Ntau tus kab mob endocrine neoplasia (MEN) Kuv

Ntau tus kab mob endocrine neoplasia (MEN) hom I yog tus kab mob uas ib lossis ntau dua ntawm cov qog endocrine muaj ntau dhau los yog tsim cov qog. Nws kis tau los ntawm tsev neeg.

Cov qog endocrine feem ntau muaj xws li:

• Qos Yis
• Parathyroid
• Pituitary

TXIV NEEJ Kuv yog tshwm sim los ntawm kev puas tsuaj hauv ib lub gene uas nqa txoj cai rau cov protein hu ua menin. Tus mob ua rau hlav ntawm ntau cov qog tshwm ntawm tib neeg, tab sis tsis tas nyob rau tib lub sijhawm.

Qhov tshwm sim no yuav tshwm sim thaum muaj hnub nyoog, thiab nws cuam tshuam rau txiv neej thiab poj niam sib npaug. Kev nrhiav tsev neeg keeb kwm ntawm qhov kev puas tsuaj no ua rau koj tus kheej muaj feem.

Cov tsos mob yuav txawv ntawm ib tug neeg mus rau lwm tus, thiab nyob ntawm seb lub caj pas twg koom nrog. Lawv suav nrog:

• Mob plab
• Ntxhov siab vim
• Dub, tarry quav
• Tsam plab lawm tom qab noj mov
• Kev hlawv lub cev, ua kom mob, lossis tsis xis nyob rau sab plab lossis hauv siab hauv siab uas tau txais txiaj ntsig los ntawm antacids, mis, lossis zaub mov
• Tsis tshua muaj kev sib deev txaus siab
• Nkees
• Mob taub hau
• Tsis muaj poj niam coj khaub ncaws (hauv cov poj niam)
• Tsis qab los noj mov
• Poob lub cev lossis ntsej muag plaub hau (hauv cov txiv neej)
• Puas siab puas ntsws hloov lossis ntxhov siab
• Mob leeg
• Xeev siab thiab ntuav
• Hnov qhov txias
• Tsis yuag yuag poob
• Cov teeb meem tsis pom kev
• Neeg tsis muaj zog

Tus kws kho mob yuav kuaj ib ce thiab nug txog koj li keeb kwm kho mob thiab cov tsos mob. Cov kev xeem hauv qab no tuaj yeem ua:

• Qib cortisol qib ntshav
• CT scan ntawm lub plab mog
• CT scan ntawm lub taub hau
• Yoo ntshav ntshav qab zib
• Kev tshuaj ntsuam caj ces
• Kev kuaj ntshav
• MRI ntawm lub plab mog
• MRI ntawm lub taub hau
• Serum adrenocorticotropic cov tshuaj hormones
• Ntshav calcium
• Ntshav cov tshuaj follicle stimulating hormone
• Ntshav dej gastrin
• Ntshav dej glucagon
• Ntshav dej luteinizing cov tshuaj hormones
• Serum parathyroid hormone
• Ntshav dej prolactin
• Ntshav cov thyroid stimulating hormone
• Ultrasound ntawm caj dab

Kev phais mob kom tshem tawm cov qog mob yog feem ntau kho mob ntawm kev xaiv. Cov tshuaj hu ua bromocriptine tuaj yeem siv ua kev phais mob rau cov qog hlwb uas tso cov tshuaj prolactin.

Parathyroid qog, uas tswj cov calcium ntau lawm, tuaj yeem tshem tawm. Txawm li cas los xij, nws nyuaj rau lub cev tswj cov qib calcium uas tsis muaj cov qog no, yog li kev tshem tawm tag nrho parathyroid tsis tau ua thawj feem ntau.

Muaj tshuaj kho mob kom txo tau cov kua qaub ntau dhau los ntawm qee cov qog (gastrinomas), thiab txo qhov muaj teeb meem ntawm cov mob txhab.

Kev kho cov tshuaj hormones yog muab thaum tag nrho cov qog tau tshem tawm lossis tsis tsim cov tshuaj hormones txaus.

Cov qog nqaij hlav Pituitary thiab parathyroid feem ntau tsis tuaj yeem mob (tsis ua haujlwm), tab sis qee qhov hlav hlav ua hlav yuav ua mob qog (malignant) thiab kis mus rau lub siab. Cov no tuaj yeem txo lub neej muaj sia.

Cov tsos mob ntawm tus mob peptic muaj txiaj ntsig, muaj ntshav qab zib tsawg, muaj calcium ntau dhau hauv cov ntshav, thiab kev ua rau lub plab khiav ua haujlwm feem ntau teb tau zoo rau kev kho mob tsim nyog.

Cov qog yuav tuaj yeem rov qab los. Cov tsos mob thiab cov kev mob tshwm sim nyob ntawm seb cov qog ua haujlwm koom nrog. Kev mus kuaj mob tsis tu ncua los ntawm koj tus kws kho mob yog qhov tseem ceeb.

Hu rau koj tus kws kho mob yog tias koj pom muaj mob MEN I lossis muaj tsev neeg muaj keeb kwm ntawm tus mob no.

Pom zoo kom kuaj cov neeg txheeb ze ntawm cov neeg cuam tshuam nrog qhov kev tsis zoo no tau pom zoo.

Tus Mob Wermer; TXIV NEEJ I

• Cov qog endocrine

Lub Tebchaws National Comprehensive Cancer Network lub vev xaib. Cov chaw txhaj tshuaj xyaum ua raws li oncology (NCCN kev qhia): neuroendocrine hlav. Version 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Hloov kho thaum Lub Peb Hlis 5, 2019. Nkag mus rau Lub Peb Hlis 8, 2020.

Newey PJ, Thakker RV. Ntau tus kab mob endocrine neoplasia. Hauv: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Phau Ntawv ntawm EndocrinologyCov. Xab 14th. Philadelphia, PA: Elsevier; 2020: cha 42.

Nieman LK, Spiegel AM. Cov teeb meem polyglandular. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 26th ed. Philadelphia, PA: Elsevier; 2020: cha 218.

Thakker RV. Ntau qhov endocrine neoplasia hom 1. Hauv: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Cov Neeg Loj thiab PediatricCov. 7 tus ed. Philadelphia, PA: Elsevier Saunders; 2016: cha 148.