Tus Thawj Cobic

Zoo Siab

• Ua ntej noj cov cobicistat,
• Cobicistat tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias qhov tsos mob no hnyav lossis tsis ploj:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

Cobicistat yog siv los ua kom ntau dua ntawm atazanavir (Reyataz, hauv Evotaz) hauv cov neeg laus thiab menyuam yaus yam tsawg li 77 phaus (35 kg) lossis darunavir (Prezista, hauv Prezcobix) rau cov neeg laus thiab menyuam yaus yam tsawg li 88 phaus (40 kg) hauv cov ntshav thaum cov tshuaj no yog siv los kho tib neeg cov tshuaj tiv thaiv kab mob HIV (HIV). Cobicistat nyob hauv chav kawm ntawm cov tshuaj hu ua cytochrome P450 3A (CYP3A) inhibitors. Nws ua haujlwm los ntawm kev nce ntawm atazanavir lossis darunavir hauv lub cev kom lawv tuaj yeem muaj cov nyhuv loj dua.

Cobicistat los ua ib ntsiav tshuaj los noj ntawm qhov ncauj. Nws feem ntau tau noj nrog zaub mov ib hnub ib zaug nrog rau atazanavir lossis darunavir. Noj cov cobicistat nrog atazanavir lossis darunavir nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj cov cobicistat raws nraim li cov lus qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nws yog ib qho tseem ceeb uas yuav tsum tau noj cobicistat tib lub sijhawm ntawm atazanavir lossis darunavir.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj cov cobicistat,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj ua xua rau cobicistat, lwm yam tshuaj noj, lossis lwm yam tshuaj hauv cov ntsiav tshuaj cobicistat. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
• qhia rau koj tus kws kho mob yog tias koj noj ib qho tshuaj hauv qab no: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid) (tsis muaj nyob hauv Asmeskas); colchicine (Colcrys, Mitigare, hauv Col-Probenecid); dronedarone (Multaq); cov tshuaj ergot xws li dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, hauv Cafergot, hauv Migergot), thiab methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Versed) los ntawm qhov ncauj; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); phom phom (Rimactane, Rifadin, hauv Rifamate, hauv Rifater); sildenafil (tsuas yog Revatio hom siv rau mob ntsws); simvastatin (Flolipid, Zocor); St. John lub wort; lossis triazolam (Halcion). Yog tias koj noj atazanavir nrog rau cov cobicistat, qhia rau koj tus kws kho mob yog tias koj noj tshuaj drospirenone thiab ethinyl estradiol (qee qhov ncauj qhov ncauj tsis zoo xws li Beyaz, Safyral, Yasmin, Yaz, lwm tus); indinavir (Crixivan), irinotecan (Camptosar), lossis nevirapine (Viramune). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj cov tshuaj cobicistat yog tias koj noj ib qho tshuaj no.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: anticoagulants ('ntshav thinners') xws li apixaban (Eliquis), betrixaban (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban (Xarelto), thiab warfarin (Coumadin, Jantoven) ; cov tshuaj antiplatelet xws li clopidogrel (Plavix) thiab ticagrelor (Brilinta); atorvastatin (Lipitor, hauv Caduet); benzodiazepines xws li diazepam (Valium), estazolam, midazolam muab rau cov leeg (rau hauv cov leeg ntshav), thiab zolpidem (Ambien, Edluar, Intermezzo); beta blockers xws li carvedilol (Coreg), metoprolol (Lopressor), thiab timolol; boceprevir (Victrelis) (tsis muaj nyob hauv Asmeskas); bosentan (Tracleer); buprenorphine (Belbuca, Butrans, Probuphine); buprenorphine thiab naloxone (Suboxone, Zubsolv); buspirone; calcium channel blockers xws li amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, lwm tus), felodipine, nifedipine (Adalat, Afeditab, Procardia), thiab verapamil (Calan, Verelan, lwm tus); clarithromycin (Biaxin, hauv PrevPac); corticosteroids xws li beclomethasone (Beconase AQ), budesonide (Rhinocort Aqua), ciclesonide (Omnaris), dexamethasone (Decadron), fluticasone (Flonase, Flovent), methylprednisolone (Medrol), momentasone (Flonase), thiab triamcinolone (Medon); dasatinib (Sprycel); efavirenz (Sustiva, hauv Atripla); erythromycin (E.E.S, Erytab, lwm