Teeb meem ntawm Myelofibrosis thiab Txoj Kev los txo koj txoj kev pheej hmoo

Zoo Siab

• Loj spleen
• Cov qog nqaij hlav (ua rau lub cev tsis nce zuj zus) hauv lwm qhov chaw ntawm koj lub cev
• Portal tawg
• Tsawg platelet suav
• Cov pob txha thiab mob pob txha
• Gout
• Mob heev heev
• Mob myeloid mob ntshav dawb (AML)
• Kho MF cov nyom
• Txo koj txoj kev pheej hmoo ntawm MF cov nyom
• Cov nqa mus

Myelofibrosis (MF) yog ib hom mob ntshav mus ntev uas cov caws pliav nyob rau ntawm cov pob txha pob txha qeeb ua rau cov qe ntshav muaj ntshav ntau tuaj. Ib cov qe ntshav tsis txaus ua rau muaj ntau cov tsos mob thiab cov teeb meem ntawm MF, xws li nkees, mob yooj yim, kub cev, thiab pob txha lossis mob pob txha.

Coob tus neeg tsis hnov ​​cov tsos mob tshwm sim thaum ntxov ntawm tus kabmob no. Thaum tus kab mob mus zuj zus, cov tsos mob thiab cov kev mob cuam tshuam uas khi rau cov ntshav ntshav hauv lub cev yuav pib tshwm sim.

Nws yog ib qho tseem ceeb uas ua hauj lwm nrog koj tus kws kho mob los kho MF, tshwj xeeb yog thaum koj pib muaj cov tsos mob. Kev kho mob tuaj yeem pab txo koj txoj kev pheej hmoo thiab muaj kev phom sij ntxiv.

Nov yog saib kom ze rau qhov yuav tshwm sim tuaj ntawm MF thiab koj yuav ua li cas koj tuaj yeem txo koj txoj kev pheej hmoo.

Loj spleen

Koj tus po yog pab tua cov kab mob thiab lim ntshav qub lossis puas hlwb. Nws tseem khaws cov ntshav liab thiab cov qe ntshav ua kom koj cov ntshav txhaws.

Thaum koj muaj MF, koj cov hlwb pob txha tsis tuaj yeem tsim cov qe ntshav txaus vim tias muaj caws pliav. Cov qe ntshav nyob rau thaum kawg tsim tawm sab nraud cov pob txha pob txha nyob rau lwm qhov chaw ntawm koj lub cev, xws li koj tus po.

Qhov no raug xa mus rau raws li extramedullary hematopoiesis. Qee zaus tus po yuav dhau mus ua neeg loj loj uas nws siv zog ua kom cov hlwb no.

Kev mob spleen (splenomegaly) tuaj yeem ua rau cov tsos mob tsis xis nyob. Nws tuaj yeem ua rau mob plab thaum nws thawb tawm ntawm lwm qhov hauv nruab nrog cev thiab ua rau koj lub siab txawm tias koj tsis tau noj ntau.

Cov qog nqaij hlav (ua rau lub cev tsis nce zuj zus) hauv lwm qhov chaw ntawm koj lub cev

Thaum cov qe ntshav tsim tawm sab nraud cov pob txha, cov qog ntshav tsis tuaj yeem tsim kho cov qe ntshav qee zaum tsim nyob rau lwm qhov chaw ntawm lub cev.

Cov qog yuav ua rau los ntshav hauv koj lub plab nyhuv. Qhov no tuaj yeem ua rau koj hnoos lossis nti tawm kom ntshav. Mob caj dab kuj tuaj yeem nias koj tus txha caj qaum lossis ua rau chua leeg.

Portal tawg

Cov ntshav ntws los ntawm tus po rau daim siab mus rau lub siab los ntawm lub portal leeg. Kev nce ntshav ntws mus rau qhov kev hnoos qeev loj hauv MF ua rau muaj ntshav siab nyob rau hauv cov ntshav portal.

Kev nce ntshav siab qee zaum yuam kom muaj ntshav ntau dhau mus rau lub plab thiab txoj hlab nqos mov. Qhov no tuaj yeem ua kom cov leeg ntshav me dua thiab ua rau los ntshav. Hais txog ntawm cov neeg uas muaj MF ntsib qhov kev cuam tshuam no.

Tsawg platelet suav

Platelets hauv ntshav pab koj cov ntshav txhaws tom qab raug mob. Platelet suav tuaj yeem poob qis dua li qub MF hloov zuj zus. Cov qe ntshav tsawg yog paub tias yog thrombocytopenia.

Yog tias tsis muaj cov platelets txaus, koj cov ntshav tuaj yeem tsis tuaj yeem ntshav kom zoo. Qhov no tuaj yeem ua rau koj cov ntshav tau yooj yim dua.

Cov pob txha thiab mob pob txha

MF tuaj yeem ua rau koj txoj hlab hlwb nruj. Nws tseem tuaj yeem ua rau mob hauv cov nqaij sib txuas ncig ntawm cov pob txha. Qhov no ua rau cov pob txha thiab mob pob txha.

