Txhua Yam Koj Yuav Tsum Tau Paub Txog Cushing's Syndrome

Zoo Siab

• Txheej txheem cej luam
• Cushing's syndrome Cov tsos mob tshwm sim
• Hauv menyuam yaus
• Hauv poj niam
• Hauv neeg
• Cushing's syndrome ua rau
• Corticosteroids
• Lub pob hlav
• Cushing's disease
• Cushing's syndrome kev kho mob
• Kev tshawb nrhiav Cushing's syndrome
• Kev txheeb xyuas qhov ua rau muaj mob Cushing's syndrome
• Cushing's syndrome cov zaub mov noj
• Cushing's syndrome phom sij txaus ntshai
• Cushing's syndrome cov kev tswj hwm
• Cushing tus mob outlook

Txheej txheem cej luam

Cushing's syndrome lossis hypercortisolism, tshwm sim vim yog lub cev tsis zoo ntau ntau ntawm cortisol. Qhov no tuaj yeem tshwm sim rau ntau yam.

Feem ntau, txais kev kho mob tuaj yeem pab koj tswj hwm koj cov qib cortisol.

Cushing's syndrome Cov tsos mob tshwm sim

Feem ntau cov tsos mob ntawm tus mob no yog:

• hnyav
• cov rog muaj roj, tshwj xeeb tshaj yog nyob rau hauv lub midsection, lub ntsej muag (ua rau puag ncig, lub hli lub ntsej muag lub ntsej muag), thiab nruab nrab ntawm lub xub pwg nyom thiab qaum sab nraub qaum (ua rau lub plab twm hump)
• paj yeeb ncab ntaus cim rau ntawm ob lub mis, caj npab, plab, thiab ncej puab
• thinning ntawm daim tawv nqaij uas doog tau yooj yim
• daim tawv nqaij raug mob uas qeeb los kho
• pob txuv
• nkees
• leeg tsis muaj zog

Ntxiv rau cov tsos mob tshwm sim saum toj no, tseem muaj lwm cov tsos mob uas qee zaum pom nyob hauv cov neeg muaj Cushing's syndrome.

Cov no tuaj yeem suav nrog:

• ntshav qab zib kom ntau
• nce nqhis dej
• nce tso zis
• txha txha caj qaum
• ntshav siab (tawg)
• mob taub hau
• mus ob peb vas sw
• ntxhov siab
• txob taus
• kev nyuaj siab
• muaj kev kis ntau zuj zus ntxiv

Hauv menyuam yaus

Cov menyuam yaus tuaj yeem muaj Cushing's syndrome thiab, txawm tias lawv pib nws tsawg dua li neeg laus. Raws li kev tshawb nrhiav xyoo 2019, txog ntawm Cushing's syndrome cov kab mob tshiab txhua xyoo tshwm sim hauv cov menyuam yaus.

Ntxiv rau cov tsos mob saum toj no, cov menyuam yaus Cushing's syndrome kuj tseem yuav muaj:

• rog dhau
• qeeb qeeb ntawm kev loj hlob
• ntshav siab (tawg)

Hauv poj niam

Cushing's syndrome feem ntau muaj rau cov poj niam ntau dua li cov txiv neej. Raws li National Institutes of Health (NIH), peb zaug li ntau tus poj niam muaj mob Cushing's syndrome piv rau txiv neej.

Cov poj niam nrog Cushing's syndrome tej zaum yuav ua plaub hau ntxiv thiab lub cev.

Feem ntau qhov no tshwm sim ntawm:

• ntsej muag thiab caj dab
• hauv siab
• plab
• tus ncej puab

Ib qho ntxiv, cov poj niam mob Cushing's syndrome kuj tseem tuaj yeem muaj kev coj khaub ncaws tsis xwm yeem. Muaj qee kis, kev coj khaub ncaws tsis tuaj raws sijhawm. Yog tsis kho mob Cushing's syndrome rau cov poj niam tuaj yeem ua rau qhov menyuam cev xeeb tub.

Hauv neeg

Xws li cov poj niam thiab cov menyuam yaus, cov txiv neej nrog Cushing's syndrome kuj tuaj yeem pom qee cov tsos mob ntxiv.

Tus txiv neej nrog Cushing's syndrome tej zaum yuav muaj:

• erectile kawg
• ib tug ploj ntawm kev txaus siab ntawm kev sib deev
• tsawg fertility

Cushing's syndrome ua rau

Cushing's syndrome yog tshwm sim los ntawm qhov tshaj dhau ntawm cov tshuaj hormone cortisol. Koj lub qog ua kua cortisol.

