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Azathioprine - Pharmacology, mechanism of action, side effects,
Daim Duab: Azathioprine - Pharmacology, mechanism of action, side effects,

Zoo Siab

Azathioprine yuav ua rau koj muaj feem ntau los ua qee yam mob cancer, tshwj xeeb yog mob qog nqaij hlav thiab mob qog nqaij hlav (mob qog nqaij hlav uas pib hauv cov hlwb ua mob sib kis) Yog tias koj muaj lub raum hloov pauv, nws yuav muaj feem ntau uas koj yuav muaj mob qog noj ntshav txawm tias koj tsis noj azathioprine. Qhia rau koj tus kws kho mob yog tias koj tau lossis muaj mob qog noj ntshav dua thiab yog tias koj noj lossis tau noj ntau dua cov kab mob alkylating xws li chlorambucil (Leukeran), cyclophosphamide (Cytoxan), lossis melphalan (Alkeran) rau mob qog noj ntshav. Txo qhov kev pheej hmoo uas koj yuav ua mob qog nqaij daim tawv, zam kom tsis txhob muaj hnub ntev lossis tsis raug rau hnub ci thiab hnav khaub ncaws tiv thaiv, tsom iav, thiab tshuaj pleev thaiv hnub. Qhia rau koj tus kws kho mob tam sim ntawd yog tias koj pom muaj kev txawv txav ntawm koj cov tawv nqaij lossis cov qog lossis ib qho loj hauv koj lub cev.

Qee tus menyuam hluas thiab cov tub ntxhais hluas lub hnub nyoog laus uas tau siv tshuaj azathioprine ib leeg lossis nrog lwm cov tshuaj hu ua qog necrosis factor (TNF) blocker los kho tus kab mob Crohn (mob uas lub cev tawm tsam cov hlab hauv lub plab ua rau mob, raws plab, poob phaus, thiab) mob ua npaws) los yog mob ua mob ua kiav txhab (mob uas ua rau o thiab ua mob rau sab hauv txoj hnyuv [txoj hnyuv loj thiab lub qhov quav) tau tsim kab mob siab hepatosplenic T-cell lymphoma (HSTCL). HSTCL yog hom mob cancer uas feem ntau ua rau kev tuag nyob rau lub sijhawm luv luv. Azathioprine tsis tau pom zoo los ntawm Food and Drug Administration (FDA) rau kev kho tus kab mob Crohn lossis mob plab hnyuv, tab sis qee zaum kws kho mob qee zaum sau ntawv azathioprine los kho cov mob no. Yog tias koj muaj ib qho ntawm cov tsos mob no thaum kho koj tus mob, hu rau koj tus kws kho mob tam sim ntawd: mob plab; ua npaws; piav tsis hnyav poob; tawm hws hmo ntuj lossis tawm hws los ntshav yooj yim.


Azathioprine tuaj yeem ua rau txo qis cov qe ntshav hauv koj cov pob txha pob txha, uas yuav ua rau mob hnyav lossis tuag taus. Qhov kev pheej hmoo tias cov lej ntawm cov ntshav koj yuav muaj tsawg yog qhov ntau tshaj yog tias koj muaj caj ces (raug tsim los ntawm txoj kev phom sij). Koj tus kws kho mob yuav xaj kuaj ua ntej lossis sijhawm kho koj tus kws tshuaj seb koj puas muaj feem yuav muaj feem ua kom zoo li no. Kev noj qee yam tshuaj kuj tseem tuaj yeem ua rau muaj kev pheej hmoo tias koj cov qe ntshav yuav tsawg zuj zus, yog li qhia koj tus kws kho mob yog tias koj noj ib qho twg hauv qab no: angiotensin hloov mus rau enzyme (ACE) inhibitors xws li benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril , lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), Ramipril (Altace), lossis trandolapril (Mavik); trimethoprim thiab sulfamethoxazole (Bactrim, Septra); thiab ribavirin (Copegus, Rebetol, Virazole). Yog tias koj pom muaj cov tsos mob hauv qab no, hu rau koj tus kws kho mob tam sim ntawd: ntshav los ntshav txawv txav; kev nkees ntau dhau; daj ntseg tawv nqaij; mob taub hau; tsis meej pem; kiv taub hau; lub plawv dhia ceev; nyuaj pw tsaug zog; tsis muaj zog; txog siav; thiab mob caj pas, kub taub hau, ua daus no, thiab lwm yam cim ntawm tus kab mob. Koj tus kws kho mob yuav xaj kuaj ua ntej, thaum, thiab tom qab kho koj tus mob seb koj cov ntshav puas cuam tshuam los ntawm cov tshuaj no.


Tham nrog koj tus kws kho mob txog kev pheej hmoo ntawm kev noj cov tshuaj no.

