj rog thiab noj koj lub sijhawm noj tshuaj ntxiv. Txawm li cas los xij, yog tias ntau dua 6 teev tau dhau mus txij li lub sijhawm tau teem sijhawm los noj koj cov tshuaj rau yav sawv ntxov, noj cov tshuaj thaum sawv ntxov uas tsis pom zoo sai li sai tau thiab hla kev noj tshuaj rau yav tsaus ntuj, tom qab ntawv txuas ntxiv koj cov sijhawm noj tshuaj tas li. Yog tias ntau dua 6 teev tau dhau mus txij li lub sijhawm tau teem sijhawm los noj rau yav tsaus ntuj, hla lub sijhawm noj hmo uas ploj mus thiab rov qab noj tshuaj li qub. Tsis txhob noj thaum sawv ntxov thiab yav tsaus ntuj noj hmo ua ke los ua ib qho tshuaj xiam ib qho.

Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor tuaj yeem ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob taub hau
• los ntswg, txham, thiab txhaws ntswg; ua npaws; hnoos; lossis lwm cov cim ntawm kev kis mob
• mob plab los yog o
• zawv plab
• ua pob
• roj
• qhov muag daj
• khaus

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

• daj ntawm daim tawv nqaij lossis qhov muag
• tsis qab los noj mov
• xeev siab
• ntuav
• daj ntseg quav
• mob plab
• tsaus zis

Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor tuaj yeem ua rau mob cataracts (zawm ntawm lub teeb meem ntawm lub qhov muag uas yuav ua teeb meem tsis pom kev) hauv cov menyuam yaus thiab cov hluas. Cov menyuam yaus thiab tub ntxhais hluas tau noj elexacaftor, tezacaftor, thiab ivacaftor yuav tsum mus ntsib kws kho qhov muag ua ntej thiab thaum kho lawv. Tham nrog koj tus menyuam tus kws khomob txog cov kev pheej hmoo ntawm kev muab elexacaftor, tezacaftor, thiab ivacaftor rau koj tus menyuam.

Kev sib xyaw ntawm elexacaftor, tezacaftor, thiab ivacaftor tuaj yeem ua rau lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj kuaj qhov muag (rau menyuam yaus thiab tub ntxhais hluas) thiab qee qhov kev kuaj ntshav kuaj xws li daim siab ua ntej thiab thaum kho koj lub cev kom kuaj xyuas koj lub cev cov lus teb rau elexacaftor, tezacaftor, thiab ivacaftor.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Trikafta^®