Nws pab nrog koj tus lej ua haujlwm ntawm koj lub cev, suav nrog:

• kev tswj ntshav siab thiab cov kab mob plawv
• txo cov tshuaj tiv thaiv kab mob hauv lub cev
• kev hloov pauv cov carbohydrates, cov rog, thiab cov protein rau hauv lub zog
• ntsuas kev cuam tshuam cov insulin
• teb kev ntxhov siab

Koj lub cev yuav ua cov cortisol siab rau ntau yam laj thawj, suav nrog:

• cov kev ntxhov siab siab heev, suav nrog kev ntxhov siab ntsig txog mob hnyav, phais mob, raug mob, lossis cev xeeb tub, tshwj xeeb tshaj yog nyob rau ntawm peb lub hlis kawg
• kev qhia kis las
• khoom noj khoom haus tsis muaj zog
• quav cawv
• kev nyuaj siab, ceeb ntshai, lossis theem siab ntawm kev ntxhov siab

Corticosteroids

Cov teeb meem tshwm sim feem ntau ntawm Cushing's syndrome yog siv cov tshuaj corticosteroid, xws li prednisone, nyob rau hauv lub siab ntev rau ib lub sijhawm ntev. Cov kws saib xyuas kev noj qab haus huv tuaj yeem sau cov tshuaj no los kho cov mob xws li mob lupus, lossis tiv thaiv kom tsis txhob lees lub cev hloov ntshav.

Kev txhaj tshuaj ntau dua ntawm cov tshuaj steroids rau kev kho mob nraub qaum kuj tseem tuaj yeem ua rau Cushing's syndrome. Txawm li cas los xij, cov tshuaj steroids qis dua hauv cov tshuaj txau, xws li cov tshuaj siv rau hawb pob, lossis tshuaj pleev, xws li cov tshuaj siv rau eczema, feem ntau tsis txaus ua rau muaj tus mob.

Lub pob hlav

Ntau hom qog kuj tseem tuaj yeem ua rau kom muaj cortisol ntau dua.

Qee qhov ntawm no suav nrog:

• Cov qog Pituitary hlav. Lub caj pas pituitary tso tawm ntau dhau adrenocorticotropic hormone (ACTH), uas ua rau cortisol ntau lawm hauv cov qog adrenal. Qhov no hu ua Cushing's disease.
• Cov hlav hlav ectopic. Cov no yog cov qog nyob sab nraud ntawm qhov tshis uas tsim ACTH. Feem ntau lawv tshwm sim hauv lub ntsws, tus mob ua paug, mob caj pas, lossis rau cov qog ua kua.
• Adrenal caj pas ua haujlwm tsis zoo los yog qog. Kev ua xiam adrenal lossis cov qog tuaj yeem tuaj yeem ua rau cov qauv tsis xws li cortisol ntau lawm, uas tuaj yeem ua rau Cushing's syndrome.
• Familial Cushing's syndrome. Txawm hais tias Cushing's syndrome feem ntau tsis tau muaj caj ces, nws muaj peev xwm ua tau txoj kev los ntawm qog cov qog endocrine qog.

Cushing's disease

Yog tias Cushing's syndrome tshwm sim los ntawm lub caj pas pituitary los ua haujlwm ntau dua ntawm ACTH uas ua rau cortisol, nws hu ua Cushing's disease.

Ib yam li Cushing's syndrome, Cushing's disease muaj feem cuam rau poj niam ntau dua li tus txiv neej.

Cushing's syndrome kev kho mob

Lub hom phiaj tag nrho ntawm kev kho mob Cushing's syndrome yog ua kom cov qib cortisol hauv koj lub cev txo qis. Qhov no tuaj yeem ua tiav hauv ntau txoj kev. Cov kev kho mob uas koj tau txais yuav yog nyob ntawm dab tsi ua rau koj tus mob.

Koj tus kws kho mob yuav sau ntawv muab tshuaj los pab tswj cov qib cortisol. Qee cov tshuaj txo qis cortisol ntau ntxiv hauv cov qog adrenal los yog txo qis ACTH ntau lawm hauv cov qog pituitary. Lwm cov tshuaj thaiv cov nyhuv ntawm cortisol ntawm koj cov ntaub so ntswg.

Piv txwv li:

• ketoconazole (Nizoral)
• mitotane (Lysodren)
• metyrapone (Metopirone)
• pasireotide (Signifor)
• mifepristone (Korlym, Mifeprex) rau cov tib neeg muaj ntshav qab zib hom 2 lossis ntshav qabzib tsis kam txais

Yog tias koj siv corticosteroids, kev hloov pauv ntawm cov tshuaj lossis cov tshuaj ntau dua yuav tsim nyog. Tsis txhob sim hloov cov tshuaj koj tus kheej. Koj yuav tsum ua qhov no nrog kev saib xyuas mob nkeeg.

Cov qog tuaj yeem tuaj yeem yog malignant, uas txhais tau tias mob qog, lossis benign, uas txhais tau tias tsis yog lub cev.

