Axicabtagene Ciloleucel Txhaj Tshuaj

Zoo Siab

• Ua ntej txhaj tshuaj axicabtagene ciloleucel,
• Axicabtagene ciloleucel tuaj yeem tshwm sim phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd:

Cov tshuaj hu ua axicabtagene ciloleucel txhaj tshuaj tuaj yeem ua rau muaj kev mob hnyav lossis tuag taus uas hu ua cytokine tso syndrome (CRS). Tus kws kho mob lossis tus nais maum yuav saib xyuas koj kom zoo thaum lub sijhawm koj nqus dej thiab tsawg kawg 4 lub lis piam tom qab. Qhia koj tus kws kho mob yog tias koj muaj mob voos los sis yog tias koj muaj lossis xav tias koj muaj qee yam mob tam sim no. Koj yuav tau muab tshuaj rau 60 feeb ua ntej koj txoj kev lis ntshav los pab tiv thaiv kev tsis haum rau axicabtagene ciloleucel. Yog tias koj pom cov tsos mob hauv qab no thaum lub sijhawm thiab tom qab koj qhov hnoos qeev, qhia koj tus kws kho mob tam sim ntawd: kub taub hau, ua daus no, ceev ceev lossis lub plawv dhia, tshee, raws plab, nkees, qaug zog, tsis muaj zog, ua pa nyuaj, ua pa luv, xeev siab, ntuav, ntuav , lossis teeb pom kev loj.

Cov tshuaj hu ua axicabtagene ciloleucel txhaj tshuaj tuaj yeem ua rau mob hnyav lossis tuag taus rau lub nruab nrog lub paj hlwb loj. Cov kev tsis haum no tuaj yeem tshwm sim tom qab kho nrog axicabtagene ciloleucel. Qhia rau koj tus kws kho mob yog tias koj tau ua lossis tau muaj mob chua leeg dua, mob stroke lossis nco nco. Yog tias koj muaj cov tsos mob li hais hauv qab no, qhia rau koj tus kws kho mob tam sim ntawd: mob taub hau, kiv taub hau, teeb meem tsis tsaug zog lossis pw tsaug zog, nyob tsis tswm, ntxhov siab, ntxhov siab, tsis tuaj yeem tuav ntawm ib feem ntawm lub cev, tsis nco qab, ntxhov siab, qaug dab peg, ploj ntawm sib npaug, nyuaj to taub, lossis nyuaj hais lus.

Axicabtagene ciloleucel kev txhaj tshuaj tsuas yog muaj los ntawm cov kev txwv tshwj xeeb txwv txoj kev pabcuam vim tias muaj kev pheej hmoo ntawm CRS thiab cov hlab ntsha tsis zoo. Koj tsuas tau txais cov tshuaj los ntawm kws kho mob thiab chaw kho mob uas koom nrog txoj haujlwm. Nug koj tus kws kho mob yog tias koj muaj lus nug dab tsi txog txoj haujlwm no.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (phau Qhia Siv Tshuaj) thaum koj pib kho nrog axicabtagene ciloleucel. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Axicabtagene ciloleucel txhaj tshuaj yog siv los kho qee hom mob uas tsis yog Hodgkin lymphoma (mob qog nqaij hlav uas pib hauv cov qe ntshav dawb uas ib txwm sib ntaus sib tua) uas tau rov qab los lossis tsis cuam tshuam rau lwm txoj kev kho mob hauv cov neeg uas twb tau kho nrog tsawg kawg ob lwm tshuaj zuaj tshuaj. Axicabtagene ciloleucel kev txhaj tshuaj yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua autologous cellular immunotherapy, ib hom tshuaj uas tau npaj los siv hlwb los ntawm tus neeg mob cov ntshav. Nws ua haujlwm los ntawm kev ua rau lub cev tiv thaiv kab mob (ib pawg ntawm cov hlwb, cov nqaij thiab lub cev uas tiv thaiv lub cev los ntawm kev tua los ntawm cov kab mob, kab mob, mob hlwb, thiab lwm yam khoom uas ua rau muaj kabmob) los tua cov qog nqaij hlav cancer.

Tus mob axicabtagene ciloleucel kev txhaj tshuaj yog los ntawm qhov raug tshem tawm (ua kua) los txhaj tshuaj rau hauv ntshav (los ntshav) los ntawm tus kws kho mob lossis kws saib xyuas mob hauv kws kho mob lub chaw haujlwm lossis qhov chaw nruab nrab. Nws ib txwm muab rau ncua sijhawm ntev txog 30 feeb raws li kev noj tshuaj ib zaug. Ua ntej koj tau txais koj cov axicabtagene ciloleucel koob tshuaj, koj tus kws kho mob lossis kws saib xyuas neeg mob yuav muab lwm cov tshuaj kho mob los kho koj lub cev rau axicabtagene ciloleucel.

