Ovarian overproduction ntawm androgens

Ovarian overproduction ntawm androgens yog ib yam mob uas zes qe menyuam ua rau muaj testosterone ntau dhau. Qhov no ua rau muaj kev txhim kho txiv neej tus yam ntxwv hauv poj niam. Androgens los ntawm lwm qhov ntawm lub cev kuj tseem tuaj yeem ua rau tus txiv neej tus yam ntxwv txhim kho hauv poj niam.

Hauv cov pojniam muaj kev noj qab haus huv, lub zes qe menyuam thiab cov qog ua qog ua tawm txog 40% mus rau 50% ntawm lub cev testosterone. Cov qog ntawm lub zes qe menyuam thiab polycystic ovary syndrome (PCOS) tuaj yeem ua rau ob qho dhau heev lawm androgen ntau lawm.

Cushing disease yog ib qho teeb meem nrog lub caj pas pituitary uas ua rau ntau dhau ntawm corticosteroids. Corticosteroids ua rau lub cev hloov ntawm tus txiv neej hauv cov poj niam. Cov hlav nyob rau cov qog adrenal kuj tseem tuaj yeem ua ntau dhau ntawm cov androgens thiab tuaj yeem ua rau tus txiv neej lub cev tus yam ntxwv hauv poj niam.

Theem siab ntawm androgens hauv tus poj niam tuaj yeem ua rau:

• Pob txuv
• Cov kev hloov pauv ntawm poj niam lub cev duab
• Txo lub mis loj
• Tshaj tawm hauv lub cev plaub hau hauv tus qauv txiv neej, xws li ntawm lub ntsej muag, puab tsaig, thiab plab
• Tsis muaj poj niam coj khaub ncaws (mob caj dab)
• Cov tawv nqaij oily

Tej kev pauv no tej zaum kuj yuav tshwm sim:

• Nce ntxiv rau qhov luaj li cas ntawm cov quav
• Ua ke ntawm lub suab
• Nce nyob rau hauv cov nqaij pawg
• Tawv plaub hau thiab plaub hau hle plaub hau nyob sab taub hau ntawm ob sab taub hau

Koj tus kws kho mob yuav kuaj mob lub cev. Ib qho kev kuaj ntshav thiab cov duab kos txiav txim yuav nyob ntawm koj cov tsos mob, tab sis yuav suav nrog:

• 17-hydroxyprogesterone kuaj
• ACTH xeem (txawv txawv)
• Kev kuaj ntshav roj ntshav
• Iav scan
• DHEA kuaj ntshav
• Kev kuaj qabzib
• Kev kuaj ntshav
• Pelvic ultrasound
• Prolactin kev tshuaj ntsuam (yog tias ntu tsawg los tsawg lossis tsawg txhua)
• Kev ntsuam xyuas Testosterone (ob qho tib si pub dawb thiab tag nrho testosterone)
• TSH xeem (yog tias muaj plaub hau poob)

Kev kho mob yog nyob ntawm cov teeb meem uas ua rau ntau ntxiv androgen ntau lawm. Cov tshuaj tuaj yeem muab rau txo qis hauv plaub hau rau cov poj niam uas muaj lub cev ntau dhau, los yog tswj kev coj khaub ncaws. Hauv qee kis, kev phais mob yuav tsum tau tshem tawm ovarian lossis qog adrenal.

Kev kho mob tiav yog nyob ntawm qhov ua kom dhau ntawm androgen ntau lawm. Yog tias tus mob tshwm sim los ntawm lub pob ntawm zes qe menyuam, phais mus tshem tawm cov qog tuaj yeem kho qhov teeb meem. Feem ntau cov hlav ntawm zes qe menyuam tsis mob qog nqaij hlav (tsis zoo) thiab yuav tsis rov qab los tom qab lawv tau tshem tawm.

Hauv polycystic ovary syndrome, cov kev ntsuas hauv qab no tuaj yeem txo cov tsos mob tshwm sim los ntawm theem siab androgen:

• Xyuam xim saib
• Lub cev yuag
• Kev noj haus hloov
• Cov tshuaj kho mob
• Kev tawm dag zog tsis tu ncua

Ntxiv lawm tshob thiab teeb meem thaum cev xeeb tub yuav tshwm sim.

Cov poj niam uas muaj mob polycystic zes qe menyuam muaj feem yuav raug:

• Mob ntshav qab zib
• Ntshav siab
• Cov roj (cholesterol) siab
• Kev pham
• Uterine cancer

Cov poj niam uas muaj mob polycystic zes qe menyuam tuaj yeem txo lawv cov kev hloov pauv ntawm cov teeb meem mus sij hawm ntev los ntawm kev tswj lub cev qhov hnyav los ntawm kev noj zaub mov zoo thiab tawm dag zog ib ce.

• Tshaj dhau kev zes qe menyuam
• Kev loj hlob Follicle

Bulun SE. Muaj sia thiab pathology ntawm poj niam kev muaj me nyuam axis. Hauv: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Phau Ntawv ntawm EndocrinologyCov. Xab 14th. Philadelphia, PA: Elsevier; 2020: chap 17.

Huddleston HG, Quinn M, Gibson M. Polycystic ovary syndrome thiab mob hirsutism. Hauv: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Phau Ntawv ntawm PediatricsCov. 21st ed. Philadelphia, PA: Elsevier; 2020: chap 567.

Lobo RA. Hyperandrogenism thiab androgen dhau: kev qhia kho lub cev, kev paub tshuaj, kev kuaj mob txawv txav, kev tswj hwm. Hauv: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Saib Hluag Tshaj Lij HlawvCov. 7 tus ed. Philadelphia, PA: Elsevier; 2017: chap 40.

Rosenfield RL, Barnes RB, Ehrmann DA. Hyperandrogenism, hirsutism, thiab polycystic ovary syndrome. Hauv: Jameson JL, De Groot LJ, de Kretser DM, li al, eds. Endocrinology: Cov Neeg Loj thiab PediatricCov. 7 tus ed. Philadelphia, PA: Elsevier Saunders; 2016: tshooj 133.