Venetoclax

Zoo Siab

• Ua ntej noj venetoclax,
• Venetoclax yuav ua rau muaj kev phiv tshuaj. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv TSHWJ XEEB PRECAUTIONS, hu rau koj tus kws kho mob tam sim ntawd:

Venetoclax tsuas yog siv ib leeg lossis ua ke nrog obinutuzumab (Gazyva) lossis rituximab (Rituxan) txhawm rau kho qee yam mob lymphocytic rau cov ntshav (CLL; ib hom mob qog ntshav uas pib hauv cov qe ntshav dawb) lossis qee yam mob me lymphocytic lymphoma (SLL); ib hom mob cancer uas feem ntau pib ua rau cov qog ntshav). Nws kuj tseem siv nrog kev sib xyaw nrog azacitidine (Vidaza), decitabine (Dacogen), lossis cytarabine yog thawj txoj kev kho mob rau tus mob myeloid leukemia (AML; ib hom mob cancer uas pib hauv cov qe ntshav dawb) hauv cov neeg 75 xyoo lossis laus dua, lossis rau cov neeg laus uas muaj mob kho mob uas tiv thaiv lawv los ntawm lwm txoj kev siv tshuaj kho mob. Venetoclax yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua B-cell lymphoma-2 (BCL-2) inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm qee yam protein nyob rau hauv lub cev uas pab cov kabmob kheesxaws muaj sia nyob. Qhov no pab tua neeg mob hlwb.

Venetoclax los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau yog noj nrog zaub mov thiab dej ib hnub. Siv venetoclax ncig ntawm tib lub sijhawm txhua txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj venetoclax raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov ntsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv.

Yog tias koj ntuav tom qab noj venetoclax, tsis txhob rov qab noj dua. Ua koj cov tshuaj noj tas li.

Koj tus kws kho mob tej zaum yuav pib koj noj qis dua venetoclax thiab maj mam nce koj cov koob tshuaj, tsis pub ntau tshaj ib zaug nyob rau thawj tsib lub lis piam yog tias koj raug kho rau CLL lossis SLL, thiab ib hnub ib zaug rau thawj 3 lossis 4 hnub. yog tias koj raug mus kho rau AML.

Koj tus kws khomob yuav tsum cuam tshuam lossis tso tseg kev kho mob yog tias koj muaj qee yam kev mob tshwm sim. Nco ntsoov qhia koj tus kws kho mob seb koj xav li cas thaum kho koj nrog venetoclax. Rau qee yam mob tshwm sim, koj tus kws kho mob yuav qhia koj kom pib noj venetoclax ntawm koob tshuaj qis dua.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (Phau Ntawv Qhia Tshuaj Kho Mob) thaum koj pib kho nrog venetoclax thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj venetoclax,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau venetoclax, lwm yam tshuaj, lossis lwm yam tshuaj hauv cov tshuaj venetoclax. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• qhia rau koj tus kws kho mob yog tias koj noj clarithromycin, conivaptan (Vaprisol), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (hauv Kaletra), posaconazole (Noxafil), ritonavir (Norvir, hauv Kaletra, Technivie ), lossis voriconazole (Vfend). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj venetoclax yog tias koj noj ib lossis ntau dua ntawm cov tshuaj no.
• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob sau tseg thiab cov ntawv yuav tshuaj, cov vitamins thiab zaub mov zoo uas koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog qee yam ntawm cov hauv qab no: amiodarone (Nexterone, Pacerone), bosentan (Tracleer), captopril, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), carvedilol (Coreg), ciprofloxacin (Cipro), cyclosporine (Gipro) Neoral, Sandimmune), digoxin (Lanoxin), diltiazem (Cardizem, Cartia XT, Diltzac, Taztia, Tiazac), dronedarone (Multaq), efavirenz (Sustiva, hauv Atripla), erythromycin (EES, Eryc, Eryped, Ery-tab, ), etravirine (Intelence), everolimus (Afinitor, Zortress), felodipine, fluconazole (Diflucan), modafinil (Nuvigil, Provigil), nafcillin (Nallpen), phenytoin (Dilantin, Phenytek), quinidine (hauv Nuedeazine) , rifampin (Rifadin, Rimactane, hauv Rifamate, Rifater), sirolimus (Rapamune), ticagrelor (Brilinta), verapamil (Calan, Verelan, hauv Tarka), lossis warfarin (Coumadin, Jantoven). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj noj kuj tuaj yeem cuam tshuam nrog venetoclax, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog quercetin lossis St. John's wort.
• qhia rau koj tus kws kho mob yog tias koj muaj lossis tau muaj teeb meem ntau dua txog koj qib potassium, phosphorus, lossis calcium hauv koj cov ntshav; theem siab ntawm uric acid hauv koj cov ntshav; gout (ib hom mob los ntawm mob los ntawm cov khoom siv dag siv hauv cov pob qij txha); lossis lub raum lossis mob rau daim siab.
• qhia rau koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub. Yog tias koj tuaj yeem cev xeeb tub, koj yuav tsum tau kuaj cev xeeb tub ua ntej pib kho nrog venetoclax. Koj yuav tsum tsis txhob xeeb tub hauv lub sijhawm kho koj tus kheej thiab 30 hnub tom qab koj tau txais tshuaj zaum kawg. Tham nrog koj tus kws kho mob txog cov hau kev tswj kev xeeb menyuam uas koj tuaj yeem siv thaum kho koj. Yog tias koj xeeb tub thaum noj cov tshuaj venetoclax, hu rau koj tus kws kho mob.
• qhia rau koj tus kws kho mob yog tias koj pub mis niam rau menyuam. Tsis txhob pub mis niam thaum tab tom noj venetoclax thiab rau 1 lub lis piam tom qab koj koob kawg.
• koj yuav tsum paub tias cov tshuaj no tuaj yeem txo qis kev muaj menyuam hauv cov txiv neej. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev noj venetoclax.
• tsis muaj kev txhaj tshuaj ua ntej, thaum, lossis tom qab kho nrog venetoclax yam tsis tham nrog koj tus kws kho mob.
• koj yuav tsum paub tias koj yuav muaj kev mob qog mob syys (TLS; ib qho mob tshwm sim los ntawm kev rhuav tshem cov qog nqaij hlav sai uas tuaj yeem ua rau lub raum tsis ua haujlwm thiab lwm yam kev cuam tshuam) thaum kho koj nrog venetoclax. Qhov no feem ntau yuav tshwm sim thaum koj pib kho mob, thiab txhua zaus koj cov koob tshuaj tau nce ntxiv. Txhawm rau pab txo koj txoj kev pheej hmoo ntsib TLS koj yuav tsum haus dej tsawg kawg 6 txog 8 khob (48 txog 64 ooj) ib hnub rau 2 hnub ua ntej thiab hnub koj txhaj thawj koob, thiab txhua zaus koj cov koob tshuaj tau nce ntxiv. Ntxiv rau koj tus kws kho mob yuav muab cov tshuaj rau koj noj ua ntej pib thiab thaum kho koj kom pab tiv thaiv cov kev mob tshwm sim no. Yog tias koj muaj cov tsos mob hauv qab no ntawm TLS hu rau koj tus kws kho mob tam sim ntawd: kub ib ce, ua daus no, xeev ntuav, ntuav, tsis meej pem, ua pa luv, qaug dab peg, lub plawv dhia tsis txaus, tsaus nti lossis pos huab, nkees txawv txav, lossis mob leeg lossis mob pob txha.