Yog tias koj tus mob yog los ntawm cov qog, koj tus kws kho mob yuav xav tshem cov qog mus phais. Yog tias lub qog tshem tawm tsis tau, koj tus kws kho mob kuj tseem yuav hais kom siv tshuaj tua hluav taws xob lossis siv tshuaj kho mob.

Kev tshawb nrhiav Cushing's syndrome

Cushing's syndrome yuav nyuaj rau kev txheeb xyuas. Qhov no yog vim tias ntau yam ntawm cov tsos mob, xws li nce phaus lossis rog dhau lawm, tuaj yeem muaj lwm yam ua. Ib qho ntxiv, Cushing's syndrome nws tus kheej tuaj yeem muaj ntau yam laj thawj.

Koj tus kws kho mob yuav tshuaj xyuas koj li keeb kwm kev kho mob. Lawv yuav nug txog cov tsos mob, muaj mob koj yuav muaj, thiab cov tshuaj uas koj tuaj yeem sau tseg.

Lawv kuj yuav kuaj ib ce qhov twg uas lawv yuav tau saib rau tej cim zoo li tus twm khaus, thiab caj dab thiab doog ntshav.

Tom ntej no, lawv tuaj yeem xaj kom kuaj chav tsev, nrog rau:

• 24-teev kev kuaj mob pub dawb rau cortisol: Rau qhov kev ntsuas no, koj yuav raug hais kom sau koj cov zis li ntawm 24 teev. Cov theem ntawm cortisol yuav raug kuaj.
• Ntsuas salivary cortisol ntsuas: Hauv cov neeg uas tsis muaj Cushing's syndrome, qib cortisol poob thaum yav tsaus ntuj. Qhov ntsuas ntsuas no ntsuas seb cortisol nyob hauv cov kua qaub ncaug uas khaws thaum yav hmo ntuj los saib seb puas cortisol ntau dhau.
• Tsawg-koob tshuaj dexamethasone los ntsuas: Rau qhov kev ntsuas no, koj yuav muab cov koob tshuaj dexamethasone nyob rau yav lig. Koj cov ntshav yuav raug kuaj rau qib cortisol thaum sawv ntxov. Feem ntau, dexamethasone ua rau cortisol qib poob. Yog tias koj muaj Cushing's syndrome, qhov no yuav tsis tshwm sim.

Kev txheeb xyuas qhov ua rau muaj mob Cushing's syndrome

Tom qab koj tau txais kev kuaj mob Cushing's syndrome, koj tus kws kho mob yuav tsum tseem txiav txim siab ua kom muaj ntau ntxiv cortisol ntau lawm.

Kev ntsuam xyuas los pab txiav txim qhov laj thawj yuav suav nrog:

• Kev kuaj ntshav adrenocorticotropin (ACTH) ntshav: Theem ntawm ACTH nyob rau hauv cov ntshav raug ntsuas. Qhov qis ntawm ADTH thiab theem siab ntawm cortisol tuaj yeem qhia tias muaj cov qog ntawm lub qog adrenal.
• Corticotropin-tso cov tshuaj hormones (CRH) kev sim tshuaj: Hauv qhov kev ntsuas no, txhaj tshuaj ntawm CRH yog muab. Qhov no yuav nce qib ntawm ACTH thiab cortisol hauv cov neeg uas muaj qog pituitary.
• High-koob tshuaj dexamethasone txwv: Qhov no yog tib yam li kev ntsuas tshuaj qis, tshwj tsis yog tias yuav siv tshuaj dexamethasone ntau dua. Yog tias qib cortisol poob qis, tej zaum koj yuav muaj mob qog nqaij hlav pituitary. Yog tias lawv tsis yog koj muaj cov nqaij hlav tawv ectopic.
• Petrosal qhov ntswg txhaus: Ntshav yog kos los ntawm cov hlab ntshav ze ntawm qhov pituitary thiab kuj los ntawm txoj hlab ntshav kom deb ntawm qhov pituitary. Txhaj rau CRH muab. Theem siab ntawm ACTH nyob rau hauv cov ntshav ze ntawm lub qhov tshis tuaj yeem qhia lub qog pituitary. Qib zoo sib xws los ntawm ob qho piv txwv qhia pom cov nqaij hlav ectopic.
• Kev tshawb fawb duab: Cov no tuaj yeem suav cov khoom xws li CT thiab MRI scans. Lawv tau siv los kuaj qhov qog adrenal thiab lub qog pituitary los saib qog.

Cushing's syndrome cov zaub mov noj

Txawm hais tias kev noj zaub mov zoo tsis tuaj yeem kho koj tus mob los, lawv tuaj yeem pab ua kom koj cov qib cortisol nce ntxiv lossis pab tiv thaiv qee qhov mob.

