Neeg laus Tseem muaj mob

Cov Neeg Mob Tseem Ceeb (ASD) yog ib tus mob uas tsis tshua muaj mob uas ua rau muaj kev kub taub hau heev, tawm pob, thiab mob tej pob txha. Tej zaum yuav ua rau mob caj dab ntev ntev (mob).

Cov Neeg Tseem Muaj Kab Mob Tseem Ceeb yog ib hom mob hnyav ntawm cov hluas ua tsis tau dab tsi (JIA), uas tshwm sim rau cov menyuam yaus. Cov neeg laus tuaj yeem mob tus mob tib yam, txawm hais tias nws tsawg dua. Nws kuj tseem hu ua tus neeg mob-laus qhov tseem muaj tus kabmob (AOSD).

Tsawg dua li 1 leeg ntawm 100,000 tus neeg muaj tus mob ASD txhua xyoo. Nws cuam tshuam rau cov poj niam ntau dua li cov txiv neej.

Yam tshwm sim ntawm tus neeg laus Tseem muaj tus kab mob. Tsis muaj cov feem pheej hmoo rau tus mob tau raug txheeb xyuas.

Yuav luag txhua tus neeg uas muaj tus kabmob yuav ua npaws, mob pob txha, mob caj pas, thiab tawm pob.

• Mob ua ke, sov, thiab o yog tshwm sim. Feem ntau, ntau lub pob qij txha txuam nrog tib lub sijhawm. Feem ntau, cov neeg uas muaj tus mob no sawv ntxov khov kho ntawm cov pob qij txha uas kav mus ntev li ob peb teev.
• Qhov kub taub hau tuaj sai sai ib zaug hauv ib hnub, feem ntau yav tav su lossis yav tsaus ntuj.
• Cov tawv nqaij ua pob xoo feem ntau yog salmon xim liab thiab tuaj thiab nrog kub taub hau.

Cov tsos mob ntxiv muaj xws li:

• Mob plab thiab o
• Mob thaum noj sib sib zog nqus pa (pleurisy)
• Mob caj pas
• Cov qog ntshav o (qog)
• Lub cev yuag

Tus po lossis lub siab yuav o tuaj. Lub ntsws thiab lub plawv o tuaj yeem tshwm sim.

AOSD tsuas tuaj yeem kuaj tau tom qab ntau lwm yam kab mob (xws li kev kis mob thiab mob cancer) raug txiav txim. Tej zaum koj yuav xav tau ntau yam kev kuaj mob ua ntej kev kuaj mob zaum kawg.

Txoj kev kuaj mob lub cev yuav qhia pom kev ua npaws, ua pob liab vog thiab mob caj dab. Tus kws saib xyuas kev noj qab haus huv yuav siv lub stethoscope mloog rau kev hloov suab hauv koj lub plawv lossis lub ntsws.

Kev kuaj ntshav hauv qab no tuaj yeem pab tau hauv kev txheeb xyuas tus neeg laus Kab Mob Tseem Muaj:

• Ua kom tiav cov ntshav suav (CBC), tej zaum yuav qhia cov qe ntshav dawb (granulocytes) tsawg thiab txo cov qe ntshav liab tsawg.
• C-reactive protein (CRP), ib qho kev ntsuas ntawm tus mob, yuav siab dua qhov qub.
• ESR (kev ua kom loog), ntsuas kev o, yuav siab dua qhov qub.
• Qib Ferritin yuav raug heev.
• Qib Fibrinogen yuav siab.
• Kev tshuaj ntsuam xyuas lub siab ua haujlwm yuav qhia txog qib siab ntawm AST thiab ALT.
• Rheumatoid factor thiab ANA qhov kuaj yuav tsis zoo.
• Cov kab lis ntshav thiab cov kev tshawb fawb kis kab mob yuav tsis zoo.

Lwm txoj kev kuaj mob ntxiv tuaj yeem kuaj xyuas seb puas mob pob qij txha, hauv siab, siab, thiab hnoos qeev:

• Mob plab hauv ultrasound
• CT scan ntawm lub plab mog
• Xoo hluav taws xob ntawm pob qij txha, hauv siab, lossis lub plab (tsam plab)

Lub hom phiaj ntawm kev kho mob rau cov neeg laus Txawm hais tias yog kab mob los tswj cov tsos mob ntawm tus mob caj dab. Cov tshuaj aspirin thiab lwm cov tshuaj tiv thaiv tsis haum (NSAIDs), xws li ibuprofen, feem ntau yog siv ua ntej.

