Prothrombin tsis muaj peev xwm

Prothrombin deficiency yog qhov tsis txaus ntseeg los ntawm qhov tsis muaj protein nyob hauv cov ntshav hu ua prothrombin. Nws ua rau cov teeb meem ntshav txhaws (coagulation). Prothrombin kuj tseem hu ua yam II (qhov ob).

Thaum koj los ntshav, muaj kev tshua tshwm sim hauv lub cev uas pab ua rau cov ntshav txhaws. Tus txheej txheem no yog hu ua coagulation cascade. Nws koom nrog cov protein tshwj xeeb hu ua coagulation, lossis txhaws, lwm yam. Koj yuav muaj feem ntau dua los ntshav ntau dua yog tias ib lossis ntau ntawm cov yam no ploj lossis tsis ua haujlwm zoo li lawv yuav tsum tau.

Prothrombin, los yog yam II, yog ib qhov zoo li no coagulation. Prothrombin tsis muaj peev xwm khiav hauv tsev neeg (tau txais cov roj ntsha) thiab muaj tsawg heev. Ob leeg niam txiv yuav tsum muaj tus gene kis tus kabmob mus rau lawv cov menyuam. Tsev neeg keeb kwm muaj ntshav tsis txaus yuav yog ib qho txaus ntshai.

Prothrombin tsis muaj peev xwm tseem tuaj yeem yog vim muaj lwm yam mob lossis kev siv qee yam tshuaj. Qhov no hu ua nriav kab mob prothrombin tsis txaus. Nws tuaj yeem tshwm sim los ntawm:

• Tsis muaj cov vitamin K (qee tus menyuam yaus yug los ntawm vitamin K tsis txaus)
• Mob rau daim siab hnyav
• Siv cov tshuaj uas tiv thaiv kom tsis txhob txhaws (anticoagulants xws li warfarin)

Cov tsos mob tuaj yeem suav nrog ib qho hauv qab no:

• Los ntshav tsis zoo tom qab yug menyuam
• Tus cev ntas ntshav los ntshav heev
• Los ntshav tom qab phais
• Los ntshav tom qab kev raug mob
• Bruising tau yooj yim
• Looj taub tsis nres yooj yim
• Umbilical qaum los ntshav tom qab yug

Kev ntsuam xyuas uas yuav ua tau muaj xws li:

• Qhov tseeb ua pov thawj II
• Ib nrab thromboplastin lub sijhawm
• Lub sijhawm Prothrombin (PT)
• Kev sib xyaw ua ke kawm (qhov tshwj xeeb PTT sim ua kom paub tseeb tias prothrombin deficiency)

Kev los ntshav tuaj yeem tswj tau los ntawm kev tso ntshav ntshav (IV) txoj kev nqus ntshav los yog cov ntshav txhaws. Yog tias koj tsis muaj cov vitamin K, koj tuaj yeem noj cov vitamin no los ntawm qhov ncauj, los ntawm kev txhaj tshuaj hauv qab daim tawv nqaij, lossis los ntawm txoj hlab ntshav (leeg ntshav).

Yog tias koj muaj cov ntshav tawm tsis zoo no, nco ntsoov:

• Qhia koj cov kws kho mob ua ntej koj muaj cov txheej txheem, suav nrog kev phais thiab kho hniav.
• Qhia rau koj cov neeg hauv tsev neeg vim tias lawv yuav muaj qhov tsis zoo ib yam tab sis tsis paub nws tseem.

Cov peev txheej no tuaj yeem muab cov ntaub ntawv qhia ntxiv ntawm Qhov Tsis Txaus Qhov Ntsuas VII:

• National Hemophilia Foundation: Lwm Yam Qhov Tsis Txaus Ntseeg - www.hemophilia.org/Txoj Cai-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• NIH Chaw Qhia Txog Kab Mob thiab Tsis Muaj Kab Mob - rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency NIH

Qhov tshwm sim tau zoo nrog kev kho mob kom zoo.

Inherited prothrombin deficiency yog lub neej nyob ntev.

Qhov kev cia siab ntawm kev nrhiav kom tau prothrombin deficiency yog nyob ntawm qhov ua rau. Yog tias nws tshwm sim los ntawm daim siab mob, qhov tshwm sim yog los ntawm kev kho koj tus mob siab ua tau zoo npaum li cas. Noj tshuaj vitamin K pab ntxiv yuav kho vitamin K tsis txaus.

Kev los ntshav hauv cov plab hnyuv siab tuaj yeem tshwm sim.

Tau txais kev kho mob sai sai tam sim ntawd yog tias koj tsis tuaj yeem hais txog lossis poob lub sijhawm ntev, lossis yog tias koj tsis tuaj yeem tswj tau qhov los ntshav.

Tsis muaj ib qho kev paub tiv thaiv rau cov muaj keeb prothrombin tsis muaj peev xwm. Thaum tsis muaj vitamin K yog qhov ua rau, siv cov vitamin K yuav pab tau.

Cov Tshuaj Hypoprothrombinemia; Qhov Ntsuas II tsis txaus; Dysprothrombinemia

• Cov ntshav txhaws
• Cov ntshav txhaws

Gailani D, Wheeler AP, Neff AT. Tsis tshua muaj qhov coagulation qhov tsis txaus. Hauv: Hoffman R, Benz EJ, Silberstein LE, li al, eds. Hematology: Qhov Ntsiab Cai thiab Kev Coj UaCov. 7 tus ed. Philadelphia, PA: Elsevier; 2018: chap 137.

Hall JE. Hemostasis thiab coagulation ntshav. Hauv: Hall JE, ed. Guyton thiab Hall Phau Ntawv Qhia Txog Tshuaj Kho MobCov. 13th ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 37.

Ragni MV. Hemorrhagic mob: coagulation yam tsis. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 174.