Idecabtagene Vicleucel Txhaj

Zoo Siab

• Ua ntej tau txais idecabtagene vicleucel txhaj,
• Idecabtagene vicleucel tuaj yeem ua phiv phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

Txoj kev txhaj tshuaj vuvuag vicleucel tuaj yeem ua rau muaj kev phom sij hnyav lossis tuag taus uas yog hu ua cytokine release syndrome (CRS). Tus kws kho mob lossis tus nais maum yuav saib xyuas koj kom zoo thaum lub sijhawm koj nqus dej thiab tsawg kawg 4 lub lis piam tom qab. Qhia koj tus kws kho mob yog tias koj muaj mob voos los sis yog tias koj muaj lossis xav tias koj muaj qee yam mob tam sim no. Koj yuav tau muab tshuaj rau 30 mus rau 60 feeb ua ntej koj txoj kev tawm tsam los pab tiv thaiv kev tsis haum tawm ntawm idecabtagene vicleucel. Yog tias koj muaj cov tsos mob li no thaum lub sijhawm thiab tom qab koj qhov hnoos qeev, qhia rau koj tus kws kho mob tam sim ntawd: kub taub hau, ua daus no, ceev ceev lossis lub plawv dhia, mob leeg, tshee, raws plab, nkees, qaug zog, ua tsis taus pa, ua tsis taus pa, hnoos, tsis meej, xeev siab, ntuav, kiv taub hau, lossis mob taub hau.

Txoj kev txhaj tshuaj vuvuagtus vicleucel tuaj yeem ua rau mob hnyav lossis tuag taus ntawm lub nruab nrog lub paj hlwb loj. Cov kev cuam tshuam no tuaj yeem tshwm sim tom qab kho nrog idecabtagene vicleucel. Qhia rau koj tus kws kho mob yog tias koj tau ua lossis tau muaj mob chua leeg dua, mob stroke lossis nco nco. Yog tias koj muaj cov tsos mob li hais hauv qab no, qhia rau koj tus kws kho mob tam sim ntawd: mob taub hau, kiv taub hau, teeb meem tsis tsaug zog lossis pw tsaug zog, nyob tsis tswm, ntxhov siab, ntxhov siab, tsis tuaj yeem tuav ntawm ib feem ntawm lub cev, tsis nco qab, ntxhov siab, qaug dab peg, ploj ntawm sib npaug, los yog nyuaj hais lus.

Txoj kev txhaj tshuaj Idecabtagene vicleucel tuaj yeem ua rau txo qis qee cov qe ntshav hauv koj cov ntshav. Qhov no yuav ua rau qee qhov tsos mob thiab tuaj yeem ua rau muaj kev pheej hmoo ntxiv tias koj yuav kis mob hnyav lossis los ntshav. Yog tias koj muaj cov tsos mob nram qab no tom qab kho koj tus mob, qhia rau koj tus kws kho mob tam sim ntawd: ua npaws, nkees, los sis muaj doog ntshav los ntshav.

Idecabtagene vicleucel tsuas yog muaj los ntawm txoj kev txwv tshwj xeeb txoj kev pabcuam. Ib qho kev pabcuam hu ua Abecma REMS (Kev Tshuaj Ntsuam Xyuas Qhov Nyuaj & Txuag Haujlwm) tau teeb tsa vim tias muaj kev pheej hmoo ntawm CRS, kev poob siab hauv nruab nrab, thiab cov ntshav muaj teeb meem. Koj tsuas tau txais cov tshuaj los ntawm kws kho mob thiab chaw kho mob uas koom nrog txoj haujlwm. Nug koj tus kws kho mob yog tias koj muaj lus nug dab tsi txog txoj haujlwm no.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv teev cov neeg mob rau koj (Siv Phau Ntawv Qhia Tshuaj) thaum koj pib kho nrog idecabtagene vicleucel thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Cov tshuaj tua kab mob Idecabtagene vicleucel yog siv los kho qee yam mob myeloma (hom mob qog nqaij hlav rau pob txha caj qaum) hauv cov neeg laus uas muaj mob cancer tau rov qab los yog qhov tsis mob siv tsawg kawg yog plaub yam kev kho mob. Idecabtagene vicleucel txhaj tshuaj yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua autologous cellular immunotherapy, ib hom tshuaj uas tau npaj siv cov hlwb los ntawm tus neeg mob cov ntshav. Nws ua haujlwm los ntawm kev ua rau lub cev tiv thaiv kab mob (ib pawg ntawm cov hlwb, cov nqaij thiab lub cev uas tiv thaiv lub cev los ntawm kev tua los ntawm cov kab mob, kab mob, mob hlwb, thiab lwm yam khoom uas ua rau muaj kabmob) los tua cov qog nqaij hlav cancer.

Tus kws kho mob lossis tus nais maum hauv kws kho mob hauv chaw ua haujlwm lossis lub chaw kho mob ua ke nrog lub cev tso tawm (kua) los txhaj tshuaj (tso kua ntshav). Nws ib txwm muab rau tag nrho lub sijhawm ntev txog 30 feeb raws li kev noj tshuaj ib zaug. Ua ntej koj tau txais koj cov koob tshuaj idecabtagene vicleucel, koj tus kws kho mob lossis kws saib xyuas neeg mob yuav muab lwm cov tshuaj kho mob los kho koj lub cev rau idecabtagene vicleucel.