tus); etravirine (Intelence); fentanyl (Abstral, Actiq, Fentora, lwm tus); itraconazole (Onmel, Sporanox); ketoconazole; cov tshuaj rau kev nyuaj siab xws li amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), thiab trazodone; cov tshuaj noj rau lub plawv dhia tsis xwm yeem xws li amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), thiab quinidine (hauv Nuedexta); tshuaj rau qaug dab peg xws li clonazepam (Klonopin), eslicarbazepine (Aptiom), thiab oxcarbazepine (Trileptal); cov tshuaj uas ua rau lub cev tiv thaiv tsis muaj zog xws li cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), thiab tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (hauv Kaletra); maraviroc (Selzentry); tshuaj txiav yeeb (Dolophine, Methadose); nilotinib (Tasigna); qhov ncauj tiv thaiv tsis tau noj (tshuaj txwv); perphenazine; qee yam phosphodiesterase (PDE5) inhibitors xws li avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), thiab vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); ritonavir (Norvir, hauv Kaletra); rivaroxaban (Xarelto); rosuvastatin; salmeterol (Serevent, hauv Advair); simeprevir (Olysio); telaprevir (Incivek) (tsis muaj nyob hauv Asmeskas); telithromycin (Ketek); tenofovir (Viread, hauv Atripla, Complera, Truvada, lwm tus), thioridazine; tramadol (Conzip, Ultram, hauv Ultracet); vinblastine; vincristine (Marqibo Cov Khoom Siv); thiab voriconazole (Vfend). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj yuav tuaj yeem cuam tshuam nrog cobicistat yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj noj, txawm tias tsis tshwm nyob hauv daim ntawv no.
• yog tias koj tab tom noj cov cobicistat nrog atazanavir thiab koj tseem noj tshuaj antacids (Maalox, Mylanta, Tums, lwm tus), coj lawv 2 teev ua ntej lossis 2 teev tom qab cobicistat thiab atazanavir.
• yog tias koj noj cov tshuaj cobicistat nrog atazanavir thiab koj tseem tab tom noj tshuaj rau kem plab, kub siab, lossis mob rau sab hauv (H₂ blockers) xws li cimetidine, famotidine (Pepcid, hauv Vimxis), nizatidine (Axid), lossis ranitidine (Zantac), coj lawv tib lub sijhawm lossis tsawg kawg 10 teev tom qab noj H₂ blocker.
• yog tias koj noj cov tshuaj cobicistat nrog atazanavir thiab koj tseem tab tom noj tshuaj rau kem plab, kub siab, lossis mob rau sab hauv (proton twj tso kua mis inhibitors) xws li esomeprazole (Nexium, hauv Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, hauv Zegerid), pantoprazole (Protonix), lossis rabeprazole (AcipHex) coj lawv tsawg kawg 12 teev tom qab siv cov tshuaj tiv thaiv proton twj tso kua mis.
• qhia rau koj tus kws kho mob yog tias koj tau lossis tau muaj mob raum lossis mob siab.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj cov tshuaj cobicistat, hu rau koj tus kws kho mob. Koj yuav tsum tsis txhob pub niam mis yog tias koj kis nrog HIV lossis yog tias koj noj cov cobicistat.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Yog tias koj cov tshuaj ntxiv tom qab 12 teev lossis tshaj saud, noj cov koob tshuaj uas ploj lawm thaum koj nco qab. Txawm li cas los xij, yog tias qhov koob tshuaj ntxiv yuav raug noj tsawg dua 12 teev, hla cov koob tshuaj uas tsis nco qab thiab txuas ntxiv rau koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Cobicistat tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias qhov tsos mob no hnyav lossis tsis ploj:

• xeev siab

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

• daj ntawm daim tawv nqaij lossis qhov muag
• ua pob
• tsis tso zis tsawg

Cobicistat tuaj yeem ua lwm cov kev phiv tshuaj. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim ua ntej thiab thaum kho koj lub cev kom kuaj xyuas koj lub cev cov lus teb rau cobicistat.

Khaws tshuaj muab tshuaj noj ntawm tes. Tsis txhob tos kom txog thaum koj khiav tawm ntawm cov tshuaj rau koj cov tshuaj noj.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Thabost^®

• Evotaz^® (muaj Atazanavir, Cobicistat)
• Prezcobix^® (muaj cov Cobicistat, Darunavir)