Ua ntej koj cov koob tshuaj axicabtagene ciloleucel yuav tsum tau txhaj, ib qhov piv txwv ntawm koj cov qe ntshav dawb yuav raug coj mus kuaj ntawm lub chaw khaws ntshav uas siv cov txheej txheem hu ua leukapheresis (txheej txheem uas tshem cov qe ntshav dawb hauv lub cev). Vim tias cov tshuaj no yog tsim los ntawm koj tus kheej lub hlwb, nws yuav tsum tau muab rau koj nkaus xwb. Nws yog ib qho tseem ceeb yuav tsum tuaj kom ncav sij hawm thiab kom tsis txhob ncua koj lub sijhawm teem mus kuaj ntawm tes lossis kom tau txais qhov tshuaj kho koj. Koj yuav tsum npaj kom nyob ze rau qhov chaw koj tau txais koj kev kho mob axicabtagene ciloleucel tsawg kawg 4 lub lis piam tom qab koj tau noj tshuaj. Koj tus neeg saib xyuas kev noj qab haus huv yuav tshuaj xyuas seb koj txoj kev khomob puas ua haujlwm thiab saib xyuas koj rau cov kev phiv uas tuaj yeem tshwm sim. Tham nrog koj tus kws kho mob txog kev npaj rau leukapheresis thiab dab tsi yuav tshwm sim thaum thiab tom qab ua txoj kev.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej txhaj tshuaj axicabtagene ciloleucel,

• qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj muaj kev fab tshuaj rau axicabtagene ciloleucel, gentamicin, lwm yam tshuaj noj, dimethyl sulfoxide (DMSO), lossis lwm yam tshuaj hauv axicabtagene ciloleucel txhaj. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: cov tshuaj steroids xws li dexamethasone, methylprednisolone (Medrol), prednisolone, thiab prednisone (Rayos). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia rau koj tus kws kho mob yog tias koj muaj lossis tau muaj teeb meem ua pa lossis mob ntsws, raum, mob plawv lossis siab mob siab.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum tau kuaj cev xeeb tub ua ntej koj pib kho axicabtagene ciloleucel kho mob. Yog tias koj xeeb tub thaum koj tau txhaj tshuaj axicabtagene ciloleucel, hu rau koj tus kws kho mob tam sim ntawd.
• koj yuav tsum paub tias kev txhaj tshuaj axicabtagene ciloleucel tuaj yeem ua rau koj tsaug zog thiab ua rau muaj kev kub ntxhov, qaug zog, kiv taub hau, qaug dab peg, thiab teeb meem ua kom sib haum. Tsis txhob tsav tsheb los yog tsav lub tshuab ua haujlwm tsawg kawg yog 8 lub lis piam tom qab koj cov axicabtagene ciloleucel koob tshuaj.
• tsis txhob tso cov ntshav, plab hnyuv siab raum, ntaub so ntswg, lossis lub hlwb rau kev hloov ntshav tom qab koj tau txais koj cov axicabtagene ciloleucel txhaj.
• Nug koj tus kws kho mob seb koj puas yuav tsum tau txhaj tshuaj tiv thaiv kab mob. Tsis txhob txhaj tshuaj tiv thaiv kab mob yam tsis tau tham nrog koj tus kws kho mob tsawg kawg 6 lub lis piam ua ntej pib siv tshuaj, thaum lub sijhawm koj axicabtagene ciloleucel kho, thiab txog thaum koj tus kws kho mob qhia koj tias koj lub cev tau zoo lawm.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Yog tias koj tsis tau mus ntsib raws li tau teem tseg, koj yuav tsum hu rau koj tus kws kho mob thiab lub chaw khaws khoom sai sai. Yog tias koj plam lub sijhawm teem sijhawm kom tau txais koj cov tshuaj axicabtagene ciloleucel, koj yuav tsum hu rau koj tus kws kho mob tam sim ntawd.

Axicabtagene ciloleucel tuaj yeem tshwm sim phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• cem quav
• mob plab
• rov qab mob
• mob pob qij txha lossis mob leeg
• qhov ncauj qhuav
• tsis qab los noj mov
• poob phaus

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd:

• ntshav hauv zis
• los ntshav yooj yim dua li ib txwm
• kub taub hau, mob caj pas, ua daus no, los yog lwm yam cim ntawm tus kab mob
• tsis tso zis ntau zaus lossis ntau npaum li cas
• daj ntseg tawv nqaij
• nkees
• o ntawm lub qhov muag, ntsej muag, daim di ncauj, tus nplaig, caj pas, caj npab, tes, taw, pob taws, lossis ceg qis
• teeb meem nqos
• ua pob
• khaus
• khaus

Cov tshuaj hu ua axicabtagene ciloleucel txhaj yuav ua rau koj muaj feem mob qog nqaij hlav cancer. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev tau txais cov tshuaj no.

Axicabtagene ciloleucel tuaj yeem ua rau muaj kev phiv ntxiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum tau txais cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws tag nrho cov kev teem caij ntsib nrog koj tus kws kho mob, chav tsev khaws cia ntawm tes, thiab chaw kuaj mob. Koj tus kws kho mob tuaj yeem xaj yam kev kuaj sim ua ntej, thaum, thiab tom qab koj cov tshuaj kho koj lub cev teb rau axicabtagene ciloleucel kev txhaj tshuaj.

Ua ntej muaj kev sim ntsuas, qhia rau koj tus kws kho mob thiab cov neeg ua haujlwm hauv lub chaw kuaj mob tias koj tau txhaj tshuaj axicabtagene ciloleucel. Cov tshuaj no yuav cuam tshuam rau qee yam kev sim hauv tsev sim.

Nug koj tus kws muag tshuaj yog tias koj muaj lus dab tsi txog kev txhaj tshuaj axicabtagene ciloleucel.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Yescarta^®