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Lumacaftor thiab Ivacaftor - Tshuaj Kho Mob
Lumacaftor thiab Ivacaftor - Tshuaj Kho Mob

Zoo Siab

Lumacaftor thiab ivacaftor yog siv los kho qee yam mob cystic fibrosis (ib qho mob hauv lub cev uas ua rau muaj teeb meem nrog kev ua pa, plab zom mov, thiab rov ua dua tshiab) hauv cov laus thiab menyuam hnub nyoog 2 xyoos thiab laus dua. Lumacaftor yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua cystic fibrosis transmembrane conductance regulator (CFTR) correctors. Ivacaftor yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.Ob yam tshuaj no ua haujlwm los ntawm kev txhim kho kev ua haujlwm ntawm cov protein nyob hauv lub cev kom txo qis qhov tsim tsa ntawm cov hnoos qeev hauv lub ntsws thiab txhim kho lwm cov tsos mob ntawm cystic fibrosis.

Kev sib xyaw ntawm lumacaftor thiab ivacaftor los ua ib ntsiav tshuaj thiab ua granules los noj ntawm qhov ncauj. Nws feem ntau yog noj nrog roj zaub mov ib hnub ob zaug, 12 teev sib nrug. Siv lumacaftor thiab ivacaftor nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj lumacaftor thiab ivacaftor raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.


Txhawm rau npaj ib koob tshuaj lumacaftor thiab ivacaftor granules, sib xyaw tag nrho cov pob zeb ntawm cov pob zeb hauv 1 me nyuam diav (5 mL) ntawm cov khoom noj muag muag lossis kua (txias los yog hauv chav kub) xws li kua mis nyeem qaub, txiv tsaj, paj pias, mis nyuj, lossis kua txiv. Siv cov tshuaj sib tov tag nrho hauv 1 teev tom qab tov cov granules nrog cov khoom noj lossis kua.

Noj lumacaftor thiab ivacaftor nrog cov zaub mov muaj roj xws li qe, avocados, txiv ntoo, butter, txiv laum huab xeeb, cheese pizza, mis nyuj thiab lwm yam khoom muaj mis zoo xws li cheese thiab yogurt muaj roj. Tham nrog koj tus kws kho mob txog lwm cov khoom noj muaj roj kom noj nrog lumacaftor thiab ivacaftor.

Lumacaftor thiab ivacaftor tswj hwm cystic fibrosis tab sis nws tsis kho nws. Txuas ntxiv mus noj lumacaftor thiab ivacaftor txawm hais tias koj tus kheej yuav xis nyob. Tsis txhob tsum noj lumacaftor thiab ivacaftor yam tsis tau tham nrog koj tus kws kho mob.

Yog tias koj tsis noj lumacaftor thiab ivacaftor rau 7 hnub lossis ntev dua, tsis txhob pib noj nws ntxiv yam tsis tau tham nrog koj tus kws kho mob. Koj tus kws khomob yuav tau pauv pauv koj cov tshuaj noj lossis lwm yam tshuaj koj noj.


Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj lumacaftor thiab ivacaftor,

  • qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj muaj kev fab tshuaj rau lumacaftor thiab ivacaftor, lwm yam tshuaj noj, lossis lwm yam tshuaj hauv lumacaftor thiab ivacaftor ntsiav tshuaj lossis granules. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias yam tshuaj twg thiab cov ntawv yuav tshuaj, cov vitamins, thiab cov khoom noj muaj txiaj ntsig koj noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: qee yam antifungals xws li itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), thiab voriconazole (Vfend); qee yam tshuaj tua kab mob xws li clarithromycin (Biaxin, hauv Prevpac), erythromycin (E.E.S., Erythrocin, Eryped, lwm tus), rifabutin (Mycobutin) thiab rifampin (Rifadin, Rifamate, Rifater, Rimactane); qee cov tshuaj rau cov ntshav qab zib xws li chlorpropamide (Diabinese), glimepiride (Amaryl, hauv Duetact), glipizide (Glucotrol), glyburide (Diabeta, Glynase, hauv Glucovance), repaglinide (Prandin), tolazamide thiab tolbutamide; digoxin (Lanoxin); ibuprofen (Advil, Motrin, hauv Vicoprofen); qee yam tshuaj tiv thaiv kab mob xws li cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) thiab tacrolimus (Astagraf, Prograf); midazolam; montelukast (Singulair); methylprednisolone (Medrol); prednisone (Rayos); qee yam tshuaj tiv thaiv cov tshuaj tiv thaiv (PPIs) xws li esomeprazole (Nexium, hauv Vimovo), lansoprazole (Prevacid, hauv Prevpac), thiab omeprazole (Prilosec, hauv Zegerid); ranitidine (Zantac); qee cov tshuaj rau qaug dab peg xws li carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, thiab phenytoin (Dilantin, Phenytek); qee yam xaiv cov serotonin reuptake inhibitors (SSRIs) xws li citalopram (Celexa), escitalopram (Lexapro), thiab sertraline (Zoloft); triazolam (Halcion); thiab warfarin (Coumadin, Jantoven). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog lumacaftor thiab ivacaftor, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias cov uas tsis tshwm hauv cov npe no.
  • qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort. Koj tus kws kho mob yuav qhia koj kom tsis txhob coj St. John lub wort thaum noj cov tshuaj lumacaftor thiab ivacaftor.
  • qhia rau koj tus kws kho mob yog tias koj tau ua lossis tau muaj teeb meem ua pa lossis mob ib ce, hloov khoom nruab nrog, lossis mob siab lossis mob raum.
  • koj yuav tsum paub tias lumacaftor thiab ivacaftor tuaj yeem txo qis kev ua haujlwm ntawm cov tshuaj tiv thaiv hormonal (tshuaj txwv, thaj ua rau thaj, ncig, txhaj tshuaj, siv tshuaj pleev ib ce, lossis khoom siv hauv lub cev). Tham nrog koj tus kws kho mob txog lwm txoj kev tswj tsis pub muaj menyuam uas yuav ua haujlwm rau koj thaum koj noj tshuaj lumacaftor thiab ivacaftor.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj cov tshuaj lumacaftor thiab ivacaftor, hu rau koj tus kws kho mob.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.


Yog tias koj nco qab cov koob tshuaj ploj hauv 6 teev ntawm lub sijhawm koj tau teem sijhawm mus noj, noj qhov tshuaj ploj tam sim ntawd. Txawm li cas los xij, yog tias ntau dua 6 teev tau dhau mus txij li lub sijhawm koj feem ntau noj lumacaftor thiab ivacaftor, hla cov koob tshuaj uas tsis nco qab thiab ua txuas ntxiv rau koj cov caij nyoog noj tshuaj tas li. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Lumacaftor thiab ivacaftor tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • txog siav
  • hauv siab nruj lossis mob
  • teeb meem ua pa
  • zawv plab
  • roj
  • nkees dhau heev lawm
  • ua pob
  • tsis xwm yeem, tu ncua, hnyav los yog mob coj khaub ncaws, tshwj xeeb tshaj yog rau cov poj niam noj tshuaj tiv thaiv hormonal
  • los ntswg, txham, hnoos, mob caj pas, lossis mob khaub thuas
  • mob caj pas
  • txhaws ntswg los ntswg
  • mob taub hau

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • xeev siab
  • ntuav
  • tsis qab los noj mov
  • mob hauv sab saud hauv plab
  • tsaus zis
  • tsis meej pem
  • daj ntawm daim tawv nqaij lossis qhov muag

Lumacaftor thiab ivacaftor tuaj yeem ua rau mob cataracts (clouding ntawm lub lens ntawm lub qhov muag uas tuaj yeem ua teeb meem tsis pom kev) hauv cov menyuam yaus thiab cov hluas. Cov menyuam yaus thiab tub ntxhais hluas tau noj cov tshuaj lumacaftor thiab ivacaftor yuav tsum mus ntsib kws kho qhov muag ua ntej thiab thaum kho lawv. Tham nrog koj tus menyuam tus kws khomob txog cov kev pheej hmoo ntawm kev muab lumacaftor thiab ivacaftor rau koj tus menyuam.

Lumacaftor thiab ivacaftor tuaj yeem ua rau lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev haus ntau tshaj yuav suav nrog:

  • mob taub hau
  • ua pob

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj kuaj sim ua ntej koj pib kho koj seb koj tus mob puas tuaj yeem raug kho nrog lumacaftor thiab ivacaftor vim tias nws yuav tsum tau siv rau cov tib neeg uas muaj cov caj ces tsim. Koj tus kws kho mob yuav xaj kuaj qhov muag thiab qee qhov kev sim ua ntej thiab thaum kho koj lub cev kom kuaj xyuas koj lub cev cov lus teb rau lumacaftor thiab ivacaftor. Koj cov ntshav siab yuav tsum kuaj xyuas tsis tu ncua thaum koj noj cov tshuaj no.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

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Kawg Kho - 05/15/2020

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