Azathioprine siv nrog lwm cov tshuaj los tiv thaiv kev hloov pauv hloov (tawm tsam ntawm cov khoom hloov khoom nruab nrog los ntawm kev tiv thaiv kab mob hauv lub cev) hauv cov neeg uas tau hloov raum. Nws kuj tseem siv los kho mob caj dab mob hnyav (ib qho mob uas lub cev tawm tsam nws cov pob qij txha, ua rau mob, o, thiab tsis ua haujlwm) thaum lwm yam tshuaj thiab kev kho mob tsis tau pab. Azathioprine nyob hauv chav kawm ntawm cov tshuaj hu ua immunosuppressants. Nws ua haujlwm los ntawm kev txo qis cov haujlwm ntawm lub cev tiv thaiv kab mob hauv lub cev kom nws thiaj li tsis tawm tsam cov hloov khoom nruab nrog lossis cov pob qij txha.

Azathioprine los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau noj ib zaug lossis ob zaug ib hnub tom qab noj mov. Siv azathioprine nyob rau tib lub sijhawm (s) txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj azathioprine raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.


Yog tias koj noj tshuaj azathioprine los kho tus mob rheumatoid, koj tus kws kho mob yuav pib noj tsawg thiab maj mam nce koj cov koob tshuaj tom qab 6-8 lub lis piam thiab tom qab ntawd tsis pub ntau tshaj ib zaug txhua 4 lub lis piam. Koj tus kws kho mob yuav maj mam txo koj qhov koob tshuaj thaum koj tus mob raug tswj hwm. Yog tias koj noj tshuaj azathioprine los tiv thaiv lub raum tsis ua haujlwm, koj tus kws kho mob yuav pib noj ntau thiab txo koj cov tshuaj kom tsawg zuj zus vim koj lub cev hloov kho rau kev hloov ntshav.

Azathioprine tswj hwm mob rheumatoid mob caj dab tab sis tsis kho nws. Nws yuav siv sijhawm ntev txog 12 lub lis piam ua ntej koj xav tias tag nrho cov txiaj ntsig ntawm azathioprine. Azathioprine txwv tsis pub hloov mus rau lwm qhov tsuas yog tias koj noj tshuaj lawm. Txuas ntxiv noj cov azathioprine txawm hais tias koj tus kheej yuav zoo. Tsis txhob tsum noj azathioprine tsis tham nrog koj tus kws kho mob.

Azathioprine tseem tseem siv los kho mob ulcerative colitis (ib qho mob uas ua rau o thiab mob voos hauv ob sab phlu ntawm txoj hnyuv [plab hnyuv loj] thiab lub qhov quav) thiab Crohn's kab mob. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo uas yuav siv cov tshuaj no rau koj tus mob.

Cov tshuaj no qee zaum sau tseg rau lwm qhov kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj cov azathioprine,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau azathioprine, lwm yam tshuaj, lossis lwm yam tshuaj hauv azathioprine ntsiav tshuaj. Nug koj tus kws kho mob lossis kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog cov tshuaj uas tau hais hauv ntu CEEB TOOM TSEEM CEEB thiab ib qho twg ntawm cov hauv qab no: allopurinol (Zyloprim); aminosalicylates xws li mesalamine (Apriso, Asacol, Pentasa, lwm tus), olsalazine (Dipentum), thiab sulfasalazine (Azulfidine); thiab anticoagulants ('ntshav thinners') xws li warfarin (Coumadin). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
  • qhia rau koj tus kws kho mob yog tias koj muaj ib hom mob dab tsi, lossis yog tias koj muaj lossis koj tau muaj mob raum ua ntej.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum siv tshuaj tswj kom tsis txhob muaj menyuam kom paub tseeb tias koj lossis koj tus khub yuav tsis xeeb tub thaum koj noj cov tshuaj no. Hu rau koj tus kws kho mob yog tias koj lossis koj tus khub ua cev xeeb tub thaum koj noj tshuaj azathioprine. Azathioprine tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav uas koj siv tshuaj azathioprine.
  • tsis muaj kev txhaj tshuaj tiv thaiv kab mob thaum lub sijhawm lossis tom qab kho koj tus kws kho mob yam tsis tau tham nrog koj tus kws kho mob.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Azathioprine yuav ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • xeev siab
  • ntuav
  • zawv plab

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob hauv qab no lossis cov uas tau teev tseg rau hauv seem CEEB TOOM TSEEM CEEB, hu rau koj tus kws kho mob tam sim ntawd.

  • ua pob
  • ua npaws
  • tsis muaj zog
  • mob leeg

Cov tshuaj no tuaj yeem tsim lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum koj noj azathioprine.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev noj haus ntau heev yuav suav nrog cov hauv qab no:

  • xeev siab
  • ntuav
  • zawv plab
  • mob caj pas, ua npaws, ua daus no, thiab lwm yam cim ntawm tus kab mob

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

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