Tshuaj Kho Mob rau Cov Neeg Muaj Mob Ulcerative Colitis
Zoo Siab
- Aminosalicylates (5-ASA)
- Mesalamine
- Sulfasalazine
- Olsalazine
- Balsalazide
- Corticosteroids
- Nyiaj Hoojsab
- Prednisone thiab prednisolone
- Cov tshuaj tiv thaiv kab mob ntshav
- Tocacitinib
- Methotrexate
- Azathioprine
- Mercaptopurine
- Kev phiv tshuaj ntawm methotrexate, azathioprine, thiab mercaptopurine
- Cov khoom siv roj ntsha
- Zam NSAIDs
- Tham nrog koj tus kws kho mob
Taw qhia
Ulcerative colitis yog ib hom mob ua paug ntawm lub plab hnyuv (IBD) uas feem ntau cuam tshuam cov hnyuv (hnyuv loj). Nws tuaj yeem tshwm sim los ntawm kev teb txawv txav ntawm koj lub cev. Txawm hais tias tsis muaj kev paub tias yog txoj kev kho tus mob vwm, ntau hom tshuaj yuav siv los tswj tus mob.
Cov tsos mob ntawm kev mob ncauj plab tuaj yeem suav nrog:
- mob plab, tsis xis nyob, lossis mob plab
- raws plab heev
- ntshav hauv cov quav
Cov tsos mob yuav nyob tas mus li los yog lawv yuav mob heev ntxiv thaum pauv.
Kev siv ntau yam tshuaj tuaj yeem siv los txo qhov mob (o thiab voos), txo cov roj koj cov ntshav, thiab cia koj txoj hnyuv zoo. Plaub chav kawm tseem ceeb ntawm cov tshuaj yog siv los kho cov neeg mob caj dab.
Aminosalicylates (5-ASA)
Aminosalicylates xav tias yuav txo cov tsos mob ntawm kev mob ncauj plab los ntawm kev txo tus mob hauv txoj hnyuv. Cov tshuaj no yog siv rau hauv cov neeg muaj mob me txog rau mob sib kis. Lawv tuaj yeem pab tiv thaiv kom tsis txhob muaj teeb meem lossis txo qis cov kab noj hniav uas koj muaj.
Cov ua piv txwv ntawm cov tshuaj no suav nrog:
Mesalamine
Mesalamine tuaj yeem noj ntawm qhov ncauj (los ntawm qhov ncauj) ua lub ntsiav tshuaj tso tawm qeeb, tshuaj ntsiav ntev-tso tawm, lossis tshuaj ntsiav qeeb. Mesalamine tseem muaj nyob hauv lub plab qhov quav lossis qhov quav qhov quav.
Mesalamine muaj nyob rau ntawm cov tshuaj tsis raug tshuaj hauv qee hom. Nws kuj tseem muaj ntau lub npe kev lag luam, xws li Delzicol, Apriso, Pentasa, Rowasa, sfRowasa, Canasa, Asacol HD, thiab Lialda.
Cov kev mob tshwm sim ntau dua ntawm mesalamine tuaj yeem suav nrog:
- zawv plab
- mob taub hau
- xeev siab
- mob plab, cramps, thiab tsis xis nyob
- ntau zog lub plab acidity lossis reflux
- ntuav
- nplawm
- ua pob
Tsis tshua muaj cov kev mob tshwm sim ntawm mesalamine tuaj yeem suav nrog:
- mob hauv siab
- txog siav
- lub plawv atherosclerosis ntawv
Piv txwv ntawm cov tshuaj uas mesalamine tuaj yeem sib cuam tshuam nrog:
- thioguanine
- warfarin
- tshuaj tiv thaiv varicella zoster
Sulfasalazine
Sulfasalazine tau noj ntawm qhov ncauj ua ib ntsiav tshuaj sai-tshem tawm lossis qeeb-tso tawm. Sulfasalazine muaj raws li cov tshuaj feem ntau thiab yog cov tshuaj lag luam tshuaj muaj npe Azulfidine.
Cov kev mob tshwm sim ntau dua los ntawm sulfasalazine tuaj yeem suav nrog:
- tsis qab los noj mov
- mob taub hau
- xeev siab
- ntuav
- mob plab
- phev tsawg dua cov txiv neej
Lwm yam kev mob tshwm sim tsis tshua tab sis hnyav ntawm sulfasalazine muaj xws li:
- ntshav tsis xws luag roj
- Kev fab tshuaj hnyav xws li mob Stevens-Johnson mob
- daim siab ua hauj lwm
- teeb meem raum
Sulfasalazine tuaj yeem cuam tshuam nrog lwm cov tshuaj, xws li:
- digoxin
- folic acid
Olsalazine
Olsalazine los ua ib lub tshuaj ntsiav uas koj noj los ntawm qhov ncauj. Nws muaj raws li cov tshuaj lag luam lub npe Dipentum. Nws tsis muaj tshuaj raws li cov tshuaj feem ntau.
