Ibrutinib

Zoo Siab

• Ibrutinib yog siv:
• Ua ntej noj ibrutinib,
• Ibrutinib tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

Ibrutinib yog siv:

• los kho cov neeg mob mantle cell lymphoma (MCL; mob qog nqaij hlav loj sai uas pib hauv cov kab mob hauv lub nruab nrog cev) uas twb tau kho mob tsawg kawg yog ib lwm txoj kev kho mob rau tshuaj,
• los kho cov neeg mob qog ntshav qog ntshav ntshav (CLL; ib hom mob cancer uas pib hauv cov qe ntshav dawb) thiab cov qog ntshav lymphocytic me me (SLL; ib hom mob cancer uas feem ntau pib qog ua kua)
• txhawm rau kho cov neeg mob Waldenstrom's macroglobulinemia (WM; mob qog qeeb qeeb uas pib muaj qee cov qe ntshav dawb hauv koj cov pob txha pob txha),
• kho mob rau cov neeg muaj qhov mob ua rau mob qog ua kua hlav (MZL; tus kabmob qeeb zuj zus uas pib ntawm cov qe ntshav dawb uas feem ntau sib ntaus sib tua mob) uas twb tau kho qee yam tshuaj khomob,
• thiab kho cov neeg muaj mob qog ntshav nrog tus neeg mob hlwb (cGVHD; ib qho kev hloov ntawm txoj kev hloov cov ntshav-qia-hlwb hloov [HSCT; tus txheej txheem uas hloov cov hlwb pob txha uas muaj mob hlwb pob txha zoo] uas yuav pib ib pliag tom qab hloov pauv thiab kav ntev heev ) tomqab siv tsis tiav nrog 1 lossis ntau yam tshuaj kho.

Ibrutinib nyob hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus ntseeg uas ua teeb liab rau cov cell mob qog hlav. Qhov no yuav pab kom tsis txhob kis mob hlwb.

Ibrutinib los ua tshuaj ntsiav thiab lub ntsiav tshuaj los noj ntawm qhov ncauj. Feem ntau nws tau noj ib hnub ib zaug. Siv ibrutinib nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj ibrutinib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov tsiav tshuaj tag nrho nrog ib khob dej; tsis txhob qhib, tawg, lossis zom lawv. Nqos cov ntsiav tshuaj tag nrho nrog ib khob dej; tsis txhob txiav, tsoo lossis ntxo lawv.

Yog tias koj tau txhaj tshuaj obinutuzumab (Gazyva) kev txhaj tshuaj lossis rituximab (Rituxan) kev txhaj tshuaj, koj tus kws kho mob yuav qhia koj kom noj koj cov tshuaj imbrutinib ua ntej koj txhaj tshuaj.

Koj tus kws kho mob tuaj yeem txo koj cov koob tshuaj, lossis cuam tshuam lossis tsum tsis ua ntxiv lawm. Qhov no nws nyob ntawm seb cov tshuaj ua hauj lwm zoo npaum li cas rau koj thiab kev phiv uas koj ntsib. Tham nrog koj tus kws kho mob txog saib koj xav li cas thaum kho koj tus mob. Kav tsij noj ibrutinib ib zaug txawm hais tias koj tus kheej zoo. Tsis txhob tsum noj ibrutinib yam tsis tham nrog koj tus kws kho mob.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj ibrutinib,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau ibrutinib, lwm yam tshuaj, lossis lwm yam tshuaj hauv ibrutinib tsiav tshuaj lossis ntsiav tshuaj. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: anticoagulants ('ntshav thinners') xws li warfarin (Coumadin, Jantoven); antifungals xws li fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), thiab voriconazole (Vfend); tshuaj antiplatelet xws li clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), thiab ticlopidine; aprepitant (Hloov Kho); carbamazepine (Carbatrol, Epitol, Tegretol, Teril); clarithromycin (Biaxin, Prevpac), digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, lwm tus); erythromycin (EES, Erythrocin, lwm tus), qee cov tshuaj los kho tib neeg cov tshuaj tiv thaiv kab mob (HIV) lossis tau txais tshuaj tiv thaiv kab mob (AIDS) xws li efavirenz (Sustiva, hauv Atripla), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, hauv Kaletra), thiab saquinavir (Invirase); methotrexate (Otrexup, Rasuvo, Trexall, Xatmep); nefazodone; phenytoin (Dilantin, Phenytek); phom phom (Rifadin, Rifamate, Rimactane, lwm tus); verapamil (Calan, Covera, hauv Tarka, lwm tus); thiab telithromycin (tsis muaj nyob hauv Tebchaws Meskas; Ketek). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John's Wort.
• qhia rau koj tus kws kho mob yog tias koj muaj mob lossis nyuam qhuav raug phais. Kuj qhia koj tus kws kho mob yog tias koj haus luam yeeb lossis koj tau muaj lossis muaj ntshav qab zib tsis txaus, lub plawv dhia tsis xwm yeem, ntshav siab (ntshav siab), cov roj (cholesterol), teeb meem los ntshav, lossis lub plawv, raum, lossis mob siab.
• qhia rau koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, pub mis niam, lossis yog koj npaj yuav muaj menyuam. Koj yuav tsum tsis txhob cev xeeb tub thaum koj noj ibrutinib. Yog tias koj yog poj niam, koj yuav tsum tau mus kuaj cev xeeb tub ua ntej koj pib kho thiab yuav tsum siv kev tswj tsis pub muaj menyuam kom tiv thaiv kev xeeb tub lub sijhawm koj kho nrog ibrutinib thiab tom qab 1 hlis tom qab koj tsum tsis noj cov tshuaj. Yog tias koj yog txiv neej, koj thiab koj tus poj niam tus khub yuav tsum siv tshuaj tswj kom tsis txhob muaj menyuam thaum lub sijhawm koj kho nrog ibrutinib thiab txuas ntxiv li 1 hlis tom qab koj koob kawg. Yog tias koj lossis koj tus khub xeeb tub thaum tab tom noj ibrutinib, hu rau koj tus kws kho mob tam sim ntawd. Ibrutinib tuaj yeem ua rau me nyuam muaj mob.
• yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav tias koj noj ibrutinib. Koj tus kws kho mob yuav qhia koj kom tsis txhob noj ibrutinib 3 txog 7 hnub ua ntej kev phais mob lossis txheej txheem.

