Tus Sau: Gregory Harris
Hnub Kev Tsim: 15 Lub Plaub Hlis Ntuj 2021
Hloov Hnub: 10 Lub Kaum Ib Hli Ntuj 2024
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Membranoproliferative Glomerulonephritis (Type 1 and 2) | MPGN-I & MPGN-II | Nephrology
Daim Duab: Membranoproliferative Glomerulonephritis (Type 1 and 2) | MPGN-I & MPGN-II | Nephrology

Membranoproliferative glomerulonephritis yog lub raum mob uas yuav ua rau muaj mob thiab hloov mus rau lub raum. Nws tuaj yeem ua lub raum tsis ua haujlwm.

Glomerulonephritis yog ib qho mob ntawm glomeruli. Lub glomeruli ntawm lub raum pab lim tawm thiab kua dej los ntawm cov ntshav tuaj rau hauv cov zis.

Membranoproliferative glomerulonephritis (MPGN) yog ib hom kev tiv thaiv glomerulonephritis los ntawm kev tiv thaiv lub cev tsis haum. Kev tso tawm ntawm cov tshuaj tiv thaiv txhim kho hauv ib feem ntawm lub raum hu ua glomerular hauv qab daus daim nyias nyias. Daim nyias nyias no pab kom lim dej thiab kua dej ntxiv hauv cov ntshav.

Kev puas tsuaj rau daim nyias nyias no cuam tshuam rau lub raum lub peev xwm los tsim cov zis ib txwm. Nws yuav ua rau tso ntshav thiab cov protein tawm mus rau hauv cov zis. Yog tias cov protein txaus mus rau hauv cov zis, cov kua dej yuav tuaj tawm ntawm cov hlab ntshav mus rau hauv lub cev nqaij, ua rau muaj qhov o (o qhuav). Nitrogen cov khoom pov tseg kuj tseem tuaj yeem txhim kho hauv cov ntshav (azotemia).

Ob daim ntawv ntawm tus kabmob no yog MPGN I thiab MPGN II.

Feem ntau ntawm cov neeg muaj tus mob no muaj hom I. MPGN II muaj tsawg dua. Nws tseem ua rau mob siab dua sai dua MPGN I.


Cov ua rau MPGN yuav suav nrog:

  • Cov kab mob autoimmune (kab mob lupus erythematosus, scleroderma, Sjögren syndrome, sarcoidosis)
  • Mob Cancer (kab mob ntshav siab, ntsws)
  • Cov kab mob (kab mob siab B, kab mob siab C, endocarditis, mob npaws)

Cov tsos mob tuaj yeem suav nrog ib qho hauv qab no:

  • Cov ntshav hauv cov zis
  • Hloov pauv hauv txoj kev xav hauv lub hlwb xws li tsis meej pem lossis tsis hnov ​​qab
  • Cloudy tso zis
  • Cov zis tsaus nti (haus luam yeeb, kafes, lossis dej xas kas fes)
  • Txo hauv cov zis ntau ntxiv
  • O rau qee qhov ntawm lub cev

Tus kws kho mob yuav kuaj xyuas koj thiab nug koj cov tsos mob. Tus kws kho mob yuav pom tias koj muaj paib ntau dhau ntawm lub cev, xws li:

  • O, ntau zaus nyob ntawm ceg
  • Lub suab tsis zoo thaum mloog koj lub siab thiab lub ntsws nrog lub stethoscope
  • Tej zaum koj muaj ntshav siab

Cov kev sim no hauv qab no pab txheeb xyuas qhov kev kuaj mob:

  • BUN thiab creatinine kev kuaj ntshav
  • Ntshav ntxiv qib
  • Mob Lub Hlaus
  • Zis protein
  • Siv raum (kom paub meej tias membranoproliferative GN I lossis II)

Txoj kev kho yog nyob ntawm tus tsos mob. Lub hom phiaj ntawm kev kho mob yog los txo cov tsos mob, tiv thaiv cov teeb meem, thiab qeeb tus txheej txheem ntawm qhov tshwm sim.


Tej zaum koj yuav xav tau pauv pauv kev noj haus. Qhov no suav nrog kev lim dej qab ntsev, kua lossis protein kom pab tswj ntshav siab, o, thiab txhim kho cov khoom pov tseg hauv cov ntshav.

Cov tshuaj uas yuav muab tshuaj suav nrog:

  • Tshuaj ntshav siab
  • Dipyridamole, nrog lossis tsis muaj tshuaj aspirin
  • Kev tshuaj ntsuab
  • Tshuaj noj rau tshuaj tiv thaiv kab mob, xws li cyclophosphamide
  • Steroids

Kev kho mob zoo dua rau menyuam yaus dua li cov laus. Limlysis lossis raum hloov raum tej zaum xav tau los tswj raum tsis ua haujlwm.

Qhov kev cuam tshuam no maj mam dhau zuj zus thiab thaum kawg ua rau lub raum tsis ua haujlwm lawm.

Ib nrab ntawm cov neeg muaj tus mob no yuav muaj mob raum (ncua ntev) raum tsis pub dhau 10 xyoo. Qhov no yuav muaj feem ntau dua hauv cov neeg uas muaj protein ntau dua hauv lawv cov zis.

Lwm yam mob uas yuav yog los ntawm tus kab mob no suav nrog:

  • Mob puas hlwb nephritic
  • Mob raum tsis ua hauj lwm
  • Mob raum

Hu mus teem sijhawm nrog koj tus kws khomob yog:


  • Koj muaj cov tsos mob ntawm tus mob no
  • Koj cov tsos mob mob heev dua los yog tsis ploj mus
  • Koj muaj cov tsos mob tshiab, suav nrog cov zis tso zis tsawg dua

Tiv thaiv kev kis mob xws li mob siab lossis tswj cov mob xws li mob pob ntseg tuaj yeem tiv thaiv MPGN.

Membranoproliferative GN Kuv; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Membranoproliferative glomerulonephritis; Lobular GN; Glomerulonephritis - membranoproliferative; MPGN hom I; MPGN hom II

  • Raum anatomy

Roberts ISD. Kab mob rau lub raum. Hauv: Hla SS, ed. Underwood's Pathology: Kev Qhia Txog Kev Soj NtsuamCov. 7 tus ed. Philadelphia, PA: Elsevier; 2019: chap 21.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Thawj tus kab mob glomerular. Hauv: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner thiab Rector's RaumCov. 11th ed. Philadelphia, PA: Elsevier; 2020: chap 31.

Sethi S, De Vriese AS, Fervenza FC. Membranoproliferative glomerulonephritis thiab cryoglobulinemic glomerulonephritis. Hauv: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Cov Chaw Kho Mob Tshaj LojCov. 6 tus ed. Philadelphia, PA: Elsevier; 2019: chap 21.

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