PDL1 (Kev Txhaj Tshuaj Tiv Thaiv Kab Mob)

Zoo Siab

• PDL1 kev xeem yog dab tsi?
• Nws siv rau dab tsi?
• Vim li cas kuv thiaj xav tau PDL1 kuaj?
• Muaj dab tsi tshwm sim thaum kuaj PDL1?
• Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?
• Puas muaj kev pheej hmoo rau kev kuaj?
• Cov txiaj ntsig li cas?
• Puas muaj lwm yam ntxiv uas kuv xav paub txog ntsuas PDL1?
• Ua tim khawv

PDL1 kev xeem yog dab tsi?

Qhov ntsuas ntshav no ntsuas qhov ntsuas PDL1 ntau npaum li cas ntawm cov qog ntshav. PDL1 yog cov protein uas pab ua kom lub cev tiv thaiv kab mob ntawm lub hlwb tsis zoo nyob hauv lub cev. Feem ntau, lub cev tiv thaiv kab mob tua cov tshuaj txawv teb chaws zoo li kab mob thiab kab mob, thiab tsis yog koj lub hlwb noj qab haus huv. Qee cov kabmob kheesxaws muaj ntau ntawm PDL1. Qhov no tso cai rau cov kabmob kheesxaws "ua kom" kev tiv thaiv kab mob hauv lub cev, thiab zam kom tsis txhob raug cov tshuaj xws li txawv teb chaws, cov tshuaj phem.

Yog tias koj cov qog nqaij hlav cancer muaj PDL1 ntau, koj yuav tau txais txiaj ntsig los ntawm kev kho mob hu ua tshuaj tiv thaiv. Kev Siv Tshuaj Tiv Thaiv yog ib txoj kev kho uas ua kom koj lub cev muaj zog tiv thaiv nws kom nws paub thiab tiv thaiv mob hlwb. Kev txhaj tshuaj tiv thaiv kab mob tau pom tias muaj txiaj ntsig zoo hauv kev kho qee yam mob qog noj ntshav. Nws tseem ua rau muaj kev mob tshwm sim tsawg dua li lwm cov kev kho mob qog noj ntshav.

Lwm lub npe: programmed tuag-ligand 1, PD-LI, PDL-1 los ntawm immunohistochemistry (IHC)

Nws siv rau dab tsi?

Kev ntsuam xyuas PDL1 yog siv los tshawb nrhiav seb koj puas muaj mob qog noj ntshav uas yuav tau txais txiaj ntsig los ntawm kev siv tshuaj tiv thaiv.

Vim li cas kuv thiaj xav tau PDL1 kuaj?

Koj yuav xav tau kev ntsuam xyuas PDL1 yog tias koj tau kuaj mob nrog ib qho ntawm cov qog nqaij hlav hauv qab no:

• Cov kab mob ntsws uas tsis yog mob me
• Melanoma
• Hodgkin lymphoma
• Lub zais zis mob hlwb
• Mob raum
• Tus mob cancer mis

Cov qib siab ntawm PDL1 feem ntau pom nyob hauv cov no, nrog rau qee yam mob qog noj ntshav. Cov kab mob khees xaws uas muaj PDL1 siab kawg tau tuaj yeem kho nrog kev kho mob kom zoo.

Muaj dab tsi tshwm sim thaum kuaj PDL1?

Feem ntau qhov ntsuas PDL1 tau ua nyob hauv tus txheej txheem hu ua me me. Muaj peb lub ntsiab ntawm kev ua li no:

• Kev siv rab koob xav tau koob hno, uas siv rab koob heev kom tshem tau cov hnoos qeev lossis kua dej
• Siv rab koob coj mus kuaj, uas siv ib rab koob loj dua los tshem tawm ib qho piv txwv
• Kev phais me me, uas tshem tus qauv hauv cov hnub nyoog me, tus txheej txheem sab nraud

Kev siv rab koob zoo thiab cov koob txhaj tshuaj feem ntau suav nrog cov hauv qab no:

