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PV: Clinical Use of Hydroxyurea
Daim Duab: PV: Clinical Use of Hydroxyurea

Zoo Siab

Hydroxyurea tuaj yeem ua rau txo qis cov qe ntshav hauv koj cov hlwb pob txha. Qhov no yuav ua rau muaj kev pheej hmoo ntxiv tias koj yuav kis mob hnyav lossis los ntshav. Yog tias koj muaj cov tsos mob li hais hauv qab no, hu rau koj tus kws kho mob tam sim ntawd: kub cev, ua daus no, nkees dhau heev lossis qaug zog, mob ib ce, mob caj pas, ua pa ceev, hnoos tsis tu ncua thiab txhaws, lossis lwm yam cim ntawm kev kis mob; los ntshav los sis doog ntshav; los ntshav lossis dub, tarry tso quav; lossis ntuav ntshav lossis tawv nqaij daj uas zoo li thaj chaw kas fes.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev tshuaj xyuas ib ntus kom kuaj xyuas koj lub cev cov lus teb rau hydroxyurea thiab saib seb koj cov ntshav puas poob qis. Koj tus kws kho mob yuav xav hloov koj qhov tshuaj lossis hais kom koj tsum tsis txhob noj hydroxyurea rau lub sijhawm kom koj cov ntshav rov qab nyob li qub yog tias nws poob qis.

Hydroxyurea tuaj yeem ua rau muaj kev pheej hmoo ntxiv tias koj yuav tsim lwm yam qog nqaij hlav, nrog rau mob qog nqaij tawv Npaj yuav zam kom tsis txhob muaj lub hnub ci thiab hnub ci thiab hnav khaub ncaws tiv thaiv, tsom iav, thiab tshuaj pleev thaiv hnub. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev siv hydroxyurea.


Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (Phau Ntawv Qhia Tshuaj Kho Mob) thaum koj pib kho nrog hydroxyurea thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib zaub mov thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kom tau Phau Ntawv Qhia Tshuaj.

Hydroxyurea (Hydrea) tsuas yog siv ib leeg los yog nrog lwm yam tshuaj kho mob los yog kho hluav taws xob los kho qee yam mob myelogenous leukemia (CML; ib hom mob cancer ntawm cov qe ntshav dawb) thiab qee yam mob qog taub hau thiab caj dab (suav nrog mob cancer ntawm lub qhov ncauj , sab plhu, nplaig, caj pas, tonsils, thiab hlab ntsws). Hydroxyurea (Droxia, Siklos) yog siv los txo cov teeb meem mob heev thiab txo cov kev xav hloov ntshav hauv cov neeg laus thiab cov menyuam hnub nyoog 2 xyoos thiab laus dua nrog sickle cell anemia (ib qho ntshav muaj ntshav uas cov ntshav liab tau hloov tsis zoo) [zoo li tus neeg mob taub hau] thiab tsis tuaj yeem nqa oxygen txaus rau txhua qhov ntawm lub cev). Hydroxyurea yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua antimetabolites. Hydroxyurea kho cov kabmob kheesxaws los ntawm kev maj mam lossis nres kev loj hlob ntawm cov kabmob kheesxaws hauv koj lub cev. Hydroxyurea kho cov ntshav liab uas tsis muaj ntshav los ntawm kev pab tiv thaiv kom tsis txhob muaj cov qe ntshav liab li ntshav liab.


Hydroxyurea los ua tshuaj ntsiav thiab ntsiav tshuaj los noj ntawm qhov ncauj. Nws yog feem ntau noj ib zaug ib hnub nrog ib khob dej. Thaum hydroxyurea siv los kho qee yam mob qog ntshav, nws yuav noj ib zaug txhua peb hnub. Siv hydroxyurea nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj hydroxyurea raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Koj tus kws kho mob yuav xav ncua koj txoj kev kho mob lossis kho qhov tshuaj ntau ntxiv ntawm yog koj nyob ntawm koj cov lus teb rau kev kho thiab tej kev phiv uas koj yuav pom. Tham nrog koj tus kws kho mob txog saib koj xav li cas thaum kho koj tus mob. Tsis txhob tsum tsis txhob noj hydroxyurea yam tsis tham nrog koj tus kws kho mob.