Siv Prednisone siv rau ntau qhov mob hnyav dua.

Yog tias tus kab mob no hnyav los yog mob ntev mus (mob ntev ntev), cov tshuaj uas los tiv thaiv cov kab mob tiv thaiv lub cev tej zaum yuav xav tau. Cov tshuaj no suav nrog:

• Methotrexate
• Anakinra (interleukin-1 receptor agonist)
• Tocilizumab (interleukin 6 inhibitor)
• Cov hlav qog nqaij hlav necrosis (TNF) antagonists xws li etanercept (Enbrel)

Hauv ntau tus neeg, cov tsos mob yuav rov qab los ntau zaus hauv ob peb xyoos tom ntej no.

Cov tsos mob mus txuas ntxiv tau ntev (mob ntev) nyob li ib feem peb ntawm cov neeg mob Cov Neeg Tseem Muaj Kab Mob.

Ib daim ntawv tsis tshua muaj kab mob, hu ua macrophage activation syndrome, muaj peev xwm ua tau mob hnyav nrog kev kub taub hau heev, mob hnyav thiab ntshav tsawg ntawm cov ntshav suav. Lub pob txha caj qaum yog koom tes thiab biopsy xav tau los ua qhov kev kuaj mob.

Lwm yam teeb meem yuav muaj xws li:

• Mob caj dab nyob hauv ob peb leeg
• Mob siab
• Mob rau hlwv
• Lub ntsej muag zoo nkauj effusion
• Spleen enlargement

Hu rau koj tus kws kho mob yog tias koj muaj cov tsos mob ntawm Cov Neeg Tseem Muaj Kab Mob.

Yog tias koj twb tau kuaj pom tus mob no, koj yuav tsum hu rau koj tus kws kho mob yog tias koj hnoos lossis ua pa nyuaj.

Tsis muaj kev paub txog kev tiv thaiv.

Tseem muaj tus kab mob - neeg loj; Neeg laus-pib tseem muaj kab mob; AOSD; Wissler-Fanconi syndrome

Alonso ER, Marques AO. Cov neeg laus-thaum pib tseem muaj tus kabmob. Hauv: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Pob tsuasCov. 7 tus ed. Philadelphia, PA: Elsevier; 2019: chap 173.

Gerfaud-Valentin M, Maucort-Boulch D, Kub A, li al. Cov neeg laus thaum tseem muaj mob: kev nthuav qhia, kev kho mob, qhov tshwm sim, thiab qhov tshwm sim ntawm 57 tus neeg mob. Tshuaj (Baltimore)Cov. Xyoo 2014; 93 (2): 91-99. PMID: 24646465 www.ncbi.nlm.nih.gov/pubmed/24646465.

Kaneko Y, Kameda H, Ikeda K, li al. Tocilizumab nyob rau hauv cov neeg mob uas muaj hnub nyoog laus-pib tseem muaj kab mob rau kev kho tus mob glucocorticoid: kev sim, ob qhov muag tsis pom, tshuaj placebo-theem sim III. Ann Rheum DisCov. 2018; 77 (12): 1720-1729. PMID: 30279267 www.ncbi.nlm.nih.gov/pubmed/30279267.

Lub Koom Haum Hauv Lub Tebchaws rau Tsis tshua muaj teeb meem lub vev xaib. Tsis tshua muaj kab mob.org. Cov neeg laus thiaj li tseem muaj mob. rarediseases.org/rare-diseases/adult-onset-stills-disease/. Nkag Mus Saib Lub Peb Hlis 30, 2019.

Ortiz-Sanjuán F, Blanco R, Riancho-Zarrabeitia L, li al. Efficacy ntawm anakinra nyob rau hauv refractory cov neeg laus-pib Tseem muaj tus kab mob: kev tshawb fawb ntau tus neeg ntawm 41 cov neeg mob thiab kev tshuaj xyuas cov ntawv nyeem. Tshuaj (Baltimore)Cov. Xyoo 2015; 94 (39): e1554. PMID: 26426623 www.ncbi.nlm.nih.gov/pubmed/26426623.