• Koj yuav pw koj ib sab lossis zaum ntawm ib lub rooj kawm.
• Tus kws kho mob yuav ntxuav qhov chaw biopsy thiab txhaj tshuaj loog kom koj thiaj li tsis hnov ​​mob thaum lub sijhawm ua haujlwm.
• Thaum thaj chaw loog, tus kws kho mob yuav ntxiv rab koob xav tshuaj los yog rab koob hno rau hauv qhov chaw muab coj mus kuaj thiab hle cov hno lossis kua dej.
• Koj tuaj yeem hnov ​​me ntsis thaum cov qauv rub tawm.
• Yuav muab qhov siab mus rau qhov chaw me me kom txog rau thaum cov ntshav tawm plaws.
• Koj tus kws kho mob yuav siv cov ntaub qhwv lub cev tsis huv ntawm qhov chaw me me.

Hauv kev phais me me, Tus kws phais yuav txiav me me rau hauv koj cov tawv nqaij kom tshem tawm txhua qhov lossis qee yam ntawm lub hauv siab menyuam yaus. Tej zaum yuav tau txiav me ntsis es yuav tsum tau phais yog tias siv tsis tau lub koob hno. Kev phais me me feem ntau suav cov hauv qab no.

• Koj yuav tau pw ntawm lub rooj ua haujlwm. Qhov IV (tso dej kab) yuav muab tso rau hauv koj txhais caj npab lossis txhais tes.
• Tej zaum koj yuav tau muab tshuaj, hu ua sedative, los pab koj so.
• Koj yuav muab cov tshuaj loog hauv zos lossis ib puag ncig kom koj thiaj li tsis hnov ​​mob thaum ua haujlwm.
  • Rau cov tshuaj loog hauv ib cheeb tsam, tus kws kho mob yuav txhaj tshuaj qhov nqaij me me rau hauv qhov chaw mus loog.
  • Txog kev tso tshuaj kom tsaug zog, kws tshwj xeeb hu ua tshuaj loog yuav muab tshuaj rau koj yog li koj yuav tsis nco qab nyob hauv tus txheej txheem.
• Thaum qhov chaw mos los loog lossis koj tsis nco qab lawm, tus kws phais yuav txiav ib qho me me rau hauv lub mis thiab tshem ib feem lossis tagnrho ib qho mob. Qee qhov nqaij mos nyob ib ncig ntawm lub qog kuj tseem yuav raug tshem tawm.
• Qhov kev txiav hauv koj cov tawv nqaij yuav raug kaw nrog cov hlua khi lossis cov nplaum ib qho ntxiv.

Nws muaj ntau yam me. Lub dab li cas uas koj txais yuav yog nyob ntawm qhov chaw thiab qhov loj ntawm koj cov qog ntshav.

Kuv puas yuav tau ua ib yam dab tsi txhawm rau npaj rau qhov kev xeem?

Koj yuav tsis tas npaj dab tsi tshwj xeeb yog tias koj tau txais tshuaj loog hauv zos (suav cov khoom siv ntawm qhov chaw). Yog tias koj tau txais tshuaj loog dav dav, koj yuav xav yoo mov (tsis noj los yog haus) rau ob peb teev ua ntej kev phais mob. Koj tus kws phais mob yuav muab cov lus qhia tshwj xeeb rau koj. Thiab, yog tias koj tab tom siv tshuaj loog lossis tshuaj loog ib txwm siv, nco ntsoov npaj ib tus neeg tsav koj lub tsev. Tej zaum koj yuav ua neeg khab theeb thiab tsis meej pem tom qab koj sawv ntawm qhov txheej txheem.

Puas muaj kev pheej hmoo rau kev kuaj?

Tej zaum koj yuav muaj nqaij me me los ntshav los ntawm qhov nqaij me. Qee zaum tus xaib tau kis. Yog tias qhov ntawd tshwm sim, koj yuav raug kho nrog tshuaj tua kab mob. Kev phais me me yuav ua rau mob ntxiv thiab tsis xis nyob. Koj tus kws kho mob yuav pom zoo lossis sau ntawv yuav tshuaj los pab koj kom koj xis nyob.