Tej zaum koj tus kws kho mob yuav qhia koj kom noj lwm yam tshuaj, folic acid (a vitamin), kom txo qee qhov kev phiv los ntawm cov tshuaj no. Noj cov tshuaj no raws nraim li qhia.


Nqos cov tsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv.

Cov tshuaj hydroxyurea 1,000-mg ntsiav tshuaj (Siklos) tau muab qhab nia kom lawv tuaj yeem muab faib ua ob peb ntu hauv ib nrab lossis ib ntu kom muab cov koob tshuaj me dua. Tsis txhob tawg lub hydroxyurea 100-mg ntsiav tshuaj rau hauv qhov me me. Koj tus kws kho mob yuav qhia koj seb yuav rhuav tshem cov ntsiav tshuaj thiab pes tsawg lub ntsiav tshuaj lossis qhov chaw ntawm lub ntsiav tshuaj koj yuav tsum tau noj.

Yog tias koj tsis tuaj yeem nqos cov tshuaj hydroxyurea lossis feem me ntawm cov ntsiav tshuaj, koj yuav yaj tau hauv koj cov dej hauv dej. Tso koj cov tshuaj rau hauv rab diav thiab ntxiv me me ntawm cov dej. Tos li 1 feeb kom cia lub (cov) ntsiav tshuaj yaj kom yaj, tom qab ntawd nqos cov dej kom sib xyaw.

Koj yuav tsum hnav cov hnab looj tes roj hmab lossis looj hnab looj thaum koj kov cov tshuaj ntsiav lossis tshuaj ntsiav kom koj cov tawv nqaij tsis chwv nrog cov tshuaj. Ntxuav koj txhais tes nrog xab npum thiab dej ua ntej thiab tom qab koj kov lub raj mis lossis noj tshuaj. Yog tias hydroxyurea nkag mus rau hauv koj lub qhov muag, tam sim ntawd yaug koj lub qhov muag nrog dej li tsawg kawg 15 feeb. Yog tias cov hmoov los ntawm tshuaj ntsiav lossis tshuaj ntsiav nchuav, so nws tam sim ntawd nrog cov phuam uas siv tas. Tom qab ntawv muab txoj phuam rau hauv lub thawv kaw, xws li hnab yas, thiab muab nws pov tseg rau hauv thoob khib nyiab uas tsis ncav cuag cov menyuam yaus thiab tsiaj. Ntxuav thaj chaw nchuav siv cov tshuaj ntxuav tom qab siv dej huv.