Gout

MF ua rau lub cev tsim cov tshuaj uric acid dua li ib txwm. Yog hais tias uric acid crystallizes, nws qee zaum nyob rau hauv cov pob qij txha. Qhov no hu ua gout. Gout tuaj yeem ua rau o thiab mob pob qij txha.

Mob heev heev

Muaj cov qe ntshav liab tsawg uas paub tias muaj ntshav yog ib qho MF tshwm sim. Qee lub sij hawm anemia ua rau hnyav thiab ua rau lub cev tsis muaj zog, ua kom doog, thiab lwm cov tsos mob.

Mob myeloid mob ntshav dawb (AML)

Txog thaj tsam li 15 txog 20 feem pua ​​ntawm tib neeg, MF hloov zuj zus mus rau ntau hom mob qog nqaij hlav cancer hu ua mob leeg hu ua myeloid leukemia (AML). AML yog kev hloov pauv sai ntawm cov ntshav thiab cov pob txha pob txha.

Kho MF cov nyom

Koj tus kws kho mob yuav sau ntawv tawm ntau txoj kev kho mob kom daws tau MF cov nyom. Cov no suav nrog:

• JAK inhibitors, suav nrog ruxolitinib (Jakafi) thiab fedratinib (Inrebic)
• cov tshuaj tiv thaiv kab mob, xws li thalidomide (Thalomid), lenalidomide (Revlimid), interferons, thiab pomalidomide (Pomalyst)
• corticosteroids, xws li prednisone
• kev phais mob tshem tawm ntawm tus po (splenectomy)
• androgen kho
• Siv tshuaj khomob, xws li hydroxyurea

Txo koj txoj kev pheej hmoo ntawm MF cov nyom

Nws yog ib qho tseem ceeb uas ua hauj lwm nrog koj tus kws kho mob los tswj MF. Kev nquag saib xyuas yog qhov tseem ceeb rau txo koj txoj kev pheej hmoo ntawm MF teeb meem. Koj tus kws kho mob tuaj yeem thov kom koj tuaj kuaj ntshav thiab kuaj lub cev ib zaug lossis ob zaug hauv ib xyoos lossis ib zaug ib zaug ib asthiv.

Yog tias koj tam sim no tsis muaj cov tsos mob thiab MF pheej hmoo, nws tsis muaj pov thawj tias koj yuav tau txais txiaj ntsig los ntawm cov kev tiv thaiv thaum ntxov. Koj tus kws kho mob tuaj yeem tos pib kho kom txog thaum koj tus mob zoo zuj zus.

Yog tias koj muaj cov tsos mob lossis nruab nrab-lossis pheej hmoo MF, koj tus kws kho mob yuav sau ntawv kho.

Lub JAK inhibitors ruxolitinib thiab fedratinib phiaj ua rau lub cev tsis sib xws ntawm cov paib tshwm sim los ntawm ib qho kev hloov pauv MF cov noob. Cov tshuaj no tau pom tias txo qis spleen qhov loj me thiab hais txog lwm yam kev mob tshwm sim xws li mob pob txha thiab mob pob txha. Kev tshawb fawb lawv yuav txo tau qhov kev pheej hmoo ntawm qhov teeb meem thiab nce kev muaj sia nyob ntxiv.

Kev hloov cov pob txha caj qaum yog kev kho mob nkaus xwb uas tuaj yeem kho MF. Nws koom nrog kom tau txais qhov kev faib tawm ntawm cov qia hlwb los ntawm tus neeg pub noj qab haus huv, uas hloov pauv cov qia hlwb ua rau MF cov tsos mob.

Cov txheej txheem no coj tau teeb meem loj thiab muaj feem yuav txo sia txoj sia. Feem ntau tsuas yog pom zoo rau cov neeg hluas uas tsis muaj lwm tus kab mob kev noj qab haus huv.

Kev kho mob MF tshiab tau tsim tas li. Sim nyob nrog kev soj ntsuam tshiab kawg hauv MF, thiab nug koj tus kws kho mob txog seb koj puas yuav xav txog kev rau npe koom hauv kev sim kho mob.

Cov nqa mus

Myelofibrosis yog ib yam mob qog nqaij hlav ntshav tsawg uas txoj kev tawv ncauj ua rau koj cov leeg pob txha los ntawm kev tsim cov qe ntshav muaj ntshav txaus txaus. Yog tias koj muaj MF nruab nrab- lossis siab pheej hmoo MF, ntau txoj kev kho mob tuaj yeem daws cov tsos mob, txo koj qhov kev pheej hmoo ntawm cov kev mob tshwm sim, thiab muaj feem yuav ua kom muaj sia nyob ntev.

Ntau qhov kev sim txuas ntxiv tshawb nrhiav cov kev kho mob tshiab. Sib txuas nrog koj tus kws kho mob thiab sib tham txog cov kev kho mob twg tuaj yeem tsim nyog rau koj.