Qee cov lus qhia noj zaub mov zoo rau cov neeg mob Cushing's syndrome muaj xws li:

• Soj ntsuam koj cov khoom noj kom tsawg. Taug qab saib koj cov zaub mov kom tsuas yog ib qho tseem ceeb vim tias kev rog hnyav yog ib qho ntawm cov tsos mob tseem ceeb ntawm Cushing's syndrome.
• Sim kom tsis txhob haus cawv. Kev haus cawv tau cuam tshuam nrog kev nce qib hauv cortisol, tshwj xeeb, raws li kev tshawb fawb xyoo 2007.
• Saib xyuas koj cov ntshav qab zib. Cushing's syndrome tuaj yeem ua rau muaj ntshav qabzib cov ntshav siab, yog li tsis txhob noj cov zaub mov uas tuaj yeem ua rau nce siab hauv cov ntshav qab zib. Piv txwv ntawm cov khoom noj uas yuav tsom rau kev noj xws li zaub, txiv hmab txiv ntoo, cov nplej thiab nqaij ntses.
• Txiav rov qab los rau ntawm sodium. Cushing's syndrome kuj muaj feem cuam tshuam nrog ntshav siab (tawg). Vim tias qhov no, sim txwv koj txoj kev noj ntsev kom tsawg. Qee txoj hauv kev yooj yim los ua qhov no suav nrog tsis ntxiv ntsev rau zaub mov thiab ua tib zoo nyeem cov ntawv zaub mov kom xyuas cov ntsev.
• Nco ntsoov tias kom tau txais calcium thiab vitamin d txaus. Cushing's syndrome tuaj yeem ua rau koj cov pob txha tsis muaj zog, ua rau koj lub cev puas yooj yim. Ob qho calcium thiab vitamin D tuaj yeem pab koj cov pob txha zoo.

Cushing's syndrome phom sij txaus ntshai

Qhov kev pheej hmoo txaus ntshai rau kev tsim Cushing's syndrome yog noj tshuaj ntau dua corticosteroids nyob rau lub sijhawm ntev. Yog koj tus kws kho mob tau sau corticosteroids los kho ib qho mob, nug lawv txog kev noj tshuaj thiab koj yuav siv sijhawm ntev npaum li cas.

Lwm yam kev pheej hmoo tuaj yeem suav nrog:

• ntshav qab zib hom 2 uas tsis tuaj yeem tshuaj tau zoo
• ntshav siab (tawg)
• rog dhau

Qee kis ntawm Cushing's syndrome yog vim muaj cov qog ntshav. Txawm hais tias nws tuaj yeem muaj cov caj ces tsim kho cov qog endocrine (tsev neeg Cushing's syndrome), nws tsis muaj txoj hauv kev los tiv thaiv qog ntawm kev tsim.

Cushing's syndrome cov kev tswj hwm

Yog tias koj muaj Cushing's syndrome, nws yog ib qho tseem ceeb uas nws tau tswj hwm kom zoo. Yog tias koj tsis tau txais kev kho nws, Cushing's syndrome tuaj yeem ua rau ntau qhov muaj mob txaus ntshai txog kev mob nkeeg.

Cov no tuaj yeem suav nrog:

• osteoporosis, uas tuaj yeem ua rau koj pheej hmoo ntawm pob txha lov
• cov leeg tsis muaj zog (atrophy) thiab tsis muaj zog
• ntshav siab (tawg)
• ntshav qab zib hom 2
• nquag muaj tus kab mob
• mob plawv lossis mob stroke
• kev nyuaj siab lossis ntxhov siab
• cov teeb meem kev txawj ntse zoo ib yam li cov teeb meem kev xav ua lossis teeb meem nrog lub cim xeeb
• kev loj hlob ntawm ib qho qog uas twb muaj lawm

Cushing tus mob outlook

Thaum koj pib kho sai dua, qhov tshwm sim yuav zoo dua. Nws tseem ceeb heev kom nco ntsoov tias koj qhov kev xam pom ntawm tus kheej yog nyob ntawm qhov laj thawj thiab kev kho mob uas koj tau txais.

Nws yuav siv sijhawm me ntsis rau koj cov tsos mob zoo tuaj. Nco ntsoov nug koj tus neeg saib xyuas kev noj qab haus huv rau cov txheej txheem qhia txog kev noj zaub mov zoo, ua raws li cov sijhawm teem sijhawm mus ntsib, thiab nce koj qib haujlwm qeeb.

Cov pab neeg pabcuam tuaj yeem pab koj daws cov Cushing's syndrome. Koj lub tsev kho mob lossis chaw kho mob hauv cheeb tsam tuaj yeem qhia koj txog cov pab pawg uas ntsib hauv koj thaj chaw.