Cov txiaj ntsig li cas?

Yog tias koj cov txiaj ntsig pom tau tias koj cov qog nqaij hlav ntshav muaj PDL1 ntau, koj yuav tau pib siv tshuaj tiv thaiv. Yog tias koj cov txiaj ntsig tsis tshwm sim qhia qhov siab ntau ntawm PDL1, kev kho tshuaj tiv thaiv kab mob kuj yuav tsis zoo rau koj. Tab sis koj tuaj yeem tau txais txiaj ntsig los ntawm lwm txoj kev kho mob qog noj ntshav. Yog koj muaj lus nug txog koj cov txiaj ntsig, nrog koj tus kws kho mob tham.

Kawm paub ntau ntxiv txog cov kev sim hauv chaw soj ntsuam, cov chaw siv ntsuas, thiab nkag siab cov txiaj ntsig tau.

Puas muaj lwm yam ntxiv uas kuv xav paub txog ntsuas PDL1?

Kev txhaj tshuaj tiv thaiv kab mob tsis ua hauj lwm rau txhua tus, txawm tias koj muaj qog ua hlav nrog PDL1 siab. Cov kabmob kheesxaws muaj mob nyuaj thiab feem ntau tsis tuaj yeem lees paub. Cov kws saib xyuas kev noj qab haus huv thiab cov kws tshawb nrhiav tseem tab tom kawm txog kev txhaj tshuaj tiv thaiv kab mob thiab yuav ua li cas twv seb leej twg yuav tau txais txiaj ntsig zoo tshaj plaws los ntawm cov tshuaj no.