Cov kev mob tshwm sim ntau ntawm olsalazine tuaj yeem suav nrog:
- zawv plab los yog tso quav poob
- mob hauv koj lub plab
- ua pob lossis khaus
Cov kev phiv loj heev ntawm olsalazine tuaj yeem suav nrog:
- ntshav tsis xws luag roj
- daim siab ua hauj lwm
- teeb meem mob plawv xws li lub plawv hloov ceev thiab mob hauv koj lub plawv
Piv txwv ntawm cov tshuaj uas olsalazine tuaj yeem cuam tshuam nrog muaj xws li:
- heparin
- cov cev muaj ceeb thawj cov roj heparins xws li enoxaparin los yog dalteparin
- mercaptopurine
- thioguanine
- tshuaj tiv thaiv varicella zoster
Balsalazide
Balsalazide noj yog qhov ncauj ua tshuaj ntsiav lossis ntsiav tshuaj. Cov tshuaj ntsiav muaj nyob rau ntawm cov tshuaj tsis raug cai thiab raws li cov tshuaj muaj npe lag luam Colazal. Cov ntsiav tshuaj tsuas yog muaj raws li lub npe tshuaj uas muaj npe Giazo.
Cov kev phiv ntau ntawm balsalazide tuaj yeem suav nrog:
- mob taub hau
- mob plab
- zawv plab
- xeev siab
- ntuav
- ua pa tau kab mob
- mob tej pob txha
Cov kev mob tshwm sim hnyav ntawm balsalazide tuaj yeem suav nrog:
- ntshav tsis xws luag roj
- daim siab ua hauj lwm
Piv txwv ntawm cov tshuaj uas balsalazide tuaj yeem cuam tshuam nrog nrog:
- thioguanine
- warfarin
- tshuaj tiv thaiv varicella zoster
Corticosteroids
Corticosteroids ua rau koj lub cev tsis muaj zog hauv lub cev los teb rau txo tus mob hauv koj lub cev. Cov tshuaj no yog siv los kho cov neeg mob me los ntawm mob nyhav mus rau mob lub plab hlaub. Corticosteroids muaj xws li:
Nyiaj Hoojsab
Ob daim ntawv ntawm budesonide uas tau pom zoo rau ulcerative mob plab yog tso tawm cov ntsiav tshuaj thiab lub qhov ncauj ua npuas. Ob leeg puav leej muaj cov tshuaj uas nrov npe Uceris. Cov tshuaj no tsis muaj tshuaj li cas li.
Cov kev phiv ntau ntawm cov tshuaj budesonide tuaj yeem suav nrog:
- mob taub hau
- xeev siab
- txo qis theem ntawm hormone cortisol
- mob hauv koj lub plab mog
- nkees nkees
- tsam plab
- pob txuv
- mob txeeb zig
- mob tej pob txha
- cem quav
Cov kev mob tshwm sim hnyav ntawm budesonide tuaj yeem suav nrog:
- cov teeb meem tsis pom kev xws li lub ntsej muag ci ntsa iab, cataracts, thiab dig muag
- ntshav siab
Budesonide tuaj yeem cuam tshuam nrog lwm cov tshuaj xws li:
- protease inhibitors xws li ritonavir, indinavir, thiab saquinavir, uas yog siv los kho kab mob HIV
- antifungal tshuaj xws li itraconazole thiab ketoconazole
- erythromycin
- qhov ncauj tiv thaiv uas muaj ethinyl estradiol
Prednisone thiab prednisolone
Prednisone muaj nyob rau hauv cov ntsiav tshuaj, ncua ntsiav tshuaj tso tawm, thiab cov qauv ua kua. Koj noj ib qho ntawm qhov ncauj. Prednisone muaj nyob rau ntawm cov tshuaj tsis raug cai thiab raws li cov tshuaj lag luam muaj npe Deltasone, Prednisone Intensol, thiab Rayos.
Cov foos ntawm prednisolone uas tau pom zoo rau cov mob plab ua paug yog:
- ntsiav tshuaj
- dissolving ntsiav tshuaj
- kua ua kua
- phoov
Koj tuaj yeem nqa ib qho ntawm cov foos los ntawm qhov ncauj. Prednisolone muaj rau cov tshuaj tsis raug cai thiab raws li cov tshuaj lag luam muaj koob npe Millipred.
