Felty syndrome

Felty syndrome yog ib qho kev tsis sib haum xeeb uas suav nrog mob caj dab, mob caj dab o, txo cov qe ntshav dawb, thiab rov kis mob dua. Nws yog tsawg.

Cov ua kom muaj tus mob Felty syndrome tsis paub meej. Nws yog ntau dua rau cov neeg uas muaj kev mob caj dab (RA) ntev. Cov neeg muaj tus mob no yuav muaj kev pheej hmoo kis tus mob vim tias lawv muaj cov qe ntshav dawb tsawg.

Cov tsos mob muaj xws li:

• Qhov kev xav ntawm tsis xis nyob (malaise)
• Nkees
• Tsis muaj zog ntawm txhais ceg lossis sab caj npab
• Tsis qab los noj mov
• Tsis yuag yuag poob
• Mob nqaij tawv nqaij
• Kev sib koom tes o, mob txhav, mob, thiab deformity
• Cov kab mob kis
• Lub qhov muag liab nrog hlawv lossis tso tawm

Kev kuaj mob lub cev yuav qhia:

• O o
• Cov pob qij txha uas pom cov paib ntawm RA
• Tejzaum tuaj yeem o ua rau lub siab thiab cov qog ntshav

Ib qho kev ua tiav ntawm cov ntshav (CBC) nrog qhov sib txawv yuav qhia pom tsawg ntawm cov qe ntshav dawb hu ua neutrophils. Yuav luag txhua tus neeg uas muaj tus mob Felty syndrome muaj cov tshuaj kuaj mob rau qhov mob rheumatoid factor.

Qhov ntsuas plab hauv plab tuaj yeem paub meej tias qhov hnoos qeev o o.

Feem ntau, cov neeg muaj tus mob no tseem tsis tau txais kev kho mob RA. Lawv yuav xav tau lwm yam tshuaj los txo lawv lub cev tiv thaiv kab mob thiab txo qhov haujlwm ntawm lawv RA.

Methotrexate tuaj yeem txhim kho kev suav cov neutrophil qis. Cov tshuaj rituximab tau ua tiav rau cov tib neeg uas tsis teb cov methotrexate.

Granulocyte-colony stimulating factor (G-CSF) yuav nce cov neutrophil suav.

Qee cov neeg tau txais txiaj ntsig los ntawm kev tshem tawm ntawm tus po (spleectomy).

Yog tias tsis kho, kev mob yuav tshwm sim txuas ntxiv.

RA feem ntau yuav tsis zoo.

Kho tus RA, li cas los xij, yuav tsum txhim kho Felty syndrome.

Tej zaum koj yuav muaj mob uas ua kom rov qab los.

Qee tus neeg mob Felty syndrome tau nce ntau ntawm cov muaj cov lymphocytes loj, tseem hu ua LGL mob ntsws. Qhov no yuav kho nrog methotrexate hauv ntau kis.

Hu koj tus kws kho mob yog tias koj muaj cov tsos mob ntawm qhov kev tsis zoo no.

Kev kho mob sai sai ntawm RA nrog cov tshuaj pom zoo tam sim no txo ​​qis kev pheej hmoo ntawm kev loj hlob Felty syndrome.

Seropositive rheumatoid mob caj dab (RA); Kev plees kev yi

• Tshuaj tua kabmob

Bellistri JP, Muscarella P. Splenectomy rau hematologic ntshawv siab. Hauv: Cameron JL, Cameron AM, eds. Kev Kho Mob Tam Sim NoCov. 12th ed. Philadelphia, PA: Elsevier; 2017: 603-610.

Erickson AR, Cannella AC, Mikuls TR. Cov kab mob kev sib tw ntawm kev mob caj dab. Hauv: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley thiab Firestein Cov Ntawv Phau Ntawv ntawm RheumatologyCov. 10 tus ed. Philadelphia, PA: Elsevier; 2017: chap 70.

Gazitt T, Loughran TP Jr. Cov mob neutropenia mob ntsws hauv LGL cov ntshav qog thiab mob caj dab. Hematology Am Soc Hematol Qhia Kev KawmCov. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

Myasoedova E, Turesson C, Matteson EL. Cov yam ntxwv mob ntxiv ntawm kev mob caj dab. Hauv: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Pob tsuasCov. 7 tus ed. Philadelphia, PA: Elsevier; 2019: cha 95.

Savola P, Brück O, Olson T, li al. Somatic STAT3 kev hloov pauv hauv Felty syndrome: qhov cuam tshuam rau ib qho tshwm sim ntawm cov kab mob tshwm sim uas muaj cov roj ntshav ntau li cov roj ntsha lymphocyte. HaematologicaCov. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Wang CR, Chiu YC, Chen YC. Kev kho mob zoo ntawm refutory neutropenia hauv Felty's syndrome nrog rituximab. Scand J RheumatolCov. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.