Ua tim khawv

1. Allina Kev Noj Qab Haus Huv [Is Taws Nem]. Minneapolis: Allina Kev Noj Qab Haus Huv; c2018. Tshuaj tiv thaiv kabmob rau mob qog noj ntshav; [hais 2018 2018 14; [txog 3 ntxaij]. Muaj los ntawm: https://wellness.allinahealth.org/library/content/60/903
2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Kev siv tshuaj tiv thaiv kab mob hauv lub cev tuaj yeem kho mob qog noj ntshav; [kho tshiab 2017 Tsib Hlis 1; hais 2018 Aug 14]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/immune-checkpoint-inhibitors.html
3. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Lub Hom Phiaj Kho Mob Cancer Yog Dab Tsi ?; [kho tshiab 2016 Jun 6; hais 2018 Aug 14]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/targeted-therapy/what-is.html
4. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Dab tsi tshiab nyob rau hauv kev tshawb fawb tshuaj tiv thaiv kab mob cancer ?; [kho tshiab 2017 Oct 31; hais 2018 Aug 14]; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/whats-new-in-immunotherapy-research.html
5. Cancer.Net [Is Taws Nem]. Alexandria (VA): Asmeskas Cov Neeg Sib Koom Hauv Kev Kho Mob oncology; c2005-–2018. 9 Yam Yuav Tau Paub Txog Kev Kho Mob Tshuaj Tiv Thaiv thiab Mob ntsws; 2016 Nov 8 [raug nplua 2018 Aug 14]; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.net/blog/2016-11/9-things-know-about-immunotherapy-thiab-lung-cancer
6. Lub koom haum Cancer Dana-Farber [Internet]. Boston: Lub koom haum Dana-Farber Cancer; c2018. PDL-1 Kuaj yog dab tsi ?; 2017 Tsib Hlis 22 [hloov tshiab 2017 Jun 23; hais 2018 Aug 14]; [txog 3 ntxaij]. Muaj los ntawm: https://blog.dana-farber.org/insight/2017/05/what-is-a-pd-l1-test
7. Integrated Oncology [Is Taws Nem]. Kuaj Lub Tebchaws Ntawm Tebchaws Asmeskas, c2018. PDL1-1 los ntawm IHC, Opdivo; [hais 2018 2018 14; [txog 3 ntxaij]. Muaj los ntawm: https://www.integratedoncology.com/test-menu/pd-l1-by-ihc-opdivo%C2%AE/cec2cfcc-c365-4e90-8b79-3722568d5700
8. Kev Tshuaj Ntsuam Xyuas online [Internet]. Washington D.C .: Koom Haum Asmeskas Rau Chaw Kuaj Mob; c2001–2018. Kev tshuaj ntsuam caj ces rau Hom Phiaj Kho Mob; [kho tshiab 2018 Jun 18; hais 2018 Aug 14]; [txog 2 ntxaij]. Muaj los ntawm: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
9. Mayo Clinic: Mayo Medical Laboratories [Is Taws Nem]. Mayo Foundation for Medical Education thiab Tshawb Fawb; c1995–2018. Test ID: PDL1: Programmed Tuag-Ligand 1 (PD-L1) (SP263), Semi-Quantitative Immunohistochemistry, Los Ntawm Txhais Tes: Chaw Kho Mob thiab Txhais; [hais 2018 2018 14; [txog 4 ntxaij]. Muaj los ntawm: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/71468
10. MD Anderson Cancer Center [Is Taws Nem]. University of Texas MD Anderson Cancer Center; c2018. Qhov kev tshawb pom no yuav ua rau muaj kev tiv thaiv zoo ntau ntxiv; 2016 Sep 7 [raug nplua 2018 Aug 14]; [txog 3 ntxaij]. Muaj los ntawm: https://www.mdanderson.org/publications/cancer-frontline/2016/09/discovery-may-increase-immunotherapy-effectiveness.html
11. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; NCI Lus Txhais ntawm Cancer Cov Lus Cog Tseg: tshuaj tiv thaiv kab mob; [hais 2018 2018 14; [txog 3 ntxaij]. Muaj los ntawm: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/immunotherap
12. National Cancer Institute [Internet]. Bethesda (MD): Asmeskas Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Tib Neeg; Tumor Cim; [hais 2018 2018 14; [txog 4 ntxaij]. Muaj los ntawm: https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet
13. Sydney Kimmel Comprehensive Cancer Center [Is Taws Nem]. Baltimore: Johns Hopkins University; Mis Mis: Qhov Kev Kho Mob Ua Kom Yooj Yim Kho Tus Mob Hlawv Mis; [hais 2018 2018 14; [txog 3 ntxaij]. Muaj los ntawm: https://www.hopkinsmedicine.org/news/publications/breast_matters/files/sebindoc/a/p/ca4831b326e7b9ff7ac4b8f6e0cea8ba.pdf
14. UW Kev Noj Qab Haus Huv [Is Taws Nem]. Madison (WI): University of Wisconsin Cov Tsev Kho Mob thiab Chaw Kho Mob; c2018. Cov Ntaub Ntawv Noj Qab Haus Huv: Kev Noj Qab Haus Huv; [kho tshiab 2017 Oct 9; hais 2018 Aug 14]; [txog 3 ntxaij]. Muaj los ntawm: https://www.uwhealth.org/health/topic/ConditionCenter/Immune%20System/center1024.html
15. UW Kev Noj Qab Haus Huv [Is Taws Nem]. Madison (WI): University of Wisconsin Cov Tsev Kho Mob thiab Chaw Kho Mob; c2018. Xov Xwm thiab Xwm Txheej: Qhia Txog Txheej Txheem Txheej Txheem Tiv Thaiv Mob Cancer; [kho tshiab 2017 Aug 7; hais 2018 Aug 14]; [txog 3 ntxaij]. Muaj los ntawm: https://www.uwhealth.org/news/the-immune-system-goes-to-school-to-learn-how-to-fight-cancer/51234

Cov ntaub ntawv ntawm lub xaib no yuav tsum tsis txhob siv los hloov chaw kho mob lossis tswv yim kho mob. Hu rau kws kho mob yog tias koj muaj lus nug txog koj txoj kev noj qab haus huv.