Tsis txhob noj txiv kab ntxwv qaub, txiv kab ntxwv qaub, lossis txiv kab ntxwv Seville (qee zaum siv hauv marmalades), lossis haus kua txiv txiv kab ntxwv thaum noj cov tshuaj no.

Yog tias koj nco qab cov koob tshuaj ploj hauv lub sijhawm 8 teev ntawm lub sijhawm koj tau teem sijhawm los noj nws, noj qhov tshuaj ploj tam sim ntawd. Txawm li cas los xij, yog tias ntau dua 8 teev tau dhau mus txij li lub sijhawm koj feem ntau noj venetoclax, hla cov koob tshuaj uas tsis nco qab thiab ua ntxiv rau koj cov sijhawm noj tshuaj tas li. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Yog tias koj tsis tuaj noj tshuaj venetoclax ntau dua 7 hnub, koj yuav tsum hu rau koj tus kws kho mob ua ntej noj ib qho tshuaj ntxiv. Koj tus kws kho mob yuav xav rov pib noj koj cov tshuaj kom tsawg dua.

Venetoclax yuav ua rau muaj kev phiv tshuaj. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• zawv plab
• cem quav
• xeev siab
• ntuav
• tsis qab los
• nkees heev
• o koj ob sab caj npab lossis tes
• rov qab mob
• pob txha, leeg, lossis mob pob qij txha
• mob plab
• o los yog mob nyob rau hauv lub qhov ncauj
• qhov ncauj los yog caj pas mob
• mob taub hau
• los ntswg lossis txhaws ntswg, hnoos
• txog siav
• kiv taub hau
• ua pob
• teeb meem tsis tsaug zog los yog pw tsaug zog

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv TSHWJ XEEB PRECAUTIONS, hu rau koj tus kws kho mob tam sim ntawd:

• kub ib leeg los yog nrog rau mob caj pas, hnoos, ua daus no, sov, liab, mob los yog o ntawm daim tawv nqaij, tso zis sai, nquag, lossis mob heev, thiab lwm yam cim ntawm tus kab mob
• tsis tso zis tsawg
• o ntawm koj txhais ceg, pob taws, lossis ko taw
• muaj ntshav txawv lossis doog ntshav lossis doog ntshav
• tawv nqaij daj ntseg, ua tsis taus pa, kiv taub hau, nkees heev, lub plawv dhia ceev

Venetoclax yuav muaj lwm cov kev phiv lwm yam. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Ua tsis tau hloov cov tshuaj rau ib lub thauv sib txawv. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim ua ntej thiab thaum kho koj lub cev kom kuaj xyuas koj lub cev cov lus teb rau venetoclax.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

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