Cov kev mob tshwm sim ntau dua los ntawm prednisone thiab prednisolone tuaj yeem suav nrog:
- ntxiv ntshav qab zib ntau ntau
- nyob tsis tswm lossis ntxhov siab
- nce ntshav siab
- o vim muaj dej ceev ceev hauv koj txhais ceg lossis pob taws
- nce qab los noj mov
- hnyav
Cov kev phiv loj heev ntawm kev mob prednisone thiab prednisolone tuaj yeem suav nrog:
- txha thiab nce kev pheej hmoo ntawm pob txha lov
- teeb meem hauv lub plawv xws li mob plawv, mob hauv siab, thiab lub plawv hloov
- qaug dab peg
Piv txwv ntawm cov tshuaj uas prednisone thiab prednisolone tuaj yeem sib cuam tshuam nrog:
- antiseizure tshuaj xws li phenobarbital thiab phenytoin
- cov ntshav ua thooj ntshav xws li warfarin
- rab phom phom
- ketoconazole
- tshuaj aspirin
Cov tshuaj tiv thaiv kab mob ntshav
Immunomodulators yog tshuaj uas txo lub cev ua rau lub cev tsis muaj zog. Qhov tshwm sim yog txo qis thoob plaws hauv tus neeg lub cev. Cov tshuaj txhaj tiv thaiv kab mob tej zaum yuav txo qis qhov mob plab kiav txhab uas koj muaj thiab pab koj ua kom tsis muaj tsos mob ntev dua.
Immunomodulators feem ntau siv rau cov neeg uas muaj cov tsos mob tsis tau tswj nrog aminosalicylates thiab corticosteroids. Txawm li cas los xij, cov tshuaj no yuav siv sijhawm ntau lub hlis los pib ua haujlwm.
Immunomodulators suav nrog:
Tocacitinib
Txog thaum nyuam qhuav tsis ntev, cov neeg siv tshuaj tiv thaiv kab mob tsis tau pom zoo los ntawm Tsoom Fwv Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) los kho cov neeg mob plab. Txawm li cas los xij, chav kawm ntawm cov tshuaj no yog qee zaum siv tawm daim ntawv lo tawm los kho cov neeg muaj mob voos.
Ib qhov kev siv tawm ntawm daim ntawv lo no tau dhau los ua ib qho khoom siv dhau los xyoo 2018 thaum FDA tau pom zoo siv tshuaj tiv thaiv kab mob rau cov neeg mob caj dab. Qhov tshuaj tiv thaiv kab mob no yog hu ua tofacitinib (Xeljanz). Yav dhau los FDA tau pom zoo rau cov neeg mob caj dab tab sis tau siv daim ntawv lo rau cov neeg muaj mob caj dab. Xeljanz yog thawj qhov tshuaj ntawm nws yam uas yog muab qhov ncauj - tsis yog los ntawm kev txhaj tshuaj - rau kev kho mob ntev ntev ntawm cov neeg muaj mob ulcerative.
Kawm paub ntau ntxiv txog kev siv tshuaj tua cov ntawv cim.
Methotrexate
Methotrexate muaj nyob rau hauv cov ntsiav tshuaj uas koj noj ntawm qhov ncauj. Nws tseem raug muab los ntawm cov leeg ntshav (IV) Txoj kev lis ntshav nrog rau subcutaneous thiab intramuscular li. Cov ntsiav tshuaj muaj nyob rau ntawm cov tshuaj tsis raug cai thiab raws li lub npe lag luam tshuaj Trexall. Cov tshuaj IV thiab kev txhaj tshuaj rau cov tshuaj intramuscular tsuas yog muaj tshuaj ua ntej. Lub subcutaneous txhaj tshuaj tsuas yog muaj raws li cov tshuaj lag luam muaj npe Otrexup thiab Rasuvo.
Azathioprine
Txog kev kho mob rau txoj hnyuv, azathioprine los ua ib ntsiav tshuaj uas koj noj ntawm qhov ncauj. Nws muaj nyob rau ntawm cov tshuaj tsis raug cai thiab raws li cov tshuaj lag luam muaj npe Azasan thiab Imuran.
Mercaptopurine
Mercaptopurine muaj nyob rau hauv ntsiav tshuaj lossis ua kua ncua kev ua kua, ob leeg noj ntawm qhov ncauj. Cov ntsiav tshuaj tsuas yog muaj raws li cov tshuaj feem ntau, thiab cov kev ncua tsuas yog muaj raws li cov npe uas muaj cov tshuaj muaj npe Purixan.