Ua ntej koj cov koob tshuaj idecabtagene vicleucel yuav tsum tau txhaj, ib qho piv txwv ntawm koj cov ntshav dawb yuav raug coj los ntawm lub chaw khaws ntaub ntawv ntawm tes siv cov txheej txheem hu ua leukapheresis (cov txheej txheem uas tshem cov qe ntshav dawb hauv lub cev). Vim tias cov tshuaj no yog tsim los ntawm koj tus kheej lub hlwb, nws yuav tsum tau muab rau koj nkaus xwb. Nws yog ib qho tseem ceeb yuav tsum tuaj kom ncav sij hawm thiab kom tsis txhob ncua koj lub sijhawm teem mus kuaj ntawm tes lossis kom tau txais qhov tshuaj kho koj. Koj yuav tsum npaj kom nyob tsis pub dhau 2 teev ntawm qhov chaw koj tau txais koj cov kev kho mob idecabtagene vicleucel rau tsawg kawg 4 lub lis piam tom qab koj tau noj tshuaj. Koj tus neeg saib xyuas kev noj qab haus huv yuav tshuaj xyuas seb koj txoj kev khomob puas ua haujlwm thiab saib xyuas koj rau cov kev phiv uas tuaj yeem tshwm sim. Tham nrog koj tus kws kho mob txog kev npaj rau leukapheresis thiab dab tsi yuav tshwm sim thaum thiab tom qab ua txoj kev.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej tau txais idecabtagene vicleucel txhaj,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau idecabtagene vicleucel, lwm yam tshuaj noj, dimethyl sulfoxide (DMSO), lossis ib qho twg ntawm cov khoom xyaw rau hauv kev txhaj tshuaj idecabtagene vicleucel. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: cov tshuaj steroids xws li dexamethasone, methylprednisolone (Medrol), prednisolone, thiab prednisone (Rayos). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia rau koj tus kws kho mob yog tias koj tau muaj kev tawm tsam dua los ntawm kev kho cov tshuaj kho mob yav dhau los xws li teeb meem ua pa lossis plawv dhia tsis xwm yeem. Thiab, qhia koj tus kws kho mob yog tias koj tau lossis muaj mob ntsws, raum, mob plawv, lossis mob siab.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum muaj kev ntsuas cev xeeb tub ua ntej koj pib idecabtagene vicleucel. Yog tias koj cev xeeb tub thaum tau txais idecabtagene vicleucel, hu rau koj tus kws kho mob tam sim ntawd. Cov tshuaj Idecabtagene vicleucel tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.
• koj yuav tsum paub hais tias kev txhaj tshuaj idecabtagene vicleucel tuaj yeem ua rau koj nkees nkees thiab ua rau tsis meej pem, tsis muaj zog, kiv taub hau, qaug dab peg, thiab teeb meem ua kom sib haum. Tsis txhob tsav tsheb los yog tsav lub tshuab ua haujlwm tsawg kawg yog 8 lub lis piam tom qab koj cov koob tshuaj idecabtagene vicleucel.
• tsis txhob tso cov ntshav, plab hnyuv siab raum, ntaub so ntswg, lossis lub hlwb rau kev hloov ntshav tom qab koj tau txais koj txoj kev txhaj tshuaj idecabtagene vicleucel.
• Nug koj tus kws kho mob seb koj puas yuav tsum tau txhaj tshuaj tiv thaiv kab mob. Tsis muaj kev txhaj tshuaj yam tsis tau tham nrog koj tus kws kho mob rau tsawg kawg 6 lub lis piam ua ntej pib siv tshuaj, thaum lub sijhawm koj siv tshuaj kho mob idecabtagene vicleucel, thiab txog thaum koj tus kws kho mob qhia koj tias koj lub cev tau zoo lawm.

Yog tias koj tsis tau mus ntsib raws li tau teem tseg, koj yuav tsum hu rau koj tus kws kho mob thiab lub chaw khaws khoom sai sai. Yog tias koj plam lub sijhawm teem sijhawm kom tau txais koj cov koob tshuaj idecabtagene vicleucel, koj yuav tsum hu rau koj tus kws kho mob tam sim ntawd.

Idecabtagene vicleucel tuaj yeem ua phiv phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• cem quav
• poob phaus
• tsis qab los noj mov
• qhov ncauj mob
• qhov ncauj qhuav
• qhov muag qhuav

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

• tsis tso zis ntau zaus lossis ntau npaum li cas
• o ntawm lub qhov muag, ntsej muag, daim di ncauj, tus nplaig, caj pas, caj npab, tes, taw, pob taws, lossis ceg qis
• teeb meem nqos
• ua pob
• khaus
• khaus

Cov tshuaj Idecabtagene vicleucel yuav ua rau koj muaj feem ntau mob qog noj ntshav. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev tau txais cov tshuaj no.

Cov tshuaj Idecabtagene vicleucel tuaj yeem ua rau muaj kev phiv ntxiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum tau txais cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws tag nrho cov kev teem caij ntsib nrog koj tus kws kho mob, chav tsev khaws cia ntawm tes, thiab chaw kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim ua ntej, thaum, thiab tom qab koj txoj kev kho mob kuaj koj lub cev teb rau idecabtagene vicleucel txhaj.

Ua ntej muaj kev sim ntsuas, qhia rau koj tus kws kho mob thiab cov neeg ua haujlwm hauv chaw kuaj pom tias koj tau txais tshuaj idecabtagene vicleucel. Cov tshuaj no yuav cuam tshuam rau qee yam kev sim hauv tsev sim.

Nug koj tus kws muag tshuaj yog muaj lus nug dab tsi uas koj muaj txog kev txhaj tshuaj idecabtagene vicleucel.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Abecma^®