Tsis txhob noj txiv kab ntxwv qaub lossis txiv kab ntxwv Seville (qee zaum siv hauv marmalades), lossis haus kua txiv txiv kab ntxwv thaum noj cov tshuaj no.

Nco ntsoov tias koj haus dej ntau lossis lwm yam dej txhua hnub thaum koj tseem noj ibrutinib.

Noj cov tshuaj uas ploj lawm kom sai li sai tau thaum koj nco txog nws hnub ntawd. Txawm li cas los xij, yog tias koj tsis nco qab txog hnub tom qab, hla qhov tsis nco qab lub sijhawm thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Ibrutinib tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• zawv plab
• xeev siab
• cem quav
• ntuav
• mob plab
• Lub siab ua haujlwm lossis kem plab
• tsis qab los
• nkees dhau heev lawm lossis tsis muaj zog
• leeg, pob txha, thiab mob pob qij txha
• mob leeg pob txha
• o ntawm tes, taw, pob taws, lossis ceg qis
• ua pob
• khaus
• cov qhov ncauj tawm hauv qhov ncauj thiab caj pas
• ntxhov siab
• teeb meem tsis tsaug zog los yog pw tsaug zog
• hnoos, los ntswg lossis txhaws ntswg
• qhov muag plooj
• qhov muag qhuav lossis watery
• qhov muag daj

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

• o ntawm lub ntsej muag, lub caj pas, tus nplaig, daim di ncauj, thiab qhov muag
• teeb meem nqos lossis ua pa
• khaus
• doog ntshav los ntshav tsis txawv
• liab, xim liab, lossis tso zis tsaus xim av
• los ntshav lossis dub, quav ua quav
• los ntswg los ntshav
• ntshav ntuav; lossis ntuav ntshav lossis tawv nqaij daj uas zoo li thaj chaw kas fes
• qaug dab peg
• lub plawv dhia ceev lossis ceev
• txog siav
• lub hauv siab tsis xis nyob
• kiv taub hau, ntaj pom kev lossis tsaus muag
• kev pom kev hloov
• mob taub hau (uas kav sijhawm ntev)
• kub taub hau, ua daus no, hnoos, liab, tawv nqaij sov, lossis lwm yam cim ntawm tus kab mob
• tsis meej pem
• hloov hauv koj hais lus
• tsis tso zis tsawg
• mob, nquag, los sis ceev tso zis

Ibrutinib tuaj yeem ua kom koj pheej hmoo ntawm kev mob qee yam mob cancer nrog rau mob cancer ntawm daim tawv lossis lwm yam hauv nrog cev. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev noj ibrutinib.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm lub teeb, tshaj cua sov thiab noo noo tsis nyob hauv chav dej.

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws khomob yuav xaj kuaj qee yam kev kuaj ntshav thiab kuaj xyuas koj cov ntshav siab txhawm rau soj koj lub cev cov lus teb rau ibrutinib.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Imbruvica^®