Kev phiv tshuaj ntawm methotrexate, azathioprine, thiab mercaptopurine
Cov kev mob tshwm sim ntau ntawm cov tshuaj tiv thaiv kab mob tuaj yeem suav nrog:
- mob taub hau
- xeev siab
- ntuav
- zawv plab
- qhov ncauj tawm
- nkees nkees
- cov ntshav muaj ntshav tsawg
Piv txwv ntawm cov tshuaj uas siv tshuaj tiv thaiv kab mob tuaj yeem cuam tshuam nrog muaj xws li:
- allopurinol
- aminosalicylates xws li sulfasalazine, mesalamine, thiab olsalazine
- angiotensin-converting enzyme (ACE) inhibitors xws li lisinopril thiab enalapril
- warfarin
- ribavirin
- nonsteroidal anti-inflammatory tshuaj (NSAIDs) xws li naproxen thiab ibuprofen
- phenylbutazone
- phenytoin
- sulfonamides
- probenecid
- retinoids
- theophylline
Cov khoom siv roj ntsha
Kev siv roj ntsha yog tsim los ntawm cov tshuaj tsim nyob hauv ib lab los ntawm cov muaj sia. Cov tshuaj no tiv thaiv qee yam protein hauv koj lub cev kom tsis txhob ua mob. Kev siv tshuaj lom yog siv rau cov neeg muaj mob me thiab mob sib kis rau lub plab hlaub. Lawv kuj tseem siv rau cov neeg uas muaj cov tsos mob tsis tau tswj nrog kev kho mob xws li aminosalicylates, immunomodulators, lossis corticosteroids.
Muaj tsib lub tshuaj me me siv rau kev kho mob rau kev mob ua paug rau txoj hnyuv. Cov no tsuas yog muaj cov tshuaj muaj npe ua lag luam, suav nrog:
- adalimumab (Humira), muab los ntawm kev txhaj tshuaj subcutaneous
- golimumab (Simponi), muab los ntawm kev txhaj tshuaj subcutaneous
- infliximab (Remicade), muab los ntawm IV Txoj kev lis ntshav
- infliximab-dyyb (Inflectra), muab los ntawm IV Txoj kev lis ntshav
- vedolizumab (Entyvio), muab los ntawm IV Txoj kev lis ntshav
Koj yuav tsum tau noj tshuaj adalimumab, golimumab, infliximab, lossis infliximab-dyyb kom ntev txog yim lub lis piam ua ntej koj pom muaj kev txhim kho. Vedolizumab feem ntau pib ua haujlwm hauv rau lub lis piam.
Cov kev mob tshwm sim ntau dua ntawm cov tshuaj biologic tuaj yeem suav nrog:
- mob taub hau
- ua npaws
- ua daus no
- khaus lossis pob
- nce kis
Cov tshuaj lom neeg tuaj yeem sib cuam tshuam nrog lwm cov neeg ua haujlwm biologic. Piv txwv ntawm cov no suav nrog:
- natalizumab
- adalimumab
- golimumab
- infliximab
- anakinra
- abatacept
- tocilizumab
- warfarin
- cyclosporine
- theophylline
- nyob cov tshuaj tiv thaiv xws li cov tshuaj tiv thaiv varicella zoster
Zam NSAIDs
NSAIDs, xws li ibuprofen thiab naproxen, feem ntau txo qis kev mob hauv lub cev. Yog tias koj muaj mob ua plab, txawm hais tias, cov tshuaj no tuaj yeem ua rau koj cov tsos mob hnyav dua. Nco ntsoov nrog koj tus kws kho mob tham ua ntej siv tshuaj NSAID.
Tham nrog koj tus kws kho mob
Ntau yam tshuaj yuav pab txo koj cov tsos mob ua paug. Yog tias koj muaj mob caj dab, saib tsab xov xwm no nrog koj tus kws kho mob thiab tham txog cov tshuaj uas yuav zoo rau koj. Koj tus kws kho mob yuav tawm tswv yim muab tshuaj kho raws cov teeb meem xws li koj kev noj qab haus huv tag nrho thiab koj mob npaum li cas.
Koj yuav tsum tau sim ob peb yam tshuaj ua ntej koj pom qhov phiaj xwm kho mob uas ua haujlwm rau koj. Yog tias noj ib qho tshuaj tsis txo koj tus mob txaus, koj tus kws kho mob yuav ntxiv ib qho tshuaj thib ob uas ua rau kom qhov tshuaj zoo dua thib ib. Nws yuav siv sijhawm qee lub sijhawm, tabsis koj tus kws khomob yuav ua haujlwm nrog koj kom nrhiav tau cov tshuaj zoo los pab ua rau koj lub plab mob ua paug.