Hydroxyurea kuj tseem siv qee zaum los kho polycythemia vera (kab mob ntshav uas koj lub cev ua rau cov ntshav liab ntau dhau). Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev siv cov tshuaj no rau koj tus mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj hydroxyurea,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau hydroxyurea, lwm yam tshuaj, lossis ib qho tshuaj tsis haum hauv hydroxyurea tsiav tshuaj lossis ntsiav tshuaj. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txhua yam ntawm cov hauv qab no: qee yam tshuaj rau HIV (tib neeg cov tshuaj tiv thaiv kab mob) xws li didanosine (Videx) thiab stavudine (Zerit) thiab interferon (Actimmune, Avonex, Betaseron, Infergen, Intron A, lwm tus). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
  • qhia rau koj tus kws kho mob yog tias koj muaj tus kab mob human immunodeficiency virus (HIV), nrhiav kev tiv thaiv kab mob ntsws (AIDS), muaj cov kab mob siab uric acid hauv koj cov ntshav, lossis mob rau ntawm txhais ceg; yog tias koj raug kho nrog lossis tau kho dua nrog kev siv hluav taws xob, kho tshuaj tua kab mob cancer, lossis kho cov leeg hlwb; lossis yog tias koj tau lossis muaj dua li mob raum lossis mob siab.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum tsis txhob cev xeeb tub lossis pub niam mis thaum koj noj tshuaj hydroxyurea. Koj yuav tsum muaj kev ntsuas cev xeeb tub ua ntej koj pib kho nrog hydroxyurea. Yog tias koj yog poj niam, koj yuav tsum siv kev tswj tsis pub muaj menyuam thaum noj hydroxyurea thiab tsawg kawg 6 lub hlis tom qab koj tsum tsis kho. Yog tias koj yog txiv neej, koj thiab koj tus poj niam tus khub yuav tsum siv tshuaj tswj kom muaj txiaj ntsig zoo thaum siv hydroxyurea thiab tsawg kawg 6 lub hlis (Siklos) lossis tsawg kawg 1 xyoos (Droxia, Hydrea) tom qab txiav kev kho mob. Tham nrog koj tus kws kho mob txog cov hau kev tswj kev xeeb menyuam uas koj tuaj yeem siv thaum thiab tom qab kho koj thiab ntev li cas koj yuav tsum tau siv ntxiv. Yog tias koj cev xeeb tub thaum noj hydroxyurea, hu rau koj tus kws kho mob tam sim ntawd. Hydroxyurea tuaj yeem tsim kev puas tsuaj rau tus me nyuam hauv plab.
  • koj yuav tsum paub tias cov tshuaj no tuaj yeem txo qis kev muaj menyuam hauv cov txiv neej. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev siv hydroxyurea.
  • tsis muaj kev txhaj tshuaj yam tsis tau tham nrog koj tus kws kho mob.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Hydroxyurea tuaj yeem ua rau phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • xeev siab
  • ntuav
  • zawv plab
  • tsis qab los noj mov
  • hnyav
  • cov qhov ncauj tawm hauv qhov ncauj thiab caj pas
  • cem quav
  • ua pob
  • daj ntseg tawv nqaij
  • kiv taub hau
  • mob taub hau
  • plaub hau poob
  • kev hloov pauv tawv nqaij thiab ntsia hlau

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

  • lub plawv dhia ceev
  • kev mob tsis tu ncua uas pib hauv plab thaj chaw tab sis tuaj yeem kis rau sab nraub qaum
  • ceg mob lossis mob rwj
  • mob, khaus, liab, o, lossis tawm hlwv ntawm daim tawv nqaij
  • mob hauv sab saud hauv plab
  • daj ntawm daim tawv nqaij lossis qhov muag
  • loog loog, hlawv, lossis kov hauv tes lossis taw
  • kub taub hau, hnoos, txog siav siav, thiab lwm yam teeb meem ua pa

Hydroxyurea tuaj yeem ua rau lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm menyuam yaus thiab tsiaj. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej). Cov pob tawg 1,000-mg yuav tsum muab cia rau hauv lub ntim thiab yuav tsum siv tsis pub dhau 3 hlis.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev noj haus ntau heev yuav suav nrog cov hauv qab no:

  • cov qhov ncauj tawm hauv qhov ncauj thiab caj pas
  • mob, liab, o, thiab ua rau tes thiab taw
  • darkening ntawm daim tawv nqaij

Ua ntej muaj kev sim ntsuas, qhia rau koj tus kws kho mob thiab cov neeg ua haujlwm hauv chav kuaj pom tias koj noj tshuaj hydroxyurea.

Tsis txhob cia lwm tus noj koj cov tshuaj.Cov neeg uas tsis noj tshuaj hydroxyurea yuav tsum tsis txhob kov qhov tshuaj lossis lub raj mis uas muaj cov tshuaj.

Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Droxia®
  • Hydrea®
  • Siklos®
  • Hydroxycarbamide
Kawg Kho - 01/15/2020

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